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The Faculty of Medicine - Biochemistry and Molecular Biology: Yedgar Saul

Researchers

 Last updated September 2024 - Biochemistry and Molecular Biology 

List of Publications

1.            Barshtein, G. et al. Hemoglobin Binding to the Red Blood Cell (RBC) Membrane Is Associated with Decreased Cell Deformability. Int. J. Mol. Sci. 25, (2024).

2.            Barshtein, G. et al. Red Blood Cell Deformability Is Expressed by a Set of Interrelated Membrane Proteins. Int. J. Mol. Sci. 24, (2023).

3.            Yedgar, S., Barshtein, G. & Gural, A. Hemolytic Activity of Nanoparticles as a Marker of Their Hemocompatibility. Micromachines 13, (2022).

4.            Tsohar, T. et al. Double-Facet Effect of Artificial Mechanical Stress on Red Blood Cell Deformability: Implications for Blood Salvage. Appl. Sci. 12, (2022).

5.            Arbell, D., Barshtein, G., Gural, A., Eventov-Friedman, S. & Yedgar, S. Plasma transfusion to premature newborns as a risk factor of necrotizing enterocolitis development: Proposed mechanism. Transfusion 62, 1310–1311 (2022).

6.            Barshtein, G., Zelig, O., Gural, A., Arbell, D. & Yedgar, S. Determination of red blood cell adhesion to vascular endothelial cells: A critical role for blood plasma. Colloids Surfaces B Biointerfaces 210, (2022).

7.            Arbell, D. et al. Deformability of cord blood vs. newborns’ red blood cells: implication for blood transfusion. J. Matern. Neonatal Med. 35, 3270–3275 (2022).

8.            Barshtein, G., Rasmusen, T. L., Zelig, O., Arbell, D. & Yedgar, S. Inter-donor variability in deformability of red blood cells in blood units. Transfus. Med. 30, 492–496 (2020).

9.            Barshtein, G., Gural, A., Zelig, O., Arbell, D. & Yedgar, S. Unit-to-unit variability in the deformability of red blood cells. Transfus. Apher. Sci. 59, (2020).

10.          McVey, M. J. et al. Reduced deformability of stored red blood cells is associated with generation of extracellular vesicles. Transfus. Apher. Sci. 59, (2020).

11.          Koshkaryev, A. et al. Non-oxidative band-3 clustering agents cause the externalization of phosphatidylserine on erythrocyte surfaces by a calcium-independent mechanism. Biochim. Biophys. Acta - Biomembr. 1862, (2020).

12.          Barshtein, G., Gural, A., Zelig, O., Arbell, D. & Yedgar, S. Preparation of packed red blood cell units in the blood bank: Alteration in red blood cell deformability. Transfus. Apher. Sci. 59, (2020).

13.          Biran, R. et al. Phototherapy decreases red blood cell deformability in patients with psoriasis. Clin. Hemorheol. Microcirc. 73, 489–496 (2020).

14.          Yedgar, S., Arbell, D. & Barshtein, G. Hemodynamic Functionality of Stored Red Blood Cells: An Important Metric of Blood Unit Quality. Ann. Thorac. Surg. 108, 1587–1588 (2019).

15.          Arbell, D. et al. Risk of red cell exposure to the water anomaly upon blood unit cold-storage. Am. J. Hematol. 93, E397–E398 (2018).

16.          Barshtein, G., Arbell, D. & Yedgar, S. Hemodynamic functionality of transfused red blood cells in the microcirculation of blood recipients. Front. Physiol. 9, (2018).

17.          Barshtein, G. et al. Deformability of transfused red blood cells is a potent effector of transfusion-induced hemoglobin increment: A study with β-thalassemia major patients. Am. J. Hematol. 92, E559–E560 (2017).

18.          David, M. et al. The dielectric spectroscopy of human red blood cells: The differentiation of old from fresh cells. Physiol. Meas. 38, 1335–1348 (2017).

19.          Orbach, A., Zelig, O., Yedgar, S. & Barshtein, G. Biophysical and Biochemical Markers of Red Blood Cell Fragility. Transfus. Med. Hemotherapy 44, 183–187 (2017).

20.          Levy, E. et al. Dielectric Response of Cytoplasmic Water and Its Connection to the Vitality of Human Red Blood Cells. II. the Influence of Storage. J. Phys. Chem. B 121, 5273–5278 (2017).

