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The Faculty of Medicine - Medical Neurobiology: Yaari Yoel


Last updated September 2023 - Medical Neurobiology

List of Publications

(1) Tiwari MN, Mohan S, Biala Y, Shor O, Benninger F, Yaari Y. Corticotropin releasing factor mediates KCa3.1 inhibition, hyperexcitability and seizures in acquired epilepsy. J Neurosci 2022;42(30).

(2) Mohan S, Tiwari MN, Stanojević M, Biala Y, Yaari Y. Muscarinic regulation of the neuronal Na+/K+-ATPase in rat hippocampus. J Physiol 2021;599(15):3735-3754.

(3) Licht T, Kreisel T, Biala Y, Mohan S, Yaari Y, Anisimov A, et al. Age-dependent remarkable regenerative potential of the dentate gyrus provided by intrinsic stem cells. J Neurosci 2020;40(5):974-995.

(4) Tiwari MN, Mohan S, Biala Y, Yaari Y. Protein kinase a-mediated suppression of the slow afterhyperpolarizing KCa3.1 current in temporal lobe epilepsy. J Neurosci 2019;39(50):9914-9926.

(5) Mohan S, Tiwari MN, Biala Y, Yaari Y. Regulation of neuronal Na+/K+-atpase by specific protein kinases and protein phosphatases. J Neurosci 2019;39(28):5440-5451.

(6) Tiwari MN, Mohan S, Biala Y, Yaari Y. Differential contributions of Ca2+-activated K+ channels and Na+/K+-ATPases to the generation of the slow afterhyperpolarization in CA1 pyramidal cells. Hippocampus 2018;28(5):338-357.

(7) Tamir I, Daninos M, Yaari Y. Plasticity of intrinsic firing response gain in principal hippocampal neurons following pilocarpine-induced status epilepticus. Neuroscience 2017;357:325-337.

(8) Tzour A, Leibovich H, Barkai O, Biala Y, Lev S, Yaari Y, et al. KV7/M channels as targets for lipopolysaccharide-induced inflammatory neuronal hyperexcitability. J Physiol 2017;595(3):713-738.

(9) Royeck M, Kelly T, Opitz T, Otte D-, Rennhack A, Woitecki A, et al. Downregulation of spermine augments dendritic persistent sodium currents and synaptic integration after status epilepticus. J Neurosci 2015;35(46):15240-15253.

(10) Van Loo KMJ, Schaub C, Pitsch J, Kulbida R, Opitz T, Ekstein D, et al. Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1. Nat Commun 2015;6.

(11) Shrot S, Ramaty E, Biala Y, Bar-Klein G, Daninos M, Kamintsky L, et al. Prevention of organophosphate-induced chronic epilepsy by early benzodiazepine treatment. Toxicology 2014;323:19-25.

(12) Chen S, Benninger F, Yaari Y. Role of small conductance Ca2+-Activated K+ channels in controlling CA1 pyramidal cell excitability. J Neurosci 2014;34(24):8219-8230.

(13) Ekstein D, Benninger F, Daninos M, Pitsch J, van Loo KMJ, Becker AJ, et al. Zinc induces long-term upregulation of T-type calcium current in hippocampal neurons in vivo. J Physiol 2012;590(22):5895-5905.

(14) Van Loo KMJ, Schaub C, Pernhorst K, Yaari Y, Beck H, Schoch S, et al. Transcriptional regulation of T-type calcium channel CaV3.2: Bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein -silencing transcription factor (REST). J Biol Chem 2012;287(19):15489-15501.

(15) Yakunin E, Loeb V, Kisos H, Biala Y, Yehuda S, Yaari Y, et al. α-Synuclein neuropathology is controlled by nuclear hormone receptors and enhanced by docosahexaenoic acid in a mouse model for Parkinson's disease. Brain Pathol 2012;22(3):280-294.

(16) Chen S, Su H, Yue C, Remy S, Royeck M, Sochivko D, et al. An increase in persistent sodium current contributes to intrinsic neuronal bursting after status epilepticus. J Neurophysiol 2011;105(1):117-129.

(17) Remy S, Beck H, Yaari Y. Plasticity of voltage-gated ion channels in pyramidal cell dendrites. Curr Opin Neurobiol 2010;20(4):503-509.

(18) Caspi A, Benninger F, Yaari Y. KV7/M channels mediate osmotic modulation of intrinsic neuronal excitability. J Neurosci 2009;29(36):11098-11111.

(19) Yaari Y, Beck H. Pyramidal Cells: Intrinsic Plasticity of Hippocampal CA1 Pyramidal Cells and its Relevance to Epileptic Discharge and Epileptogenesis. Encyclopedia of Basic Epilepsy Research; 2009. p. 1272-1277.

