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The Faculty of Medicine - Developmental Biology and Cancer Research: Katzav Shulamit


 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Salaymeh Y, Farago M, Sebban S, Shalom B, Pikarsky E, Katzav S. Vav1 and mutant K-Ras synergize in the early development of pancreatic ductal adenocarcinoma in mice. Life Sci Alliance 2020;3(5).

(2) Farago M, Yarnitzky T, Shalom B, Katzav S. Vav1 mutations: What makes them oncogenic? Cell Signal 2020;65.

(3) Shalom B, Farago M, Pikarsky E, Katzav S. Vav1 mutations identified in human cancers give rise to different oncogenic phenotypes. Oncogenesis 2018;7(10).

(4) Katzav S. Vav1: A Dr. Jekyll and Mr. Hyde protein - good for the hematopoietic system, bad for cancer. Oncotarget 2015;6(30):28731-28742.

(5) Katzav S, Schmitz ML. Mutations of c-Cbl in myeloid malignancies. Oncotarget 2015;6(13):10689-10696.

(6) Razanadrakoto L, Cormier F, Laurienté V, Dondi E, Gardano L, Katzav S, et al. Mutation of Vav1 adaptor region reveals a new oncogenic activation. Oncotarget 2015;6(4):2524-2537.

(7) Sebban S, Farago M, Rabinovich S, Lazer G, Idelchuck Y, Ilan L, et al. Vav1 promotes lung cancer growth by instigating tumor-microenvironment cross-talk via growth factor secretion. Oncotarget 2014;5(19):9214-9226.

(8) Fernández-Espartero CH, Ramel D, Farago M, Malartre M, Luque CM, Limanovich S, et al. GTP exchange factor Vav regulates guided cell migration by coupling guidance receptor signalling to local rac activation. J Cell Sci 2013;126(10):2285-2293.

(9) Sebban S, Farago M, Gashai D, Ilan L, Pikarsky E, Ben-Porath I, et al. Vav1 Fine Tunes p53 Control of Apoptosis versus Proliferation in Breast Cancer. PLoS ONE 2013;8(1).

(10) Ilan L, Katzav S. Human Vav1 expression in hematopoietic and cancer cell lines is regulated by c-Myb and by CpG methylation. PLoS ONE 2012;7(1).

(11) Benjamin S, Weidberg H, Rapaport D, Pekar O, Nudelman M, Segal D, et al. EHD2 mediates trafficking from the plasma membrane by modulating Rac1 activity. Biochem J 2011;439(3):433-442.

(12) Lazer G, Katzav S. Guanine nucleotide exchange factors for RhoGTPases: Good therapeutic targets for cancer therapy? Cell Signal 2011;23(6):969-979.

(13) Lazer G, Pe'er L, Farago M, Machida K, Mayer BJ, Katzav S. Tyrosine residues at the carboxyl terminus of Vav1 play an important role in regulation of its biological activity. J Biol Chem 2010;285(30):23075-23085.

(14) Lazer G, Idelchuk Y, Schapira V, Pikarsky E, Katzav S. The haematopoietic specific signal transducer Vav1 is aberrantly expressed in lung cancer and plays a role in tumourigenesis. J Pathol 2009;219(1):25-34.

(15) Katzav S. Vav1: A hematopoietic signal transduction molecule involved in human malignancies. Int J Biochem Cell Biol 2009;41(6):1245-1248.

(16) Lazer G, Pe'er L, Schapira V, Richard S, Katzav S. The association of Sam68 with Vav1 contributes to tumorigenesis. Cell Signal 2007;19(12):2479-2486.

(17) Katzav S. Flesh and blood: The story of Vav1, a gene that signals in hematopoietic cells but can be transforming in human malignancies. Cancer Lett 2007;255(2):241-254.

(18) Gazit R, Aker M, Elboim M, Achdout H, Katz G, Wolf DG, et al. NK cytotoxicity mediated by CD16 but not by NKp30 is functional in Griscelli syndrome. Blood 2007;109(10):4306-4312.

(19) Schapira V, Lazer G, Katzav S. Osteopontin is an oncogenic Vav1- but not wild-type Vav1-responsive gene: Implications for fibroblast transformation. Cancer Res 2006;66(12):6183-6191.

(20) Katzav S. Vav1: An oncogene that regulates specific transcriptional activation of T cells. Blood 2004;103(7):2443-2451.

(21) Hornstein I, Alcover A, Katzav S. Vav proteins, masters of the world of cytoskeleton organization. Cell Signal 2004;16(1):1-11.

(22) Hornstein I, Mortin MA, Katzav S. DroVav, the Drosophila melanogaster homologue of the mammalian Vav proteins, serves as a signal transducer protein in the Rac and DER pathways. Oncogene 2003;22(42 REV. ISS. 4):6774-6784.

(23) Hornstein I, Pikarsky E, Groysman M, Amir G, Peylan-Ramu N, Katzav S. The haematopoietic specific signal transducer Vav1 is expressed in a subset of human neuroblastomas. J Pathol 2003;199(4):526-533.

