1.            Horesh, N. et al. Involvement of the Na+, K+-ATPase α1 Isoform and Endogenous Cardiac Steroids in Depression- and Manic-like Behaviors. Int. J. Mol. Sci. 25, (2024).

2.            Zilberstein, A., Krivoy, N., Horesh, N., Klein, E. & Lichtstein, D. Beneficial effect of digoxin-specific Fab fragments in bipolar disorder- a preliminary study. J. Affect. Disord. Reports 13, (2023).

3.            Sampath, V. P. et al. Chemical Element Profiling in the Sera and Brain of Bipolar Disorders Patients and Healthy Controls. Int. J. Mol. Sci. 23, (2022).

4.            Sampath, V. P. et al. Vanadium in Bipolar Disorders—Reviving an Old Hypothesis. Int. J. Mol. Sci. 23, (2022).

5.            Sampath, V. et al. Synthesis and Biological Evaluation of Novel Bufalin Derivatives. Int. J. Mol. Sci. 23, (2022).

6.            El-Mallakh, R. S., Sampath, V. P., Horesh, N. & Lichtstein, D. Endogenous Cardiac Steroids in Bipolar Disorder: State of the Art. Int. J. Mol. Sci. 23, (2022).

7.            Shin, E.-J. et al. Ouabain inhibitor rostafuroxin attenuates dextromethorphan-induced manic potential. Food Chem. Toxicol. 158, (2021).

8.            Singh, S. V et al. Na+, k+-atpase α isoforms and endogenous cardiac steroids in prefrontal cortex of bipolar patients and controls. Int. J. Mol. Sci. 21, 1–16 (2020).

9.            Leibovich, H. et al. Abnormal reinnervation of denervated areas following nerve injury facilitates neuropathic pain. Cells 9, (2020).

10.          Hodes, A., Rosen, H., Cohen-Ben Ami, H. & Lichtstein, D. Na+, K+-ATPase α3 isoform in frontal cortex GABAergic neurons in psychiatric diseases. J. Psychiatr. Res. 115, 21–28 (2019).

11.          Gross, N. B. et al. Endogenous Na+, K+-ATPase inhibitors and CSF [Na+] contribute to migraine formation. PLoS One 14, (2019).

12.          Buzaglo, N. et al. Augmentation of Ouabain-Induced Increase in Heart Muscle Contractility by Akt Inhibitor MK-2206. J. Cardiovasc. Pharmacol. Ther. 24, 78–89 (2019).

13.          Lichtstein, D. et al. Na+, K+-ATPase signaling and bipolar disorder. Int. J. Mol. Sci. 19, (2018).

14.          Hodes, A., Lifschytz, T., Rosen, H., Cohen Ben-Ami, H. & Lichtstein, D. Reduction in endogenous cardiac steroids protects the brain from oxidative stress in a mouse model of mania induced by amphetamine. Brain Res. Bull. 137, 356–362 (2018).

15.          Hodes, A. et al. Endogenous cardiac steroids in animal models of mania. Bipolar Disord. 18, 451–459 (2016).

16.          Buzaglo, N., Rosen, H., Ami, H. C. B., Inbal, A. & Lichtstein, D. Essential opposite roles of ERK and akt signaling in cardiac steroid-induced increase in heart contractility. J. Pharmacol. Exp. Ther. 357, 345–356 (2016).

17.          Leinonen, J. V et al. Macrophage precursor cells from the left atrial appendage of the heart spontaneously reprogram into a C-kit +/CD45 - Stem cell-like phenotype. Int. J. Cardiol. 209, 296–306 (2016).

18.          Dvela-Levitt, M. et al. Reduction in maternal circulating ouabain impairs offspring growth and kidney development. J. Am. Soc. Nephrol. 26, 1103–1114 (2015).

19.          Dvela-Levitt, M., Ami, H. C.-B., Rosen, H., Shohami, E. & Lichtstein, D. Ouabain improves functional recovery following traumatic brain injury. J. Neurotrauma 31, 1942–1947 (2014).

20.          Hodes, A. & Lichtstein, D. Natriuretic hormones in brain function. Front. Endocrinol. (Lausanne). 5, (2014).

