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School of Public Health: Konijn Abraham

Researchers / חוקרים

 Last updated June 2021 - School of Public Health

List of Publications

(1) Bulvik BE, Berenshtein E, Meyron-Holtz EG, Konijn AM, Chevion M. Cardiac Protection by Preconditioning Is Generated via an Iron-Signal Created by Proteasomal Degradation of Iron Proteins. PLoS ONE 2012;7(11).

(2) Bulvik BE, Berenshtein E, Konijn AM, Grinberg L, Vinokur V, Eliashar R, et al. Aging is an organ-specific process: Changes in homeostasis of iron and redox proteins in the rat. Age 2012;34(3):693-704.

(3) Chevion M, Leibowitz S, Aye NN, Novogrodsky O, Singer A, Avizemer O, et al. Heart protection by ischemic preconditioning: A novel pathway initiated by iron and mediated by ferritin. J Mol Cell Cardiol 2008;45(6):839-845.

(4) Obolensky A, Berenshtein E, Konijn AM, Banin E, Chevion M. Ischemic preconditioning of the rat retina: Protective role of ferritin. Free Radic Biol Med 2008;44(7):1286-1294.

(5) Leimberg MJ, Prus E, Konijn AM, Fibach E. Macrophages function as a ferritin iron source for cultured human erythroid precursors. J Cell Biochem 2008;103(4):1211-1218.

(6) Leimberg JM, Prus E, Link G, Fibach E, Konijn AM. Iron-chelator complexes as iron sources for early developing human erythroid precursors. Transl Res 2008;151(2):88-96.

(7) Glickstein H, El RB, Link G, Breuer W, Konijn AM, Hershko C, et al. Action of chelators in iron-loaded cardiac cells: Accessibility to intracellular labile iron and functional consequences. Blood 2006;108(9):3195-3203.

(8) Hershko C, Link G, Konijn AM, Cabantchik ZI. Iron overload and chelation. Hematology 2005;10(SUPPL. 1):171-173.

(9) Leimberg JM, Konijn AM, Fibach E. Macrophages promote development of human erythroid precursors in transferrin-free culture medium. Hematology 2005;10(1):73-76.

(10) Hershko C, Link G, Konijn AM, Cabantchik ZI. Objectives and mechanism of iron chelation therapy. Ann New York Acad Sci 2005;1054:124-135.

(11) Hershko CM, Link GM, Konijn AM, Cabantchik ZI. Iron chelation therapy. Curr Hematol Rep 2005;4(2):110-116.

(12) Hershko C, Link G, Konijn AM. Cardioprotective effect of iron chelators. Adv Exp Med Biol 2003;509:77-89.

(13) Leimberg JM, Konijn AM, Fibach E. Developing human erythroid cells grown in transferrin-free medium utilize iron originating from extracellular ferritin. Am J Hematol 2003;73(3):211-212.

(14) Link G, Ponka P, Konijn AM, Breuer W, Cabantchik ZI, Hershko C. Effects of combined chelation treatment with pyridoxal isonicotinoyl hydrazone analogs and deferoxamine in hypertransfused rats and in iron-loaded rat heart cells. Blood 2003;101(10):4172-4179.

(15) Hershko C, Abrahamov A, Konijn AM, Breuer W, Cabantchik IZ, Pootrakul P, et al. Objectives and methods of iron chelation therapy. Bioinorg Chem Appl 2003;1(2):151-168.

(16) Hirsh M, Konijn AM, Iancu TC. Acquisition, storage and release of iron by cultured human hepatoma cells. J Hepatol 2002;36(1):30-38.

(17) Berenshtein E, Vaisman B, Goldberg-Langerman C, Kitrossky N, Konijn AM, Chevion M. Roles of ferritin and iron in ischemic preconditioning of the heart. Mol Cell Biochem 2002;234-235:283-292.

(18) Hershko C, Link G, Konijn AM, Huerta M, Rosenmann E, Reinus C. The iron-loaded gerbil model revisited: Effects of deferoxamine and deferiprone treatment. J Lab Clin Med 2002;139(1):50-58.

(19) Zanninelli G, Loréal O, Brissot P, Konijn AM, Slotki IN, Hider RC, et al. The labile iron pool of hepatocytes in chronic and acute iron overload and chelator-induced iron deprivation. J Hepatol 2002;36(1):39-46.