21.          Rivkin, N. et al. Erythrocyte survival is controlled by microRNA-142. Haematologica 102, 676–685 (2017).

22.          Harel-Dassa, K., Yedgar, S., Tropé, C. G., Davidson, B. & Reich, R. Phospholipase D messenger RNA expression and clinical role in high-grade serous carcinoma. Hum. Pathol. 62, 115–121 (2017).

23.          Barshtein, G. et al. Deformability of transfused red blood cells is a potent determinant of transfusion-induced change in recipient’s blood flow. Microcirculation 23, 479–486 (2016).

24.          Cahn, A. et al. Diabetic foot disease is associated with reduced erythrocyte deformability. Int. Wound J. 13, 500–504 (2016).

25.          Barshtein, G. et al. Polystyrene Nanoparticles Activate Erythrocyte Aggregation and Adhesion to Endothelial Cells. Cell Biochem. Biophys. 74, 19–27 (2016).

26.          Mruwat, R., Kivity, S., Landsberg, R., Yedgar, S. & Langier, S. Phospholipase A2-dependent release of inflammatory cytokines by superantigen-stimulated nasal polyps of patients with chronic rhinosinusitis. Am. J. Rhinol. Allergy 29, e122–e128 (2015).

27.          Barshtein, G. et al. Storage-induced damage to red blood cell mechanical properties can be only partially reversed by rejuvenation. Transfus. Med. Hemotherapy 41, 197–204 (2014).

28.          Mruwat, R. et al. Phospholipase A2 in experimental allergic bronchitis: A lesson from mouse and rat models. PLoS One 8, (2013).

29.          Mruwat, R., Cohen, Y. & Yedgar, S. Phospholipase A2 inhibition as potential therapy for inflammatory skin diseases. Immunotherapy 5, 315–317 (2013).

30.          Matot, I. et al. Resuscitation with aged blood exacerbates liver injury in a hemorrhagic rat model. Crit. Care Med. 41, 842–849 (2013).

31.          Dan, P., Rosenblat, G. & Yedgar, S. Phospholipase A2 activities in skin physiology and pathology. Eur. J. Pharmacol. 691, 1–8 (2012).

32.          Arbel, Y. et al. Erythrocyte aggregation as a cause of slow flow in patients of acute coronary syndromes. Int. J. Cardiol. 154, 322–327 (2012).

33.          Livshits, L. et al. Effect of short-term hyperglycemia on protein kinase C alpha activation in human erythrocytes. Rev. Diabet. Stud. 9, 94–103 (2012).

34.          Livshits, L. et al. Effect of short-term hyperglycemia on protein kinase C alpha activation in human erythrocytes. Rev. Diabet. Stud. 9, 1–23 (2012).

35.          Otuki, M. F. et al. Attenuation of experimental TPA-induced dermatitis by acetylenic acetogenins is associated with inhibition of PLA 2 activity. Eur. J. Pharmacol. 672, 175–179 (2011).

36.          Barshtein, G., Arbell, D. & Yedgar, S. Hemolytic effect of polymeric nanoparticles: Role of albumin. IEEE Trans. Nanobioscience 10, 259–261 (2011).

37.          Barshtein, G., Manny, N. & Yedgar, S. Circulatory Risk in the Transfusion of Red Blood Cells With Impaired Flow Properties Induced by Storage. Transfus. Med. Rev. 25, 24–35 (2011).

38.          Schlager, A., Zamir, G., Barshtein, G., Yedgar, S. & Arbell, D. Plasma Factor in Red Blood Cells Adhesion to Endothelial Cells: Humans and Rats. Cell Biochem. Biophys. 58, 157–161 (2010).

39.          Koshkaryev, A., Barshtein, G. & Yedgar, S. Vitamin E induces phosphatidylserine externalization and red cell adhesion to endothelial cells. Cell Biochem. Biophys. 56, 109–114 (2010).

40.          Koshkaryev, A., Zelig, O., Manny, N., Yedgar, S. & Barshtein, G. Rejuvenation treatment of stored red blood cells reverses storage-induced adhesion to vascular endothelial cells. Transfusion 49, 2136–2143 (2009).

41.          Maharshak, N. et al. Increased strength of erythrocyte aggregates in blood of patients with inflammatory bowel disease. Inflamm. Bowel Dis. 15, 707–713 (2009).

