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The Faculty of Medicine - Medical Neurobiology: Ornoy Asher

Researchers

Last updated September 2024 - Medical Neurobiology

List of Publications

1.            Ornoy, A., Echefu, B. & Becker, M. Valproic Acid in Pregnancy Revisited: Neurobehavioral, Biochemical and Molecular Changes Affecting the Embryo and Fetus in Humans and in Animals: A Narrative Review. Int. J. Mol. Sci. 25, (2024).

2.            Cohen-Eliraz, L. et al. Prenatal exposure to phthalates and emotional/behavioral development in young children. Neurotoxicology 98, 39–47 (2023).

3.            Ornoy, A. & Miller, R. K. Yolk sac development, function and role in rodent pregnancy. Birth Defects Res. 115, 1243–1254 (2023).

4.            Lapidot, Y. et al. Relationships of the gut microbiome with cognitive development among healthy school-age children. Front. Pediatr. 11, (2023).

5.            Becker, M. et al. Prenatal SAMe Treatment Changes via Epigenetic Mechanism/s USVs in Young Mice and Hippocampal Monoamines Turnover at Adulthood in a Mouse Model of Social Hierarchy and Depression. Int. J. Mol. Sci. 24, (2023).

6.            Tenami, S. et al. The impact of minor trauma during pregnancy on maternal and neonatal outcomes: A tertiary centre experience. Surg. Pract. Sci. 13, (2023).

7.            Na’amnih, W. et al. Associations of early-life exposures and socioeconomic status with cognitive development at preadolescence. Pediatr. Neonatol. 64, 192–200 (2023).

8.            Ornoy, A., Gorobets, D., Weinstein-Fudim, L. & Becker, M. Sex-Related Changes in the Clinical, Genetic, Electrophysiological, Connectivity, and Molecular Presentations of ASD: A Comparison between Human and Animal Models of ASD with Reference to Our Data. Int. J. Mol. Sci. 24, (2023).

9.            Ornoy, A., Weinstein-Fudim, L., Becker, M., Gorobets, D. & Szyf, M. Gender specific neurobehavioral and gene expression changes in a valproic acid (VPA)–induced mouse model of autistic like behavior and correction by S-adenosylmethionine (SAMe). in Sex, Gender, and Epigenetics: From Molecule to Bedside 163–180 (Elsevier, 2023). doi:10.1016/B978-0-12-823937-7.00024-9.

10.          Bromley, R. L. et al. Expert consensus on neurodevelopmental outcomes in pregnancy pharmacovigilance studies. Front. Pharmacol. 14, (2023).

11.          Kassem, E., Na’amnih, W., Shapira, M., Ornoy, A. & Muhsen, K. Comparison between School-Age Children with and without Obesity in Nutritional and Inflammation Biomarkers. J. Clin. Med. 11, (2022).

12.          Becker, M. et al. Prenatal SAMe Treatment Induces Changes in Brain Monoamines and in the Expression of Genes Related to Monoamine Metabolism in a Mouse Model of Social Hierarchy and Depression, Probably via an Epigenetic Mechanism. Int. J. Mol. Sci. 23, (2022).

13.          Becker, M., Abaev, K., Pinhasov, A. & Ornoy, A. S-Adenosyl-Methionine alleviates sociability aversion and reduces changes in gene expression in a mouse model of social hierarchy. Behav. Brain Res. 427, (2022).

14.          Ornoy, A., Weinstein-Fudim, L. & Becker, M. SAMe, Choline, and Valproic Acid as Possible Epigenetic Drugs: Their Effects in Pregnancy with a Special Emphasis on Animal Studies. Pharmaceuticals 15, (2022).

15.          Tal-Saban, M., Ornoy, A. & Parush, S. Participation of soldiers with DCD in the military. Mil. Psychol. 34, 47–54 (2022).

16.          Koren, G. & Ornoy, A. Gestational Exposure to Serotonin Reuptake Inhibitors and Pregnancy Outcome; Exploring the Role of Bias and Confounders. Curr. Neuropharmacol. 19, 2227–2232 (2021).

17.          Ornoy, A. & Koren, G. The Effects of Drugs used for the Treatment of Attention Deficit Hyperactivity Disorder (ADHD) on Pregnancy Outcome and Breast-feeding: A Critical Review. Curr. Neuropharmacol. 19, 1794–1804 (2021).

18.          Rimawi, I., Ornoy, A. & Yanai, J. Paternal and/or maternal preconception-induced neurobehavioral teratogenicity in animal and human models. Brain Res. Bull. 174, 103–121 (2021).

19.          Lapidot, Y. et al. The associations between diet and socioeconomic disparities and the intestinal microbiome in preadolescence. Nutrients 13, (2021).

20.          Muhsen, K. et al. Associations of feeding practices in early life and dietary intake at school age with obesity in 10-to 12-year-old arab children. Nutrients 13, (2021).

21.          Lubotzky-Gete, S., Ornoy, A., Grotto, I. & Calderon-Margalit, R. Postpartum depression and infant development up to 24 months: A nationwide population-based study. J. Affect. Disord. 285, 136–143 (2021).

22.          Ornoy, A., Becker, M., Weinstein-Fudim, L. & Ergaz, Z. Diabetes during pregnancy: A maternal disease complicating the course of pregnancy with long-term deleterious effects on the offspring. a clinical review. Int. J. Mol. Sci. 22, 1–38 (2021).

23.          Ornoy, A. The Developmental Interrelation Between the Nervous System and Craniofacial Complex as Evidenced from Craniofacial Malformations. in Fundamentals of Craniofacial Malformations: Vol. 1, Disease and Diagnostics vol. 1 39–52 (Springer International Publishing, 2021).

24.          Ornoy, A. & Koren, G. Neurotropic drugs in pregnancy and lactation from the point of view of the clinical teratologist. Curr. Neuropharmacol. 19, 1792–1793 (2021).

25.          Becker, M., Pinhasov, A. & Ornoy, A. Animal models of depression: What can they teach us about the human disease? Diagnostics 11, (2021).

26.          Koren, G. & Ornoy, A. Institutionalized Children and the Risk of Fetal Alcohol Spectrum Disorder (FASD); A Primer for Clinicians, Adoption Staff and Parents. Glob. Pediatr. Heal. 8, (2021).

27.          Kozhuhov, A. et al. Implementation of a six-around-one optical probe based on diffuse light spectroscopy for study of cerebral properties in a murine mouse model of autism spectrum disorder. Appl. Opt. 59, 6809–6816 (2020).

28.          Hellwig, K. et al. Pregnancy outcomes in interferon-beta-exposed patients with multiple sclerosis: results from the European Interferon-beta Pregnancy Registry. J. Neurol. 267, 1715–1723 (2020).

29.          Ornoy, A., Becker, M., Weinstein-Fudim, L. & Ergaz, Z. S-adenosine methionine (SAME) and valproic acid (VPA) as epigenetic modulators: Special emphasis on their interactions affecting nervous tissue during pregnancy. Int. J. Mol. Sci. 21, (2020).

30.          Weinstein-Fudim, L., Ergaz, Z., Szyf, M. & Ornoy, A. Prenatal s-adenosine methionine (SAMe) induces changes in gene expression in the brain of newborn mice that are prevented by co-administration of valproic acid (VPA). Int. J. Mol. Sci. 21, (2020).

31.          Koren, G., Barer, Y. & Ornoy, A. Fetal safety of methylphenidate—A scoping review and meta analysis. Reprod. Toxicol. 93, 230–234 (2020).

32.          Michlin, M., Argaev-Frenkel, L., Weinstein-Fudim, L., Ornoy, A. & Rosenzweig, T. Maternal n-acetyl cysteine intake improved glucose tolerance in obese mice offspring. Int. J. Mol. Sci. 21, (2020).

33.          Blumenfeld, O., Ben-Pazi, H., Ornoy, A., Josef, A. & Shohat, T. Prevalence of cerebral palsy with Gross Motor Function Classification System levels IV and V in children in Israel: a cross-cultural comparison. Child’s Nerv. Syst. 36, 411–416 (2020).

34.          Ornoy, A. Animal Models of Cerebral Palsy: What Can We Learn About Cerebral Palsy in Humans. in Cerebral Palsy: Second Edition 85–96 (Springer International Publishing, 2020). doi:10.1007/978-3-319-74558-9_218.

35.          Koren, G. & Ornoy, A. Searching for the Fetal Alcohol Behavioral Phenotype. Glob. Pediatr. Heal. 7, (2020).

36.          Ornoy, A. Craniofacial malformations and their association with brain development: the importance of a multidisciplinary approach for treatment. Odontology 108, (2020).

37.          Weinstein-Fudim, L. et al. Gender related changes in gene expression induced by valproic acid in a mouse model of autism and the correction by s-adenosyl methionine. Does it explain the gender differences in autistic like behavior? Int. J. Mol. Sci. 20, (2019).

38.          Yanai, J., Vigoda, M. J. & Ornoy, A. Reversal of neurobehavioral teratogenicity in animal models and human: Three decades of progress. Brain Res. Bull. 150, 328–342 (2019).

39.          Ornoy, A. & Spivak, A. Cost effectiveness of optimal treatment of ADHD in Israel: A suggestion for national policy. Health Econ. Rev. 9, (2019).

40.          Shilo, D. et al. Tuftelin’s involvement in embryonic development. J. Exp. Zool. Part B Mol. Dev. Evol. 332, 125–135 (2019).

41.          Ornoy, A. & Koren, G. Ssris and snris (Sri) in pregnancy: Effects on the course of pregnancy and the offspring: How far are we from having all the answers? Int. J. Mol. Sci. 20, (2019).

42.          Ornoy, A., Weinstein-Fudim, L. & Ergaz, Z. Prevention or amelioration of autism-like symptoms in animal models: Will it bring us closer to treating human ASD? Int. J. Mol. Sci. 20, (2019).

43.          Ornoy, A. et al. S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice. Neurotoxicol. Teratol. 71, 64–74 (2019).

44.          Ornoy, A., Koren, G. & Yanai, J. Is post exposure prevention of teratogenic damage possible: Studies on diabetes, valproic acid, alcohol and anti folates in pregnancy: Animal studies with reflection to human. Reprod. Toxicol. 80, 92–104 (2018).

45.          Diav-Citrin, O., Steinmetz-Shoob, S., Shechtman, S. & Ornoy, A. In-utero exposure to metformin for type 2 diabetes or polycystic ovary syndrome: A prospective comparative observational study. Reprod. Toxicol. 80, 85–91 (2018).

46.          Koren, G., Ornoy, A. & Berkovitch, M. Hyperemesis gravidarum—Is it a cause of abnormal fetal brain development? Reprod. Toxicol. 79, 84–88 (2018).

47.          Koren, G., Berkovitch, M. & Ornoy, A. Dose-Dependent Teratology in Humans: Clinical Implications for Prevention. Pediatr. Drugs 20, 331–335 (2018).

