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The Faculty of Medicine - Developmental Biology and Cancer Research: Laskov Reuven

Researchers

 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Reynaud C-, Moutel S, Dieu-Nosjean M-, Laskov R, Teillaud J-. 1st French-Israeli international conference on B cells and therapeutic antibodies: October 23-25, 2011, Jerusalem, Israel. mAbs 2012;4(4):426-433.

(2) Laskov R, Yahud V, Hamo R, Steinitz M. Preferential targeting of somatic hypermutation to hotspot motifs and hypermutable sites and generation of mutational clusters in the IgVH alleles of a rheumatoid factor producing lymphoblastoid cell line. Mol Immunol 2011;48(5):733-745.

(3) Chezar I, Lobel-Lavi L, Steinitz M, Laskov R. Ongoing somatic hypermutation of the rearranged VH but not of the V-lambda gene in EBV-transformed rheumatoid factor-producing lymphoblastoid cell line. Mol Immunol 2008;46(1):80-90.

(4) Berger N, Ben Bassat H, Klein BY, Laskov R. Cytotoxicity of NF-κB inhibitors Bay 11-7085 and caffeic acid phenethyl ester to Ramos and other human B-lymphoma cell lines. Exp Hematol 2007;35(10):1495-1509.

(5) Gil Y, Levy-Nabot S, Steinitz M, Laskov R. Somatic mutations and activation-induced cytidine deaminase (AID) expression in established rheumatoid factor-producing lymphoblastoid cell line. Mol Immunol 2007;44(4):494-505.

(6) Laskov R, Berger N, Scharff MD, Horwitz MS. Tumor necrosis factor-α and CD40L modulate cell surface morphology and induce aggregation in Ramos Burkitt's lymphoma cells. Leuk Lymphoma 2006;47(3):507-519.

(7) Laskov R, Berger N, Horwitz MS. Differential effects of tumor necrosis factor-α and CD40L on NF-κB inhibitory proteins IκBα, β and ε and on the induction of the Jun amino-terminal kinase pathway in Ramos Burkitt lymphoma cellsNF. Eur Cytokine Netw 2005;16(4):267-276.

(8) Riss J, Laskov R. Expression of novel alternatively spliced isoforms of the oct-1 transcription factor. Biochim Biophys Acta Gene Struct Expr 1999;1444(2):295-298.

(9) Gabay C, Ben-Bassat H, Schlesinger M, Laskov R. Somatic mutations and intraclonal variations in the rearranged V(K) genes of B-non-Hodgkin's lymphoma cell lines. Eur J Haematol 1999;63(3):180-191.

(10) Hochberg M, Gabay C, Laskov R. Somatic mutations in the Ig variable region genes and expression of novel Cμ-germline transcripts in a B-lymphoma cell line ('Farage') not producing Ig polypeptide chains. Leuk Lymphoma 1998;30(5-6):637-649.

(11) Shurman L, Laskov R, Bergman Y. Identification of two novel negative regulatory elements in the tcrα gene. FASEB J 1996;10(6).

(12) Shurman L, Laskov R, Bergman Y. Direct and indirect mechanisms of repression participate in suppression of T-cell-specific gene expression in T x L-cell hybrids. Gene Expr 1996;5(6):285-300.

(13) Reich L, Sharir H, Ber R, Wirth T, Bergman Y, Laskov R. Coordinate suppression of myeloma-specific genes and expression of fibroblast-specific genes in myeloma X fibroblast somatic cell hybrids. SOMATIC CELL MOL GENET 1996;22(1):1-20.

(14) Baruch M, Hochberg M, Gabay C, Ben-Bassat H, Shlomai Z, Laskov R. Molecular characterization of an unusual non-Hodgkin's B-lymphoma cell line ("farage") lacking the ability to produce immunoglobulin polypeptide chains. Leuk Lymphoma 1996;21(5-6):485-495.

(15) Jaffe J, Hochberg M, Riss J, Hasin T, Reich L, Laskov R. Cloning, sequencing and expression of two isoforms of the murine oct-1 transcription factor. Biochim Biophys Acta Gene Struct Expr 1995;1261(2):201-209.

(16) Catalano-Sherman J, Laskov R, Palmon A, David S, Deutsch D. Production of a monoclonal antibody against human amelogenin. Calcif Tissue Int 1994;54(1):76-80.

(17) Bergsagel PL, Timblin CR, Eckhardt L, Laskov R, Kuehl WM. Sequence and expression of a murine cDNA encoding PC326, a novel gene expressed in plasmacytomas but not normal plasma cells. Oncogene 1992;7(10):2059-2064.