(20) Becker AJ, Pitsch J, Sochivko D, Opitz T, Staniek M, Chen C-, et al. Transcriptional upregulation of Cav3.2 mediates epileptogenesis in the pilocarpine model of epilepsy. J Neurosci 2008;28(49):13341-13353.

(21) Safiulina VF, Zacchi P, Taglialatela M, Yaari Y, Cherubini E. Low expression of Kv7/M channels facilitates intrinsic and network bursting in the developing rat hippocampus. J Physiol 2008;586(22):5437-5453.

(22) Royeck M, Horstmann M-, Remy S, Reitze M, Yaari Y, Beck H. Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neurons. J Neurophysiol 2008;100(4):2361-2380.

(23) Beck H, Yaari Y. Plasticity of intrinsic neuronal properties in CNS disorders. Nat Rev Neurosci 2008;9(5):357-369.

(24) Chen S, Yaari Y. Spike Ca2+ influx upmodulates the spike afterdepolarization and bursting via intracellular inhibition of KV7/M channels. J Physiol 2008;586(5):1351-1363.

(25) Yaari Y, Yue C, Su H. Recruitment of apical dendritic T-type Ca2+ channels by backpropagating spikes underlies de novo intrinsic bursting in hippocampal epileptogenesis. J Physiol 2007;580(2):435-450.

(26) Peretz A, Sheinin A, Yue C, Degani-Katzav N, Gibor G, Nachman R, et al. Pre- and postsynaptic activation of M-channels by a novel opener dampens neuronal firing and transmitter release. J Neurophysiol 2007;97(1):283-295.

(27) Golomb D, Yue C, Yaari Y. Contribution of persistent Na+ current and M-type K+ current to somatic bursting in CA1 pyramidal cells: Combined experimental and modeling study. J Neurophysiol 2006;96(4):1912-1926.

(28) Yue C, Yaari Y. Axo-somatic and apical dendritic Kv7/M channels differentially regulate the intrinsic excitability of adult rat CA1 pyramidal cells. J Neurophysiol 2006;95(6):3480-3495.

(29) Yue C, Remy S, Su H, Beck H, Yaari Y. Proximal persistent Na+ channels drive spike afterdepolarizations and associated bursting in adult CA1 pyramidal cells. J Neurosci 2005;25(42):9704-9720.

(30) Chen S, Yue C, Yaari Y. A transitional period of Ca2+-dependent spike afterdepolarization and bursting in developing rat CA1 pyramidal cells. J Physiol 2005;567(1):79-93.

(31) Yue C, Yaari Y. KCNQ/M channels control spike afterdepolarization and burst generation in hippocampal neurons. J Neurosci 2004;24(19):4614-4624.

(32) Wellmer J, Su H, Beck H, Yaari Y. Long-lasting modification of intrinsic discharge properties in subicular neurons following status epilepticus. Eur J Neurosci 2002;16(2):259-266.

(33) Su H, Sochivko D, Becker A, Chen J, Jiang Y, Yaari Y, et al. Upregulation of a T-Type Ca2+ Channel Causes a Long-Lasting Modification of Neuronal Firing Mode after Status Epilepticus. J Neurosci 2002;22(9):3645-3655.

(34) Yaari Y, Beck H. "Epileptic neurons" in temporal lobe epilepsy. Brain Pathol 2002;12(2):234-239.

(35) Su H, Alroy G, Kirson ED, Yaari Y. Extracellular calcium modulates persistent sodium current-dependent burst-firing in hippocampal pyramidal neurons. J Neurosci 2001;21(12):4173-4182.

(36) Sanabria ERG, Su H, Yaari Y. Initiation of network bursts by Ca2+-dependent intrinsic bursting in the rat pilocarpine model of temporal lobe epilepsy. J Physiol 2001;532(1):205-216.

(37) Eilon D, Yaari Y. Unique properties of NMDA receptors enhance synaptic excitation of radiatum giant cells in rat hippocampus. J Neurosci 2000;20(13):4844-4854.

(38) Kirson ED, Yaari Y. A novel technique for micro-dissection of neuronal processes. J Neurosci Methods 2000;98(2):119-122.

(39) Kirson ED, Schirra C, Konnerth A, Yaari Y. Early postnatal switch in magnesium sensitivity of NMDA receptors in rat CA1 pyramidal cells. J Physiol 1999;521(1):99-111.

(40) Alroy G, Su H, Yaari Y. Protein kinase C mediates muscarinic block of intrinsic bursting in rat hippocampal neurons. J Physiol 1999;518(1):71-79.