48.          Ergaz, Z., Weinstein-Fudim, L. & Ornoy, A. High sucrose low copper diet in pregnant diabetic rats induces transient oxidative stress, hypoxia, and apoptosis in the offspring’s liver. Birth Defects Res. 110, 1001–1015 (2018).

49.          Ornoy, A. & Bischitz, N. Diabetic embryopathy in the preimplantation embryo. in Textbook of Diabetes and Pregnancy 321–328 (CRC Press, 2018).

50.          Koren, G. & Ornoy, A. The role of the placenta in drug transport and fetal drug exposure. Expert Rev. Clin. Pharmacol. 11, 373–385 (2018).

51.          Ornoy, A. & Koren, G. Selective serotonin reuptake inhibitor use in pregnant women; pharmacogenetics, drug-drug interactions and adverse effects. Expert Opin. Drug Metab. Toxicol. 14, 247–259 (2018).

52.          Tal-Saban, M., Ornoy, A. & Parush, S. Success in adults with probable developmental coordination disorder using structural equation modeling. Am. J. Occup. Ther. 72, (2018).

53.          Ornoy, A. Pharmacological Treatment of Attention Deficit Hyperactivity Disorder During Pregnancy and Lactation. Pharm. Res. 35, (2018).

54.          Koren, G. & Ornoy, A. Clinical implications of selective serotonin reuptake inhibitors-selective serotonin norepinephrine reuptake inhibitors pharmacogenetics during pregnancy and lactation. Pharmacogenomics 19, 1139–1145 (2018).

55.          Guggenheim, K. Y., Wolinsky, I. & Ornoy, A. Nutrition and bone formation. in CRC Handbook of Nutritional Requirements in a Functional Context: Volume I: Development and Conditions of Physiologic Stress 209–256 (CRC Press, 2018). doi:10.1201/9781351072960.

56.          Ornoy, A. & Ergaz, Z. Parvovirus B19 (PVB19) in pregnancy: The impact of a partially neglected problem. in Advances in Health and Disease vol. 4 33–68 (Nova Science Publishers, Inc., 2018).

57.          Diav-Citrin, O., Shechtman, S., Zvi, N., Finkel-Pekarsky, V. & Ornoy, A. Is it safe to use lamotrigine during pregnancy? A prospective comparative observational study. Birth Defects Res. 109, 1196–1203 (2017).

58.          Ornoy, A. Neurobehavioral risks of SSRIs in pregnancy: Comparing human and animal data. Reprod. Toxicol. 72, 191–200 (2017).

59.          Ornoy, A. & Koren, G. Selective Serotonin Reuptake Inhibitors during Pregnancy: Do We Have Now More Definite Answers Related to Prenatal Exposure? Birth Defects Res. 109, 898–908 (2017).

60.          Ornoy, A., Weinstein-Fudim, L. & Ergaz, Z. Antidepressants, Antipsychotics, and Mood Stabilizers in Pregnancy: What Do We Know and How Should We Treat Pregnant Women with Depression. Birth Defects Res. 109, 933–956 (2017).

61.          Howdeshell, K. L. & Ornoy, A. Depression and Its Treatment During Pregnancy: Overview and Highlights. Birth Defects Res. 109, 877–878 (2017).

62.          Ornoy, A. & Ergaz, Z. Parvovirus B19 infection during pregnancy and risks to the fetus. Birth Defects Res. 109, 311–323 (2017).

63.          Diav-Citrin, O. et al. Methylphenidate in pregnancy: A multicenter, prospective, comparative, observational study. J. Clin. Psychiatry 77, 1176–1181 (2016).

64.          Ergaz, Z., Weinstein-Fudim, L. & Ornoy, A. Genetic and non-genetic animal models for autism spectrum disorders (ASD). Reprod. Toxicol. 64, 116–140 (2016).

65.          Ergaz, Z. & Ornoy, A. Perinatal and early postnatal factors underlying developmental delay and disabilities. Dev. Disabil. Res. Rev. 17, 59–70 (2011).

66.          Ornoy, A. et al. ADHD risk alleles associated with opiate addiction: Study of addicted parents and their children. Pediatr. Res. 80, 228–236 (2016).

67.          Ergaz, Z. et al. Diabetes in the Cohen Rat Intensifies the Fetal Pancreatic Damage Induced by the Diabetogenic High Sucrose Low Copper Diet. Birth Defects Res. Part B - Dev. Reprod. Toxicol. 107, 21–31 (2016).

68.          Ornoy, A., Ovadia, M., Rivkin, D., Milshtein, E. & Barlev, L. Prevalence of ADHD among 7-9-year-old children in israel. A comparison between jewish and arab populations. Isr. J. Psychiatry 53, 3–9 (2016).

69.          Ornoy, A., Liza, W. & Ergaz, Z. Genetic syndromes, maternal diseases and antenatal factors associated with autism spectrum disorders (ASD). Front. Neurosci. 10, (2016).

70.          Ornoy, A., Weinstein-Fudim, L. & Ergaz, Z. Prenatal factors associated with autism spectrum disorder (ASD). Reprod. Toxicol. 56, 155–169 (2015).

71.          Hagai, A., Diav-Citrin, O., Shechtman, S. & Ornoy, A. Pregnancy outcome after in utero exposure to local anesthetics as part of dental treatment: A prospective comparative cohort study. J. Am. Dent. Assoc. 146, 572–580 (2015).

72.          Petropoulos, S. et al. Gestational diabetes alters offspring DNA methylation profiles in human and rat: Identification of key pathways involved in endocrine system disorders, insulin signaling, diabetes signaling, and ILK signaling. Endocrinology 156, 2222–2238 (2015).

73.          Ornoy, A., Reece, E. A., Pavlinkova, G., Kappen, C. & Miller, R. K. Effect of maternal diabetes on the embryo, fetus, and children: Congenital anomalies, genetic and epigenetic changes and developmental outcomes. Birth Defects Res. Part C - Embryo Today Rev. 105, 53–72 (2015).

74.          Hagai, A., Diav-Citrin, O., Shechtman, S. & Ornoy, A. Authors’ response. J. Am. Dent. Assoc. 146, 869–870 (2015).

75.          Hagai, A., Diav-Citrin, O., Shechtman, S. & Ornoy, A. Authors’ response. J. Am. Dent. Assoc. 146, 868 (2015).

76.          Ornoy, A. & Weber-Schöndorfer, C. Hormones. in Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment: Third Edition 413–450 (Elsevier Inc., 2015). doi:10.1016/B978-0-12-408078-2.00016-0.

77.          Hultzsch, S. & Ornoy, A. General and local anesthetics and muscle relaxants. in Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment: Third Edition 451–465 (Elsevier Inc., 2015). doi:10.1016/B978-0-12-408078-2.00017-2.

78.          Diav-Citrin, O. et al. Pregnancy outcome following in utero exposure to lithium: A prospective, comparative, observational study. Am. J. Psychiatry 171, 785–794 (2014).

79.          Tal-Saban, M., Ornoy, A. & Parush, S. Young adults with developmental coordination disorder: A longitudinal study. Am. J. Occup. Ther. 68, 307–316 (2014).

80.          Ergaz, Z. et al. Placental oxidative stress and decreased global DNA methylation are corrected by copper in the Cohen diabetic rat. Toxicol. Appl. Pharmacol. 276, 220–230 (2014).

81.          Tal Saban, M., Ornoy, A. & Parush, S. Executive function and attention in young adults with and without Developmental Coordination Disorder - A comparative study. Res. Dev. Disabil. 35, 2644–2650 (2014).

82.          Yolton, K. et al. Exposure to neurotoxicants and the development of attention deficit hyperactivity disorder and its related behaviors in childhood. Neurotoxicol. Teratol. 44, 30–45 (2014).

83.          Ornoy, A. & Koren, G. Selective serotonin reuptake inhibitors in human pregnancy: On the way to resolving the controversy. Semin. Fetal Neonatal Med. 19, 188–194 (2014).

84.          Weber-Schoendorfer, C. et al. Pregnancy outcome after methotrexate treatment for rheumatic disease prior to or during early pregnancy: A prospective multicenter cohort study. Arthritis Rheumatol. 66, 1101–1110 (2014).

85.          Diav-Citrin, O., Otcheretianski-Volodarsky, A., Shechtman, S. & Ornoy, A. Pregnancy outcome following gestational exposure to TNF-alpha-inhibitors: A prospective, comparative, observational study. Reprod. Toxicol. 43, 78–84 (2014).

86.          Rihtman, T., Parush, S. & Ornoy, A. Developmental outcomes at preschool age after fetal exposure to valproic acid and lamotrigine: Cognitive, motor, sensory and behavioral function. Reprod. Toxicol. 41, 115–125 (2013).

87.          Diav-Citrin, O., Blyakhman, S., Shechtman, S. & Ornoy, A. Pregnancy outcome following in utero exposure to hydroxychloroquine: A prospective comparative observational study. Reprod. Toxicol. 39, 58–62 (2013).

88.          Ornoy, A. et al. Lack of severe long-term outcomes of acute, subclinical B 1 deficiency in 216 children in Israel exposed in early infancy. Pediatr. Res. 73, 111–119 (2013).

89.          Ornoy, A. Environmental Exposure to Anesthetic Agents. in Anesthesia and the Fetus 139–146 (Wiley-Blackwell, 2012). doi:10.1002/9781118477076.ch15.

90.          Ergaz, Z. et al. The effect of copper deficiency on fetal growth and liver anti-oxidant capacity in the Cohen diabetic rat model. Toxicol. Appl. Pharmacol. 265, 209–220 (2012).

91.          Rihtman, T., Parush, S. & Ornoy, A. Preliminary findings of the developmental effects of in utero exposure to topiramate. Reprod. Toxicol. 34, 308–311 (2012).

92.          Tal-Saban, M., Zarka, S., Grotto, I., Ornoy, A. & Parush, S. The functional profile of young adults with suspected Developmental Coordination Disorder (DCD). Res. Dev. Disabil. 33, 2193–2202 (2012).

93.          Ornoy, A. Biomarkers of maternal diabetes and its complication in pregnancy. Reprod. Toxicol. 34, 174–179 (2012).

94.          Saban, M. T., Ornoy, A., Grotto, I. & Parush, S. Adolescents and adults coordination questionnaire: Development and psychometric properties. Am. J. Occup. Ther. 66, 406–413 (2012).

95.          Levy, Y., Ornoy, A. & Nevo, Y. Special issue on developmental delay. Dev. Disabil. Res. Rev. 17, 57–58 (2011).

96.          Ornoy, A. Prenatal origin of obesity and their complications: Gestational diabetes, maternal overweight and the paradoxical effects of fetal growth restriction and macrosomia. Reprod. Toxicol. 32, 205–212 (2011).

97.          Ornoy, A., Livshitz, A., Ergaz, Z., Stodgell, C. J. & Miller, R. K. Hyperglycemia, hypoxia and their combination exert oxidative stress and changes in antioxidant gene expression: Studies on cultured rat embryos. Birth Defects Res. Part B - Dev. Reprod. Toxicol. 92, 231–239 (2011).