(18) Laskov R, Michaeli R‐, Sharir H, Yefenof E, Vlodavsky I. Production of heparanase by normal and neoplastic murine B‐lymphocytes. Int J Cancer 1991;47(1):92-98.

(19) Laskov R, Sharir H, Tzieger‐Dickbuch S, Hijazzi M, Greenberg A, Ber R. Suppression of the translocated myc gene and expression of intracisternal A‐particle genes in tumorigenic and non‐tumorigenic hybrids between murine myeloma and normal fibroblasts. Int J Cancer 1991;48(4):574-582.

(20) Bibi E, Laskov R. Selection and application of antibodies modifying the function of β-lactamase. Biochim Biophys Acta Gen Subj 1990;1035(2):237-241.

(21) Bergman Y, Strich B, Sharir H, Ber R, Laskov R. Extinction of Ig genes expression in myeloma x fibroblast somatic cell hybrids is accompanied by repression of the oct-2 gene encoding a B-cell specific transcription factor. EMBO J 1990;9(3):849-855.

(22) Laskov R, Lancz G, Ruddle NH, McGrath KM, Specter S, Klein T, et al. Production of tumor necrosis factor (TNF-α) and lymphotoxin (TNF-β) by murine pre-B and B cell lymphomas. J Immunol 1990;144(9):3424-3430.

(23) French DL, Laskov R, Scharff MD. The role of somatic hypermutation in the generation of antibody diversity. Science 1989;244(4909):1152-1157.

(24) Greenberg A, Huazzi M, Sharir H, Cohen L, Bergman Y, Ber R, et al. Extinction of expression of the translocated myc gene in somatic cell hybrids between mouse myeloma and l‐cells. Int J Cancer 1989;43(1):87-92.

(25) Panet R, Amir I, Snyder D, Zonenshein L, Atlan H, Laskov R, et al. Effect of Na+ flux inhibitors on induction of c‐fos, c‐myc, and ODC genes during cell cycle. J Cell Physiol 1989;140(1):161-168.

(26) Pakala R, Laskov R, Rottem S, Bachrach U. Effect of mycoplasma on polyamine synthesis and levels in NIH 3T3 cells and in cells transformed by Rous sarcoma virus. FEMS Microbiol Lett 1988;49(3):357-361.

(27) Deutsch D, Palmon A, Catalano-Sherman J, Laskov R. Production of monoclonal antibodies against enamelin and against amelogenin proteins of developing enamel matrix. Adv Dent Res 1987;1(2):282-288.

(28) Greenberg A, Ber R, Kra-Oz Z, Laskov R. Extinction of expression of immunoglobulin genes in myeloma x fibroblast somatic cell hybrids. Mol Cell Biol 1987;7(2):936-939.

(29) Rabinowitz R, Hadar R, Laskov R, Schlesinger M. A new autoreactive monoclonal antibody specific for the Thy-1 antigen. Thymus 1986;8(5):279-294.

(30) Pass A, Avidor B, Golenser J, Laskov R, Sulitzeanu D. Use of a monoclonal, anti Plasmodium berghei antibody, cross reacting with P. falciparum, for the detection of P. falciparum in in vitro infected blood. Immunol Lett 1985;10(1):31-34.

(31) Treves AJ, Fuks Z, Voss R, Tal T, Barak V, Konijn AM, et al. Establishment of cell lines from somatic cell hybrids between human monocytes and mouse myeloma cells. J Immunol 1984;132(2):690-694.

(32) Laskov R, Muller S, Hochberg M, Giloh H, van Regenmortel MHV, Eilat D. Monoclonal autoantibodies to histones from autoimmune NZB/NZW F1 mice. Eur J Immunol 1984;14(1):74-81.

(33) Laskov R, Ishay-Michaeli R, Wallach M, Givol D, Kim KJ. Simultaneous expression of mu- and gamma-chain mRNA in cloned murine B-lymphoma cell lines. EMBO J 1983;2(2):167-172.

(34) Schlesinger M, Levy J, Laskov R, Hadar R, Weinstock J, Ben-Bassat H, et al. The role of E receptors in the attachment of thymocytes and T lymphocytes to human target cells. Clin Immunol Immunopathol 1983;29(3):349-358.

(35) Wallach M, Ishay-Michaeli R, Givol D, Laskov R. Analysis of immunoglobulin mRNA in murine myeloma cell variants defective in the synthesis of the light or heavy polypeptide chains. J Immunol 1982;128(2):684-690.

