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The Faculty of Medicine - Medical Neurobiology: Lichtstein David

Researchers

Last updated September 2023 - Medical Neurobiology

List of Publications

1.

Zilberstein A, Krivoy N, Horesh N, Klein E, Lichtstein D. Beneficial effect of digoxin-specific Fab fragments in bipolar disorder- a preliminary study. Journal of Affective Disorders Reports [Internet]. 2023;13. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85160332890&doi=10.1016%252fj.jadr.2023.100600&partnerID=40&md5=c2d6dd8fd6a3da21787e879ff8805510

2.

Sampath V, Horesh N, Sasi B, Zannadeh H, Pogodin I, Singh SV, et al. Synthesis and Biological Evaluation of Novel Bufalin Derivatives. International Journal of Molecular Sciences [Internet]. 2022;23(7). Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85127562018&doi=10.3390%252fijms23074007&partnerID=40&md5=93da7a1cda3c821d8f42f6052398afff

3.

El-Mallakh RS, Sampath VP, Horesh N, Lichtstein D. Endogenous Cardiac Steroids in Bipolar Disorder: State of the Art. International Journal of Molecular Sciences [Internet]. 2022;23(3). Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123931289&doi=10.3390%252fijms23031846&partnerID=40&md5=1945853a563c3490ae9d0d37c7a3fdb2

4.

Shin EJ, Nguyen BT, Jeong JH, Hoai Nguyen BC, Tran NKC, Sharma N, et al. Ouabain inhibitor rostafuroxin attenuates dextromethorphan-induced manic potential. Food and Chemical Toxicology [Internet]. 2021;158. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119279337&doi=10.1016%252fj.fct.2021.112657&partnerID=40&md5=3a03db77228266ae3ed7d2e780f8f1a9

5.

Singh SV, Fedorova OV, Wei W, Rosen H, Horesh N, Ilani A, et al. Na+, k+-atpase α isoforms and endogenous cardiac steroids in prefrontal cortex of bipolar patients and controls. International Journal of Molecular Sciences [Internet]. 2020;21(16):1–16. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089693919&doi=10.3390%252fijms21165912&partnerID=40&md5=4f0a9406326704a19ccd2bf0f36dcc7e

6.

Leibovich H, Buzaglo N, Tsuriel S, Peretz L, Caspi Y, Katz B, et al. Abnormal Reinnervation of Denervated Areas Following Nerve Injury Facilitates Neuropathic Pain. Cells [Internet]. 2020;9(4). Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85084031181&doi=10.3390%252fcells9041007&partnerID=40&md5=67554b3ac43bbed4f4e8776c15dd4c51

7.

Hodes A, Rosen H, Cohen-Ben Ami H, Lichtstein D. Na+, K+-ATPase α3 isoform in frontal cortex GABAergic neurons in psychiatric diseases. Journal of Psychiatric Research [Internet]. 2019;115:21–8. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065772764&doi=10.1016%252fj.jpsychires.2019.04.014&partnerID=40&md5=50ae1319a71d5975940b20f953385016

8.

Gross NB, Abad N, Lichtstein D, Taron S, Aparicio L, Fonteh AN, et al. Endogenous Na+, K+-ATPase inhibitors and CSF [Na+] contribute to migraine formation. PLoS ONE [Internet]. 2019;14(6). Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85067000363&doi=10.1371%252fjournal.pone.0218041&partnerID=40&md5=e22226e475d6929d6c56bb9af7f05371

9.

Buzaglo N, Golomb M, Rosen H, Beeri R, Ami HCB, Langane F, et al. Augmentation of Ouabain-Induced Increase in Heart Muscle Contractility by Akt Inhibitor MK-2206. Journal of Cardiovascular Pharmacology and Therapeutics [Internet]. 2019;24(1):78–89. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050545125&doi=10.1177%252f1074248418788301&partnerID=40&md5=bac0e68aa463d4200f98a5ca1f1bbe85

10.

Lichtstein D, Ilani A, Rosen H, Horesh N, Singh SV, Buzaglo N, et al. Na+, K+-ATPase signaling and bipolar disorder. International Journal of Molecular Sciences [Internet]. 2018;19(8). Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052112758&doi=10.3390%252fijms19082314&partnerID=40&md5=77344002871fb52ffbcc5542f7bbd10d

11.