21.          Nesher, M. et al. Interaction of atrial natriuretic peptide and ouabain in the myocardium. Can. J. Physiol. Pharmacol. 90, 1386–1393 (2012).

22.          Fridman, E., Lichtstein, D. & Rosen, H. Formation of new high density glycogen-microtubule structures is induced by cardiac steroids. J. Biol. Chem. 287, 6518–6529 (2012).

23.          Lichtstein, D., Rosen, H. & Dvela, M. Cardenolides and bufadienolides as hormones: What is missing? Am. J. Physiol. - Ren. Physiol. 302, F957–F958 (2012).

24.          Dvela, M., Rosen, H., Ben-Ami, H. C. & Lichtstein, D. Endogenous ou0061bain regulates cell viability. Am. J. Physiol. - Cell Physiol. 302, C442–C452 (2012).

25.          Goldstein, I. et al. Neutralization of endogenous digitalis-like compounds alters catecholamines metabolism in the brain and elicits anti-depressive behavior. Eur. Neuropsychopharmacol. 22, 72–79 (2012).

26.          Feldmann, T. et al. The Na+/Ca2+-exchanger: An essential component in the mechanism governing cardiac steroid-induced slow Ca2+ oscillations. Cell Calcium 50, 424–432 (2011).

27.          Nesher, M. et al. Ouabain attenuates cardiotoxicity induced by other cardiac steroids. Br. J. Pharmacol. 160, 346–354 (2010).

28.          Guttmann-Rubinstein, L. et al. Evidence of a parathyroid hormone-independent chronic effect of estrogen on renal phosphate handling and sodium-dependent phosphate cotransporter type IIa expression. Horm. Metab. Res. 42, 230–236 (2010).

29.          Jaiswal, M. K., Dvela, M., Lichtstein, D. & Mallick, B. N. Endogenous ouabain-like compounds in locus coeruleus modulate rapid eye movement sleep in rats. J. Sleep Res. 19, 183–191 (2010).

30.          Nesher, M., Dvela, M., Igbokwe, V. U., Rosen, H. & Lichtstein, D. Physiological roles of endogenous ouabain in normal rats. Am. J. Physiol. - Hear. Circ. Physiol. 297, H2026–H2034 (2009).

31.          Klar, A., Haver, E., Lichtstein, D., Hurvitz, H. & Foah-Shauli, T. Atrial natriuretic peptide in young and elderly children with mild gastroenteritis. Gastroenterol. Res. Pract. (2009) doi:10.1155/2009/623871.

32.          Goldstein, I. et al. Association Between Sodium- and Potassium-Activated Adenosine Triphosphatase α Isoforms and Bipolar Disorders. Biol. Psychiatry 65, 985–991 (2009).

33.          Nesher, M. et al. Reversible pegylation prolongs the hypotensive effect of atrial natriuretic peptide. Bioconjug. Chem. 19, 342–348 (2008).

34.          Dvela, M., Rosen, H., Feldmann, T., Nesher, M. & Lichtstein, D. Diverse biological responses to different cardiotonic steroids. Pathophysiology 14, 159–166 (2007).

35.          Feldmann, T. et al. Role of endosomal Na+-K+-ATPase and cardiac steroids in the regulation of endocytosis. Am. J. Physiol. - Cell Physiol. 293, C885–C896 (2007).

36.          Nesher, M., Shpolansky, U., Rosen, H. & Lichtstein, D. The digitalis-like steroid hormones: New mechanisms of action and biological significance. Life Sci. 80, 2093–2107 (2007).

37.          Rosen, H., Glukmann, V., Feldmann, T., Fridman, E. & Lichtstein, D. Short-term effects of cardiac steroids on intracellular membrane traffic in neuronal NT2 cells. Cell. Mol. Biol. 52, 78–86 (2006).

38.          Goldstein, I. et al. Involvement of Na+, K+-ATPase and Endogenous Digitalis-Like Compounds in Depressive Disorders. Biol. Psychiatry 60, 491–499 (2006).