(36) Eilat D, Hochberg M, Fischel R, Laskov R. Antibodies to RNA from autoimmune NZB/NZW mice recognize a similar antigenic determinant and show a large idiotypic diversity. Proc Natl Acad Sci U S A 1982;79(12 I):3818-3822.

(37) Eilat D, Laskov R. Production of anti-RNA antibody by hybridoma cells: Purification from mixed immunoglobulin products. Mol Immunol 1981;18(7):589-595.

(38) Benbassat J, Eliakim M, Hershko CC, Laskov R. Effect of Iron Deficiency on Transplantable Murine Plasmacytoma. Nutr Cancer 1981;3(1):20-26.

(39) Laskov R, Kim JK, Woods VL, McKeever PE, Asofsky R. Membrane immunoglobulins of spontaneous B lymphomas of aged BALB/c mice. Eur J Immunol 1981;11(6):462-468.

(40) WALLACH M, LASKOV R. A High Production Rate of Translatable IgG mRNA Accounts for the Amplified Synthesis of IgG in Myeloma Cells. Eur J Biochem 1980;110(2):545-554.

(41) Eilat D, Sasson SAB, Laskov R. A ribonucleic acid‐specific antibody produced during autoimmune disease: evidence for nucleotide sequence specificity. Eur J Immunol 1980;10(11):841-845.

(42) Rabinowitz R, Laskov R, Schlesinger M. Inhibition of cell‐mediated lysis by xenoantibodies reactive with effector T lymphocytes. Eur J Immunol 1980;10(3):219-223.

(43) Eilat D, Asofsky R, Laskov R. A hybridoma from an autoimmune NZB/NZW mouse producing monoclonal antibody to ribosomal-RNA. J Immunol 1980;124(2):766-768.

(44) Laskov R, Kim K, Kanellopoulos-Langevin C, Asofsky R. Extinction of B-cell surface differentiation markers in hybrids between murine B-lymphoma and myeloma cells. Cell Immunol 1980;55(2):251-264.

(45) Rabinowitz R, Laskov R, Schlesinger M. The effect of xenoantisera on T-lymphocyte functions in the absence of complement. Adv Exp Med Biol 1979;121 B:247-260.

(46) McKeever PE, Kim KJ, Nero GB, Laskov R, Merwin RM, Logan WJ, et al. Two spontaneous BALB/c lymphomas synthesize IgM: Monomers and half molecules are isolated and characterized whereas another molecule resembles IgD. J Immunol 1979;122(4):1261-1265.

(47) Rabinowitz R, Laskov R, Schlesinger M. Antigenic properties of lymph-node cells responding to allogeneic lymphocytes and to various concentrations of lectins. Immunology 1978;34(6):959-967.

(48) Laskov R, Baumal R, Polliack A. Surface morphology of cultured myeloma cells: Bleb formation in cell variants with defects in immunoglobulin production and secretion. RES J RETICULOENDOTHEL SOC 1978;23(5):361-372.

(49) Polliack A, Gamliel H, Froimovici M, Laskov R. Myeloma cells: Surface morphology as seen by scanning and transmission electron microscopy. Isr J Med Sci 1978;14(12):1252-1258.

(50) Baumal R, Sklar S, Wilson B, Laskov R. Casein-induced murine amyloidosis. Amyloidogenesis in vitro by monolayer spleen explants of casein-injected mice. Lab Invest 1978;39(6):632-639.

(51) Laskov R, Kimm KJ, Asofsky R. Induction of IgM secretion by fusing murine B-lymphoma with myeloma cells. Curr Top Microbiol Immunol 1978;81:173-175.

(52) Polliack A, Nilsson K, Laskov R, Biberfeld P. Characteristic Surface Morphology of Human and Murine Myeloma Cells: a Scanning and Transmission Electron Microscopic Study. Br J Haematol 1978;39(1):25-32.

(53) Laskov R, Rabinowitz R, Haimovitz A, Schlesinger M. Cell surface antigens as differentiation markers of the B lymphocyte lineage. Isr J Med Sci 1977;13(8):767-776.

(54) Naor D, Berman-Goldman R, Kahan M, Goldfisher H, Laskov R, Simon E, et al. Induction of hapten recognizing helper function by heavily trinitrophenylated sheep erythrocytes. Adv Exp Med Biol 1976;66:253-260.

(55) Laskov R, Mitelman S. Immune precipitation of immunoglobulin producing polysomes from mouse myeloma cells. J Immunol 1975;114(2 I):566-570.

(56) Rabinowitz R, Laskov R, Schlesinger M. Proceedings: Alloantigenic characterization of responder cells in the mixed lymphocyte reaction. Isr J Med Sci 1975;11(12):1387.