98.          Muhsen, K., Ornoy, A., Akawi, A., Alpert, G. & Cohen, D. An association between Helicobacter pylori infection and cognitive function in children at early school age: A community-based study. BMC Pediatr. 11, (2011).

99.          Diav-Citrin, O. et al. Pregnancy outcome after in utero exposure to angiotensin converting enzyme inhibitors or angiotensin receptor blockers. Reprod. Toxicol. 31, 540–545 (2011).

100.        Ergaz, Z. et al. The embryotoxicity of sera from patients with autoimmune diseases on post-implantation rat embryos in culture persists during remission and is not related to oxidative stress. Lupus 19, 1623–1631 (2010).

101.        Muhsen, K. et al. Is the association between Helicobacter pylori infection and anemia age dependent? Helicobacter 15, 467–472 (2010).

102.        Ornoy, A. et al. Neurodevelopmental and psychological assessment of adolescents born to drug-addicted parents: Effects of SES and adoption. Child Abus. Negl. 34, 354–368 (2010).

103.        Ergaz, Z. & Ornoy, A. Psychotropic Drugs and Lactation: To Nurse or not to Nurse. in Parenthood and Mental Health: A Bridge between Infant and Adult Psychiatry 385–399 (John Wiley and Sons, 2010). doi:10.1002/9780470660683.ch34.

104.        Ornoy, A., Rand, S. B. & Bischitz, N. Hyperglycemia and hypoxia are interrelated in their teratogenic mechanism: Studies on cultured rat embryos. Birth Defects Res. Part B - Dev. Reprod. Toxicol. 89, 106–115 (2010).

105.        Diav-Citrin, O. et al. Pregnancy outcome after in utero exposure to colchicine. Am. J. Obstet. Gynecol. 203, 144.e1-144.e6 (2010).

106.        Ornoy, A. & Ergaz, Z. Alcohol abuse in pregnant women: Effects on the fetus and newborn, mode of action and maternal treatment. Int. J. Environ. Res. Public Health 7, 364–379 (2010).

107.        Rihtman, T. et al. Are the cognitive functions of children with Down syndrome related to their participation? Dev. Med. Child Neurol. 52, 72–78 (2010).

108.        Ornoy, A., Avgil Tsadok, M., Yaffe, P. & Zangen, S. W. The Cohen diabetic rat as a model for fetal growth restriction: Vitamins C and E reduce fetal oxidative stress but do not restore normal growth. Reprod. Toxicol. 28, 521–529 (2009).

109.        Rosenfeld, H., Ornoy, A., Shechtman, S. & Diav-Citrin, O. Pregnancy outcome, thyroid dysfunction and fetal goitre after in utero exposure to propylthiouracil: A controlled cohort study. Br. J. Clin. Pharmacol. 68, 609–617 (2009).

110.        Gruenbaum-Cohen, Y. et al. Amelogenin in cranio-facial development: The tooth as a model to study the role of amelogenin during embryogenesis. J. Exp. Zool. Part B Mol. Dev. Evol. 312, 445–457 (2009).

111.        Ornoy, A. Valproic acid in pregnancy: How much are we endangering the embryo and fetus? Reprod. Toxicol. 28, 1–10 (2009).

112.        Kogot-Levin, A., Zeigler, M., Ornoy, A. & Bach, G. Mucolipidosis type IV: The effect of increased lysosomal ph on the abnormal lysosomal storage. Pediatr. Res. 65, 686–690 (2009).

113.        Calderon-Margalit, R., Qiu, C., Ornoy, A., Siscovick, D. S. & Williams, M. A. Risk of preterm delivery and other adverse perinatal outcomes in relation to maternal use of psychotropic medications during pregnancy. Am. J. Obstet. Gynecol. 201, 579.e1-579.e8 (2009).

114.        Carp, H. J. A., Ornoy, A. & Shoenfeld, Y. Chapter 14 Autoantibodies and Infertility in Autoimmune Diseases. Handbook of Systemic Autoimmune Diseases vol. 9 157–172 (2008).

115.        Olivares-Navarrete, R. et al. Integrin α2β1 plays a critical role in osteoblast response to micron-scale surface structure and surface energy of titanium substrates. Proc. Natl. Acad. Sci. U. S. A. 105, 15767–15772 (2008).

116.        Ryu, S., Ornoy, A., Samuni, A., Zangen, S. & Kohen, R. Oxidative stress in Cohen diabetic rat model by high-sucrose, low-copper diet: inducing pancreatic damage and diabetes. Metabolism. 57, 1253–1261 (2008).

117.        Schaefer, C., Ornoy, A., Clementi, M., Meister, R. & Weber-Schoendorfer, C. Using observational cohort data for studying drug effects on pregnancy outcome-Methodological considerations. Reprod. Toxicol. 26, 36–41 (2008).

118.        Avgil, M. et al. Epstein-Barr virus infection in pregnancy-A prospective controlled study. Reprod. Toxicol. 25, 468–471 (2008).

119.        Ornoy, A. et al. The outcome of pregnancy following topiramate treatment: A study on 52 pregnancies. Reprod. Toxicol. 25, 388–389 (2008).

120.        Diav-Citrin, O. et al. Pregnancy outcome after in utero exposure to valproate: Evidence of dose relationship in teratogenic effect. CNS Drugs 22, 325–334 (2008).

121.        Foster, W., Myllynen, P., Winn, L. M., Ornoy, A. & Miller, R. K. Reactive Oxygen Species, Diabetes and Toxicity in the Placenta - A Workshop Report. Placenta 29, 105–107 (2008).

122.        Tartakover Matalon, S., Drucker, L., Fishman, A., Ornoy, A. & Lishner, M. The role of heat shock protein 27 in extravillous trophoblast differentiation. J. Cell. Biochem. 103, 719–729 (2008).

123.        Ornoy, A. & Yacobi, S. Response by authors, Professor Ornoy and Dr. Yacobi. Isr. J. Psychiatry Relat. Sci. 45, 301 (2008).

124.        Diav-Citrin, O. et al. Paroxetine and fluoxetine in pregnancy: A prospective, multicentre, controlled, observational study. Br. J. Clin. Pharmacol. 66, 695–705 (2008).

125.        Bar-Oz, B. et al. Pregnancy outcome after gestational exposure to the new macrolides: A prospective multi-center observational study. Eur. J. Obstet. Gynecol. Reprod. Biol. 141, 31–34 (2008).

126.        Yacobi, S. & Ornoy, A. Is lithium a real teratogen? What can we conclude from the prospective versus retrospective studies? A review. Isr. J. Psychiatry Relat. Sci. 45, 95–106 (2008).

127.        Ornoy, A. General and local anesthetics and muscle relaxants. in Drugs During Pregnancy and Lactation 423–440 (Elsevier Ltd, 2007). doi:10.1016/B978-044452072-2/50020-3.

128.        Goldstein, L. H. et al. Pregnancy outcome of women exposed to azathioprine during pregnancy. Birth Defects Res. Part A - Clin. Mol. Teratol. 79, 696–701 (2007).

129.        Ryu, S., Kohen, R., Samuni, A. & Ornoy, A. Nitroxide radicals protect cultured rat embryos and yolk sacs from diabetic-induced damage. Birth Defects Res. Part A - Clin. Mol. Teratol. 79, 604–611 (2007).

130.        Ornoy, A. General and Local Anesthetics and Muscle Relaxants. in Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment: Second Edition 423–440 (Elsevier, 2007). doi:10.1016/B978-044452072-2/50020-3.

131.        Ornoy, A. Embryonic oxidative stress as a mechanism of teratogenesis with special emphasis on diabetic embryopathy. Reprod. Toxicol. 24, 31–41 (2007).

132.        Ornoy, A. Fetal effects of primary and non-primary cytomegalovirus infection in pregnancy: Are we close to prevention? Isr. Med. Assoc. J. 9, 398–401 (2007).

133.        Schwartz, N. et al. Reduced placental growth and hCG secretion in vitro induced by antiphospholipid antibodies but not by anti-Ro or anti-La: Studies on sera from women with SLE/PAPS. Lupus 16, 110–120 (2007).

134.        Rahav, G. et al. Primary versus nonprimary cytomegalovirus infection during pregnancy, Israel. Emerg. Infect. Dis. 13, (2007).

135.        Ornoy, A., Wajnberg, R. & Diav-Citrin, O. The outcome of pregnancy following pre-pregnancy or early pregnancy alendronate treatment. Reprod. Toxicol. 22, 578–579 (2006).

136.        Ornoy, A., Yaffe, P., Zangen, S. W., Patlas, N. & Schwartz, Z. Decreased response of osteoblasts obtained from aged Cohen diabetic sensitive rats to sex steroid hormones and 1,25(OH)2 D3 in culture. Odontology 94, 38–43 (2006).

137.        Ornoy, A. Neuroteratogens in man: An overview with special emphasis on the teratogenicity of antiepileptic drugs in pregnancy. Reprod. Toxicol. 22, 214–226 (2006).

138.        Patlas, N., Avgil, M., Ziv, E., Ornoy, A. & Shafrir, E. Pregnancy outcome in the Psammomys obesus gerbil on low- and high-energy diets. Biol. Neonate 90, 58–65 (2006).

139.        Yochman, A., Ornoy, A. & Parush, S. Co-occurrence of developmental delays among preschool children with attention-deficit-hyperactivity disorder. Dev. Med. Child Neurol. 48, 483–488 (2006).

140.        Ornoy, A. & Diav-Citrin, O. Fetal effects of primary and secondary cytomegalovirus infection in pregnancy. Reprod. Toxicol. 21, 399–409 (2006).

141.        Ergaz, Z. & Ornoy, A. Parvovirus B19 in pregnancy. Reprod. Toxicol. 21, 421–435 (2006).

142.        Avgil, M. & Ornoy, A. Herpes simplex virus and Epstein-Barr virus infections in pregnancy: consequences of neonatal or intrauterine infection. Reprod. Toxicol. 21, 436–445 (2006).

143.        Ornoy, A. Intrauterine infections: Introductory comments. Reprod. Toxicol. 21, 343–344 (2006).

144.        Ornoy, A. & Tenenbaum, A. Pregnancy outcome following infections by coxsackie, echo, measles, mumps, hepatitis, polio and encephalitis viruses. Reprod. Toxicol. 21, 446–457 (2006).

145.        Yochman, A., Ornoy, A. & Parush, S. Perceptuomotor functioning in preschool children with symptoms of attention deficit hyperactivity disorder. Percept. Mot. Skills 102, 175–186 (2006).

146.        Zangen, S. W., Ryu, S. & Ornoy, A. Alterations in the expression of antioxidant genes and the levels of transcription factor NF-Kappa B in relation to diabetic embryopathy in the cohen diabetic rat model. Birth Defects Res. Part A - Clin. Mol. Teratol. 76, 107–114 (2006).

