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Hadassah Medical Center: Bar-Shavit Rachel

Last updated December 2021 - Hadassah Medical Center

List of Publications

(1) Nag JK, Malka H, Appasamy P, Sedley S, Bar-Shavit R. Gpcr partners as cancer driver genes: Association with ph-signal proteins in a distinctive signaling network. Int J Mol Sci 2021;22(16).

(2) Grisaru-Granovsky S, Kumar Nag J, Zakar L, Rudina T, Lal Gupta C, Maoz M, et al. PAR1&2 driven placenta EVT invasion act via LRP5/6 as coreceptors. FASEB J 2020;34(12):15701-15717.

(3) Nag JK, Bar-Shavit R. Transcriptional landscape of pars in epithelial malignancies. Int J Mol Sci 2018;19(11).

(4) Nag JK, Rudina T, Maoz M, Grisaru-Granovsky S, Uziely B, Bar-Shavit R. Correction to: Cancer driver G-protein coupled receptor (GPCR) induced β-catenin nuclear localization: the transcriptional junction (Cancer and Metastasis Reviews, (2018), 37, 1, (147-157), 10.1007/s10555-017-9711-z). Cancer Metastasis Rev 2018;37(1):197.

(5) Nag JK, Rudina T, Maoz M, Grisaru-Granovsky S, Uziely B, Bar-Shavit R. Cancer driver G-protein coupled receptor (GPCR) induced β-catenin nuclear localization: the transcriptional junction. Cancer Metastasis Rev 2018;37(1):147-157.

(6) Jaber M, Maoz M, Kancharla A, Agranovich D, Peretz T, Grisaru-Granovsky S, et al. Erratum to: Protease-activated-receptor-2 affects protease-activated-receptor-1-driven breast cancer (Cellular and Molecular Life Sciences, (2014), 71, 13, (2517-2533), 10.1007/s00018-013-1498-7). Cell Mol Life Sci 2017;74(3):571-577.

(7) Nag JK, Kancharla A, Maoz M, Turm H, Agranovich D, Gupta CL, et al. Low-density lipoprotein receptor-related protein 6 is a novel coreceptor of protease-activated receptor-2 in the dynamics of cancer-associated β-catenin stabilization. Oncotarget 2017;8(24):38650-38667.

(8) Bar-Shavit R, Maoz M, Kancharla A, Nag JK, Agranovich D, Grisaru-Granovsky S, et al. G protein-coupled receptors in cancer. Int J Mol Sci 2016;17(8).

(9) Bar-Shavit R, Grisaru-Granovsky S, Uziely B. PH-domains as central modulators driving tumor growth. Cell Cycle 2016;15(5):615-616.

(10) Bar-Shavit R, Nag JK, Grisaru-Granovsky S, Uziely B. G-protein coupled receptor PAR1 is overexpressed in glioma progenitor cells. Transl Cancer Res 2016;5:S1185-S1188.

(11) Bar-Shavit R, Maoz M, Kancharla A, Jaber M, Agranovich D, Grisaru-Granovsky S, et al. Protease-activated receptors (PARs) in cancer: Novel biased signaling and targets for therapy. Methods Cell Biol 2016;132:341-358.

(12) Kancharla A, Maoz M, Jaber M, Agranovich D, Peretz T, Grisaru-Granovsky S, et al. PH motifs in PAR1&2 endow breast cancer growth. Nat Commun 2015;6.

(13) Grisaru-Granovsky S, Salah Z, Maoz M, Tevet A, Margalioth E, Samueloff A, et al. Protease-activated-receptor 1 polymorphisms correlate with risk for unexplained recurrent pregnancy loss: A pilot study querying an association beyond coagulation. European Journal of Obstetrics and Gynecology and Reproductive Biology 2015;185:13-18.

(14) Jaber M, Maoz M, Kancharla A, Agranovich D, Peretz T, Grisaru-Granovsky S, et al. Protease-activated-receptor-2 affects protease-activated-receptor-1-driven breast cancer. Cell Mol Life Sci 2014;71(13):2517-2533.

