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The Faculty of Medicine - Medical Neurobiology: Lichtstein David


Last updated December 2021 - Medical Neurobiology

List of Publications

(1) Shin E-, Nguyen B-, Jeong JH, Hoai Nguyen B-, Tran NKC, Sharma N, et al. Ouabain inhibitor rostafuroxin attenuates dextromethorphan-induced manic potential. Food Chem Toxicol 2021;158.

(2) Singh SV, Fedorova OV, Wei W, Rosen H, Horesh N, Ilani A, et al. Na+, k+-atpase α isoforms and endogenous cardiac steroids in prefrontal cortex of bipolar patients and controls. Int J Mol Sci 2020;21(16):1-16.

(3) Leibovich H, Buzaglo N, Tsuriel S, Peretz L, Caspi Y, Katz B, et al. Abnormal Reinnervation of Denervated Areas Following Nerve Injury Facilitates Neuropathic Pain. Cells 2020;9(4).

(4) Hodes A, Rosen H, Cohen-Ben Ami H, Lichtstein D. Na+, K+-ATPase α3 isoform in frontal cortex GABAergic neurons in psychiatric diseases. J Psychiatr Res 2019;115:21-28.

(5) Gross NB, Abad N, Lichtstein D, Taron S, Aparicio L, Fonteh AN, et al. Endogenous Na+, K+-ATPase inhibitors and CSF [Na+] contribute to migraine formation. PLoS ONE 2019;14(6).

(6) Buzaglo N, Golomb M, Rosen H, Beeri R, Ami HC-, Langane F, et al. Augmentation of Ouabain-Induced Increase in Heart Muscle Contractility by Akt Inhibitor MK-2206. J Cardiovasc Pharmacol Ther 2019;24(1):78-89.

(7) Lichtstein D, Ilani A, Rosen H, Horesh N, Singh SV, Buzaglo N, et al. Na+, K+-ATPase signaling and bipolar disorder. Int J Mol Sci 2018;19(8).

(8) Hodes A, Lifschytz T, Rosen H, Cohen Ben-Ami H, Lichtstein D. Reduction in endogenous cardiac steroids protects the brain from oxidative stress in a mouse model of mania induced by amphetamine. Brain Res Bull 2018;137:356-362.

(9) Hodes A, Rosen H, Deutsch J, Lifschytz T, Einat H, Lichtstein D. Endogenous cardiac steroids in animal models of mania. Bipolar Disord 2016;18(5):451-459.

(10) Buzaglo N, Rosen H, Ami HCB, Inbal A, Lichtstein D. Essential opposite roles of ERK and akt signaling in cardiac steroid-induced increase in heart contractility. J Pharmacol Exp Ther 2016;357(2):345-356.

(11) Leinonen JV, Korkus-Emanuelov A, Wolf Y, Milgrom-Hoffman M, Lichtstein D, Hoss S, et al. Macrophage precursor cells from the left atrial appendage of the heart spontaneously reprogram into a C-kit +/CD45 - Stem cell-like phenotype. Int J Cardiol 2016;209:296-306.

(12) Dvela-Levitt M, Cohen-Ben Ami H, Rosen H, Ornoy A, Hochner-Celnikier D, Granat M, et al. Reduction in maternal circulating ouabain impairs offspring growth and kidney development. J Am Soc Nephrol 2015;26(5):1103-1114.

(13) Dvela-Levitt M, Ami HC-, Rosen H, Shohami E, Lichtstein D. Ouabain improves functional recovery following traumatic brain injury. J Neurotrauma 2014;31(23):1942-1947.

(14) Hodes A, Lichtstein D. Natriuretic hormones in brain function. Front Endocrinol 2014;5(NOV).

(15) Nesher M, Bai Y, Li D, Rosen H, Lichtstein D, Liu L. Interaction of atrial natriuretic peptide and ouabain in the myocardium. Can J Physiol Pharmacol 2012;90(10):1386-1393.

(16) Lichtstein D, Rosen H, Dvela M. Cardenolides and bufadienolides as hormones: What is missing? Am J Physiol Renal Physiol 2012;302(8):F957-F958.