147.        Ornoy, A. Growth and neurodevelopmental outcome of children born to mothers with pregestational and gestational diabetes. Pediatr. Endocrinol. Rev. 3, 104–113 (2005).

148.        Ekstein, J., Nasatzky, E., Boyan, B. D., Ornoy, A. & Schwartz, Z. Growth-plate chondrocytes respond to 17β-estradiol with sex-specific increases in IP3 and intracellular calcium ion signalling via a capacitative entry mechanism. Steroids 70, 775–786 (2005).

149.        Patlas, N. et al. The response to sex steroid hormones and vitamin D of cultured osteoblasts derived from ovariectomized mice with and without 17β-estradiol pretreatment. Odontology 93, 16–23 (2005).

150.        Ergaz, Z., Avgil, M. & Ornoy, A. Intrauterine growth restriction - Etiology and consequences: What do we know about the human situation and experimental animal models? Reprod. Toxicol. 20, 301–322 (2005).

151.        Raz, P., Nasatzky, E., Boyan, B. D., Ornoy, A. & Schwartz, Z. Sexual dimorphism of growth plate prehypertrophic and hypertrophic chondrocytes in response to testosterone requires metabolism to dihydrotestosterone (DHT) by steroid 5-alpha reductase type 1. J. Cell. Biochem. 95, 108–119 (2005).

152.        Bar-Oz, B. et al. Metamizol (dipyrone, optalgin) in pregnancy, is it safe? A prospective comparative study. Eur. J. Obstet. Gynecol. Reprod. Biol. 119, 176–179 (2005).

153.        Diav-Citrin, O. et al. The safety of proton pump inhibitors in pregnancy: A multicentre prospective controlled study. Aliment. Pharmacol. Ther. 21, 269–275 (2005).

154.        Matalon, S. T., Ornoy, A., Fishman, A., Drucker, L. & Lishner, M. The effect of 6-mercaptopurine on early human placental explants. Hum. Reprod. 20, 1390–1397 (2005).

155.        Diav-Citrin, O. et al. Safety of haloperidol and penfluridol in pregnancy: A multicenter, prospective, controlled study. J. Clin. Psychiatry 66, 317–322 (2005).

156.        Berkovitch, M. et al. First-trimester exposure to amoxycillin/clavulanic acid: A prospective, controlled study. Br. J. Clin. Pharmacol. 58, 298–302 (2004).

157.        Ratzon, N. Z., Ornoy, A., Pardo, A., Rachel, M. & Hatch, M. Developmental evaluation of children born to mothers occupationally exposed to waste anesthetic gases. Birth Defects Res. Part A - Clin. Mol. Teratol. 70, 476–482 (2004).

158.        Ornoy, A., Chen, L., Silver, R. M. & Miller, R. K. Maternal autoimmune diseases and immunologically induced embryonic and fetoplacental damage. Birth Defects Res. Part A - Clin. Mol. Teratol. 70, 371–381 (2004).

159.        Yochman, A., Parush, S. & Ornoy, A. Responses of preschool children with and without ADHD to sensory events in daily life. Am. J. Occup. Ther. 58, 294–302 (2004).

160.        Matalon, S. T., Ornoy, A. & Lishner, M. Review of the potential effects of three commonly used antineoplastic and immunosuppressive drugs (cyclophosphamide, azathioprine, doxorubicin on the embryo and placenta). Reprod. Toxicol. 18, 219–230 (2004).

161.        Matalon, S. T. et al. Antiphosphatidylserine antibodies affect rat yolk sacs in culture: A mechanism for fetal loss in antiphospholipid syndrome. Am. J. Reprod. Immunol. 51, 144–151 (2004).

162.        Otremski, I., Irga, D., Edelstein, S., Ornoy, A. & Newman, R. Does laser irradiation effect fracture healing? Med. Laser Appl. 19, 146–149 (2004).

163.        Gur, C., Diav-Citrin, O., Shechtman, S., Arnon, J. & Ornoy, A. Pregnancy outcome after first trimester exposure to corticosteroids: A prospective controlled study. Reprod. Toxicol. 18, 93–101 (2004).

164.        Matalon, S. T. et al. Immunization of naïve mice with mouse laminin-1 affected pregnancy outcome in a mouse model. Am. J. Reprod. Immunol. 50, 159–165 (2003).

165.        Ornoy, A. et al. The effects of antiphospholipid antibodies obtained from women with SLE/APS and associated pregnancy loss on rat embryos and placental explants in culture. Lupus 12, 573–578 (2003).

166.        Weksler-Zangen, S., Yaffe, P. & Ornoy, A. Reduced SOD Activity and Increased Neural Tube Defects in Embryos of the Sensitive but Not of the Resistant Cohen Diabetic Rats Cultured under Diabetic Conditions. Birth Defects Res. Part A - Clin. Mol. Teratol. 67, 429–437 (2003).

167.        Diav-Citrin, O. et al. Pregnancy outcome after gestational exposure to loratadine or antihistamines: A prospective controlled cohort study. J. Allergy Clin. Immunol. 111, 1239–1243 (2003).

168.        Matalon, S. T. et al. The pathogenic role of anti-thyroglobulin antibody on pregnancy: Evidence from an active immunization model in mice. Hum. Reprod. 18, 1094–1099 (2003).

169.        Ornoy, A. The impact of intrauterine exposure versus postnatal environment in neurodevelopmental toxicity: Long-term neurobehavioral studies in children at risk for developmental disorders. Toxicol. Lett. 140–141, 171–181 (2003).

170.        Levy, Y., Tennebaum, A. & Ornoy, A. Repair behavior in children with intellectual impairments: Evidence for metalinguistic competence. J. Speech, Lang. Hear. Res. 46, 368–381 (2003).

171.        Ornoy, A., Yacobi, S. & Yaffee, P. A simple method of culture of 11.5-day-old rat embryos in DMEM/F12 and 20% fetal bovine serum. J. Anat. 203, 419–423 (2003).

172.        Diav-Citrin, O., Shechtman, S., Arnon, J., Lubart, I. & Ornoy, A. Pregnancy outcome after gestational exposure to mebendazole: A prospective controlled cohort study. Am. J. Obstet. Gynecol. 188, 282–285 (2003).

173.        Yacobi, S., Ornoy, A., Blumenfeld, Z. & Miller, R. K. Effect of sera from women with systemic lupus erythematosus or antiphospholipid syndrome and recurrent abortions on human placental explants in culture. Teratology 66, 300–308 (2002).

174.        Clementi, M., Di Gianantonio, E. & Ornoy, A. Teratology information services in Europe and their contribution to the prevention of congenital anomalies. Community Genet. 5, 8–12 (2002).

175.        Zangen, S. W., Yaffe, P., Shechtman, S., Zangen, D. H. & Ornoy, A. The role of reactive oxygen species in diabetic-induced anomalies in embryos of Cohen diabetic rats. Int. J. Exp. Diabetes Res. 3, 247–255 (2002).

176.        Berkovitch, M. et al. Metoclopramide for nausea and vomiting of pregnancy: A prospective multicenter international study. Am. J. Perinatol. 19, 311–316 (2002).

177.        Fein, A. et al. Diabetes teratogenicity in mice is accompanied with distorted expression of TGF-β2 in the uterus. Teratog. Carcinog. Mutagen. 22, 59–71 (2002).

178.        Matalon, S. T. et al. The effects of IgG purified from women with SLE and associated pregnancy loss on rat embryos in culture. Am. J. Reprod. Immunol. 48, 296–304 (2002).

179.        Ornoy, A. The effects of Cytomegalic virus (CMV) infection during pregnancy on the developing human fetus. Harefuah 141, 565-568,577 (2002).

180.        Diav-Citrin, O. & Ornoy, A. Teratogen update: Antithyroid drugs - Methimazole, carbimazole, and propylthiouracil. Teratology 65, 38–44 (2002).

181.        Ornoy, A. The effects of alcohol and illicit drugs on the human embryo and fetus. Isr. J. Psychiatry Relat. Sci. 39, 120–132 (2002).

182.        Matalon, S., Schechtman, S., Goldzweig, G. & Ornoy, A. The teratogenic effect of carbamazepine: A meta-analysis of 1255 exposures. Reprod. Toxicol. 16, 9–17 (2002).

183.        Yagil, Y. et al. The Newly Inbred Cohen Diabetic Rat: A Nonobese Normolipidemic Genetic Model of Diet-Induced Type 2 Diabetes Expressing Sex Differences. Diabetes 50, 2521–2529 (2001).

184.        Diav-Citrin, O., Shechtman, S., Arnon, J. & Ornoy, A. Is carbamazepine teratogenic? A prospective controlled study of 210 pregnancies. Neurology 57, 321–324 (2001).

185.        Zaken, V., Kohen, R. & Ornoy, A. Geometric morphometrics of corpus callosum and subcortical structures in the fetal-alcohol-affected brain. Teratology 64, 4–32 (2001).

186.        Matalon, S. T., Blank, M., Ornoy, A. & Shoenfeld, Y. The association between anti-thyroid antibodies and pregnancy loss. Am. J. Reprod. Immunol. 45, 72–77 (2001).

187.        Katzburg, S. et al. Age and gender specific stimulation of creatine kinase specific activity by gonadal steroids in human bone-derived cells in culture. J. Endocrinol. Invest. 24, 166–172 (2001).

188.        Ornoy, A., Ratzon, N., Greenbaum, C., Wolf, A. & Dulitzky, M. School-age children born to diabetic mothers and to mothers with gestational diabetes exhibit a high rate of inattention and fine and gross motor impairment. J. Pediatr. Endocrinol. Metab. 14, 681–689 (2001).

189.        Diav-Citrin, O., Shechtman, S., Gotteiner, T., Arnon, J. & Ornoy, A. Pregnancy outcome after gestational exposure to metronidazole: A prospective controlled cohort study. Teratology 63, 186–192 (2001).

190.        Arnon, J., Meirow, D., Lewis-Roness, H. & Ornoy, A. Genetic and teratogenic effects of cancer treatments on gametes and embryos. Hum. Reprod. Update 7, 394–403 (2001).

191.        Fein, A. et al. Expression of tumor necrosis factor-α in the pregnant uterus of diabetic mice: Effect of maternal immunopotentiation. Am. J. Reprod. Immunol. 46, 161–168 (2001).

192.        Ornoy, A., Segal, J., Bar-Hamburger, R. & Greenbaum, C. Developmental outcome of school-age children born to mothers with heroin dependency: Importance of environmental factors. Dev. Med. Child Neurol. 43, 668–675 (2001).

193.        Ornoy, A. The role of the placenta in the maintenance of normal pregnancy. Isr. Med. Assoc. J. 2, 838–840 (2000).

194.        Berkovitch, M., Elbirt, D., Addis, A., Schuler-Faccini, L. & Ornoy, A. Fetal effects of metoclopramide therapy for nausea and vomiting of pregnancy [5]. N. Engl. J. Med. 343, 445–446 (2000).