42.          Yedgar, S., Kaul, D. K. & Barshtein, G. RBC adhesion to vascular endothelial cells: More potent than RBC aggregation in inducing circulatory disorders. Microcirculation 15, 581–583 (2008).

43.          Adar, T. et al. Increased red blood cell aggregation in patients with Gaucher disease is non-inflammatory. Clin. Hemorheol. Microcirc. 40, 113–118 (2008).

44.          Kaul, D. K., Koshkaryev, A., Artmann, G., Barshtein, G. & Yedgar, S. Additive effect of red blood cell rigidity and adherence to endothelial cells in inducing vascular resistance. Am. J. Physiol. - Hear. Circ. Physiol. 295, H1788–H1793 (2008).

45.          Gluck, N., Schwob, O., Krimsky, M. & Yedgar, S. Activation of cytosolic phospholipase A2 and fatty acid transacylase is essential but not sufficient for thrombin-induced smooth muscle cell proliferation. Am. J. Physiol. - Cell Physiol. 294, C1597–C1603 (2008).

46.          Arbell, D., Orkin, B., Bar-Oz, B., Barshtein, G. & Yedgar, S. Premature red blood cells have decreased aggregation and enhanced aggregability. J. Physiol. Sci. 58, 161–165 (2008).

47.          Ramot, Y., Koshkaryev, A., Goldfarb, A., Yedgar, S. & Barshtein, G. Phenylhydrazine as a partial model for β-thalassaemia red blood cell hemodynamic properties. Br. J. Haematol. 140, 692–700 (2008).

48.          Dan, P. et al. Inhibition of type I and type II phospholipase A2 by phosphatidyl-ethanolamine linked to polymeric carriers (Biochemistry (1998) 37, 17, (6199-6204)). Biochemistry 47, 857 (2008).

49.          Relevy, H., Koshkaryev, A., Manny, N., Yedgar, S. & Barshtein, G. Blood banking-induced alteration of red blood cell flow properties. Transfusion 48, 136–146 (2008).

50.          Gorovetz, M., Schwob, O., Krimsky, M., Yedgar, S. & Reich, R. MMP production in human fibrosarcoma cells and their invasiveness are regulated by group IB secretory phospholipase A2 receptor-mediated activation of cytosolic phospholipase A2. Front. Biosci. 13, 1917–1925 (2008).

51.          Yedgar, S., Krimsky, M., Cohen, Y. & Flower, R. J. Treatment of inflammatory diseases by selective eicosanoid inhibition: a double-edged sword? Trends Pharmacol. Sci. 28, 459–464 (2007).

52.          Barshtein, G., Ben-Ami, R. & Yedgar, S. Role of red blood cell flow behavior in hemodynamics and hemostasis. Expert Rev. Cardiovasc. Ther. 5, 743–752 (2007).

53.          Ingber, A., Cohen, Y., Krimsky, M. & Yedgar, S. A novel treatment of contact dermatitis by topical application of phospholipase A2 inhibitor: A double-blind placebo-controlled pilot study. Int. J. Immunopathol. Pharmacol. 20, 191–195 (2007).

54.          Yedgar, S., Cohen, Y. & Shoseyov, D. Control of phospholipase A2 activities for the treatment of inflammatory conditions. Biochim. Biophys. Acta - Mol. Cell Biol. Lipids 1761, 1373–1382 (2006).

55.          Adar, T. et al. Aggregation of red blood cells in patients with Gaucher disease. Br. J. Haematol. 134, 432–437 (2006).

56.          Schechner, V. et al. Plasma dependent reduction in red blood cell aggregation after dextran sulfate low-density lipoprotein apheresis - Implications for rheological studies. Ther. Apher. Dial. 9, 379–384 (2005).

57.          Shoseyov, D. et al. Treatment of ovalbumin-induced experimental allergic bronchitis in rats by inhaled inhibitor of secretory phospholipase A2. Thorax 60, 747–753 (2005).

58.          Nyska, M. et al. Disseminated thrombosis-induced growth plate necrosis in rat: A unique model for growth plate arrest. J. Pediatr. Orthop. 25, 346–350 (2005).

59.          Offer, S. et al. Negative feedback between secretory and cytosolic phospholipase A 2 and their opposing roles in ovalbumin-induced bronchoconstriction in rats. Am. J. Physiol. - Lung Cell. Mol. Physiol. 288, L523–L529 (2005).