(15) Grisaru-Granovsky S, Maoz M, Turm H, Bar-Shavit R. Emerging tasks of PAR1 and PAR2 in the placenta trophoblast anchoring to the uterus deciduas. The Placenta: Development, Function and Diseases; 2013. p. 31-42.

(16) Uziely B, Maoz M, Salah Z, Jaber M, Turm H, Grisaru-Granovsky S, et al. Emerging tasks of thrombin and its receptors in epithelial tumor development. Thrombin: Function and Pathophysiology; 2012. p. 199-213.

(17) Salah Z, Uziely B, Jaber M, Maoz M, Cohen I, Hamburger T, et al. Regulation of human protease-activated receptor 1 (hPar1) gene expression in breast cancer by estrogen. FASEB J 2012;26(5):2031-2042.

(18) Bar-Shavit R, Turm H, Salah Z, Maoz M, Cohen I, Weiss E, et al. PAR1 plays a role in epithelial malignancies: Transcriptional regulation and novel signaling pathway. IUBMB Life 2011;63(6):397-402.

(19) Turm H, Grisaru-Granvosky S, Maoz M, Offermanns S, Bar-Shavit R. DVL as a scaffold protein capturing classical GPCRs. Commun Integr Biol 2010;3(6):495-498.

(20) Cohen I, Maoz M, Turm H, Grisaru-Granovsky S, Maly B, Uziely B, et al. Etk/Bmx regulates proteinase-activated-receptor1 (PAR1) in breast cancer invasion: Signaling partners, hierarchy and physiological significance. PLoS ONE 2010;5(6).

(21) Turm H, Maoz M, Katz V, Yin Y-, Offermanns S, Bar-Shavit R. Protease-activated receptor-1 (PAR1) acts via a novel Gα 13-dishevelled axis to stabilize β-catenin levels. J Biol Chem 2010;285(20):15137-15148.

(22) Grisaru-Granovsky S, Maoz M, Barzilay O, Yin Y-, Prus D, Bar-Shavit R. Protease Activated Receptor-1, PAR1, promotes placenta trophoblast invasion and β-catenin stabilization. J Cell Physiol 2009;218(3):512-521.

(23) Salah Z, Grisaru-Granovsky S, Maoz M, Uziely B, Cohen I, Turm H, et al. The role of thrombin and its receptors in epithelial malignancies: Lessons from a transgenic mouse model and transcriptional regulation. Thrombin: Physiology and Disease; 2009. p. 173-188.

(24) Salah Z, Haupt S, Maoz M, Baraz L, Rotter V, Peretz T, et al. p53 controls hPar1 function and expression. Oncogene 2008;27(54):6866-6874.

(25) Shavit E, Beilin O, Korczyn AD, Sylantiev C, Aronovich R, Drory VE, et al. Thrombin receptor PAR-1 on myelin at the node of Ranvier: A new anatomy and physiology of conduction block. Brain 2008;131(4):1113-1122.

(26) Grisaru-Granovsky S, Tevet A, Bar-Shavit R, Salah Z, Elstein D, Samueloff A, et al. Association study of protease activated receptor 1 gene polymorphisms and adverse pregnancy outcomes: Results of a pilot study in Israel. Am J Med Genet Part A 2007;143(21):2557-2563.

(27) Salah Z, Maoz M, Pizov G, Bar-Shavit R. Transcriptional regulation of human protease-activated receptor 1: A role for the early growth response-1 protein in prostate cancer. Cancer Res 2007;67(20):9835-9843.

(28) Salah Z, Maoz M, Pokroy E, Lotem M, Bar-Shavit R, Uziely B. Protease-activated receptor-1 (hPar1), a survival factor eliciting tumor progression. Mol Cancer Res 2007;5(3):229-240.

