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The Faculty of Medicine - Developmental Biology and Cancer Research: Dror Erez

Researchers

Last updated September 2024 - Developmental Biology and Cancer Research

List of Publications

1.        Hofwimmer K, de Paula Souza J, Subramanian N, et al. IL-1β promotes adipogenesis by directly targeting adipocyte precursors. Nat Commun . 2024;15(1). doi:10.1038/s41467-024-51938-x

2.        Dror E, Fagnocchi L, Wegert V, et al. Epigenetic dosage identifies two major and functionally distinct β cell subtypes. Cell Metab. 2023;35(5):821-836.e7. doi:10.1016/j.cmet.2023.03.008

3.        Drougard A, Ma EH, Wegert V, et al. A rapid microglial metabolic response controls metabolism and improves memory. Elife. 2023;12. doi:10.7554/eLife.87120.1

4.        Yang C-H, Fagnocchi L, Apostle S, et al. Independent phenotypic plasticity axes define distinct obesity sub-types. Nat Metab. 2022;4(9):1150-1165. doi:10.1038/s42255-022-00629-2

5.        Wiedemann SJ, Trimigliozzi K, Dror E, et al. The cephalic phase of insulin release is modulated by IL-1β. Cell Metab. 2022;34(7):991-1003.e6. doi:10.1016/j.cmet.2022.06.001

6.        Schulze F, Wehner J, Kratschmar D V, et al. Inhibition of IL-1beta improves Glycaemia in a Mouse Model for Gestational Diabetes. Sci Rep. 2020;10(1). doi:10.1038/s41598-020-59701-0

7.        Brykczynska U, Geigges M, Wiedemann SJ, et al. Distinct Transcriptional Responses across Tissue-Resident Macrophages to Short-Term and Long-Term Metabolic Challenge. Cell Rep. 2020;30(5):1627-1643.e7. doi:10.1016/j.celrep.2020.01.005

8.        Weingarten G, Yaakov AB, Dror E, et al. Insulin receptor plays a central role in skin carcinogenesis by regulating cytoskeleton assembly. FASEB J. 2019;33(2):2241-2251. doi:10.1096/fj.201800847R

9.        Ruiz A, Dror E, Handschin C, et al. Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance. Sci Rep. 2018;8(1). doi:10.1038/s41598-017-18844-3

10.      Lu TT-H, Heyne S, Dror E, et al. The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes. Cell Metab. 2018;27(6):1294-1308.e7. doi:10.1016/j.cmet.2018.04.013

11.      Böni-Schnetzler M, Häuselmann SP, Dalmas E, et al. β Cell-Specific Deletion of the IL-1 Receptor Antagonist Impairs β Cell Proliferation and Insulin Secretion. Cell Rep. 2018;22(7):1774-1786. doi:10.1016/j.celrep.2018.01.063

12.      Nordmann TM, Dror E, Schulze F, et al. The Role of Inflammation in β-cell Dedifferentiation. Sci Rep. 2017;7(1). doi:10.1038/s41598-017-06731-w

13.      Dalmas E, Lehmann FM, Dror E, et al. Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production. Immunity. 2017;47(5):928-942.e7. doi:10.1016/j.immuni.2017.10.015

14.      Traub S, Meier DT, Schulze F, et al. Pancreatic α Cell-Derived Glucagon-Related Peptides Are Required for β Cell Adaptation and Glucose Homeostasis. Cell Rep. 2017;18(13):3192-3203. doi:10.1016/j.celrep.2017.03.005

15.      Dror E, Dalmas E, Meier DT, et al. Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation. Nat Immunol. 2017;18(3):283-292. doi:10.1038/ni.3659

16.      Timper K, Dalmas E, Dror E, et al. Glucose-Dependent Insulinotropic Peptide Stimulates Glucagon-Like Peptide 1 Production by Pancreatic Islets via Interleukin 6, Produced by α Cells. Gastroenterology. 2016;151(1):165-179. doi:10.1053/j.gastro.2016.03.003

17.       Sauter NS, Thienel C, Plutino Y, et al. Angiotensin II induces interleukin-1b-mediated islet inflammation and β-cell dysfunction independently of vasoconstrictive effects. Diabetes. 2015;64(4):1273-1283. doi:10.2337/db14-1282