(41) Perouansky M, Kirson ED, Yaari Y. Mechanism of action of volatile anesthetics: Effects of halothane on glutamate receptors in vitro. Toxicol Lett 1998;100-101:65-69.

(42) Kirson ED, Yaari Y, Perouansky M. Presynaptic and postsynaptic actions of halothane at glutamatergic synapses in the mouse hippocampus. Br J Pharmacol 1998;124(8):1607-1614.

(43) Garaschuk O, Yaari Y, Konnerth A. Release and sequestration of calcium by ryanodine-sensitive stores in rat hippocampal neurones. J PHYSIOL 1997;502(1):13-30.

(44) Azouz R, Alroy G, Yaari Y. Modulation of endogenous firing patterns by osmolarity in rat hippocampal neurones. J PHYSIOL 1997;502(1):175-187.

(45) Jensen MS, Yaari Y. Role of intrinsic burst firing, potassium accumulation, and electrical coupling in the elevated potassium model of hippocampal epilepsy. J Neurophysiol 1997;77(3):1224-1233.

(46) Perouansky M, Kirson ED, Yaari Y. Halothane blocks synaptic excitation of inhibitory interneurons. Anesthesiology 1996;85(6):1431-1438.

(47) Azouz R, Jensen MS, Yaari Y. Ionic basis of spike after-depolarization and burst generation in adult rat hippocampal CA1 pyramidal cells. J PHYSIOL 1996;492(1):211-223.

(48) Jensen MS, Azouz R, Yaari Y. Spike after-depolarization and burst generation in adult rat hippocampal CA1 pyramidal cells. J PHYSIOL 1996;492(1):199-210.

(49) Kirson ED, Yaari Y. Synaptic NMDA receptors in developing mouse hippocampal neurones: Functional properties and sensitivity to ifenprodil. J PHYSIOL 1996;497(2):437-455.

(50) Perouansky M, Baranov D, Salman M, Yaari Y. Effects of halothane on glutamate receptor-mediated excitatory postsynaptic currents: A patch-clamp study in adult mouse hippocampal slices. Anesthesiology 1995;83(1):109-119.

(51) Azouz R, Jensen MS, Yaari Y. Muscarinic Modulation of Intrinsic Burst Firing in Rat Hippocampal Neurons. Eur J Neurosci 1994;6(6):961-966.

(52) Jensen MS, Azouz R, Yaari Y. Variant firing patterns in rat hippocampal pyramidal cells modulated by extracellular potassium. J Neurophysiol 1994;71(3):831-839.

(53) Perouansky M, Yaari Y. Kinetic properties of NMDA receptor‐mediated synaptic currents in rat hippocampal pyramidal cells versus interneurones. J Physiol 1993;465(1):223-244.

(54) Jensen MS, Cherubini E, Yaari Y. Opponent effects of potassium on GABA(A)-mediated postsynaptic inhibition in the rat hippocampus. J Neurophysiol 1993;69(3):764-771.

(55) Azouz R, Jensen MS, Yaari Y. Interictal activity induces long-term enhancement of excitatory postsynaptic potentials in the hippocampus. Epilepsy Res Suppl 1992;9:313-316; discussion 316-317.

(56) Yaari Y, Jensen MS. Two types of epileptic foci generating brief and sustained paroxysms in the in vitro rat hippocampus. Epilepsy Res Suppl 1992;8:263-269.

(57) Keller BU, Konnerth A, Yaari Y. Patch clamp analysis of excitatory synaptic currents in granule cells of rat hippocampus. J Physiol 1991;435(1):275-293.

(58) Konnerth A, Keller BU, Ballanyi K, Yaari Y. Voltage sensitivity of NMDA-receptor mediated postsynaptic currents. Exp Brain Res 1990;81(1):209-212.

(59) Yaari Y, Jensen MS, Perouansky M, Keller BU, Konnerth A. Enhanced synaptic activation of nmda receptors during hippocampal seizures. J Basic Clin Physiol Pharmacol 1990;1(1-4):41-48.

(60) Yaari Y, Jensen MS. Cholinergic modulation of hippocampal epileptic activity in vitro. EXS 1989;57:150-158.

(61) Jensen MS, Yaari Y. The relationship between interictal and ictal paroxysms in an in vitro model of focal hippocampal epilepsy. Ann Neurol 1988;24(5):591-598.

(62) Nelken I, Yaari Y. The role of interstitial potassium in the generation of low-calcium hippocampal seizures. Isr J Med Sci 1987;23(1-2):124-131.

(63) Yaari Y, Hamon B, Lux HD. Development of two types of calcium channels in cultured mammalian hippocampal neurons. Science 1987;235(4789):680-682.