(29) Granovsky-Grisaru S, Zaidoun S, Grisaru D, Yekel Y, Prus D, Beller U, et al. The pattern of Protease Activated Receptor 1 (PAR1) expression in endometrial carcinoma. Gynecol Oncol 2006;103(3):802-806.

(30) Yin Y-, Katz V, Salah Z, Maoz M, Cohen I, Uziely B, et al. Mammary gland tissue targeted overexpression of human protease-activated receptor 1 reveals a novel link to β-catenin stabilization. Cancer Res 2006;66(10):5224-5233.

(31) Cohen I, Pappo O, Elkin M, San T, Bar-Shavit R, Hazan R, et al. Heparanase promotes growth, angiogenesis and survival of primary breast tumors. Int J Cancer 2006;118(7):1609-1617.

(32) Grisaru-Granovsky S, Salah Z, Maoz M, Pruss D, Beller U, Bar-Shavit R. Differential expression of Protease activated receptor 1 (Par1) and pY397FAK in benign and malignant human ovarian tissue samples. Int J Cancer 2005;113(3):372-378.

(33) Salah Z, Maoz M, Cohen I, Pizov G, Pode D, Runge MS, et al. Identification of a novel functional androgen response element within hPar1 promoter: Implications to prostate cancer progression. FASEB J 2005;19(1):62-72.

(34) Yin Y-, Salah Z, Grisaru-Granovsky S, Cohen I, Even-Ram SC, Maoz M, et al. Human protease-activated receptor 1 expression in malignant epithelia: A role in invasiveness. Arterioscler Thromb Vasc Biol 2003;23(6):940-944.

(35) Even-Ram SC, Grisaru-Granovsky S, Pruss D, Maoz M, Salah Z, Yong-Jun Y, et al. The pattern of expression of protease-activated receptors (PARs) during early trophoblast development. J Pathol 2003;200(1):47-52.

(36) Yin Y-, Salah Z, Maoz M, Ram SCE, Ochayon S, Neufeld G, et al. Oncogenic transformation induces tumor angiogenesis: A role for PAR1 activation. FASEB J 2003;17(2):163-174.

(37) Nassar T, Akkawi S, Bar-Shavit R, Haj-Yehia A, Bdeir K, Al-Mehdi A-, et al. Human α-defensin regulates smooth muscle cell contraction: A role for low-density lipoprotein receptor-related protein/α2-macroglobulin receptor. Blood 2002;100(12):4026-4032.

(38) Bar-Shavit R, Maoz M, Yongjun Y, Groysman M, Dekel I, Katzav S. Signalling pathways induced by protease-activated receptors and integrins in T cells. Immunology 2002;105(1):35-46.

(39) Schiffenbauer YS, Meir G, Maoz M, Even-Ram SC, Bar-Shavit R, Neeman M. Gonadotropin stimulation of MLS human epithelial ovarian carcinoma cells augments cell adhesion mediated by CD44 and by αv-integrin. Gynecol Oncol 2002;84(2):296-302.

(40) Even-Ram SC, Maoz M, Pokroy E, Reich R, Katz B-, Gutwein P, et al. Tumor Cell Invasion Is Promoted by Activation of Protease Activated Receptor-1 in Cooperation with the αvβ5 Integrin. J Biol Chem 2001;276(14):10952-10962.

(41) Landau E, Tirosh R, Pinson A, Banai S, Even-Ram S, Maoz M, et al. Protection of thrombin receptor expression under hypoxia. J Biol Chem 2000;275(4):2281-2287.

(42) Even-Ram S, Uziely B, Cohen P, Grisaru-Granovsky S, Maoz M, Ginzburg Y, et al. Thrombin receptor overexpression in malignant and physiological invasion processes. Nat Med 1998;4(8):909-914.

(43) Bar-Shavit R, Maoz M, Ginzburg Y, Vlodavsky I. Specific involvement of glypican in thrombin adhesive properties. J Cell Biochem 1996;61(2):278-291.