(20) Seligmann H, Levi R, Konijn AM, Prokocimer M. Thiamine deficiency in patients with B-chronic lymphocytic leukaemia: A pilot study. Postgrad Med J 2001;77(911):582-585.

(21) Hershko C, Konijn AM, Nick HP, Breuer W, Cabantchik ZI, Link G. ICL670A: A new synthetic oral chelator: Evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture. Blood 2001;97(4):1115-1122.

(22) Link G, Konijn AM, Breuer W, Cabantchik ZI, Hershko C. Exploring the "iron shuttle" hypothesis in chelation therapy: Effects of combined deferoxamine and deferiprone treatment in hypertransfused rats with labeled iron stores and in iron-loaded rat heart cells in culture. J Lab Clin Med 2001;138(2):130-138.

(23) Hershko C, Konijn AM, Nick HP, Link G. ICL670A,a powerful new synthetic oral iron chelator: evaluation in hypertransfused rats and in cultured ironloaded rat heart cells. Blood 2000;96(11 PART I).

(24) Vaisman B, Meyron-Holtz EG, Fibach E, Krichevsky AM, Konijn AM. Ferritin expression in maturing normal human erythroid precursors. Br J Haematol 2000;110(2):394-401.

(25) El-Sharif N, Fischbein A, Konijn A, Gorodetsky R, El-Sharif H, Kaul B, et al. Re-emergence of lead poisoning from contaminated flour in a West Bank Palestinian village. Int J Occup Environ Health 2000;6(3):183-186.

(26) Meyron-Holtz EG, Vaisman B, Cabantchik ZI, Fibach E, Rouault TA, Hershko C, et al. Regulation of intracellular iron metabolism in human erythroid precursors by internalized extracellular ferritin. Blood 1999;94(9):3205-3211.

(27) Konijn AM, Glickstein H, Vaisman B, Meyron-Holtz EG, Slotki IN, Cabantchik ZI. The cellular labile iron pool and intracellular ferritin in K562 cells. Blood 1999;94(6):2128-2134.

(28) Pountney DJ, Konijn AM, McKie AT, Peters TJ, Raja KB, Salisbury JR, et al. Iron proteins of duodenal enterocytes isolated from mice with genetically and experimentally altered iron metabolism. Br J Haematol 1999;105(4):1066-1073.

(29) Vaisman B, Konijn AM, Fibach E. Isolation of large and pure samples of human erythroid precursors at different stages of maturation using immunomagnetic separation of cells from liquid cultures. Acta Haematol 1999;101(3):135-139.

(30) Link G, Konijn AM, Hershko C. Cardioprotective effect of α-tocopherol, ascorbate, deferoxamine, and deferiprone: Mitochondrial function in cultured, iron-loaded heart cells. J Lab Clin Med 1999;133(2):179-188.

(31) Vaisman B, Santambrogio P, Arosio P, Fibach E, Konijn AM. An ELISA for the H-subunit of human ferritin which employs a combination of rabbit poly- and mice monoclonal antibodies and an enzyme labeled anti-mouse-IgG. Clin Chem Lab Med 1999;37(2):121-125.

(32) Hershko C, Konijn AM, Link G. Iron chelators for thalassaemia. Br J Haematol 1998;101(3):399-406.

(33) Link G, Saada A, Pinson A, Konijn AM, Hershko C. Mitochondrial respiratory enzymes are a major target of iron toxicity in rat heart cells. J Lab Clin Med 1998;131(5):466-474.

(34) Vaisman B, Fibach E, Konijn AM. Utilization of intracellular ferritin iron for hemoglobin synthesis in developing human erythroid precursors. Blood 1997;90(2):831-838.

(35) Ponka P, Richardson DR, Konijn AM, Gelvan D, Meyron-Holtz E, Fibach E. Can ferritin provide iron for hemoglobin synthesis? [2]. Blood 1997;89(7):2611-2613.

(36) Zanninelli G, Glickstein H, Breuer W, Milgram P, Brissot P, Hider RC, et al. Chelation and mobilization of cellular iron by different classes of chelators. Mol Pharmacol 1997;51(5):842-852.

(37) Gelvan D, Fibach E, Meyron-Holtz EG, Konijn AM. Ferritin uptake by human erythroid precursors is a regulated iron uptake pathway. Blood 1996;88(8):3200-3207.