(17) Fridman E, Lichtstein D, Rosen H. Formation of new high density glycogen-microtubule structures is induced by cardiac steroids. J Biol Chem 2012;287(9):6518-6529.

(18) Dvela M, Rosen H, Ben-Ami HC, Lichtstein D. Endogenous ou0061bain regulates cell viability. Am J Physiol Cell Physiol 2012;302(2):C442-C452.

(19) Goldstein I, Lax E, Gispan-Herman I, Ovadia H, Rosen H, Yadid G, et al. Neutralization of endogenous digitalis-like compounds alters catecholamines metabolism in the brain and elicits anti-depressive behavior. Eur Neuropsychopharmacol 2012;22(1):72-79.

(20) Feldmann T, Shahar M, Baba A, Matsuda T, Lichtstein D, Rosen H. The Na+/Ca2+-exchanger: An essential component in the mechanism governing cardiac steroid-induced slow Ca2+ oscillations. Cell Calcium 2011;50(5):424-432.

(21) Nesher M, Shpolansky U, Viola N, Dvela M, Buzaglo N, Ben-Ami HC, et al. Ouabain attenuates cardiotoxicity induced by other cardiac steroids. Br J Pharmacol 2010;160(2):346-354.

(22) Guttmann-Rubinstein L, Lichtstein D, Ilani A, Gal-Moscovici A, Scherzer P, Rubinger D. Evidence of a parathyroid hormone-independent chronic effect of estrogen on renal phosphate handling and sodium-dependent phosphate cotransporter type IIa expression. Horm Metab Res 2010;42(4):230-236.

(23) Jaiswal MK, Dvela M, Lichtstein D, Mallick BN. Endogenous ouabain-like compounds in locus coeruleus modulate rapid eye movement sleep in rats. J Sleep Res 2010;19(1 PART. 2):183-191.

(24) Nesher M, Dvela M, Igbokwe VU, Rosen H, Lichtstein D. Physiological roles of endogenous ouabain in normal rats. Am J Physiol Heart Circ Physiol 2009;297(6):H2026-H2034.

(25) Klar A, Haver E, Lichtstein D, Hurvitz H, Foah-Shauli T. Atrial natriuretic peptide in young and elderly children with mild gastroenteritis. Gastroenterol Res Pract 2009.

(26) Goldstein I, Lerer E, Laiba E, Mallet J, Mujaheed M, Laurent C, et al. Association Between Sodium- and Potassium-Activated Adenosine Triphosphatase α Isoforms and Bipolar Disorders. Biol Psychiatry 2009;65(11):985-991.

(27) Nesher M, Vachutinsky Y, Fridkin G, Schwarz Y, Sasson K, Fridkin M, et al. Reversible pegylation prolongs the hypotensive effect of atrial natriuretic peptide. Bioconjugate Chem 2008;19(1):342-348.

(28) Dvela M, Rosen H, Feldmann T, Nesher M, Lichtstein D. Diverse biological responses to different cardiotonic steroids. Pathophysiology 2007;14(3-4):159-166.

(29) Feldmann T, Glukmann V, Medvenev E, Shpolansky U, Galili D, Lichtstein D, et al. Role of endosomal Na+-K+-ATPase and cardiac steroids in the regulation of endocytosis. Am J Physiol Cell Physiol 2007;293(3):C885-C896.

(30) Nesher M, Shpolansky U, Rosen H, Lichtstein D. The digitalis-like steroid hormones: New mechanisms of action and biological significance. Life Sci 2007;80(23):2093-2107.

(31) Rosen H, Glukmann V, Feldmann T, Fridman E, Lichtstein D. Short-term effects of cardiac steroids on intracellular membrane traffic in neuronal NT2 cells. Cell Mol Biol 2006;52(8):78-86.

(32) Goldstein I, Levy T, Galili D, Ovadia H, Yirmiya R, Rosen H, et al. Involvement of Na+, K+-ATPase and Endogenous Digitalis-Like Compounds in Depressive Disorders. Biol Psychiatry 2006;60(5):491-499.

(33) Deutsch J, Jang HG, Mansur N, Ilovich O, Shpolansky U, Galili D, et al. 4-(3′α15′β-dihydroxy-5′β-estran- 17′β-yl)furan-2-methyl alcohol: An anti-digoxin agent with a novel mechanism of action. J Med Chem 2006;49(2):600-606.