Hodes A, Lifschytz T, Rosen H, Cohen Ben-Ami H, Lichtstein D. Reduction in endogenous cardiac steroids protects the brain from oxidative stress in a mouse model of mania induced by amphetamine. Brain Research Bulletin [Internet]. 2018;137:356–62. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043310724&doi=10.1016%252fj.brainresbull.2018.01.016&partnerID=40&md5=cad77ce3b1a5e2c92caf98a3e04236db

12.

Hodes A, Rosen H, Deutsch J, Lifschytz T, Einat H, Lichtstein D. Endogenous cardiac steroids in animal models of mania. Bipolar Disorders [Internet]. 2016;18(5):451–9. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84983754942&doi=10.1111%252fbdi.12413&partnerID=40&md5=816e70402b4a045968af1d2938901bb2

13.

Buzaglo N, Rosen H, Ami HCB, Inbal A, Lichtstein D. Essential opposite roles of ERK and akt signaling in cardiac steroid-induced increase in heart contractility. Journal of Pharmacology and Experimental Therapeutics [Internet]. 2016;357(2):345–56. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84963904996&doi=10.1124%252fjpet.115.230763&partnerID=40&md5=ce0cdb5dbe5ac984090052e947e94b91

14.

Leinonen JV, Korkus-Emanuelov A, Wolf Y, Milgrom-Hoffman M, Lichtstein D, Hoss S, et al. Macrophage precursor cells from the left atrial appendage of the heart spontaneously reprogram into a C-kit +/CD45 - Stem cell-like phenotype. International Journal of Cardiology [Internet]. 2016;209:296–306. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961695931&doi=10.1016%252fj.ijcard.2016.02.040&partnerID=40&md5=cf4c8873c83123166779d76e36e5728b

15.

Dvela-Levitt M, Cohen-Ben Ami H, Rosen H, Ornoy A, Hochner-Celnikier D, Granat M, et al. Reduction in maternal circulating ouabain impairs offspring growth and kidney development. Journal of the American Society of Nephrology [Internet]. 2015;26(5):1103–14. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84929379191&doi=10.1681%252fASN.2014020130&partnerID=40&md5=32c78cd43f81561d2bcbe1ff211f8937

16.

Dvela-Levitt M, Ami HCB, Rosen H, Shohami E, Lichtstein D. Ouabain improves functional recovery following traumatic brain injury. Journal of Neurotrauma [Internet]. 2014;31(23):1942–7. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84911995644&doi=10.1089%252fneu.2014.3544&partnerID=40&md5=95f33aa7c9ba5167d2c31c7b03be744e

17.

Hodes A, Lichtstein D. Natriuretic hormones in brain function. Frontiers in Endocrinology [Internet]. 2014;5(NOV). Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84920197898&doi=10.3389%252ffendo.2014.00201&partnerID=40&md5=e82b4053d05dd97871731f6a040bb331

18.

Nesher M, Bai Y, Li D, Rosen H, Lichtstein D, Liu L. Interaction of atrial natriuretic peptide and ouabain in the myocardium. Canadian Journal of Physiology and Pharmacology [Internet]. 2012;90(10):1386–93. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84868099061&doi=10.1139%252fY2012-112&partnerID=40&md5=374f2b925439490c3c627462f41ab439

19.

Fridman E, Lichtstein D, Rosen H. Formation of new high density glycogen-microtubule structures is induced by cardiac steroids. Journal of Biological Chemistry [Internet]. 2012;287(9):6518–29. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84857461970&doi=10.1074%252fjbc.M111.273698&partnerID=40&md5=18add40893e533cf190e905214c2f0bb

20.

Lichtstein D, Rosen H, Dvela M. Cardenolides and bufadienolides as hormones: What is missing? American Journal of Physiology - Renal Physiology [Internet]. 2012;302(8):F957–8. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84859762032&doi=10.1152%252fajprenal.00042.2012&partnerID=40&md5=261d50db347ae45a4417307484d0c571

21.

Dvela M, Rosen H, Ben-Ami HC, Lichtstein D. Endogenous ou0061bain regulates cell viability. American Journal of Physiology - Cell Physiology [Internet]. 2012;302(2):C442–52. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84855323100&doi=10.1152%252fajpcell.00336.2011&partnerID=40&md5=9c813cc1d60a71fc73994f390e8fdc47

22.

Goldstein I, Lax E, Gispan-Herman I, Ovadia H, Rosen H, Yadid G, et al. Neutralization of endogenous digitalis-like compounds alters catecholamines metabolism in the brain and elicits anti-depressive behavior. European Neuropsychopharmacology [Internet]. 2012;22(1):72–9. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84155167906&doi=10.1016%252fj.euroneuro.2011.05.007&partnerID=40&md5=c1f2e300b491708df945829d914454de

23.