(38) Glickstein H, Breuer W, Loyevsky M, Konijn AM, Libman J, Shanzer A, et al. Differential cytotoxicity of iron chelators on malaria-infected cells versus mammalian cells. Blood 1996;87(11):4871-4878.

(39) Treffry A, Gelvan D, Konijn AM, Harrison PM. Ferritin does not accumulate iron oxidized by caeruloplasmin. Biochem J 1995;305(1):21-23.

(40) Konijn AM. 5 Iron metabolism in inflammation. Bailliere's Clin Haematol 1994;7(4):829-849.

(41) Hershko C, Konijn AM, Aisen P. Progress in iron research: Preface. Adv Exp Med Biol 1994;356.

(42) Meyron-Holtz EG, Fibach E, Gelvan D, Konijn AM. Binding and uptake of exogenous isoferritins by cultured human erythroid precursor cells. Br J Haematol 1994;86(3):635-641.

(43) Konijn AM, Meyron-Holtz EG, Fibach E, Gelvan D. Cellular ferritin uptake: A highly regulated pathway for iron assimilation in human erythroid precursor cells. ADV EXP MED BIOL 1994;356:189-197.

(44) Simpson RJ, Konijn AM, Lombard M, Raja KB, Salisbury JR, Peters TJ. Tissue iron loading and histopathological changes in hypotransferrinaemic mice. J Pathol 1993;171(3):237-244.

(45) Simpson RJ, Cooper CE, Raja KB, Halliwell B, Evans PJ, Arouma OI, et al. Non-transferrin-bound iron species in the serum of hypotransferrinaemic mice. Biochim Biophys Acta Gen Subj 1992;1156(1):19-26.

(46) Konijn AM, Kaplan R, Or R, Matzner Y. Glycosylated serum ferritin in patients with hematological malignancies before and after bone marrow transplantation. Leuk Lymphoma 1992;7(1-2):151-156.

(47) Bauminger ER, Fibach E, Konijn AM, Ofer S, Rachmilewitz EA. Mössbauer studies of iron uptake, ferritin and hemoglobin synthesis and denaturation in erythroid cell cultures. Hyperfine Interact 1991;66(1-4):11-23.

(48) Konijn AM, Meyron-Holtz EG, Levy R, Ben-Bassat H, Matzner Y. Specific binding of placental acidic isoferritin to cells of the T-cell line HD-MAR. FEBS Lett 1990;263(2):229-232.

(49) Holtz EG, Konijn AM. Stability of ferritin following solid-state enzymatic radioiodination. Clin Chim Acta 1988;178(1):113-114.

(50) Yinnon A, Konijn AM, Link G, Moreb J, Hershko C. Diagnostic value of ferritin in malignant pleural and peritoneal effusions. Cancer 1988;62(12):2564-2568.

(51) Arad I, Konijn AM, Linder N, Goldstein M, Kaufmann NA. Serum Ferritin Levels in Preterm Infants after Multiple Blood Transfusions. Am J Perinatol 1988;5(1):40-43.

(52) Or R, Matzner Y, Konijn AM. Serum ferritin in patients undergoing bone marrow transplantation. Cancer 1987;60(5):1127-1131.

(53) Fibach E, Konijn AM, Bauminger RE, Ofer S, Rachmilewitz EA. Effect of extracellular hemin on hemoglobin and ferritin content of erythroleukemia cells. J Cell Physiol 1987;130(3):460-465.

(54) Zandman‐Goddard G, Matzner Y, Konijn AM, Hershko C. Cerebrospinal fluid ferritin in malignant CNS involvement. Cancer 1986;58(6):1346-1349.

(55) Konijn AM, Tal R, Levy R, Matzner Y. Isolation and fractionation of ferritin from human term placenta-A source for human isoferritins. Anal Biochem 1985;144(2):423-428.

(56) Fibach E, Konijn AM, Rachmilewitz EA. Changes in cellular ferritin content during myeloid differentiation of human leukemic cell lines. Am J Hematol 1985;18(2):143-151.

(57) Matzner Y, Konijn AM, Shlomai Z, Ben‐Bassat H. Differential effect of isolated placental isoferritins on in vitro T‐lymphocyte function. Br J Haematol 1985;59(3):443-448.