60.          Samocha-Bonet, D. et al. Flow-resistant red blood cell aggregation in morbid obesity. Int. J. Obes. 28, 1528–1534 (2004).

61.          Berliner, S. et al. The degree of red blood cell aggregation on peripheral blood glass slides corresponds to inter-erythrocyte cohesive forces in laminar flow. Thromb. Res. 114, 37–44 (2004).

62.          Darville, T. et al. Protection against Chlamydia trachomatis infection in vitro and modulation of inflammatory response in vivo by membrane-bound glycosaminoglycans. Microbes Infect. 6, 369–376 (2004).

63.          Chen, W. et al. Control of angiogenesis by inhibitor of phospholipase A2. Chinese Med. Sci. J. 19, 6–12 (2004).

64.          Shabat, S. et al. Osteonecrosis in a Chemically Induced Rat Model of Human Hemolytic Disorders Associated with Thrombosis - A New Model for Avascular Necrosis of Bone. Calcif. Tissue Int. 74, 220–228 (2004).

65.          Barshtein, G. et al. Aggregability of red blood cells of schizophrenia patients with negative syndrome is selectively enhanced. Schizophr. Bull. 30, 913–922 (2004).

66.          Pinto, F., Brenner, T., Dan, P., Krimsky, M. & Yedgar, S. Extracellular Phospholipase A2 Inhibitors Suppress Central Nervous System Inflammation. Glia 44, 275–282 (2003).

67.          Koshkaryev, A., Yedgar, S., Relevy, H., Fibach, E. & Barshtein, G. Acridine orange induces translocation of phosphatidylserine to red blood cell surface. Am. J. Physiol. - Cell Physiol. 285, C720–C722 (2003).

68.          Krimsky, M. et al. Amelioration of TNBS-induced colon inflammation in rats by phospholipase A2 inhibitor. Am. J. Physiol. - Gastrointest. Liver Physiol. 285, G586–G592 (2003).

69.          Koshkaryev, A. et al. 2-Butoxyethanol enhances the adherence of red blood cells. Arch. Toxicol. 77, 465–469 (2003).

70.          Beck, G. C. et al. Amelioration of endotoxin-induced sepsis in rats by membrane anchored lipid conjugates. Crit. Care Med. 31, 2015–2021 (2003).

71.          Nyska, A. et al. Ocular expression of vascular cell adhesion molecule (VCAM-1) in 2-butoxyethanol-induced hemolysis and thrombosis in female rats. Exp. Toxicol. Pathol. 55, 231–236 (2003).

72.          Ben-Ami, R. et al. A synergistic effect of albumin and fibrinogen on immunoglobulin-induced red blood cell aggregation. Am. J. Physiol. - Hear. Circ. Physiol. 285, H2663–H2669 (2003).

73.          Yedgar, S., Krimsky, M. & Schwob, O. Protection of cell membrane from exogenous PLA2 and related inflammatory stimuli by membrane-anchored lipid conjugates. Advances in Experimental Medicine and Biology vol. 525 97–101 (2003).

74.          Gamzu, R. et al. Pregnancy-induced hypertension is associated with elevation of aggregability of red blood cells. Clin. Hemorheol. Microcirc. 27, 163–169 (2002).

75.          Yedgar, S., Koshkaryev, A. & Barshtein, G. The red blood cell in vascular occlusion. Pathophysiol. Haemost. Thromb. 32, 263–268 (2002).

76.          Ezov, N. et al. A chemically induced rat model of hemolysis with disseminated thrombosis. Cardiovasc. Toxicol. 2, 181–193 (2002).

77.          Beck, G. C. et al. Inhibition of LPS-induced chemokine production in human lung endothelial cells by lipid conjugates anchored to the membrane. Br. J. Pharmacol. 135, 1665–1674 (2002).

78.          Chen, W. M., Soria, J., Soria, C., Krimsky, M. & Yedgar, S. Control of capillary formation by membrane-anchored extracellular inhibitor of phospholipase A2. FEBS Lett. 522, 113–118 (2002).

79.          Yard, B. A. et al. Modulation of IFN-γ-induced immunogenicity by phosphatidylethanolamine-linked hyaluronic acid. Transplantation 73, 984–992 (2002).