Feldmann T, Shahar M, Baba A, Matsuda T, Lichtstein D, Rosen H. The Na+/Ca2+-exchanger: An essential component in the mechanism governing cardiac steroid-induced slow Ca2+ oscillations. Cell Calcium [Internet]. 2011;50(5):424–32. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-80053959109&doi=10.1016%252fj.ceca.2011.07.001&partnerID=40&md5=03742bb423cda7ecc882ea12ff45dd9f

24.

Nesher M, Shpolansky U, Viola N, Dvela M, Buzaglo N, Ben-Ami HC, et al. Ouabain attenuates cardiotoxicity induced by other cardiac steroids. British Journal of Pharmacology [Internet]. 2010;160(2):346–54. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-77951673270&doi=10.1111%252fj.1476-5381.2010.00701.x&partnerID=40&md5=17519968c517e6afb34b397d7d1cf7c4

25.

Guttmann-Rubinstein L, Lichtstein D, Ilani A, Gal-Moscovici A, Scherzer P, Rubinger D. Evidence of a parathyroid hormone-independent chronic effect of estrogen on renal phosphate handling and sodium-dependent phosphate cotransporter type IIa expression. Hormone and Metabolic Research [Internet]. 2010;42(4):230–6. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-77950484282&doi=10.1055%252fs-0029-1246182&partnerID=40&md5=fbc75b134789bfca6a6b44ffdff7b9b7

26.

Jaiswal MK, Dvela M, Lichtstein D, Mallick BN. Endogenous ouabain-like compounds in locus coeruleus modulate rapid eye movement sleep in rats. Journal of Sleep Research [Internet]. 2010;19(1 PART. 2):183–91. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-77950661897&doi=10.1111%252fj.1365-2869.2009.00781.x&partnerID=40&md5=c306194c6ac2b49ba425d15fde402109

27.

Nesher M, Dvela M, Igbokwe VU, Rosen H, Lichtstein D. Physiological roles of endogenous ouabain in normal rats. American Journal of Physiology - Heart and Circulatory Physiology [Internet]. 2009;297(6):H2026–34. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-72249113150&doi=10.1152%252fajpheart.00734.2009&partnerID=40&md5=668999e9fe57dc42d6aa13abf1b4e16b

28.

Klar A, Haver E, Lichtstein D, Hurvitz H, Foah-Shauli T. Atrial natriuretic peptide in young and elderly children with mild gastroenteritis. Gastroenterology Research and Practice [Internet]. 2009; Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-68949109949&doi=10.1155%252f2009%252f623871&partnerID=40&md5=14181a142cc6cbd4e29ecebddb95b5e5

29.

Goldstein I, Lerer E, Laiba E, Mallet J, Mujaheed M, Laurent C, et al. Association Between Sodium- and Potassium-Activated Adenosine Triphosphatase α Isoforms and Bipolar Disorders. Biological Psychiatry [Internet]. 2009;65(11):985–91. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-67349124103&doi=10.1016%252fj.biopsych.2008.10.033&partnerID=40&md5=7426b8a13307ff21d97987c5702f54b3

30.

Nesher M, Vachutinsky Y, Fridkin G, Schwarz Y, Sasson K, Fridkin M, et al. Reversible pegylation prolongs the hypotensive effect of atrial natriuretic peptide. Bioconjugate Chemistry [Internet]. 2008;19(1):342–8. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-38949083505&doi=10.1021%252fbc700294w&partnerID=40&md5=bc47b21e64171ef951b3e3baab00e9a7

31.

Dvela M, Rosen H, Feldmann T, Nesher M, Lichtstein D. Diverse biological responses to different cardiotonic steroids. Pathophysiology [Internet]. 2007;14(3–4):159–66. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-36448949741&doi=10.1016%252fj.pathophys.2007.09.011&partnerID=40&md5=f09d2ae66465001fc708c58a30ba16e8

32.

Feldmann T, Glukmann V, Medvenev E, Shpolansky U, Galili D, Lichtstein D, et al. Role of endosomal Na+-K+-ATPase and cardiac steroids in the regulation of endocytosis. American Journal of Physiology - Cell Physiology [Internet]. 2007;293(3):C885–96. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-34548770741&doi=10.1152%252fajpcell.00602.2006&partnerID=40&md5=ddad00866f685add42f8cdb42c13e49c

33.