(24) Yin Y-, Salah Z, Maoz M, Ram SCE, Ochayon S, Neufeld G, et al. Oncogenic transformation induces tumor angiogenesis: A role for PAR1 activation. FASEB J 2003;17(2):163-174.

(25) Groysman M, Hornstein I, Alcover A, Katzav S. Vav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathways. J Biol Chem 2002;277(51):50121-50130.

(26) Bar-Shavit R, Maoz M, Yongjun Y, Groysman M, Dekel I, Katzav S. Signalling pathways induced by protease-activated receptors and integrins in T cells. Immunology 2002;105(1):35-46.

(27) Dekel I, Russek N, Jones T, Mortin MA, Katzav S. Identification of the Drosophila melanogaster homologue of the mammalian signal transducer protein, Vav. FEBS Lett 2000;472(1):99-104.

(28) Groysman M, Russek CSN, Katzav S. Vav, a GDP/GTP nucleotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation. FEBS Lett 2000;467(1):75-80.

(29) Landau E, Tirosh R, Pinson A, Banai S, Even-Ram S, Maoz M, et al. Protection of thrombin receptor expression under hypoxia. J Biol Chem 2000;275(4):2281-2287.

(30) Zilberman Y, Yefenof E, Katzav S, Dorogin A, Rosenheimer-Goudsmid N, Guy R. Apoptosis of thymic lymphoma clones by thymic epithelial cells: A putative model for 'death by neglect'. Immunol Lett 1999;67(2):95-104.

(31) Groysman M, Nagano M, Shaanan B, Katzav S. Mutagenic analysis of Vav reveals that an intact SH3 domain is required for transformation. Oncogene 1998;17(12):1597-1606.

(32) Uddin S, Yetter A, Katzav S, Hofmann C, White MF, Platanias LC. Insulin-like growth factor-1 induces rapid tyrosine phosphorylation of the vav proto-oncogene product. Exp Hematol 1996;24(5):622-627.

(33) Katzav S. Vav: Captain Hook for signal transduction? Crit Rev Oncog 1995;6(2):87-97.

(34) Wu J, Katzav S, Weiss A. A functional T-cell receptor signaling pathway is required for p95(vav) activity. Mol Cell Biol 1995;15(8):4337-4346.

(35) Uddin S, Katzav S, White MF, Platanias LC. Insulin-dependent tyrosine phosphorylation of the vav proto-oncogene product in cells of hematopoietic origin. J Biol Chem 1995;270(13):7712-7716.

(36) Katzav S, Packham G, Sutherland M, Aroca P, Santos E, Cleveland JL. Vav and Ras induce fibroblast transformation by overlapping signaling pathways which require c-Myc function. Oncogene 1995;11(6):1079-1088.

(37) Katzav S, Sutherland M, Packham G, Yi T, Weiss A. The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav. J Biol Chem 1994;269(51):32579-32585.

(38) Gulbins E, Coggeshall KM, Langlet C, Baier G, Bonnefoy-Berard N, Burn P, et al. Activation of Ras in vitro and in intact fibroblasts by the Vav guanine nucleotide exchange protein. Mol Cell Biol 1994;14(2):906-913.

(39) Katzav S. Single point mutations in the SH2 domain impair the transforming potential of vav and fail to activate proto-vav. Oncogene 1993;8(7):1757-1763.

(40) Gulbins E, Coggeshall KM, Baier G, Katzav S, Burn P, Altman A. Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation. Science 1993;260(5109):822-825.

(41) Katzav S. vav: A MOLECULE FOR ALL HAEMOPOIESIS? Br J Haematol 1992;81(2):141-144.

(42) Galland F, Katzav S, Birnbaum D. The products of the mcf-2 and vav proto-oncogenes and of the yeast gene cdc-24 share sequence similarities. Oncogene 1992;7(3):585-587.

(43) Margolis B, Hu P, Katzav S, Li W, Oliver JM, Ullrich A, et al. Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs. Nature 1992;356(6364):71-74.

(44) Katzav S, Cleveland JL, Heslop HE, Pulido D. Loss of the Amino-Terminal Helix-Loop-Helix Domain of the vav Proto-Oncogene Activates Its Transforming Potential. Mol Cell Biol 1991;11(4):1912-1920.

(45) Cimino G, Moir DT, Canaani O, Williams K, Crist WM, Katzav S, et al. Cloning ofALL-1, the Locus Involved in Leukemias with the t(4;ll)(q21;q23), t(9;ll)(p22;q23), and t(ll;19)(q23;pl3) Chromosome Translocations. Cancer Res 1991;51(24):6712-6714.

(46) Martinerie C, Cannizzaro LA, Croce CM, Huebner K, Katzav S, Barbacid M. The human VAV proto-oncogene maps to chromosome region 19p12→19p13.2. Hum Genet 1990;86(1):65-68.

(47) Katzav S, Martin-Zanca D, Barbacid M. vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. EMBO J 1989;8(8):2283-2290.

(48) Katzav S, Martin-Zanca D, Barbacid M, Hedge A-, Isfort R, Ihle JN. The trk oncogene abrogates growth factor requirements and transforms hematopoietic cells. Oncogene 1989;4(9):1129-1135.