80.          Ben-Ami, R. et al. Thrombolytic therapy reduces red blood cell aggregation in plasma without affecting intrinsic aggregability. Thromb. Res. 105, 487–492 (2002).

81.          Ginsburg, I., Sadovnic, M., Yedgar, S., Kohen, R. & Hrbac, J. Hemolysis of human erythrocytes by hypochlorous acid is modulated by amino acids, antioxidants, oxidants, membrane-perforating agents and by divalent metals. Free Radic. Res. 36, 607–619 (2002).

82.          Ponizovsky, A. M. et al. Phospholipid patterns of erythrocytes in schizophrenia: Relationships to symptomatology. Schizophr. Res. 52, 121–126 (2001).

83.          Ami, R. B. et al. Parameters of red blood cell aggregation as correlates of the inflammatory state. Am. J. Physiol. - Hear. Circ. Physiol. 280, H1982–H1988 (2001).

84.          Nitzan, D. W., Nitzan, U., Dan, P. & Yedgar, S. The role of hyaluronic acid in protecting surface-active phospholipids from lysis by exogenous phospholipase A2. Rheumatology 40, 336–340 (2001).

85.          Yedgar, S., Lichtenberg, D. & Schnitzer, E. Inhibition of phospholipase A2 as a therapeutic target. Biochim. Biophys. Acta - Mol. Cell Biol. Lipids 1488, 182–187 (2000).

86.          Balsinde, J., Balboa, M. A., Yedgar, S. & Dennis, E. A. Group V phospholipase A2-mediated oleic acid mobilization in lipopolysaccharide-stimulated P388D1 macrophages. J. Biol. Chem. 275, 4783–4786 (2000).

87.          Schnitzer, E. et al. Interaction of hyaluronic acid-linked phosphatidylethanolamine (HyPE) with LDL and its effect on the susceptibility of LDL lipids to oxidation. Chem. Phys. Lipids 104, 149–160 (2000).

88.          Barshtein, G., Wajnblum, D. & Yedgar, S. Kinetics of linear rouleaux formation studied by visual monitoring of red cell dynamic organization. Biophys. J. 78, 2470–2474 (2000).

89.          Krimsky, M., Dagan, A., Yedgar, S., Aptekar, L. & Ligumsky, M. Assessment Of Intestinal Permeability In Rats By Permeation Of Inulin-Fluorescein. J. Basic Clin. Physiol. Pharmacol. 11, 143–154 (2000).

90.          Yedgar, S., Hovav, T. & Barshtein, G. Red blood cell intercellular interactions in oxidative stress states. Clin. Hemorheol. Microcirc. 21, 189–193 (1999).

91.          Hovav, T., Goldfarb, A., Artmann, G., Yedgar, S. & Barshtein, G. Enhanced adherence of β-thalassaemic erythrocytes to endothelial cells. Br. J. Haematol. 106, 178–181 (1999).

92.          Hovav, T., Yedgar, S., Manny, N. & Barshtein, G. Alteration of red cell aggregability and shape during blood storage. Transfusion 39, 277–281 (1999).

93.          Taylor, W. F., Chen, S., Barshtein, G., Hyde, D. E. & Yedgar, S. Enhanced aggregability of human red blood cells by diving. Undersea Hyperb. Med. 25, 167–170 (1998).

94.          Schnitzer, E., Pinchuk, I., Fainaru, M., Lichtenberg, D. & Yedgar, S. LDL-associated phospholipase a does not protect LDL against lipid peroxidation in vitro. Free Radic. Biol. Med. 24, 1294–1303 (1998).

95.          Dan, P. et al. Inhibition of type I and type II phospholipase A2 by phosphatidyl- ethanolamine linked to polymeric carriers. Biochemistry 37, 6199–6204 (1998).

96.          Barshtein, G., Tamir, I. & Yedgar, S. Red blood cell rouleaux formation in dextran solution: Dependence on polymer conformation. Eur. Biophys. J. 27, 177–181 (1998).

97.          Almagor, A., Priev, A., Barshtein, G., Gavish, B. & Yedgar, S. Reduction of protein volume and compressibility by macromolecular cosolvents: Dependence on the cosolvent molecular weight. Biochim. Biophys. Acta - Protein Struct. Mol. Enzymol. 1382, 151–156 (1998).