Nesher M, Shpolansky U, Rosen H, Lichtstein D. The digitalis-like steroid hormones: New mechanisms of action and biological significance. Life Sciences [Internet]. 2007;80(23):2093–107. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-34248570330&doi=10.1016%252fj.lfs.2007.03.013&partnerID=40&md5=867bac9ba7a290789b01882321d016ab

34.

Rosen H, Glukmann V, Feldmann T, Fridman E, Lichtstein D. Short-term effects of cardiac steroids on intracellular membrane traffic in neuronal NT2 cells. Cellular and Molecular Biology [Internet]. 2006;52(8):78–86. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-34249072238&doi=10.1170%252fT764&partnerID=40&md5=1d036ee57cc437c19f3fb9c6b52d96d1

35.

Goldstein I, Levy T, Galili D, Ovadia H, Yirmiya R, Rosen H, et al. Involvement of Na+, K+-ATPase and Endogenous Digitalis-Like Compounds in Depressive Disorders. Biological Psychiatry [Internet]. 2006;60(5):491–9. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-33747886633&doi=10.1016%252fj.biopsych.2005.12.021&partnerID=40&md5=9a63a7fa45899885b53495add453af1e

36.

Deutsch J, Jang HG, Mansur N, Ilovich O, Shpolansky U, Galili D, et al. 4-(3′α15′β-dihydroxy-5′β-estran- 17′β-yl)furan-2-methyl alcohol: An anti-digoxin agent with a novel mechanism of action. Journal of Medicinal Chemistry [Internet]. 2006;49(2):600–6. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-31544450048&doi=10.1021%252fjm0505819&partnerID=40&md5=9173a472b649274b24be45558a7fc1e0

37.

Haviv M, Haver E, Lichtstein D, Hurvitz H, Klar A. Atrial natriuretic peptide in children with pneumonia. Pediatric Pulmonology [Internet]. 2005;40(4):306–9. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-26444460366&doi=10.1002%252fppul.20233&partnerID=40&md5=233a057015949c9299f0bc95cb64c3ce

38.

Landsman A, Lichtstein D, Ilani A. Distinctive features of dietary phosphate supply. Journal of Applied Physiology [Internet]. 2005;99(3):1214–9. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-24044545537&doi=10.1152%252fjapplphysiol.00095.2005&partnerID=40&md5=ecf5847c9dbb7fce88a62ec75e0ecbbf

39.

Rosen H, Glukhman V, Feldmann T, Fridman E, Lichtstein D. Cardiac Steroids Induce Changes in Recycling of the Plasma Membrane in Human NT2 Cells. Molecular Biology of the Cell [Internet]. 2004;15(3):1044–54. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-1542283814&doi=10.1091%252fmbc.E03-06-0391&partnerID=40&md5=0063e5e5d39c31858555b6d83c953cb2

40.

Lichtstein D, Rosen H. Endogenous digitalis-like Na+, K+-ATPase inhibitors, and brain function. Neurochemical Research [Internet]. 2001;26(8–9):971–8. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034753270&doi=10.1023%252fA%253a1012340702763&partnerID=40&md5=697b4dd6ee56e8be9d681303cb0cc9ff

41.

Landsman A, Lichtstein D, Bacaner M, Ilani A. Dietary phosphate-dependent growth is not mediated by changes in plasma phosphate concentration. British Journal of Nutrition [Internet]. 2001;86(2):217–23. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034893662&partnerID=40&md5=f9aaffbc451135bef0c7959011124301

42.

Cheng Q, Lichtstein D, Russell P, Zigler Jr. JS. Use of lipophilic cation to monitor electrical membrane potential in the intact rat lens. Investigative Ophthalmology and Visual Science [Internet]. 2000;41(2):482–7. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033983238&partnerID=40&md5=be41b2bea30c11630889901f6f3da748

43.

Traub N, Lichtstein D. The Mood Cycle Hypothesis: Possible Involvement Of Steroid Hormones In Mood Regulation By Means Of Na+,K+-Atpase Inhibition. Journal of Basic and Clinical Physiology and Pharmacology [Internet]. 2000;11(4):375–94. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034474422&doi=10.1515%252fJBCPP.2000.11.4.375&partnerID=40&md5=e52b3a1625d479bc7cfa0cca46eb46f0

44.

Lichtstein D, Mcgowan MH, Russell P, Carper DA. Digitalis and Digitalislike Compounds Down-Regulate Gene Expression of the Intracellular Signaling Protein 14-3-3 in Rat Lens. Hypertension Research - Clinical and Experimental [Internet]. 2000;23. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033802397&doi=10.1291%252fhypres.23.Supplement_S51&partnerID=40&md5=4c16feebbb006902fcec8f79e0fde94c

45.