(57) Solage A, Laskov R. Proceedings: Cytoplasmic DNA in mouse myeloma cells. Isr J Med Sci 1975;11(11):1204.

(58) SOLAGE A, LASKOV R. Characterization of Cytoplasmic DNA of Mouse‐Myeloma Cells. Eur J Biochem 1975;60(1):23-33.

(59) Laskov R, Scharff MD. Independent synthesis of light and heavy chains: Quantitation of light-chain production by mouse myeloma variants. J Exp Med 1974;140(4):1112-1116.

(60) Laskov R, Rabinowitz R, Schlesinger M. Differences in the expression of a cell surface antigen among various murine myeloma tumor cells. Isr J Med Sci 1974;10(8):847-855.

(61) Rabinowitz R, Cohen A, Laskov R, Schlesinger M. Antibodies specific for the theta and Ly alloantigens in various rabbit antisera. J Immunol 1974;112(2):683-692.

(62) Laskov R, Simon E. Rosette-forming cells in mice immunized with sheep and chicken red cells. Isr J Med Sci 1973;9(2):175-184.

(63) Laskov R, Rabinowitz R, Schlesinger M. Antigenic characterization of murine rosette and plaque forming cells. Immunology 1973;24(6):934-954.

(64) Laskov R. Myeloma as a tool for elucidation of the mechanism of antibody diversity. Harefuah 1972;82(2):78-85.

(65) Fields BN, Laskov R, Scharff MD. Temperature-sensitive mutants of reovirus type 3: Studies on the synthesis of viral peptides. Virology 1972;50(1):209-215.

(66) Coffino P, Baumal R, Laskov R, Scharff MD. Cloning of mouse myeloma cells and detection of rare variants. J Cell Physiol 1972;79(3):429-440.

(67) Laskov R, Lanzerotti R, Scharff MD. Synthesis, assembly and secretion of gamma globulin by mouse myeloma cells. II. Assembly of IgG2b immunoglobulin by MPC 11 tumor and culture cells. J Mol Biol 1971;56(2):327-339.

(68) Baumal R, Coffino P, Bargellesi A, Buxbaum J, Laskov R, Scharff MD. THE REGULATION OF IMMUNOGLOBULIN SYNTHESIS AND ASSEMBLY. Ann New York Acad Sci 1971;190(1):235-249.

(69) Scharff MD, Laskov R. Synthesis and assembly of immunoglobulin polypeptide chains. Prog Allergy 1970;14:37-80.

(70) Laskov R, Scharff MD. Synthesis, assembly, and secretion of gamma globulin by mouse myeloma cells: I. adaptation of the merwin plasma cell tumor-11 to ciylture, cloning, and characterization of gamma globulin siybunit. J Exp Med 1970;131(3):515-541.

(71) Coffino P, Laskov R, Scharff MD. Immunoglobulin production: Method for quantitatively detecting variant myeloma cells. Science 1970;167(3915):186-188.

(72) Scharff MD, Bargellesi A, Baumal R, Buxbaum J, Coffino P, Laskov R. Variations in the synthesis and assembly of immunoglobulins by mouse myeloma cells: A genetic and biochemical analysis. J Cell Physiol 1970;76(3):331-348.

(73) Laskov R. Erratum: Rosette forming cells in non-immunized mice(Nature (1968) 219 (973)). Nature 1968;220(5163):206.

(74) Laskov R. Rosette forming cells in non-immunized mice. Nature 1968;219(5157):973-975.

(75) Laskov R, Simon E, Gross J. Studies on a naturally occurring human antibody active against mouse landschutz ascites tumor cells III. The nature of the antigenic site on the tumor cell. Int J Cancer 1968;3(4):511-522.

(76) Laskov R, Simon E, Gross J. Studies on a naturally occurring human antibody active against mouse landschutz ascites tumor cells: I. Cytotoxicity assay system and quantitation in normal sera. Int J Cancer 1968;3(1):96-106.

(77) Laskov R, Simon E, Ram D, Gross J. Studies on a naturally occurring human antibody active against mouse landschutz ascites tumor cells: II. Identification of the antibody as igm and its partial purification. Int J Cancer 1968;3(1):107-115.

(78) LASKOV R, GROSS J. THE SIZE AND SHAPE OF RAT LIVER GLYCOGEN PREPARED BY PHENOL EXTRACTION. Isr J Med Sci 1965;1:26-42.

(79) Laskov R, Margoliash E, Littauer UZ, Eisenberg H. High-molecular-weight ribonucleic acid from rat liver. BBA - Biochimica et Biophysica Acta 1959;33(1):247-248.