(64) Hevron E, David G, Arnon A, Yaari Y. Acetylcholine modulates two types of presynaptic potassium channels in vertebrate motor nerve terminals. Neurosci Lett 1986;72(1):87-92.

(65) David G, Selzer ME, Yaari Y. Activity-dependent depression of nerve action potential by phenytoin. Neurosci Lett 1986;66(2):163-168.

(66) Adler EM, Yaari Y, David G, Selzer ME. Frequency-dependent action of phenytoin on lamprey spinal axons. Brain Res 1986;362(2):271-280.

(67) Yaari Y, Konnerth A, Heinemann U. Nonsynaptic epileptogenesis in the mammalian hippocampus in vitro. II. Role of extracellular potassium. J Neurophysiol 1986;56(2):424-438.

(68) Yaari Y, Selzer ME, Pincus JH. Phenytoin: Mechanisms of its anticonvulsant action. Ann Neurol 1986;20(2):171-184.

(69) Konnerth A, Heinemann U, Yaari Y. Nonsynaptic epileptogenesis in the mammalian hippocampus in vitro. I. Development of seizurelike activity in low extracellular calcium. J Neurophysiol 1986;56(2):409-423.

(70) Yaari Y, Selzer ME, David G. Frequency-dependent effects of phenytoin on frog junctional transmission: Presynaptic mechanisms. Brain Res 1985;345(1):102-110.

(71) David G, Selzer ME, Yaari Y. Suppression by phenytoin of convulsant-induced afterdischarges at presynaptic nerve terminals. Brain Res 1985;339(1):57-65.

(72) Yaari Y, Devor M. Phenytoin suppresses spontaneous ectopic discharge in rat sciatic nerve neuromas. Neurosci Lett 1985;58(1):117-122.

(73) Heinemann U, Franceschetti S, Hamon B, Konnerth A, Yaari Y. Effects of anticonvulsants on spontaneous epileptiform activity which develops in the absence of chemical synaptic transmission in hippocampal slices. Brain Res 1985;325(1-2):349-352.

(74) Selzer ME, David G, Yaari Y. On the mechanism by which phenytoin blocks post-tetanic potentiation at the frog neuromuscular junction. J Neurosci 1985;5(11):2894-2899.

(75) Konnerth A, Heinemann U, Yaari Y. Slow transmission of neural activity in hippocampal area CA1 in absence of active chemical synapses. Nature 1984;307(5946):69-71.

(76) Selzer ME, David G, Yaari Y. Phenytoin reduces frequency potentiation of synaptic potentials at the frog neuromuscular junction. Brain Res 1984;304(1):149-152.

(77) Yaari Y, Konnerth A, Heinemann U. Spontaneous epileptiform activity of ca1 hippocampal neurons in low extracellular calcium solutions. Exp Brain Res 1983;51(1):153-156.

(78) Kolton L, Yaari Y. Sites of action of lead on spontaneous transmitter release from motor nerve terminals. Isr J Med Sci 1982;18(1):165-170.

(79) Carlen PL, Werman R, Yaari Y. Post‐synaptic conductance increase associated with presynaptic inhibition in cat lumbar motoneurones. J Physiol 1980;298(1):539-556.

(80) Pincus JH, Yaari Y, Argov Z. Phenytoin: electrophysiological effects at the neuromuscular junction. Adv Neurol 1980;27:363-376.

(81) Argov Z, Yaari Y. The action of chlorpromazine at an isolated cholinergic synapse. Brain Res 1979;164(1-2):227-236.

(82) Yaari Y, Pincus JH, Argov Z. Phenytoin and transmitter release at the neuromuscular junction of the frog. Brain Res 1979;160(3):479-487.

(83) Grinvald A, Yaari Y. Utilization of fluorescent lanthanide ions for the study of cation binding to extracellular sites in frog skeletal muscle. Life Sci 1978;22(18):1573-1583.

(84) Yaari Y, Pincus JH, Argov Z. Depression of synaptic transmission by diphenylhydantoin. Ann Neurol 1977;1(4):334-338.

(85) Argov Z, Yaari Y. The effect of chlorpromazine on the frog neuromuscular junction. Isr J Med Sci 1977;13(5):538.

(86) Yaari Y, Pincus JH, Argov Z. Inhibition of synaptic transmission by diphenylhydantoin. Trans Am Neurol Assoc 1976;101:195-199.

(87) Yaari Y, Erulkar SD. Recurrent inhibition in the frog spinal cord - is it really presynaptic? Isr J Med Sci 1975;11(8):857.

(88) Rahamimoff R, Yaari Y. Delayed release of transmitter at the frog neuromuscular junction. J Physiol 1973;228(1):241-257.