McGowan MH, Russell P, Carper DA, Lichtstein D. Na+, K+-ATPase inhibitors down-regulate gene expression of the intracellular signaling protein 14-3-3 in rat lens. Journal of Pharmacology and Experimental Therapeutics [Internet]. 1999;289(3):1559–63. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032990716&partnerID=40&md5=23c4a4afd8376664874dc9e2e9a568e4

46.

Lichtstein D, Levy T, Deutsch J, Steinitz M, Zigler Jr. JS, Russell P. The effects of digitalis-like compounds on rat lenses. Investigative Ophthalmology and Visual Science [Internet]. 1999;40(2):407–13. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032946879&partnerID=40&md5=f26defc8c7c8d1ec5800ef2e68cfaa62

47.

Lichtstein D, Steinitz M, Gati I, Samuelov S, Deutsch J, Orly J. Biosynthesis of digitalis-like compounds in rat adrenal cells: Hydroxycholesterol as possible precursor. Life Sciences [Internet]. 1998;62(23):2109–26. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032078274&doi=10.1016%2fS0024-3205%2898%2900186-6&partnerID=40&md5=f37627937be09c79b29eef908e3647ee

48.

Lichtstein D, Steinitz M, Gati I, Samuelov S, Deutsch J, Orly J. Bufodienolides as Endogenous Na+, K+-ATPase Inhibitors: Biosynthesis in Bovine and Rat Adrenals. Clinical and Experimental Hypertension [Internet]. 1998;20(42130):573–9. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031595363&doi=10.3109%252f10641969809053235&partnerID=40&md5=e9df9d39e6d222bd58a9db1c4b909e71

49.

Morris JF, Ismail-Beigi F, Butler Jr. VP, Gati I, Lichtstein D. Ouabain-sensitive Na+,K+-ATPase activity in toad brain. Comparative Biochemistry and Physiology - A Physiology [Internet]. 1997;118(3):599–606. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031280437&doi=10.1016%2fS0300-9629%2896%2900465-3&partnerID=40&md5=de0c251512f0010220d840b638e0036a

50.

Furman S, Lichtstein D, Ilani A. Sodium-dependent transport of phosphate in neuronal and related cells. Biochimica et Biophysica Acta - Biomembranes [Internet]. 1997;1325(1):34–40. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031551016&doi=10.1016%2fS0005-2736%2896%2900238-6&partnerID=40&md5=c7c891609479577e13f01774aaf669ca

51.

Samuelov S, Lichtstein D. Digitalis-like compounds and Na+, K+-ATPase activity in bovine lens. Pflugers Archiv European Journal of Physiology [Internet]. 1997;433(4):435–41. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031012406&doi=10.1007%252fs004240050297&partnerID=40&md5=87f7250f2a3668a46079ff158ae727fd

52.

Antolovic R, Kost H, Linder D, Linder M, Thönges D, Lichtstein D, et al. Demonstration of a specific transport protein for cardiac glycosides in bovine blood. Annals of the New York Academy of Sciences [Internet]. 1997;834:618–20. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031458787&doi=10.1111%252fj.1749-6632.1997.tb52331.x&partnerID=40&md5=94cea1029d7c121adfd77e204c4b69f2

53.

Bachar C, Haver E, Kadar T, Levy A, Lichtstein D. Possible involvement of atrial natriuretic peptides in olfaction. Brain Research [Internet]. 1995;682(1–2):231–4. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029001092&doi=10.1016%2f0006-8993%2895%2900353-R&partnerID=40&md5=1c1c5631cb7470a99559e45e4def3ca2

54.

Haver E, Lichtstein D, Munson PJ. Multiple types of binding sites for atrial natriuretic peptide in rat olfactory bulb membranes and synaptosomes. Brain Research [Internet]. 1995;681(1–2):75–83. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029051109&doi=10.1016%2f0006-8993%2895%2900287-Z&partnerID=40&md5=674c9787986f51eeeb9513be835bf885

55.

Lichtstein D, Shainberg A, Solarao J, Marban E, Ter Keurs HEDJ, Morad M. Na+, K+-ATPase and heart excitability. Advances in Experimental Medicine and Biology [Internet]. 1995;382:23–30. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029116579&doi=10.1007%252f978-1-4615-1893-8_3&partnerID=40&md5=ba7c59f27a67b52a467665f1e0780111

56.