39.          Deutsch, J. et al. 4-(3′α15′β-dihydroxy-5′β-estran- 17′β-yl)furan-2-methyl alcohol: An anti-digoxin agent with a novel mechanism of action. J. Med. Chem. 49, 600–606 (2006).

40.          Haviv, M., Haver, E., Lichtstein, D., Hurvitz, H. & Klar, A. Atrial natriuretic peptide in children with pneumonia. Pediatr. Pulmonol. 40, 306–309 (2005).

41.          Landsman, A., Lichtstein, D. & Ilani, A. Distinctive features of dietary phosphate supply. J. Appl. Physiol. 99, 1214–1219 (2005).

42.          Rosen, H., Glukhman, V., Feldmann, T., Fridman, E. & Lichtstein, D. Cardiac Steroids Induce Changes in Recycling of the Plasma Membrane in Human NT2 Cells. Mol. Biol. Cell 15, 1044–1054 (2004).

43.          Lichtstein, D. & Rosen, H. Endogenous digitalis-like Na+, K+-ATPase inhibitors, and brain function. Neurochem. Res. 26, 971–978 (2001).

44.          Landsman, A., Lichtstein, D., Bacaner, M. & Ilani, A. Dietary phosphate-dependent growth is not mediated by changes in plasma phosphate concentration. Br. J. Nutr. 86, 217–223 (2001).

45.          Cheng, Q., Lichtstein, D., Russell, P. & Zigler Jr., J. S. Use of lipophilic cation to monitor electrical membrane potential in the intact rat lens. Investig. Ophthalmol. Vis. Sci. 41, 482–487 (2000).

46.          Traub, N. & Lichtstein, D. The Mood Cycle Hypothesis: Possible Involvement Of Steroid Hormones In Mood Regulation By Means Of Na+,K+-Atpase Inhibition. J. Basic Clin. Physiol. Pharmacol. 11, 375–394 (2000).

47.          Lichtstein, D., Mcgowan, M. H., Russell, P. & Carper, D. A. Digitalis and Digitalislike Compounds Down-Regulate Gene Expression of the Intracellular Signaling Protein 14-3-3 in Rat Lens. Hypertens. Res. - Clin. Exp. 23, (2000).

48.          McGowan, M. H., Russell, P., Carper, D. A. & Lichtstein, D. Na+, K+-ATPase inhibitors down-regulate gene expression of the intracellular signaling protein 14-3-3 in rat lens. J. Pharmacol. Exp. Ther. 289, 1559–1563 (1999).

49.          Lichtstein, D. et al. The effects of digitalis-like compounds on rat lenses. Investig. Ophthalmol. Vis. Sci. 40, 407–413 (1999).

50.          Lichtstein, D. et al. Biosynthesis of digitalis-like compounds in rat adrenal cells: Hydroxycholesterol as possible precursor. Life Sci. 62, 2109–2126 (1998).

51.          Lichtstein, D. et al. Bufodienolides as Endogenous Na+, K+-ATPase Inhibitors: Biosynthesis in Bovine and Rat Adrenals. Clin. Exp. Hypertens. 20, 573–579 (1998).

52.          Morris, J. F., Ismail-Beigi, F., Butler Jr., V. P., Gati, I. & Lichtstein, D. Ouabain-sensitive Na+,K+-ATPase activity in toad brain. Comp. Biochem. Physiol. - A Physiol. 118, 599–606 (1997).

53.          Furman, S., Lichtstein, D. & Ilani, A. Sodium-dependent transport of phosphate in neuronal and related cells. Biochim. Biophys. Acta - Biomembr. 1325, 34–40 (1997).

54.          Samuelov, S. & Lichtstein, D. Digitalis-like compounds and Na+, K+-ATPase activity in bovine lens. Pflugers Arch. Eur. J. Physiol. 433, 435–441 (1997).

55.          Antolovic, R. et al. Demonstration of a specific transport protein for cardiac glycosides in bovine blood. Annals of the New York Academy of Sciences vol. 834 618–620 (1997).

56.          Bachar, C., Haver, E., Kadar, T., Levy, A. & Lichtstein, D. Possible involvement of atrial natriuretic peptides in olfaction. Brain Res. 682, 231–234 (1995).