195.        Levtzion-Korach, O., Tennenbaum, A., Schnitzer, R. & Ornoy, A. Early motor development of blind children. J. Paediatr. Child Health 36, 226–229 (2000).

196.        Ornoy, A. & Mastroiacovo, P. More on data from teratogen information systems (TIS). Teratology 61, 327–328 (2000).

197.        Arnon, J., Shechtman, S. & Ornoy, A. The use of psychiatric drugs in pregnancy and lactation. Isr. J. Psychiatry Relat. Sci. 37, 205–222 (2000).

198.        Zaken, V., Kohen, R. & Ornoy, A. The development of antioxidant defense mechanism in young rat embryos in vivo and in vitro. Early Pregnancy 4, 110–123 (2000).

199.        Levy, Y., Tennenbaum, A. & Ornoy, A. Spontaneous Language of Children with Specific Neurological Syndromes. J. Speech, Lang. Hear. Res. 43, 351–365 (2000).

200.        Patlas, N., Zadik, Y., Yaffe, P., Schwartz, Z. & Ornoy, A. Oophorectomy-induced osteopenia in rats in relation to age and time postoophorectomy. Cells Tissues Organs 166, 267–274 (2000).

201.        Einarson, A. et al. Prospective, controlled, multicentre study of loperamide in pregnancy. Can. J. Gastroenterol. 14, 185–187 (2000).

202.        Ratzon, N., Dulitzky, M. & Ornoy, A. Comparison of the motor development of school-age children born to mothers with and without diabetes mellitus. Phys. Occup. Ther. Pediatr. 20, 43–57 (2000).

203.        Diav-Citrin, O. & Ornoy, A. Adverse environment and prevention of early pregnancy disorders. Early Pregnancy 4, 5–18 (2000).

204.        Ornoy, A., Zaken, V. & Kohen, R. Role of reactive oxygen species (ROS) in the diabetes-induced anomalies in rat embryos in vitro: Reduction in antioxidant enzymes and low-molecular-weight antioxidants (LMWA) may be the causative factor for increased anomalies. Teratology 60, 376–386 (1999).

205.        Katzburg, S. et al. Isolation and hormonal responsiveness of primary cultures of human bone-derived cells: Gender and age differences. Bone 25, 667–673 (1999).

206.        Cohen, H. et al. Synthesis and preclinical pharmacology of 2-(2-aminopyrimidinio) ethylidene-1,1-bisphosphonic acid betaine (ISA-13-1)-a novel bisphosphonate. Pharm. Res. 16, 1399–1406 (1999).

207.        Patlas, N. et al. Transplacental effects of bisphosphonates on fetal skeletal ossification and mineralization in rats. Teratology 60, 68–73 (1999).

208.        Rudnick, A., Ornoy, A., Famy, C., Streissguth, A. P. & Unis, A. S. Fetal alcohol exposure and adult psychiatric disorders [22] (multiple letters). Am. J. Psychiatry 156, 1128–1129 (1999).

209.        Mastroiacovo, P. et al. High vitamin A intake in early pregnancy and major malformations: A multicenter prospective controlled study. Teratology 59, 7–11 (1999).

210.        Nasatzky, E. et al. Transforming growth factor-β1 modulates chondrocyte responsiveness to 17β-estradiol. Endocrine 11, 241–249 (1999).

211.        Ornoy, A., Wolf, A., Ratzon, N., Greenbaum, G. & Dulitzky, M. Neurodevelopmental outcome at early school age of children born to mothers with gestational diabetes. Arch. Dis. Child. Fetal Neonatal Ed. 81, F10–F14 (1999).

212.        Wang, X., Schwartz, Z., Yaffe, P. & Ornoy, A. The expression of transforming growth factor-β and interleukin-1β mRNA and the response to 1,25(OH)2D3, 17β-estradiol, and testosterone is age dependent in primary cultures of mouse-derived osteoblasts in vitro. Endocrine 11, 13–22 (1999).

213.        Ornoy, A., Shechtman, S. & Arnon, J. The Israel Teratogen Information Service: a report of the last ten years with 20,613 calls. Harefuah 136, 1-9,96 (1999).

214.        Pedrozo, H. A. et al. Vitamin D3 metabolites regulate LTBP1 and latent TGF-β1 expression and latent TGF-β1 incorporation in the extracellular matrix of chondrocytes. J. Cell. Biochem. 72, 151–165 (1999).

215.        Ornoy, A. The VTH international symposium on vertebrate whole embryo culture: Clinical and genetic implications. Reprod. Toxicol. 12, 153 (1998).

216.        Pedrozo, H. A. et al. Growth plate chondrocytes store latent transforming growth factor (TGF)- β1 in their matrix through latent TGF-β1 binding protein-1. J. Cell. Physiol. 177, 343–354 (1998).

217.        Ornoy, A., Arnon, J., Shechtman, S., Moerman, L. & Lukashova, I. Is benzodiazepine use during pregnancy really teratogenic? Reprod. Toxicol. 12, 511–515 (1998).

218.        Cohen, H. et al. Bisphosphonates and tetracycline: Experimental models for their evaluation in calcium-related disorders. Pharm. Res. 15, 606–613 (1998).

219.        Ornoy, A., Yacobi, S., Avraham, S. & Blumenfeld, Z. The effect of sera from women with systemic lupus erythematosus and/or antiphospholipid syndrome on rat embryos in culture. Reprod. Toxicol. 12, 185–191 (1998).

220.        Rappaport, G. C., Ornoy, A. & Tenenbaum, A. Is early intervention effective in preventing ADHD? Isr. J. Psychiatry Relat. Sci. 35, 271–279 (1998).

221.        Ornoy, A. & Arnon, J. Outcome of children exposed in utero to antiepileptic drugs: Special emphasis on carbamazepine. Contemp. Rev. Obstet. Gynaecol. 10, 99–106 (1998).

222.        Parush, S. et al. Developmental correlates of school-age children with a history of benign congenital hypotonia. Dev. Med. Child Neurol. 40, 448–452 (1998).

223.        Ornoy, A. et al. Neurobehaviour of school age children born to diabetic mothers. Arch. Dis. Child. Fetal Neonatal Ed. 79, F94–F99 (1998).

224.        Ornoy, A. Effects of continuous or cyclic administration of pamidronate on the skeleton in intact and oophorectomized young rats. Acta Anat. (Basel). 159, 42–47 (1997).

225.        Ben-Hur, H. et al. Estrogen, progesterone and testosterone receptors in human fetal cartilaginous tissue: Immunohistochemical studies. Calcif. Tissue Int. 60, 520–526 (1997).

226.        Patlas, N., Yaffe, P., Kimyagarov, A., Golomb, G. & Ornoy, A. Effects of continuous or cyclic administration of pamidronate on the skeleton in intact and oophorectomized young rats; Cells Tissues Organs 159, 42–47 (1997).

227.        Van Gelder, J. M. et al. In vitro and in vivo effects of tetrakisphosphonates on bone resorption, tumor osteolysis, ectopic calcification, and macrophages. J. Pharm. Sci. 86, 283–289 (1997).

228.        Schwartz, Z. et al. The effects of 17β-estradiol on chondrocyte differentiation are modulated by vitamin D3 metabolites. Endocrine 7, 209–218 (1997).

229.        Feldkamp, M. et al. Postmarketing surveillance for angiotensin-converting enzyme inhibitor use during the first trimester of pregnancy - United States, Canada, and Israel, 1987-1995. JAMA 277, 1193 (1997).

230.        Ornoy, A. et al. Role of reactive oxygen species in diabetes-induced embryotoxicity: Studies on pre-implantation mouse embryos cultured in serum from diabetic pregnant women. Isr. J. Med. Sci. 32, 1066–1073 (1996).

231.        Zlotogora, J., Ariel, I., Ornoy, A., Yagel, S. & Eidelman, A. I. Thomas syndrome: Potter sequence with cleft lip/palate and cardiac anomalies. Am. J. Med. Genet. 62, 224–226 (1996).

232.        Ornoy, A., Patlas, N. & Schwartz, L. The effects of in utero diagnostic X-irradiation on the development of preschool-age children. Isr. J. Med. Sci. 32, 112–115 (1996).

233.        Golomb, G. et al. Novel bisphosphonates for calcium-related disorders. Phosphorus, Sulfur Silicon Relat. Elem. 109, 221–224 (1996).

234.        Ornoy, A. & Cohen, E. Outcome of children born to epileptic mothers treated with carbamazepine during pregnancy. Arch. Dis. Child. 75, 517–520 (1996).

235.        Schaefer, C. et al. Pregnancy outcome after prenatal quinolone exposure. Evaluation of a case registry of the European Network of Teratology Information Services (ENTIS). Eur. J. Obstet. Gynecol. Reprod. Biol. 69, 83–89 (1996).

236.        Hagay, Z. J., Biran, G., Ornoy, A. & Reece, E. A. Congenital cytomegalovirus infection: A long-standing problem still seeking a solution. Am. J. Obstet. Gynecol. 174, 241–245 (1996).

237.        Abir, R. & Ornoy, A. Teratogenic IgG from sera of women with spontaneous abortions seem to induce anomalies and yolk sac damage in rat embryos. A possible method to detect abortions of immunologic origin. Am. J. Reprod. Immunol. 35, 93–101 (1996).

238.        Ornoy, A., Michailevskaya, V., Lukashov, I., Bar-Hamburger, R. & Harel, S. The developmental outcome of children born to heroin-dependent mothers, raised at home or adopted. Child Abus. Negl. 20, 385–396 (1996).

239.        Ezra, A. et al. Peptidyl prodrug of bisphosphonates for improved oral absorption. Proc. Control. Release Soc. 83–84 (1996).

240.        Stoumboudi, M. et al. Effect of 17-beta-estradiol on the healing of tibial bone after marrow ablation. Cells Tissues Organs 152, 110–118 (1995).

241.        Van Gelder, J. M. et al. Anticalcification and antiresorption effects of bisacylphosphonates. Bone 16, 511–520 (1995).

242.        Arnon, J. & Ornoy, A. Clinical teratology counseling and consultation case report: Outcome of pregnancy after failure of early induced abortions. Teratology 51, 120–122 (1995).

243.        Kohn, G. et al. Bilateral ulna hypoplasia, club feet, and mental retardation: A new mesomelic syndrome. Am. J. Med. Genet. 56, 132–135 (1995).

244.        Ornoy, A., Zaken, V., Abir, R., Yaffe, P. & Raz, I. Effects on rat embryos of culture in serum of women with gestational diabetes. Toxicol. Vitr. 9, 643–651 (1995).

245.        Ornoy, A., Suissa, M., Yaffe, P., Boyan, B. D. & Schwartz, Z. Gender-related effects of vitamin D metabolites on cartilage and bone. Bone Miner. 27, 235–247 (1994).

246.        Schwartz, Z. et al. Gender-specific, maturation-dependent effects of testosterone on chondrocytes in culture. Endocrinology 134, 1640–1647 (1994).