98.          Abu-Raya, S. et al. Pardaxin, a new pharmacological tool to stimulate the arachidonic acid cascade in PC12 cells. J. Pharmacol. Exp. Ther. 287, 889–896 (1998).

99.          Tuvia, S. et al. Cell membrane fluctuations are regulated by medium macroviscosity: Evidence for a metabolic driving force. Proc. Natl. Acad. Sci. U. S. A. 94, 5045–5049 (1997).

100.        Barshtein, G., Bergelson, L., Dagan, A., Gratton, E. & Yedgar, S. Membrane lipid order of human red blood cells is altered by physiological levels of hydrostatic pressure. Am. J. Physiol. 272, H485–H492 (1997).

101.        Ben-Hur, E., Barshtein, G., Chen, S. & Yedgar, S. Photodynamic Treatment of Red Blood Cell Concentrates for Virus Inactivation Enhances Red Blood Cell Aggregation: Protection with Antioxidants. Photochem. Photobiol. 66, 509–512 (1997).

102.        Barshtein, G., Bergelson, L., Dagan, A., Gratton, E. & Yedgar, S. Membrane lipid order of human red blood cells is altered by physiological levels of hydrostatic pressure. Am. J. Physiol. - Hear. Circ. Physiol. 272, H538–H543 (1997).

103.        Ginsburg, I., Yedgar, S. & Varani, J. Diethyldithiocarbamate and nitric oxide synergize with oxidants and with membrane-damaging agents to injure mammalian cells. Free Radic. Res. 27, 143–164 (1997).

104.        Dan, P., Nitzan, D. W., Dagan, A., Ginsburg, I. & Yedgar, S. H2O2 renders cells accessible to lysis by exogenous phospholipase A2: A novel mechanism for cell damage in inflammatory processes. FEBS Lett. 383, 75–78 (1996).

105.        Priev, A., Almagor, A., Yedgar, S. & Gavish, B. Glycerol decreases the volume and compressibility of protein interior. Biochemistry 35, 2061–2066 (1996).

106.        Chen, S. et al. Enhanced aggregability of red blood cells of β-thalassemia major patients. Am. J. Physiol. - Hear. Circ. Physiol. 270, H1951–H1956 (1996).

107.        Barshtein, G., Yedgar, S., Bergelson, L. & Gratton, E. Human Red Blood Cell Shape and Volume are Changed by Physiological levels of Hydrostatic Pressure. J. Basic Clin. Physiol. Pharmacol. 7, 321–330 (1996).

108.        Breuer, R. et al. Abatement of bleomycin-induced pulmonary injury by cell-impermeable inhibitor of phospholipase A2. Life Sci. 57, PL237–PL240 (1995).

109.        Chen, S., Gavish, B., Zhang, S., Mahler, Y. & Yedgar, S. Monitoring of erythrocyte aggregate morphology under flow by computerized image analysis. Biorheology 32, 487–496 (1995).

110.        Yedgar, S., Tetreau, C., Gavish, B. & Lavalette, D. Viscosity dependence of O2 escape from respiratory proteins as a function of cosolvent molecular weight. Biophys. J. 68, 665–670 (1995).

111.        Yedgar, S. et al. Control of inflammatory processes by cell-impermeable inhibitors of phospholipase A2. Agents Actions 46, 77–84 (1995).

112.        Barshtein, G., Almagor, A., Yedgar, S. & Gavish, B. Inhomogeneity of viscous aqueous solutions. Phys. Rev. E 52, 555–557 (1995).

113.        Chen, S., Gavish, B., Barshtein, G., Mahler, Y. & Yedgar, S. Red blood cell aggregability is enhanced by physiological levels of hydrostatic pressure. BBA - Biomembr. 1192, 247–252 (1994).

114.        Chen, S., Barshtein, G., Gavish, B., Mahler, Y. & Yedgar, S. Monitoring of red blood cell aggregability in a flow-chamber by computerized image analysis. Clin. Hemorheol. Microcirc. 14, 497–508 (1994).

115.        Reisfeld, N. & Yedgar, S. Inhibition of ldl-associated phospholipase a activity in human plasma by albumin. J. Basic Clin. Physiol. Pharmacol. 5, 107–116 (1994).

116.        Reisfeld, N., Lichtenberg, D., Dagan, A. & Yedgar, S. Apolipoprotein B exhibits phospholipase A1 and phospholipase A2 activities. FEBS Lett. 315, 267–270 (1993).