Bachar H, Lichtstein D. Distribution of Atrial Natriuretic Peptides in the Sand Rat (Psammomys Obesus) in Comparison to That in the Rat. Journal of Basic and Clinical Physiology and Pharmacology [Internet]. 1993;4(1–2):47–56. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027750911&doi=10.1515%252fJBCPP.1993.4.1-2.47&partnerID=40&md5=5b8ae80762cc18d5ec0e71d25fe6485f

57.

Lichtstein D, Gati I, Ovadia H. Digitalis-like compounds in the toad Bufo viridis: Interactions with plasma proteins. Journal of Cardiovascular Pharmacology [Internet]. 1993;22(SUPPL. 2):S102–5. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027488551&doi=10.1097%252f00005344-199322002-00033&partnerID=40&md5=22dff6ecf5e749d0fa282cde48d626ff

58.

LICHTSTEIN D, GATI I, SAMUELOV S, BERSON D, ROZENMAN Y, LANDAU L, et al. Identification of digitalis‐like compounds in human cataractous lenses. European Journal of Biochemistry [Internet]. 1993;216(1):261–8. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027226175&doi=10.1111%252fj.1432-1033.1993.tb18141.x&partnerID=40&md5=cd414c9a712e14bf882a3a93a981df69

59.

Bachar H, Haver E, Ilani A, Lichtstein D. Modulation of rat olfactory bulb mitochondrial function by atrial natriuretic peptide. Pflügers Archiv European Journal of Physiology [Internet]. 1992;422(2):204–6. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026459530&doi=10.1007%252fBF00370423&partnerID=40&md5=bb87919cfaa3c948f9fb22d3175bed26

60.

Lichtstein D, Gati I, Haver E, Katz U. Digitalis-like compounds in the toad Bufo viridis: Tissue and plasma levels and significance in osmotic stress. Life Sciences [Internet]. 1992;51(2):119–28. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026696313&doi=10.1016%2f0024-3205%2892%2990005-A&partnerID=40&md5=592f99a61bb833dcd6e331c5c8749a51

61.

Lichtstein D, Gati I, Babila T, Haver E, Katz U. Effect of salt acclimation on digitalis-like compounds in the toad. BBA - General Subjects [Internet]. 1991;1073(1):65–8. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026030637&doi=10.1016%2f0304-4165%2891%2990183-H&partnerID=40&md5=959d11d9ef3afd1456eb809dde837bfd

62.

Lichtstein D, Samuelov S, Gati I, Felix AM, Gabriel TF, Deutsch J. Identification of 11,13-dihydroxy-14-octadecaenoic acid as a circulating Na+/K+-ATPase inhibitor. Journal of Endocrinology [Internet]. 1991;128(1):71–8. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025962266&doi=10.1677%252fjoe.0.1280071&partnerID=40&md5=80faf2d07c27876db345539b6af6debc

63.

Oberfrank F, Vizi ES, Baker PF, Samuelov S, Lichtstein D. Comparison of the effects of a bufodienolide and ouabain on neuronal and smooth muscle preparations. Neuroscience Research [Internet]. 1991;10(4):235–44. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025829543&doi=10.1016%2f0168-0102%2891%2990081-9&partnerID=40&md5=a70609a3f4957710e88390f8a81ca5d2

64.

Lichtstein D, Atlan H. The “cellular state”: The way to regain specificity and diversity in hormone action. Journal of Theoretical Biology [Internet]. 1990;145(3):287–94. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024986474&doi=10.1016%2fS0022-5193%2805%2980110-9&partnerID=40&md5=8e89f226b66399b00e33e7947b0b7f3f

65.

Babila T, Atlan H, Fromer I, Schwalb H, Uretzky G, Lichtstein D. Volume Regulation of Nerve Terminals. Journal of Neurochemistry [Internet]. 1990;55(6):2058–62. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025644193&doi=10.1111%252fj.1471-4159.1990.tb05795.x&partnerID=40&md5=1efc6c0927217d2d50731d3216410dc2

66.

Babila T, Gottlieb Y, Lutz RA, Lichtstein D. A bumetanide-sensitive, potassium carrier-mediated transport system in excitable tissues. Life Sciences [Internet]. 1989;44(22):1665–75. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024407263&doi=10.1016%2f0024-3205%2889%2990483-9&partnerID=40&md5=164146daa32db6ade450151504b4ae76

67.