(58) Hershko C, Konijn AM, Link G, Moreb J, Grauer F, Weissenberg E. Combined use of zinc protoporphyrin (ZPP), mean corpuscular volume and haemoglobin measurements for classifying microcytic RBC disorders in children and young adults. Clin Lab Haematol 1985;7(3):259-269.

(59) Hershko C, Konijn AM, Moreb J, Link G, Grauer F, Weissenberg E. Iron depletion and blood lead levels in a population with endemic lead poisoning. Isr J Med Sci 1984;20(11):1039-1043.

(60) Treves AJ, Fuks Z, Voss R, Tal T, Barak V, Konijn AM, et al. Establishment of cell lines from somatic cell hybrids between human monocytes and mouse myeloma cells. J Immunol 1984;132(2):690-694.

(61) Hershko C, Abrahamov A, Moreb J, Hersh M, Shiffman R, Shahin A, et al. Lead Poisoning in a West Bank Arab Village. Arch Intern Med 1984;144(10):1969-1973.

(62) Hershko C, Yaffe Y, Richter ED, Konijn AM, Abrahamov A, Hersh M, et al. Lead poisoning. Harefuah 1983;105(10):303-306+348.

(63) KAEMPFER R, KONIJN AM. Translational Competition by mRNA Species Encoding Albumin, Ferritin, Haemopexin and Globin. Eur J Biochem 1983;131(3):545-550.

(64) Fibach E, Bauminger ER, Konijn AM, Ofer S, Rachmilewitz EA. Iron storage in ferritin following intracellular hemoglobin denaturation in erythroleukemic cells. Blood 1983;62(4):928-930.

(65) Moreb J, Popovtzer MM, Friedlaender MM, Konijn AM, Hershko C. Evaluation of iron status in patients on chronic hemodialysis: Relative usefulness of bone marrow hemosiderin, serum ferritin, transferrin saturation, mean corpuscular volume and red cell protoporphyrin. Nephron 1983;35(3):196-200.

(66) Konijn AM, Levy R, Link G, Hershko C. A rapid and sensitive ELISA for serum ferritin employing a fluorogenic substrate. J Immunol Methods 1982;54(3):297-307.

(67) Hershko C, Moreb J, Gaziel Y, Konijn AM, Rachmilewitz EA. Reduced Frequency of Iron Deficiency Anaemia in Sickle Cell Trait. Scand J Haematol 1982;29(4):304-310.

(68) Konijn AM, Carmel N, Levy R, Hershko C. Ferritin Synthesis in Inflammation: II. MECHANISM OF INCREASED FERRITIN SYNTHESIS. Br J Haematol 1981;49(3):361-370.

(69) Hershko C, Bar-Or D, Gaziel Y, Naparstek E, Konijn AM, Grossowicz N, et al. Diagnosis of iron deficiency anemia in a rural population of children. Relative usefulness of serum ferritin, red cell protoporphyrin, red cell indices, and transferrin saturation determinations. Am J Clin Nutr 1981;34(8):1600-1610.

(70) Hershko C, Gaziel Y, Bar-Or D, Izak G, Naparstek E, Grossowicz N, et al. Anemia among Druze children in the Golan Heights. Isr J Med Sci 1980;16(5):384-388.

(71) Matzner Y, Konijn AM, Hershko C. Serum ferritin in hematologic malignancies. Am J Hematol 1980;9(1):13-22.

(72) Alayoff A, Kapitulnik J, Konijn A, Kaufmann NA, Blondheim SH. Bilirubin binding capacity of albumin isolated from cord-blood serum is less than that from serum of adults. Clin Chem 1980;26(6):738-740.

(73) Loria A, Hershko C, Konijn AM. Serum ferritin in an elderly population. J Gerontol 1979;34(4):521-524.

(74) Hershko C, Konijn AM, Loria A. Serum ferritin and mean corpuscular volume measurement in the diagnosis of β-thalassaemia minor and iron deficiency. Acta Haematol 1979;62(4):236-239.

(75) Konijn AM, Hershko C, Izak G. Ferritin synthesis and Iron uptake in developing erythroid cells. Am J Hematol 1979;6(4):373-379.