247.        Ornoy, A. et al. Gender dependent effects of testosterone and 17β-estradiol on bone growth and modelling in young mice. Bone Miner. 24, 43–58 (1994).

248.        Nasatzky, E. et al. Sex steroid enhancement of matrix production by chondrocytes is sex and cell maturation specific. Endocrine 2, 207–215 (1994).

249.        Abir, R., Ornoy, A., Hur, H. B., Jaffe, P. & Pinus, H. The Effects of Sera From Women With Spontaneous Abortions on the In Vitro Development of Early Somite Stage Rat Embryos. Am. J. Reprod. Immunol. 32, 73–81 (1994).

250.        Abir, R., Ornoy, A., Ben Hur, H., Jaffe, P. & Pinus, H. IgG exchange as a means of partial correction of anomalies in rat embryos in vitro, induced by sera from women with recurrent abortion. Toxicol. Vitr. 7, 817–826 (1993).

251.        Ornoy, A. & Tennenbaum, A. Are our babies becoming larger? Harefuah 125, 120–123 (1993).

252.        Ben-Hur, H. et al. Localization of estrogen receptors in long bones and vertebrae of human fetuses. Calcif. Tissue Int. 53, 91–96 (1993).

253.        Ornoy, A. & Ishai, P. B. Congenital anomalies after oral poliovirus vaccination during pregnancy. Lancet 341, 1162 (1993).

254.        Bar-Hava, I., Bronshtein, M., Ornoy, A. & Ben-Rafael, Z. First trimester sonographic diagnosis of acrania. Harefuah 124, 685-687,739 (1993).

255.        Ornoy, A. & Arnon, J. Clinical teratology. West. J. Med. 159, 382–390 (1993).

256.        Nasatzky, E., Schwartz, Z., Boyan, B. D., Soskolne, W. A. & Ornoy, A. Sex‐dependent effects of 17‐beta‐estradiol on chondrocyte differentiation in culture. J. Cell. Physiol. 154, 359–367 (1993).

257.        Ornoy, A., Uriel, L. & Tennenbaum, A. Inattention, hyperactivity and speech delay at 2-4 years of age as a predictor for ADD-ADHD syndrome. Isr. J. Psychiatry Relat. Sci. 30, 155–163 (1993).

258.        Pinus, H., Ornoy, A., Patlas, N., Yaffe, P. & Schwartz, Z. Specific β estradiol binding in cartilage and serum from Young mice and rats is age dependent. Connect. Tissue Res. 30, 85–98 (1993).

259.        Palti, H., Bendel, J. & Ornoy, A. Prevalence of disabilities in a national sample of 7-year-old Israeli children. Isr. J. Med. Sci. 28, 435–441 (1992).

260.        Turnquist, J., Ornoy, A., Eini, D. & Schwartz, Z. Effects of 1 a(OH)-vitamin D3 and 24,25(OH)2-vitamin D3 on long bones of glucocorticoid-treated rats. Cells Tissues Organs 145, 61–67 (1992).

261.        Atkin, I. et al. Enhancement of osteoinduction by vitamin D metabolites in rachitic host rats. J. Bone Miner. Res. 7, 863–875 (1992).

262.        Ornoy, A. & Arnon, J. Teratological counseling in Israel. Harefuah 120, 567–573 (1991).

263.        Schwartz, Z. et al. Direct and sex-specific enhancement of bone formation and calcification by sex steroids in fetal mice long bone in vitro biochemical and morphometric study. Endocrinology 129, 1167–1174 (1991).

264.        Ornoy, A. & Zusman, I. Embryotoxic effects of diabetes on pre-implantation embryos. Isr. J. Med. Sci. 27, 487–492 (1991).

265.        Rosenak, D. et al. Recurrent tetraamelia and pulmonary hypoplasia with multiple malformations in sibs. Am. J. Med. Genet. 38, 25–28 (1991).

266.        Beckman, D. A., Ornoy, A., Jensen, M., Arnon, J. & Brent, R. L. Ultrastructure and function of the rat yolk sac: Damage caused by teratogenic anti‐VYS serum and recovery. Teratology 44, 181–192 (1991).

267.        Ornoy, A. The effects of pharmacological agents on the human fetus. Fetal Pediatr. Pathol. 11, 807–812 (1991).

268.        Bronshtein, M. & Ornoy, A. Acrania: Anencephaly resulting from secondary degeneration of a closed neural tube: Two cases in the same family. J. Clin. Ultrasound 19, 230–234 (1991).

269.        Bendel, J., Palti, H., Ornoy, A. & Winter, S. Family health center follow-up in preschool children. Harefuah 118, 681–684 (1990).

270.        Ornoy, A., Arnon, J., Feingold, M. & Ishai, P. B. Spontaneous abortions following oral poliovirus vaccination in first trimester. Lancet 335, 800 (1990).

271.        Zusman, I., Yaffe, P., Pinus, H. & Ornoy, A. Effects of pulsing electromagnetic fields on the prenatal and postnatal development in mice and rats: In vivo and in vitro studies. Teratology 42, 157–170 (1990).

272.        Abir, R., Zusrnan, L., Hur, H. B., Yaffe, P. & Ornoy, A. The Effects Of Serum From Women With Miscarriages On The In Vitro Development Of Mouse Preimplantation Embryos. Acta Obstet. Gynecol. Scand. 69, 27–33 (1990).

273.        Zusman, I. & Ornoy, A. Embryonic resistance to chemical and physical factors: Manifestation, mechanism, role in reproduction and in adaptation to ecology. Biol. Rev. Camb. Philos. Soc. 65, 1–18 (1990).

274.        Soskolne, W. A., Schwartz, Z., Goldstein, M. & Ornoy, A. The biphasic effect of triiodothyronine compared to bone resorbing effect of PTH on bone modelling of mouse long bone in vitro. Bone 11, 301–307 (1990).

275.        Sherzer, A., Atkin, G. & Ornoy, A. Effects of surface demineralization on fracture healing in rat tibias. Harefuah 116, 620–624 (1989).

276.        Bendel, J., Palti, H., Winter, S. & Ornoy, A. Prevalence of disabilities in a national sample of 3-year-old Israeli children. Isr. J. Med. Sci. 25, 264–270 (1989).

277.        H.B. Fishman, R., Ornoy, A. & Yanai, J. Correlated ultrastructural damage between cerebellum cells after early anticonvulsant treatment in mice. Int. J. Dev. Neurosci. 7, 15–26 (1989).

278.        Schwartz, Z., Soskolne, W. A., Atkin, I., Goldstein, M. & Ornoy, A. A direct effect of 24,25‐(OH)2D3 and 1,25‐(OH)2D3 on the modeling of fetal mice long bones in vitro. J. Bone Miner. Res. 4, 157–163 (1989).

279.        Zusman, I., Yaffe, P., Raz, I., Bar‐on, H. & Ornoy, A. Effects of human diabetic serum on the in vitro development of early somite rat embryos. Teratology 39, 85–92 (1989).

280.        Zusman, I., Yaffe, P. & Ornoy, A. Effects of human diabetic serum on the in vitro development of mouse preimplantation embryos. Teratology 39, 581–589 (1989).

281.        Keshet, E., Polakiewicz, R. D., Itin, A., Ornoy, A. & Rosen, H. Proenkephalin A is expressed in mesodermal lineages during organogenesis. EMBO J. 8, 2917–2923 (1989).

282.        Arnon, J., Ornoy, A. & Bach, G. Culture conditions found to minimize false positive diagnosis of lysosomal storage disorders. Vitr. Cell. Dev. Biol. - Anim. 24, 1159–1164 (1988).

283.        Atkin, I. et al. EHDP‐induced rachitic syndrome in rats is not reversed by vitamin D metabolites. Anat. Rec. 220, 22–30 (1988).

284.        Atkin, I., Cohen, I., Schwartz, Z., Castiglione, G. & Ornoy, A. Transplacental effects of vitamin A on fetal bones in mice—follow‐up studies on postnatal recovery. J. Orthop. Res. 6, 704–712 (1988).

285.        Schwartz, S., Soskolnes, W. A. & Ornoy, A. Physiological effects of thyroid hormone on bone. Harefuah 113, 168–172 (1987).

286.        Zusman, I., Yaffe, P. & Ornoy, A. The effects of high-sucrose diets and of maternal diabetes on the ultrastructure of the visceral yolk sac endoderm in rat embryos developing in vivo and in vitro. Cells Tissues Organs 128, 11–18 (1987).

287.        Ornoy, A. et al. Pathological confirmation of cystic fibrosis in the fetus following prenatal diagnosis. Am. J. Med. Genet. 28, 935–947 (1987).

288.        Zusman, I. & Ornoy, A. Effects of hyperglycemia and ketone bodies on the in vitro development of early somite rat embryos. Fetal Pediatr. Pathol. 7, 535–547 (1987).

289.        Ornoy, A., Arnon, J., Grebner, E. E., Jackson, L. G. & Bach, G. Early prenatal diagnosis of mucolipidosis IV. Am. J. Med. Genet. 27, 983–985 (1987).

290.        Lidor, C., Atkin, I., Ornoy, A., Dekel, S. & Edelstein, S. Healing of rachitic lesions in chicks by 24R,25‐dihydroxycholecalciferol administered locally into bone. J. Bone Miner. Res. 2, 91–98 (1987).

291.        Zusman, I., Yaffe, P. & Ornoy, A. Effects of metabolic factors in the diabetic state on the in vitro development of preimplantation mouse embryos. Teratology 35, 77–85 (1987).

292.        Schwartz, Z., Soskolne, W. A. & Ornoy, A. Physiology of vitamin D. Harefuah 111, 437–441 (1986).

293.        Granat, M., Morag, A., Margalioth, E. J., Leviner, E. & Ornoy, A. Fetal outcome following primary herpetic gingivostomatitis in early pregnancy. Morphological study and updated appraisal. Isr. J. Med. Sci. 22, 455–459 (1986).

294.        Altshuler, G. & Ornoy, A. Thickness of renal glomerular capillary basement membrane in the offspring of diabetic rats fed a regular or high-sucrose diet. Cells Tissues Organs 126, 237–239 (1986).

295.        Haesaert, B. & Ornoy, A. Transplacental effects of endotoxemia on fetal mouse brain, bone, and placental tissue. Fetal Pediatr. Pathol. 5, 167–181 (1986).

296.        Soskolne, W. A., Schwartz, Z. & Ornoy, A. The development of fetal mice long bones in vitro: An assay of bone modeling. Bone 7, 41–48 (1986).

297.        Ornoy, A., Zusman, I., Cohen, A. M. & Shafrir, E. Effects of sera from Cohen, genetically determined diabetic rats, streptozotocin diabetic rats and sucrose fed rats on in vitro development of early somite rat embryos. Diabetes Res. 3, 43–51 (1986).

298.        Zusman, I. & Ornoy, A. The effects of maternal diabetes and high sucrose diets on the intrauterine development of rat fetuses. Diabetes Res. 3, 153–159 (1986).