Oberfrank F, Vizi ES, Lichtstein D. Presynaptic modulation by endogenous ouabain-like substances of noradrenaline release from blood vessels. Polish journal of pharmacology and pharmacy [Internet]. 1988;40(6):685–90. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024109302&partnerID=40&md5=32fb47d7755a40355c8602a53e967e13

68.

Xu H, Lichtstein D, Kassis S, Lutz RA, Rodbard D, Chernick SS. Multiple interactions of unsaturated fatty acids with opiate and ouabain binding sites and βadrenergic sensitive adenylate cyclase system. Journal of Receptors and Signal Transduction [Internet]. 1988;8(1–4):205–23. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023887136&doi=10.3109%252f10799898809048988&partnerID=40&md5=1bba6e5a28bcec192c9c80c66729a945

69.

Bloch KD, Zamir N, Lichtstein D, Seidman CE, Seidman JG. Ouabain induces secretion of proatrial natriuretic factor by rat atrial cardiocytes. American Journal of Physiology - Endocrinology and Metabolism [Internet]. 1988;255(3):18/3. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023787698&partnerID=40&md5=80fbc1dea158c08dba309dc9d0c82f55

70.

Lichtstein D, Rodbard D. A second look at the second messenger hypothesis. Life Sciences [Internet]. 1987;40(21):2041–51. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023664436&doi=10.1016%2f0024-3205%2887%2990096-8&partnerID=40&md5=e4b0331082d0132611a2147c88113e3c

71.

Vizi ES, Oberfrank F, Bernath S, Lichtstein D. Noradrenaline releasing effect of an ouabain-like compound on pulmonary artery. Neuropharmacology [Internet]. 1987;26(10):1541–4. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023231041&doi=10.1016%2f0028-3908%2887%2990177-8&partnerID=40&md5=5bbc1e4ca347e5f187d95245a5d7e223

72.

Lutz RA, Lichtstein D, Xu H, Rodbard D. Demonstration and characterization of two classes of cardiac glycoside binding sites to rat heart membrane preparations using quantitative computer modeling. Journal of Receptors and Signal Transduction [Internet]. 1987;7(5):679–94. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023189765&doi=10.3109%252f10799898709056779&partnerID=40&md5=245857b0dcf9798f1d81f6e2d9526c5d

73.

Lichtstein D, Samuelov S, Deutsch J, Xu H, Lutz RA, Chernick SS, et al. The ouabain receptor in animal tissues and its endogenous ligand. Klinische Wochenschrift [Internet]. 1987;65(SUPPL. 8):40–8. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023105449&partnerID=40&md5=83a3ce57342b56567d93559ec4417227

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Silva P, Lear S, Segal F, Rosen S, Spokes K, Stevens A, et al. Isolated rectal gland cells: Oxygen consumption and hormonal stimulation. Mineral and Electrolyte Metabolism [Internet]. 1986;12(5–6):286–92. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022914725&partnerID=40&md5=f690adff2407d8e26a3ecde3bac25088

75.

Lichtstein D, Lutz RA, Xu H, Rodbard D. Characterization of two classes of cardiac glycosine binding sites in rat heart and brain membrane preparations, using quantitative computer modelling. Journal of Hypertension [Internet]. 1986;4(SUPPL. 5):S227–9. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022900959&partnerID=40&md5=c26517b0ffeef7b724cae00151c340a6

76.

Lichtstein D, Kachalsky S, Deutsch J. Identification of a ouabain-like compound in toad skin and plasma as a bufodienolide derivative. Life Sciences [Internet]. 1986;38(14):1261–70. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022514928&doi=10.1016%2f0024-3205%2886%2990418-2&partnerID=40&md5=12e52e673e170efb6da4835dae88c5f4

77.

Tal DM, Katchalsky S, Lichtstein D, Karlish SJD. Endogenous “ouabain-like” activity in bovine plasma. Biochemical and Biophysical Research Communications [Internet]. 1986;135(1):1–8. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022507270&doi=10.1016%2f0006-291X%2886%2990934-4&partnerID=40&md5=ed9109122fd42f14163a26f28f609537

78.

Shimoni Y, Gotsman M, Epstein M, Kachalsky S, Deutsch J, Lichtstein D. Further characterisation of the inotropic effect of a bufodienolide glycoside - an endogenous ouabain like compound. Cardiovascular Research [Internet]. 1986;20(3):229–39. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047676516&doi=10.1093%252fcvr%252f20.3.229&partnerID=40&md5=6ae2c21b1c7e5861e9347bc830d32d8c

79.