57.          Haver, E., Lichtstein, D. & Munson, P. J. Multiple types of binding sites for atrial natriuretic peptide in rat olfactory bulb membranes and synaptosomes. Brain Res. 681, 75–83 (1995).

58.          Lichtstein, D. et al. Na+, K+-ATPase and heart excitability. Advances in Experimental Medicine and Biology vol. 382 23–30 (1995).

59.          Bachar, H. & Lichtstein, D. Distribution of Atrial Natriuretic Peptides in the Sand Rat (Psammomys Obesus) in Comparison to That in the Rat. J. Basic Clin. Physiol. Pharmacol. 4, 47–56 (1993).

60.          Lichtstein, D., Gati, I. & Ovadia, H. Digitalis-like compounds in the toad Bufo viridis: Interactions with plasma proteins. J. Cardiovasc. Pharmacol. 22, S102–S105 (1993).

61.          LICHTSTEIN, D. et al. Identification of digitalis‐like compounds in human cataractous lenses. Eur. J. Biochem. 216, 261–268 (1993).

62.          Bachar, H., Haver, E., Ilani, A. & Lichtstein, D. Modulation of rat olfactory bulb mitochondrial function by atrial natriuretic peptide. Pflügers Arch. Eur. J. Physiol. 422, 204–206 (1992).

63.          Lichtstein, D., Gati, I., Haver, E. & Katz, U. Digitalis-like compounds in the toad Bufo viridis: Tissue and plasma levels and significance in osmotic stress. Life Sci. 51, 119–128 (1992).

64.          Lichtstein, D., Gati, I., Babila, T., Haver, E. & Katz, U. Effect of salt acclimation on digitalis-like compounds in the toad. BBA - Gen. Subj. 1073, 65–68 (1991).

65.          Lichtstein, D. et al. Identification of 11,13-dihydroxy-14-octadecaenoic acid as a circulating Na+/K+-ATPase inhibitor. J. Endocrinol. 128, 71–78 (1991).

66.          Oberfrank, F., Vizi, E. S., Baker, P. F., Samuelov, S. & Lichtstein, D. Comparison of the effects of a bufodienolide and ouabain on neuronal and smooth muscle preparations. Neurosci. Res. 10, 235–244 (1991).

67.          Lichtstein, D. & Atlan, H. The ‘cellular state’: The way to regain specificity and diversity in hormone action. J. Theor. Biol. 145, 287–294 (1990).

68.          Babila, T. et al. Volume Regulation of Nerve Terminals. J. Neurochem. 55, 2058–2062 (1990).

69.          Babila, T., Gottlieb, Y., Lutz, R. A. & Lichtstein, D. A bumetanide-sensitive, potassium carrier-mediated transport system in excitable tissues. Life Sci. 44, 1665–1675 (1989).

70.          Oberfrank, F., Vizi, E. S. & Lichtstein, D. Presynaptic modulation by endogenous ouabain-like substances of noradrenaline release from blood vessels. Pol. J. Pharmacol. Pharm. 40, 685–690 (1988).

71.          Xu, H. et al. Multiple interactions of unsaturated fatty acids with opiate and ouabain binding sites and βadrenergic sensitive adenylate cyclase system. J. Recept. Signal Transduct. 8, 205–223 (1988).

72.          Bloch, K. D., Zamir, N., Lichtstein, D., Seidman, C. E. & Seidman, J. G. Ouabain induces secretion of proatrial natriuretic factor by rat atrial cardiocytes. Am. J. Physiol. - Endocrinol. Metab. 255, (1988).

73.          Lichtstein, D. & Rodbard, D. A second look at the second messenger hypothesis. Life Sci. 40, 2041–2051 (1987).

74.          Vizi, E. S., Oberfrank, F., Bernath, S. & Lichtstein, D. Noradrenaline releasing effect of an ouabain-like compound on pulmonary artery. Neuropharmacology 26, 1541–1544 (1987).

75.          Lutz, R. A., Lichtstein, D., Xu, H. & Rodbard, D. Demonstration and characterization of two classes of cardiac glycoside binding sites to rat heart membrane preparations using quantitative computer modeling. J. Recept. Signal Transduct. 7, 679–694 (1987).