(76) Matzner Y, Hershko C, Polliack A, Konijn AM, Izak G. Suppressive Effect of Ferritin on in Vitro Lymphocyte Function. Br J Haematol 1979;42(3):345-353.

(77) Loria A, Konijn AM, Hershko C. Serum ferritin in β-thalassemia trait. Isr J Med Sci 1978;14(11):1127-1131.

(78) Konijn AM, Hershko C, Izak G. Ferritin synthesis in developing erythroid precursor cells. Isr J Med Sci 1978;14(11):1181-1185.

(79) Carmel N, Konijn AM. Quantitative determination of ferritin by electroimmunoassay. Anal Biochem 1978;85(2):499-505.

(80) Konijn AM, Hershko C. Ferritin Synthesis in Inflammation: I. PATHOGENESIS OF IMPAIRED IRON RELEASE. Br J Haematol 1977;37(1):7-16.

(81) Seban A, Konijn AM, Freier S. Chemical and immunological properties of a protein hydrolysate formula. Am J Clin Nutr 1977;30(6):840-846.

(82) Konijn AM, Carmel N, Kaufmann NA. The redox state and the concentration of ketone bodies in tissues of rats fed carbohydrate free diets. J Nutr 1976;106(10):1507-1514.

(83) Carmel N, Konijn AM, Kaufmann NA, Guggenheim K. Effects of carbohydrate free diets on the insulin carbohydrate relationships in rats. J Nutr 1975;105(9):1141-1149.

(84) Konijn AM, Baliga BS, Munro HN. Synthesis of liver ferritin on free and membrane-bound polyribosomes of different sizes. FEBS Lett 1973;37(2):249-252.

(85) Konijn AM, Guggenheim K. Characterization and mode of action of a goitrogen present in soya beans. Fed Proc 1973;32(3 (I)):28.

(86) Konijn AM, Gershon B, Guggenheim K. Further purification and mode of action of a goitrogenic material from soybean flour. J Nutr 1973;103(3):378-383.

(87) Konijn AM, Edelstein S, Guggenheim K. Separation of a thyroid‐active fraction from unheated soya bean flour. J Sci Food Agric 1972;23(5):549-555.

(88) Konijn AM, Eyal Z, Birnbaum D, Guggenheim K. Amylase secretion by rat pancreas following prolonged stimulation by unheated soybean flour. Digestion 1972;6(6):330-337.

(89) Applebaum SW, Konijn AM, Menco B. Growth and biochemical adaptation of larvae of the beetle Dermestes maculatus to carbohydrate-free diets. Insect Biochemistry 1971;1(1):1-13.

(90) Konijn AM, Guggenheim K. Effect of penicillin on growth and pancreatic amylase levels of rats fed soybean diets. Experientia 1970;26(7):727.

(91) Konijn AM, Muogbo DN, Guggenheim K. Metabolic effects of carbohydrate-free diets. Isr J Med Sci 1970;6(4):498-505.

(92) Konijn AM, Birk Y, Guggenheim K. In vitro synthesis of pancreatic enzymes: effect of soybean trypsin inhibitor. Am J Physiol 1970;218(4):1113-1117.

(93) Konijn AM, Biek Y, Guggenheim K. Pancreatic enzyme pattern in rats as affected by dietary soybean flour. J Nutr 1970;100(3):361-368.

(94) Konijn AM, Guggenheim K, Birk Y. Amylase synthesis in pancreas of rats fed soybean flour. J Nutr 1969;97(2):265-270.

(95) Konijn AM, Guggenheim K. Effect of Raw Soybean Flour on the Composition of Rat Pancreas. Proc Soc Exp Biol Med 1967;126(1):65-67.

(96) Applebaum SW, Konijn AM. Factors affecting the development of Tribolium castaneum (Herbst) on wheat. J Stored Prod Res 1967;2(4):323-329.

(97) Konijn AM, Guggenheim K. Effect of raw soybean flour on the composition of rat pancreas. Riv Patol Nerv Ment 1966;87(4):65-67.

(98) Applebaum SW, Konijn AM. The presence of a Tribolium-protease inhibitor in wheat. J Insect Physiol 1966;12(6):665-669.

(99) Applebaum SW, Konijn AM. THE UTILIZATION OF STARCH BY LARVAE OF THE FLOUR BEETLE, TRIBOLIUM CASTANEUM. J Nutr 1965;85(3):275-282.