Bourrit A, Atlan H, Fromer I, Melmed RN, Lichtstein D. Basic characterization of an ouabain-resistant, bumetanide-sensitive K+ carrier-mediated transport system in J774.2 mouse macrophage-like cell line and in variants deficient in adenylate cyclase and cAMP-dependent protein kinase activities. BBA - Biomembranes [Internet]. 1985;817(1):85–94. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84886639026&doi=10.1016%2f0005-2736%2885%2990071-9&partnerID=40&md5=b2e4ad921986d9182d4e4379c864eeea

80.

Lichtstein D, Samuelov S, Bourrit A. Characterization of the stimulation of neuronal Na+, K+-ATPase activity by low concentrations of ouabain. Neurochemistry International [Internet]. 1985;7(4):709–15. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022254432&doi=10.1016%2f0197-0186%2885%2990069-5&partnerID=40&md5=c38a86e74a60e53b6cf273c874f1d7fb

81.

Lichtstein D, Minc D, Shimoni Y, Deutsch J, Mekler J, Ben-Ishay D. Demonstration of a ouabainlike plasma compound in hypertension prone and hypertension resistant rats. Hypertension [Internet]. 1985;7(5):729–33. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0021995092&doi=10.1161%252f01.HYP.7.5.729&partnerID=40&md5=e72e61032bc9fc459efd492ece7a5c6a

82.

Shimoni Y, Gotsman M, Deutsch J, Kachalsky S, Lichtstein D. Endogenous ouabain-like compound increases heart muscle contractility. Nature [Internet]. 1984;307(5949):369–71. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0021257854&doi=10.1038%252f307369a0&partnerID=40&md5=0b42a57dbee7e13a4cd10cb378b91359

83.

Ilani A, Yachin S, Lichtstein D. Comparison between bretylium and diphenylhydantoin interaction with mucosal sodium-channels. BBA - Biomembranes [Internet]. 1984;777(2):323–30. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0021721839&doi=10.1016%2f0005-2736%2884%2990434-6&partnerID=40&md5=a4c902d3a137a755ceb3e49323db7ca1

84.

Ilani A, Lichtstein D, Bacaner MB. Bretylium opens mucosal amiloride-sensitive sodium channels. BBA - Biomembranes [Internet]. 1982;693(2):503–6. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0020426079&doi=10.1016%2f0005-2736%2882%2990460-6&partnerID=40&md5=72f44ad2ff159f2777b0dc7006fa5083

85.

Lichtstein D, Mullikin-Kilpatrick D, Blume AJ. Modification of neuroblastoma X glioma hybrid NG108-15 adenylate cyclase by vanadium ions. Biochemical and Biophysical Research Communications [Internet]. 1982;105(3):1157–65. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0020376404&doi=10.1016%2f0006-291X%2882%2991091-9&partnerID=40&md5=0c9a509eb5acb70f31888449800b27d3

86.

Lichtstein D, Samuelov S. Characterization of ouabain receptor in neuronal tissue: Evidence for endogenous ouabain-like compound. Israel Journal of Medical Sciences [Internet]. 1982;18(1):45–50. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0020046396&partnerID=40&md5=ef198ce96cbafdf9140837c60dd8c568

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Lichtstein D, Mullikin-Kilpatrick D, Blume AJ. Vanadate-induced hyperpolarization of neuroblastoma-glioma hybrid NG108-15 cells. Israel Journal of Medical Sciences [Internet]. 1982;18(4):551. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0019997325&partnerID=40&md5=2c4b019a372c40daa0473c8b1c10c190

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Lichtstein D, Samuelov S. Membrane potential changes induced by the ouabain-like compound extracted from mammalian brain. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 1982;79(5):1453–6. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0019985403&doi=10.1073%252fpnas.79.5.1453&partnerID=40&md5=460f33c8608a8db30769ea7e1b5c9951

89.

Rochel S, Lichtstein D, Blume AJ, Margolis FL. Membrane potential of olfactory bulb synaptosomal fractions: Characterization with the lipophilic cation tetraphenylphosphonium. Journal of Neuroscience [Internet]. 1981;1(10):1180–92. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0019839534&doi=10.1523%252fjneurosci.01-10-01180.1981&partnerID=40&md5=0bc745e901e9b713d7a065736c4b70e9

90.

Lichtstein D, Samuelov S. Endogenous ‘ouabain like’ activity in rat brain. Topics in Catalysis [Internet]. 1980;96(4):1518–23. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0019119750&doi=10.1016%2f0006-291X%2880%2991346-7&partnerID=40&md5=4e134d1fcd220cc37c980daa28f09426