76.          Lichtstein, D. et al. The ouabain receptor in animal tissues and its endogenous ligand. Klin. Wochenschr. 65, 40–48 (1987).

77.          Silva, P. et al. Isolated rectal gland cells: Oxygen consumption and hormonal stimulation. Miner. Electrolyte Metab. 12, 286–292 (1986).

78.          Lichtstein, D., Lutz, R. A., Xu, H. & Rodbard, D. Characterization of two classes of cardiac glycosine binding sites in rat heart and brain membrane preparations, using quantitative computer modelling. J. Hypertens. 4, S227–S229 (1986).

79.          Lichtstein, D., Kachalsky, S. & Deutsch, J. Identification of a ouabain-like compound in toad skin and plasma as a bufodienolide derivative. Life Sci. 38, 1261–1270 (1986).

80.          Tal, D. M., Katchalsky, S., Lichtstein, D. & Karlish, S. J. D. Endogenous ‘ouabain-like’ activity in bovine plasma. Biochem. Biophys. Res. Commun. 135, 1–8 (1986).

81.          Shimoni, Y. et al. Further characterisation of the inotropic effect of a bufodienolide glycoside - an endogenous ouabain like compound. Cardiovasc. Res. 20, 229–239 (1986).

82.          Bourrit, A., Atlan, H., Fromer, I., Melmed, R. N. & Lichtstein, D. Basic characterization of an ouabain-resistant, bumetanide-sensitive K+ carrier-mediated transport system in J774.2 mouse macrophage-like cell line and in variants deficient in adenylate cyclase and cAMP-dependent protein kinase activities. BBA - Biomembr. 817, 85–94 (1985).

83.          Lichtstein, D., Samuelov, S. & Bourrit, A. Characterization of the stimulation of neuronal Na+, K+-ATPase activity by low concentrations of ouabain. Neurochem. Int. 7, 709–715 (1985).

84.          Lichtstein, D. et al. Demonstration of a ouabainlike plasma compound in hypertension prone and hypertension resistant rats. Hypertension 7, 729–733 (1985).

85.          Shimoni, Y., Gotsman, M., Deutsch, J., Kachalsky, S. & Lichtstein, D. Endogenous ouabain-like compound increases heart muscle contractility. Nature 307, 369–371 (1984).

86.          Ilani, A., Yachin, S. & Lichtstein, D. Comparison between bretylium and diphenylhydantoin interaction with mucosal sodium-channels. BBA - Biomembr. 777, 323–330 (1984).

87.          Ilani, A., Lichtstein, D. & Bacaner, M. B. Bretylium opens mucosal amiloride-sensitive sodium channels. BBA - Biomembr. 693, 503–506 (1982).

88.          Lichtstein, D., Mullikin-Kilpatrick, D. & Blume, A. J. Modification of neuroblastoma X glioma hybrid NG108-15 adenylate cyclase by vanadium ions. Biochem. Biophys. Res. Commun. 105, 1157–1165 (1982).

89.          Lichtstein, D. & Samuelov, S. Characterization of ouabain receptor in neuronal tissue: Evidence for endogenous ouabain-like compound. Isr. J. Med. Sci. 18, 45–50 (1982).

90.          Lichtstein, D., Mullikin-Kilpatrick, D. & Blume, A. J. Vanadate-induced hyperpolarization of neuroblastoma-glioma hybrid NG108-15 cells. Isr. J. Med. Sci. 18, 551 (1982).

91.          Lichtstein, D. & Samuelov, S. Membrane potential changes induced by the ouabain-like compound extracted from mammalian brain. Proc. Natl. Acad. Sci. U. S. A. 79, 1453–1456 (1982).

92.          Rochel, S., Lichtstein, D., Blume, A. J. & Margolis, F. L. Membrane potential of olfactory bulb synaptosomal fractions: Characterization with the lipophilic cation tetraphenylphosphonium. J. Neurosci. 1, 1180–1192 (1981).

93.          Lichtstein, D. & Samuelov, S. Endogenous ‘ouabain like’ activity in rat brain. Top. Catal. 96, 1518–1523 (1980).