117.        Meyuhas, D., Yedgar, S., Rotenberg, M., Reisfeld, N. & Lichtenberg, D. The use of C6-NBD-PC for assaying phospholipase A2-activity: Scope and limitations. Biochim. Biophys. Acta (BBA)/Lipids Lipid Metab. 1124, 223–232 (1992).

118.        Goping, G., Yedgar, S., Pollard, H. B. & Kuijpers, G. A. J. Flat embedding and immunolabelling of SW 1116 colon carcinoma cells in LR white: An improved technique in light and electron microscopy. Microsc. Res. Tech. 21, 1–9 (1992).

119.        Almagor, A., Yedgar, S. & Gavish, B. Viscous cosolvent effect on the ultrasonic absorption of bovine serum albumin. Biophys. J. 61, 480–486 (1992).

120.        Yedgar, S. et al. Cyclic AMP-independent secretion of mucin by SW1116 human colon carcinoma cells. Differential control by Ca2+ ionophore A23187 and arachidonic acid. Biochem. J. 283, 421–426 (1992).

121.        Lidan, D., Yedgar, S., Aronson, H. B. & Sohmer, H. Influence of experimentally elevated blood viscosity on the auditory nerve-brainstem evoked response and threshold. Hear. Res. 62, 57–62 (1992).

122.        Feitelson, J. & Yedgar, S. The effect of the solvent viscosity on the migration of small molecules through the structure of myoglobin. Biorheology 28, 99–105 (1991).

123.        Bennett, E. R., Yedgar, S., Lerer, B. & Ebstein, R. P. Phospholipase A2 activity in Epstein-Barr virus-transformed lymphoblast cells from schizophrenic patients. Biol. Psychiatry 29, 1058–1062 (1991).

124.        Almagor, A., Yedgar, S. & Gavish, B. Seventh International Congress of Biorheology, Nancy, France, 18-23 June 1989. Symposium: The role of fluid viscosity in cellular and biochemical processes. Solvent viscosity effects on protein dynamics studied by ultrasonic absorption. Biorheology 27, 605–610 (1990).

125.        Etcheberrigaray, R., Yedgar, S., Rojas, E. & Pollard, H. B. Multiple potassium and chloride channels in the human colon carcinoma cell line SW1116. Mol. Membr. Biol. 9, 215–225 (1990).

126.        Yedgar, S. & Reisfeld, N. Seventh International Congress of Biorheology, Nancy, France, 18-23 June 1989. Symposium: The role of fluid viscosity in cellular and biochemical processes. Regulation of cell membrane function and secretion by extracellular fluid viscosity. Biorheology 27, 581–588 (1990).

127.        Yedgar, S., Vlodavsky, I., Panet, A., Reisfeld, N. & Eldor, A. Interferon enhances phospholipase A2 activity in bovine aortic endothelial cells. Eicosanoids 3, 225–229 (1990).

128.        Ebstein, R. P. et al. Cyclic AMP second messenger signal generation in EBV-transformed lymphoblastoid cells from schizophrenic patients. J. Psychiatr. Res. 24, 121–127 (1990).

129.        Shohami, E., Shapira, Y., Yadid, G., Reisfeld, N. & Yedgar, S. Brain Phospholipase A2 Is Activated After Experimental Closed Head Injury in the Rat. J. Neurochem. 53, 1541–1546 (1989).

130.        BRENNER, T., YEDGAR, S., WEIDENFELD, J. & ABRAMSKY, O. Phospholipase A2 Activity in Cultured Glial Cells Correlation with Appearance of Myelin Markers and Effects of Steroid Hormones. Annals of the New York Academy of Sciences vol. 540 403–404 (1988).

131.        Mayer, M. et al. Effect of viscous macromolecules on peritoneal plasminogen activator activity: A potential mechanism for their ability to reduce postoperative adhesion formation. Am. J. Obstet. Gynecol. 159, 957–963 (1988).

132.        Halle, D. & Yedgar, S. Mild pressure induces resistance of erythrocytes to hemolysis by snake venom phospholipase A2. Biophys. J. 54, 393–396 (1988).

133.        Yedgar, S., Reisfeld, N., Halle, D. & Yuli, I. Medium Viscosity Regulates the Activity of Membrane-Bound and Soluble Phospholipase A2. Biochemistry 26, 3395–3401 (1987).