(34) Haviv M, Haver E, Lichtstein D, Hurvitz H, Klar A. Atrial natriuretic peptide in children with pneumonia. Pediatr Pulmonol 2005;40(4):306-309.

(35) Landsman A, Lichtstein D, Ilani A. Distinctive features of dietary phosphate supply. J Appl Physiol 2005;99(3):1214-1219.

(36) Rosen H, Glukhman V, Feldmann T, Fridman E, Lichtstein D. Cardiac Steroids Induce Changes in Recycling of the Plasma Membrane in Human NT2 Cells. Mol Biol Cell 2004;15(3):1044-1054.

(37) Lichtstein D, Rosen H. Endogenous digitalis-like Na+, K+-ATPase inhibitors, and brain function. Neurochem Res 2001;26(8-9):971-978.

(38) Landsman A, Lichtstein D, Bacaner M, Ilani A. Dietary phosphate-dependent growth is not mediated by changes in plasma phosphate concentration. Br J Nutr 2001;86(2):217-223.

(39) Cheng Q, Lichtstein D, Russell P, Zigler Jr. JS. Use of lipophilic cation to monitor electrical membrane potential in the intact rat lens. Invest Ophthalmol Vis Sci 2000;41(2):482-487.

(40) Traub N, Lichtstein D. The Mood Cycle Hypothesis: Possible Involvement Of Steroid Hormones In Mood Regulation By Means Of Na+,K+-Atpase Inhibition. J Basic Clin Physiol Pharmacol 2000;11(4):375-394.

(41) Lichtstein D, Mcgowan MH, Russell P, Carper DA. Digitalis and Digitalislike Compounds Down-Regulate Gene Expression of the Intracellular Signaling Protein 14-3-3 in Rat Lens. Hypertens Res Clin Exp 2000;23.

(42) McGowan MH, Russell P, Carper DA, Lichtstein D. Na+, K+-ATPase inhibitors down-regulate gene expression of the intracellular signaling protein 14-3-3 in rat lens. J Pharmacol Exp Ther 1999;289(3):1559-1563.

(43) Lichtstein D, Levy T, Deutsch J, Steinitz M, Zigler Jr. JS, Russell P. The effects of digitalis-like compounds on rat lenses. Invest Ophthalmol Vis Sci 1999;40(2):407-413.

(44) Lichtstein D, Steinitz M, Gati I, Samuelov S, Deutsch J, Orly J. Biosynthesis of digitalis-like compounds in rat adrenal cells: Hydroxycholesterol as possible precursor. Life Sci 1998;62(23):2109-2126.

(45) Lichtstein D, Steinitz M, Gati I, Samuelov S, Deutsch J, Orly J. Bufodienolides as Endogenous Na+, K+-ATPase Inhibitors: Biosynthesis in Bovine and Rat Adrenals. Clin Exp Hypertens 1998;20(42130):573-579.

(46) Morris JF, Ismail-Beigi F, Butler Jr. VP, Gati I, Lichtstein D. Ouabain-sensitive Na+,K+-ATPase activity in toad brain. Comp Biochem Physiol A Physiol 1997;118(3):599-606.

(47) Furman S, Lichtstein D, Ilani A. Sodium-dependent transport of phosphate in neuronal and related cells. BIOCHIM BIOPHYS ACTA BIOMEMBR 1997;1325(1):34-40.

(48) Samuelov S, Lichtstein D. Digitalis-like compounds and Na+, K+-ATPase activity in bovine lens. PFLUG ARCH EUR J PHYSIOL 1997;433(4):435-441.

(49) Antolovic R, Kost H, Linder D, Linder M, Thönges D, Lichtstein D, et al. Demonstration of a specific transport protein for cardiac glycosides in bovine blood. Ann New York Acad Sci 1997;834:618-620.

(50) Bachar C, Haver E, Kadar T, Levy A, Lichtstein D. Possible involvement of atrial natriuretic peptides in olfaction. Brain Res 1995;682(1-2):231-234.

(51) Haver E, Lichtstein D, Munson PJ. Multiple types of binding sites for atrial natriuretic peptide in rat olfactory bulb membranes and synaptosomes. Brain Res 1995;681(1-2):75-83.