299.        Schwartz, Z., Ornoy, A. & Soskolne, W. A. The effects of insulin and glucose on bone modelling in vitro. Diabetes Res. 3, 321–326 (1986).

300.        Arnon, J., Ornoy, A. & Bach, G. Cultured amniotic fluid cells for prenatal diagnosis of lysosomal storage disorders: A methodological study. Prenat. Diagn. 6, 351–361 (1986).

301.        Borochowitz, Z., Ornoy, A., Lachman, R. & Rimoin, D. L. Achondrogenesis II - Hypochondrogenesis: Variability versus heterogeneity. Am. J. Med. Genet. 24, 273–288 (1986).

302.        Ornoy, A. Teratogenic agents in man. Harefuah 109, 402–406 (1985).

303.        Ornoy, A., Adomian, G. E. & Rimoin, D. L. Histologic and ultrastructural studies on the mineralization process in hypophosphatasia. Am. J. Med. Genet. 22, 743–758 (1985).

304.        Yagel, S. et al. Imaging Case of the Month. Am. J. Perinatol. 2, 261–262 (1985).

305.        Schwartz, Z., Ornoy, A. & Soskolne, W. A. An in vitro assay of bone development using fetal long bones of mice: Morphological studies. Acta Anat. (Basel). 124, 197–205 (1985).

306.        Ornoy, A., Adomian, G. E., Eteson, D. J., Burgeson, R. E. & Rimoin, D. L. The role of mesenchyme-like tissue in the pathogenesis of thanatophoric dysplasia. Am. J. Med. Genet. 21, 613–630 (1985).

307.        Wexler, S. et al. AN ACARDIAC ACEPHALIC ANOMALY DETECTED ON SONOGRAPHY. Acta Obstet. Gynecol. Scand. 64, 93–94 (1985).

308.        Atkin, I. et al. Effects of vitamin D metabolites on healing of low phosphate, vitamin D-deficient induced rickets in rats. Bone 6, 113–123 (1985).

309.        Zusman, I., Ornoy, A., Yaffe, P. & Shafrir, E. Effects of glucose and serum from streptozotocin-diabetic and nondiabetic rats on the in vitro development of preimplantation mouse embryos. Isr. J. Med. Sci. 21, 359–365 (1985).

310.        Ben Hur, H. & Ornoy, A. Ultrastructural studies of initial stages of mineralization of long bones and vertebrae in human fetuses1. Cells Tissues Organs 119, 33–39 (1984).

311.        Eteson, D. J. et al. Fibrochondrogenesis: Radiologic and histologic studies. Am. J. Med. Genet. 19, 277–290 (1984).

312.        Atkin, I., Ornoy, A. & Soskolne, W. A. Comparison of the effects of cortisone acetate on calcification, ossification, and resorption of fetal mice long bones--in vivo and in vitro studies. Adv. Exp. Med. Biol. 171, 137–148 (1984).

313.        Zusman, I. et al. Effects of interferon and encephalomyocarditis virus on in vitro development of preimplantation mouse embryos with and without the zona pellucida. Teratology 29, 405–409 (1984).

314.        Ben Hur, H. & Ornoy, A. Ultrastructural studies of initial stages of mineralization of long bones and vertebrae in human fetuses. Acta Anat. (Basel). 119, 33–39 (1984).

315.        Fishman, R. H. B., Ornoy, A. & Yanai, J. Ultrastructural evidence of long-lasting cerebellar degeneration after early exposure to phenobarbital in mice. Exp. Neurol. 79, 212–222 (1983).

316.        Yatziv, S., Gershon, Z. L., Ornoy, A. & Bach, G. Clinical heterogeneity in a sibship with Niemann‐Pick disease type C. Clin. Genet. 23, 125–131 (1983).

317.        Weinstein, D. et al. Teratogenicity of bromocryptine in pregnant rats. Arch. Gynecol. 233, 31–35 (1982).

318.        Ornoy, A., Salamon-Arnon, J., Ben-Zur, Z. & Kohn, G. Placental findings in spontaneous abortions and stillbirths. Obstet. Gynecol. Surv. 37, 619–620 (1982).

319.        Atkin, I., Soskolne, W. A. & Ornoy, A. Ultrastructural and in vitro studies on the effects of glucocorticoids on long bones of mice fetuses and offspring. Calcif. Tissue Int. 34, 590 (1982).

320.        Fishman, R. H. B., Ornoy, A. & Yanai, J. Ultrastructural evidence of cerebellar degeneration after early exposure to phenytoin and/or phenobarbital (Phb) in mice. Teratology 26, (1982).

321.        Kohn, G., Sekeles, E., Arnon, J. & Ornoy, A. Mucolipidosis IV: Prenatal diagnosis by electron microscopy. Prenat. Diagn. 2, 301–307 (1982).

322.        Zusman, I. & Ornoy, A. Transplacental effects of vitamin D3 metabolites on bone formation in rat fetuses. Isr. J. Med. Sci. 17, 1191–1192 (1982).

323.        Fishman, R. H., Batushansky, Ornoy, A. & Yanai, J. Ultrastructural cerebellar degeneration in mice following early exposure to phenobarbital (PhB). Teratology 25, 15A-16A (1982).

324.        Ornoy, A., Menashi, M. & Antebi, S. O. Placental changes as a consequence of the interruption of midtrimester pregnancies by prostaglandin F(2alpha). A study of 23 cases. Isr. J. Med. Sci. 18, 235–240 (1982).

325.        Ornoy, A., Dudai, M. & Sadovsky, E. Placental and fetal pathology in infectious mononucleosis. A possible indicator for Epstein-Barr virus teratogenicity. Diagn. Gynecol. Obstet. 4, 11–16 (1982).

326.        Atkin, I., Ornoy, A., Sirkis, N. & Soskolne, A. Effect of triiodothyronine on fetal bone in mice: In vivo and in vitro studies. Isr. J. Med. Sci. 17, 1194–1195 (1982).

327.        Shaham, M. et al. Prenatal diagnosis of ataxia telangiectasia. J. Pediatr. 100, 134–137 (1982).

328.        Menashi, M., Ornoy, A. & Yanai, J. Transplacental effects of methylmercury chloride in mice with specific emphasis on the audiogenic seizure response. Dev. Neurosci. 5, 216–221 (1982).

329.        Zusman, I., Hirsh, B. E., Edelstein, S. & Ornoy, A. Transplacental effects of 1,25-dihydroxycholecalciferol and of 24,25-dihydroxycholecalciferol on the limb skeleton of fetuses and offspring of rats. Acta Anat. (Basel). 111, 343–351 (1981).

330.        Hirsch, B. E. & Ornoy, A. The effect of 1α,25-dihydroxycholecalciferol on the development of fetal rat bones. Anat. Rec. 199, (1981).

331.        Atkin, I., Ornoy, A., Sirkis, N. & Soskolne, W. A. The effects of tri-iodothyronine on fetal bone in mice. In vivo and in vitro studies. Calcif. Tissue Int. 33, (1981).

332.        Ornoy, A., Salamon‐Arnon, J., Ben‐Zur, Z. & Kohn, G. Placental findings in spontaneous abortions and stillbirths. Teratology 24, 243–252 (1981).

333.        Voss, R. et al. Prenatal diagnosis of Fanconi anemia. Clin. Genet. 20, 185–190 (1981).

334.        Atkin, I. & Ornoy, A. Transplacental effects of cortisone acetate on calcification and ossification of long bones in mice. Metab. Bone Dis. Relat. Res. 3, 199–207 (1981).

335.        Ornoy, A., Zusman, I. & Hirsch, B. E. Transplacental effects of vitamin D3 metabolites on the skeleton of rat fetuses. Teratology 23, (1981).

336.        Engelhard, D., Ornoy, A. & Deckelbaum, R. J. Pneumoscrotum complicating percutaneous liver biopsy. Gastroenterology 80, 390–392 (1981).

337.        Ornoy, A. & Cohen, A. M. Teratogenic effects of sucrose diet in diabetic and nondiabetic rats. Isr. J. Med. Sci. 16, 789–791 (1980).

338.        Ornoy, A., Navot, D., Menashi, M., Laufer, N. & Chemke, J. Asymmetry and discordance for congenital anomalies in conjoined twins: A report of six cases. Teratology 22, 145–154 (1980).

339.        Levy, J., Ornoy, A. & Atkin, I. Influence of tetracycline on the calcification of epiphyseal rat cartilage. Transmission and scanning electron-microscopic studies. Acta Anat. (Basel). 106, 360–369 (1980).

340.        Menashi, M., Yanai, J. & Ornoy, A. Barbiturate teratogenicity: An unsettled question. Isr. J. Med. Sci. 16, 558–559 (1980).

341.        Ornoy, A., Atkin, I. & Levy, J. Ultrastructural studies on the origin and structure of matrix vesicles in bone of young rats. Cells Tissues Organs 106, 450–461 (1980).

342.        Perlman, M., Tennenbaum, A., Menashi, M., Ron, M. & Ornoy, A. Extramembranous pregnancy: Maternal, placental, and perinatal implications. Obstet. Gynecol. 55, 34S-37S (1980).

343.        Ornoy, A., Levy, J., Atkin, I. & Salamon, J. Scanning and transmission electron microscopic observations on the origin and structure of matrix vesicles in normal and papain-digested epiphyseal cartilage of young rats. Isr. J. Med. Sci. 15, 928–936 (1979).

344.        Dekel, S., Ornoy, A., Sekeles, E., Noff, D. & Edelstein, S. Contrasting effects on bone formation and on fracture healing of cholecalciferol and of 1 α-hydroxycholecalciferol. Calcif. Tissue Int. 28, 245–251 (1979).

345.        Ganchrow, D. & Ornoy, A. Possible evidence for secondary degeneration of central nervous system in the pathogenesis of anencephaly and brain dysraphia - A study in young human fetuses. Virchows Arch. A Pathol. Anat. Histol. 384, 285–294 (1979).

346.        Dekel, S., Ornoy, A. & Sekeles, E. The contrasting effects on bone formation and fracture healing of vitamin D3 and of 1α-hydroxy vitamin D3. J. Bone Jt. Surg. - Ser. B 61, 380 (1979).

347.        Sekeles, E., Ornoy, A., Cohen, R. & Kohn, G. Mucolipidosis IV: fetal and placental pathology. A report on two subsequent interruptions of pregnancy. Monogr. Hum. Genet. 10, 47–50 (1978).

348.        Ornoy, A. & Langer, Y. Scanning electron microscopy studies on the origin and structure of matrix vesicles in epiphyseal cartilage from young rats. Isr. J. Med. Sci. 14, 745–752 (1978).

349.        Ornoy, A., Goodwin, D., Noff, D. & Edelstein, S. 24, 25-Dihydroxyvitamin D is a metabolite of vitamin D essential for bone formation [26]. Nature 276, 517–519 (1978).