134.        Hovav, E., Halle, D. & Yedgar, S. Viscous macromolecules inhibit erythrocyte hemolysis induced by snake venom phospholipase A2. Biorheology 24, 377–384 (1987).

135.        Dagan, A. & Yedgar, S. A facile method for direct determination of phospholipase A2 activity in intact cells. Biochem. Int. 15, 801–808 (1987).

136.        Yedgar, S., Reisfeld-Granot, N. & Sela, B.-A. Regulation of liver cell ganglioside composition by extracellular fluid viscosity. Lipids 21, 629–633 (1986).

137.        Yedgar, S., Reisfeld, N. & Dagan, A. Synthesis of cell-impermeable inhibitor of phospholipase A2. FEBS Lett. 200, 165–168 (1986).

138.        Yedgar, S. & Sela, B.-A. Alterations in gangliosides of rat liver cells in hyperlipidemic state. J. Biochem. 98, 673–680 (1985).

139.        Yedgar, S., Eilam, O. & Shafrir, E. Regulation of plasma lipid levels by plasma viscosity in nephrotic rats. Am. J. Physiol. - Endocrinol. Metab. 11, E10–E14 (1985).

140.        Yedgar, S. & Cooper, G. V. Organization and structure of two mixed micellar phases of the sphingomyelin/Triton X-305 system. Arch. Biochem. Biophys. 240, 191–200 (1985).

141.        Yedgar, S., Carew, T. E. & Pittman, R. C. Tissue sites of catabolism of albumin in rabbits. Am. J. Physiol. - Endocrinol. Metab. 7, E101–E107 (1983).

142.        Yedgar, S. et al. Viscosity of culture medium as a regulator of synthesis and secretion of very low density lipoproteins by cultured hepatocytes. J. Biol. Chem. 257, 2188–2192 (1982).

143.        Yedgar, S., Cohen, R., Gatt, S. & Barenholz, Y. Hydrolysis of monomolecular layers of synthetic sphingomyelins by sphingomyelinase of staphylococcus aureus. Biochem. J. 201, 597–603 (1982).

144.        Mayer, M., Yedgar, S., Joffe, M. & Shafrir, E. Urine protease and antiprotease activity in experimental aminonucleoside nephrotoxicity. Nephron 29, 223–228 (1981).

145.        Yedgar, S. & Gatt, S. Enzymic hydrolysis of sphingomyelin in the presence of bile salts. Biochem. J. 185, 749–754 (1980).

146.        Lichtenberg, D., Yedgar, S., Cooper, G. & Gatt, S. Studies on the Molecular Packing of Mixed Dispersions of Triton X-100 and Sphingomyelin and Its Dependence on Temperature and Cloud Point. Biochemistry 18, 2574–2582 (1979).

147.        Gatt, S., Dinur, T., Yedgar, S. & Leibovitz-Ben Gershon, Z. Effect of detergents on the utilization of sphingomyelin by brain sphingomyelinases. Adv. Exp. Med. Biol. 101, 487–500 (1978).

148.        Yedgar, S. & Gatt, S. Effect of Triton X-100 on the Hydrolysis of Sphingomyelin by Sphingomyelinase of Rat Brain. Biochemistry 15, 2570–2573 (1976).

149.        Yedgar, S. & Gatt, S. Proceedings: Kinetic aspects of the stimulation of enzymatic hydrolysis of sphingomyelin by triton x-100. Isr. J. Med. Sci. 11, 1172 (1975).

150.        Yedgar, S., Barenholz, Y. & Cooper, V. G. Molecular weight, shape and structure of mixed micelles of Triton X-100 and sphingomyelin. BBA - Biomembr. 363, 98–111 (1974).

151.        Cooper, V. G., Yedgar, S. & Barenholz, Y. Diffusion coefficients of mixed micelles of Triton X-100 and sphingomyelin and of sonicated sphingomyelin liposomes, measured by autocorrelation spectroscopy of Rayleigh scattered light. BBA - Biomembr. 363, 86–97 (1974).

152.        Yedgar, S., Hertz, R. & Gatt, S. Solubilization of sphingomyelin by triton X-100 effect of the method of mixing and the concentrations of detergent and lipid. Chem. Phys. Lipids 13, 404–414 (1974).