(52) Lichtstein D, Shainberg A, Solarao J, Marban E, Ter Keurs HEDJ, Morad M. Na+, K+-ATPase and heart excitability. ADV EXP MED BIOL 1995;382:23-30.

(53) Bachar H, Lichtstein D. Distribution of Atrial Natriuretic Peptides in the Sand Rat (Psammomys Obesus) in Comparison to That in the Rat. J Basic Clin Physiol Pharmacol 1993;4(1-2):47-56.

(54) Lichtstein D, Gati I, Ovadia H. Digitalis-like compounds in the toad Bufo viridis: Interactions with plasma proteins. J Cardiovasc Pharmacol 1993;22(SUPPL. 2):S102-S105.

(55) LICHTSTEIN D, GATI I, SAMUELOV S, BERSON D, ROZENMAN Y, LANDAU L, et al. Identification of digitalis‐like compounds in human cataractous lenses. Eur J Biochem 1993;216(1):261-268.

(56) Bachar H, Haver E, Ilani A, Lichtstein D. Modulation of rat olfactory bulb mitochondrial function by atrial natriuretic peptide. Pflügers Arch 1992;422(2):204-206.

(57) Lichtstein D, Gati I, Haver E, Katz U. Digitalis-like compounds in the toad Bufo viridis: Tissue and plasma levels and significance in osmotic stress. Life Sci 1992;51(2):119-128.

(58) Lichtstein D, Gati I, Babila T, Haver E, Katz U. Effect of salt acclimation on digitalis-like compounds in the toad. Biochim Biophys Acta Gen Subj 1991;1073(1):65-68.

(59) Lichtstein D, Samuelov S, Gati I, Felix AM, Gabriel TF, Deutsch J. Identification of 11,13-dihydroxy-14-octadecaenoic acid as a circulating Na+/K+-ATPase inhibitor. J Endocrinol 1991;128(1):71-78.

(60) Oberfrank F, Vizi ES, Baker PF, Samuelov S, Lichtstein D. Comparison of the effects of a bufodienolide and ouabain on neuronal and smooth muscle preparations. Neurosci Res 1991;10(4):235-244.

(61) Lichtstein D, Atlan H. The "cellular state": The way to regain specificity and diversity in hormone action. J Theor Biol 1990;145(3):287-294.

(62) Babila T, Atlan H, Fromer I, Schwalb H, Uretzky G, Lichtstein D. Volume Regulation of Nerve Terminals. J Neurochem 1990;55(6):2058-2062.

(63) Babila T, Gottlieb Y, Lutz RA, Lichtstein D. A bumetanide-sensitive, potassium carrier-mediated transport system in excitable tissues. Life Sci 1989;44(22):1665-1675.

(64) Oberfrank F, Vizi ES, Lichtstein D. Presynaptic modulation by endogenous ouabain-like substances of noradrenaline release from blood vessels. Pol J Pharmacol Pharm 1988;40(6):685-690.

(65) Xu H, Lichtstein D, Kassis S, Lutz RA, Rodbard D, Chernick SS. Multiple interactions of unsaturated fatty acids with opiate and ouabain binding sites and βadrenergic sensitive adenylate cyclase system. J Recept Signal Transduction 1988;8(1-4):205-223.

(66) Bloch KD, Zamir N, Lichtstein D, Seidman CE, Seidman JG. Ouabain induces secretion of proatrial natriuretic factor by rat atrial cardiocytes. Am J Physiol Endocrinol Metab 1988;255(3).

(67) Lichtstein D, Rodbard D. A second look at the second messenger hypothesis. Life Sci 1987;40(21):2041-2051.

(68) Vizi ES, Oberfrank F, Bernath S, Lichtstein D. Noradrenaline releasing effect of an ouabain-like compound on pulmonary artery. Neuropharmacology 1987;26(10):1541-1544.

(69) Lutz RA, Lichtstein D, Xu H, Rodbard D. Demonstration and characterization of two classes of cardiac glycoside binding sites to rat heart membrane preparations using quantitative computer modeling. J Recept Signal Transduction 1987;7(5):679-694.