350.        Ornoy, A., Sekeles, E., Cohen, R. & Kohn, G. Electron microscopy of cultured skin fibroblasts and amniotic fluid cells in the diagnosis of hereditary storage diseases. Monogr. Hum. Genet. 10, 32–39 (1978).

351.        Ornoy, A., Kohn, G., Zur, Z. B., Weinstein, D. & Cohen, M. M. Triploidy in human abortions. Teratology 18, 315–320 (1978).

352.        Kohn, G., Shaham, M., Ornoy, A., Beyth, Y. & Cohen, M. M. Small marker chromosome mosaicism confirmed in two cases ascertained prenatally. Am. J. Med. Genet. 2, 167–173 (1978).

353.        Bach, G. et al. A new variant of mannosidosis with increased residual enzymatic activity and mild clinical manifestation. Pediatr. Res. 12, 1010–1015 (1978).

354.        Dudakov, E., Perlman, M., Ornoy, A., Beyth, Y. & Cohen, M. M. Triploidy in man: A clearly recognizable syndrome? Isr. J. Med. Sci. 13, 493–499 (1977).

355.        Ornoy, A., Crone, K. & Altshuler, G. Pathological features of the placenta in fetal death. Obstet. Gynecol. Surv. 32, 20–21 (1977).

356.        Menashi, M., Ornoy, A. & Cohen, M. M. Anencephaly in trisomy 18: Related or unrelated? Teratology 15, 325–328 (1977).

357.        Ornoy, A. & Kim, O. J. Scanning electron microscopy findings in osteogenesis imperfecta fetalis. Isr. J. Med. Sci. 13, 26–32 (1977).

358.        Kohn, G., Cohen, M. M., Beyth, Y. & Ornoy, A. Prenatal diagnosis and gonadal findings in X/XXX mosaicism. J. Med. Genet. 14, 120–123 (1977).

359.        Beyth, Y., Perlman, M. & Ornoy, A. Amniogenic bands associated with facial dysplasia and paresis. J. Reprod. Med. Obstet. Gynecol. 18, 83–86 (1977).

360.        Kohn, G. et al. Prenatal diagnosis of mucolipidosis IV by electron microscopy. J. Pediatr. 90, 62–66 (1977).

361.        Ornoy, A., Sekeles, E., Smith, P., Simkin, A. & Kohn, G. Achondrogenesis type I in three sibling fetuses. Scanning and transmission electron microscopic studies. Am. J. Pathol. 82, 71–84 (1976).

362.        Ornoy, A., Crone, K. & Altshuler, G. Pathological features of the placenta in fetal death. Arch. Pathol. Lab. Med. 100, 367–371 (1976).

363.        Peshin, J., Ornoy, A. & Menczel, J. Transplacental effects of thyrocalcitonin on intestinal calcium binding protein, alkaline phosphatase activity and ossification of long bones in rat fetuses. Isr. J. Med. Sci. 12, 248–256 (1976).

364.        Ornoy, A., Benady, S., Kohen-Raz, R. & Russell, A. Association between maternal bleeding during gestation and congenital anomalies in the offspring. Am. J. Obstet. Gynecol. 124, 474–478 (1976).

365.        Segal, S., Ornoy, A., Bercovici, B., Antebi, S. O. & Polishuk, W. Z. PLACENTAL PATHOLOGY IN MIDTRIMESTER PREGNANCIES INTERRUPTED BY INTRA‐AMNIOTIC INJECTION OF HYPERTONIC UREA. BJOG An Int. J. Obstet. Gynaecol. 83, 156–159 (1976).

366.        Perlman, M., Williams, J. & Ornoy, A. Familial ureteric bud anomalies. J. Med. Genet. 13, 161–163 (1976).

367.        Ornoy, A. & Altshuler, G. Maternal endotoxemia, fetal anomalies, and central nervous system damage: a rat model of a human problem. Am. J. Obstet. Gynecol. 124, 196–204 (1976).

368.        Segal, S., Ornoy, A., Bercovici, B., Antebi, S. O. & Polishuk, W. Z. Placental pathology in midtrimester pregnancies interrupted by intra amniotic injection of hypertonic urea. BRIT.J.OBSTET.GYNAEC. 83, 156–159 (1976).

369.        Kohn, G., Sekeles, E., Beyth, Y. & Ornoy, A. Intrauterine diagnosis of mucolipidosis IV by electron microscopy. EXCERPTA MED.,AMSTERDAM,I.C.S. No.397, (1976).

370.        Ornoy, A. & Simkin, A. Proceedings: Scanning electron microscopic studies of calcification in normal and abnormal human fetuses. Isr. J. Med. Sci. 12, 87 (1976).

371.        Weinstein, D., Ornoy, A., Ben-Zur, Z., Pfeifer, Y. & Sulman, G. H. Teratogenicity of cyproheptadine in pregnant rats. Arch. Int. Pharmacodyn. Ther. 215, 345–349 (1975).

372.        Cohen, M. M., Ornoy, A., Rosenmann, A. & Kohn, G. An inherited translocation t(4;15) (p16;q22) leading to two cases of partial trisomy 15. Ann. Genet. 18, 99–103 (1975).

373.        Kohen Raz, R., Russell, A. & Ornoy, A. Early assessment and prevention of sociocultural deprivation in infancy. Ment. Health Soc. 2, 115–123 (1975).

374.        Sekeles, E. & Ornoy, A. Osseous manifestations of gestational rubella in young human fetuses. Am. J. Obstet. Gynecol. 122, 307–312 (1975).

375.        Kohn, G., Ornoy, A., Ben‐Tsur, Z., Sadovsky, E. & Cohen, M. M. Successive spontaneous abortions with diverse chromosomal aberrations in human translocation heterozygote. Teratology 12, 283–289 (1975).

376.        Kadur, A. J. & Ornoy, A. Impaired osteogenesis in the fetus induced by administration of cortisone to pregnant mice. Isr. J. Med. Sci. 10, 476–481 (1974).

377.        Ornoy, A., Wolinsky, I. & Guggenheim, K. Structure of long bones of rats and mice fed a low calcium diet. Calcif. Tissue Res. 15, 71–76 (1974).

378.        Fein, A., Ornoy, A. & Nebel, L. Effects of cortisone on the fetal and neonatal thymo lymphatic organs in rats. J. Anat. 117, 223–237 (1974).

379.        Kohn, G., Ornoy, A. & Cohen, M. M. Prenatal diagnosis: a problem in verification. J. Med. Genet. 11, 247–248 (1974).

380.        Ornoy, A., Sekeles, E. & Sadovsky, E. Amniogenic bands as a cause of syndactyly in a young human fetus. Teratology 9, 129–133 (1974).

381.        Salomon, C. D., Volpin, G. & Ornoy, A. Effect of thyrocalcitonin on metatarsal bones of normal and calcium-deficient young rats. Isr. J. Med. Sci. 9, 199–202 (1973).

382.        Ornoy, A. Transplacental effects of estrogen on osteogenesis in rat foetuses. Pathology 5, 183–188 (1973).

383.        Segal, S., Nishmi, M. & Ornoy, A. Gestational rubella: correlation between serological diagnosis and fetal and placental pathology (Hebrew). Harefuah 85, 114-117+158 (1973).

384.        Ornoy, A., Segal, S., Nishmi, M., Simcha, A. & Polishuk, W. Z. Fetal and placental pathology in gestational rubella. Am. J. Obstet. Gynecol. 116, 949–956 (1973).

385.        Ornoy, A., Kaspi, T. & Nebel, L. Persistent defects of bone formation in young rats following maternal hypervitaminosis D 2 . Isr. J. Med. Sci. 8, 943–949 (1972).

386.        Ritchie, J. et al. Administration of potassium penicillin and benzathine penicillin: comparison of penicillin levels in serum. Harefuah 82, 391–393 (1972).

387.        Ornoy, A., Horowitz, A., Kaspi, T., Michaeli, Y. & Nebel, L. Anomalous fetal and neonatal bone development induced by administration of cortisone and vitamin D2 to pregnant rats. Adv. Exp. Med. Biol. 27, 219–226 (1972).

388.        Russell, A. et al. Transplacental and neonatal effects of hypercortisonism in the rat on thymo-lymphatic system differentiation and serum immunoglobulin levels. Adv. Exp. Med. Biol. 27, 257–271 (1972).

389.        Safriel, O. J., Ornoy, A., Nebel, L. & Finkelstein, M. The effects of cortisone and of estradiol given to pregnant rats on the structural differentiation of the adrenal cortex and the ovary in their offspring. Adv. Exp. Med. Biol. 27, 243–250 (1972).

390.        Nebel, L. & Ornoy, A. Interdependence of fetal anomalies and placental impairment following maternal hypervitaminosis D and hypercortisonism. Adv. Exp. Med. Biol. 27, 251–255 (1972).

391.        Ornoy, A. & Horowitz, A. Postnatal effects of maternal hypercortisonism on skeletal development in newborn rats. Teratology 6, 153–158 (1972).

392.        Potashnick, G., Ornoy, A. & Menczel, J. Effects of steroid hormones on hypervitaminosis D2 in rats. Harefuah 81, 359–361 (1971).

393.        Ornoy, A., Ritchie, J. & Schiller, M. Small bowel obstruction due to duodenal hematoma. Harefuah 81, 273–275 (1971).

394.        Nebel, L. & Ornoy, A. Structural alterations in rat placenta following hypervitaminosis D 2 . Isr. J. Med. Sci. 7, 647–655 (1971).

395.        Ornoy, A., Horowitz, A., Homburg, R. & Insler, V. Conjoined twins. A report of a case of thoraco-omphalopagus. Isr. J. Med. Sci. 7, 679–684 (1971).

396.        Ornoy, A. Transplacental effects of cortisone and vitamin D 2 on the osteogenesis and ossification of fetal long bones in rats. Isr. J. Med. Sci. 7, 540–543 (1971).

397.        Ornoy, A. The effects of maternal hypercortisonism and hypervitaminosis D2 on fetal osteogenesis and ossification in rats. Teratology 4, 383–394 (1971).

398.        Ornoy, A. & Nebel, L. Effects of hypervitaminosis D2 altered by pregnancy in rats: hyperlipidemia and fatty liver degeneration with restrained injuries to the cardiovascular system and other organs. Isr. J. Med. Sci. 6, 622–629 (1970).

399.        Ornoy, A., Nebel, L. & Menczel, Y. Impaired osteogenesis of fetal long bones. Induced by maternal hypervitaminosis D2. Arch. Pathol. 87, 563–571 (1969).

400.        Ornoy, A., Menczel, J. & Nebel, L. Alterations in the mineral composition and metabolism of rat fetuses and their placentas induced by maternal hypervitaminosis D2. Isr. J. Med. Sci. 4, 827–832 (1968).

401.        Dvela-Levitt, M. et al. Reduction in maternal circulating ouabain impairs offspring growth and kidney development. J. Am. Soc. Nephrol. 26, 1103–1114 (2015).