(70) Lichtstein D, Samuelov S, Deutsch J, Xu H, Lutz RA, Chernick SS, et al. The ouabain receptor in animal tissues and its endogenous ligand. Klin Wochenschr 1987;65(SUPPL. 8):40-48.

(71) Silva P, Lear S, Segal F, Rosen S, Spokes K, Stevens A, et al. Isolated rectal gland cells: Oxygen consumption and hormonal stimulation. MINER ELECTROLYTE METABOL 1986;12(5-6):286-292.

(72) Lichtstein D, Lutz RA, Heng Xu, Rodbard D. Characterization of two classes of cardiac glycosine binding sites in rat heart and brain membrane preparations, using quantitative computer modelling. J Hypertens 1986;4(SUPPL. 5):S227-S229.

(73) Lichtstein D, Kachalsky S, Deutsch J. Identification of a ouabain-like compound in toad skin and plasma as a bufodienolide derivative. Life Sci 1986;38(14):1261-1270.

(74) Tal DM, Katchalsky S, Lichtstein D, Karlish SJD. Endogenous "ouabain-like" activity in bovine plasma. Biochem Biophys Res Commun 1986;135(1):1-8.

(75) Shimoni Y, Gotsman M, Epstein M, Kachalsky S, Deutsch J, Lichtstein D. Further characterisation of the inotropic effect of a bufodienolide glycoside - an endogenous ouabain like compound. Cardiovasc Res 1986;20(3):229-239.

(76) Bourrit A, Atlan H, Fromer I, Melmed RN, Lichtstein D. Basic characterization of an ouabain-resistant, bumetanide-sensitive K+ carrier-mediated transport system in J774.2 mouse macrophage-like cell line and in variants deficient in adenylate cyclase and cAMP-dependent protein kinase activities. Biochim Biophys Acta Biomembr 1985;817(1):85-94.

(77) Lichtstein D, Samuelov S, Bourrit A. Characterization of the stimulation of neuronal Na+, K+-ATPase activity by low concentrations of ouabain. Neurochem Int 1985;7(4):709-715.

(78) Lichtstein D, Minc D, Shimoni Y, Deutsch J, Mekler J, Ben-Ishay D. Demonstration of a ouabainlike plasma compound in hypertension prone and hypertension resistant rats. Hypertension 1985;7(5):729-733.

(79) Shimoni Y, Gotsman M, Deutsch J, Kachalsky S, Lichtstein D. Endogenous ouabain-like compound increases heart muscle contractility. Nature 1984;307(5949):369-371.

(80) Ilani A, Yachin S, Lichtstein D. Comparison between bretylium and diphenylhydantoin interaction with mucosal sodium-channels. Biochim Biophys Acta Biomembr 1984;777(2):323-330.

(81) Ilani A, Lichtstein D, Bacaner MB. Bretylium opens mucosal amiloride-sensitive sodium channels. Biochim Biophys Acta Biomembr 1982;693(2):503-506.

(82) Lichtstein D, Mullikin-Kilpatrick D, Blume AJ. Modification of neuroblastoma X glioma hybrid NG108-15 adenylate cyclase by vanadium ions. Biochem Biophys Res Commun 1982;105(3):1157-1165.

(83) Lichtstein D, Samuelov S. Characterization of ouabain receptor in neuronal tissue: Evidence for endogenous ouabain-like compound. Isr J Med Sci 1982;18(1):45-50.

(84) Lichtstein D, Mullikin-Kilpatrick D, Blume AJ. Vanadate-induced hyperpolarization of neuroblastoma-glioma hybrid NG108-15 cells. Isr J Med Sci 1982;18(4):551.

(85) Lichtstein D, Samuelov S. Membrane potential changes induced by the ouabain-like compound extracted from mammalian brain. Proc Natl Acad Sci U S A 1982;79(5):1453-1456.

(86) Rochel S, Lichtstein D, Blume AJ, Margolis FL. Membrane potential of olfactory bulb synaptosomal fractions: Characterization with the lipophilic cation tetraphenylphosphonium. J Neurosci 1981;1(10):1180-1192.

(87) Lichtstein D, Samuelov S. Endogenous ‘ouabain like’ activity in rat brain. Top Catal 1980;96(4):1518-1523.