(44) Bar-Shavit R, Maoz M, Ginzburg Y, Vlodavsky I. Erratum: Specific involvement of Glypican in thrombin adhesive properties (Journal of Cell Biochemistry (1996) 61 (278-291)). J Cell Biochem 1996;62(1):144.

(45) Vlodavsky I, Miao H-, Atzmon R, Levi E, Zimmermann J, Bar-Shavit R, et al. Control of cell proliferation by heparan sulfate and heparin-binding growth factors. Thromb Haemost 1995;74(1):534-540.

(46) Bitan M, Mohsen M, Levi E, Wygoda MR, Miao H-, Lider O, et al. Structural requirements for inhibition of melanoma lung colonization by heparanase inhibiting species of heparin. Isr J Med Sci 1995;31(2-3):106-118.

(47) Bar-Shavit R, Ginzburg Y, Maoz M, Vlodavsky I, Peretz T. The involvement of thrombin RGD in metastasis: Characterization of a cryptic adhesive site. Isr J Med Sci 1995;31(2-3):86-94.

(48) Herbert J-, Dupuy E, Laplace M-, Zini J-, Bar Shavit R, Tobelem G. Thrombin induces endothelial cell growth via both a proteolytic and a non-proteolytic pathway. Biochem J 1994;303(1):227-231.

(49) Benezra M, Ben-Sasson SA, Regan J, Chang M, Bar-Shavit R, Vlodavsky I. Antiproliferative activity to vascular smooth muscle cells and receptor binding of heparin-mimicking polyaromatic anionic compounds. Arterioscler Thromb Vasc Biol 1994;14(12):1992-1999.

(50) Bar-Shavit R, Eskohjido Y, Fenton II JW, Esko JD, Vlodavsky I. Thrombin adhesive properties: Induction by plasmin and heparan sulfate. J Cell Biol 1993;123(5):1279-1287.

(51) Benezra M, Vlodavsky I, Bar-Shavit R. Prothrombin conversion to thrombin by plasminogen activator residing in the subendothelial extracellular matrix. Semin Thromb Hemost 1993;19(4):405-411.

(52) Vettel U, Brunner G, Bar‐Shavit R, Vlodavsky I, Kramer MD. Charge‐dependent binding of granzyme A (MTSP‐1) to basement membranes. Eur J Immunol 1993;23(1):279-282.

(53) Benezra M, Vlodavsky I, Ishai-Michaeli R, Neufeld G, Bar-Shavit R. Thrombin-induced release of active basic fibroblast growth factor-heparan sulfate complexes from subendothelial extracellular matrix. Blood 1993;81(12):3324-3331.

(54) Bar-Shavit R, Benezra M, Sabbah V, Bode W, Vlodavsky I. Thrombin as a multifunctional protein: induction of cell adhesion and proliferation. Am J Respir Cell Mol Biol 1992;6(2):123-130.

(55) Benezra M, Vlodavsky I, Bar-Shavit R. Thrombin enhances degradation of heparan sulfate in the extracellular matrix by tumor cell heparanase. Exp Cell Res 1992;201(1):208-215.

(56) Vlodavsky I, Ishai-Michaeli R, Mohsen M, Bar-Shavit R, Catane R, Ekre H-T, et al. Modulation of neovascularization and metastasis by species of heparin. Adv Exp Med Biol 1992;313:317-327.

(57) Bar-Shavit R, Sabbah V, Grazia Lampugnani MG, Marchisio PC, Fenton II JW, Vlodavsky I, et al. An Arg-Gly-Asp sequence within thrombin promotes endothelial cell adhesion. J Cell Biol 1991;112(2):335-344.

(58) VLOAVSKY I, BASHKIN P, ISHAI‐MICHAELI R, CHAJEK‐SHAUL T, BAR‐SHAVIT R, HAIMOVITZ‐FRIEDMAN A, et al. Sequestration and Release of Basic Fibroblast Growth Factor. Ann New York Acad Sci 1991;638(1):207-220.

(59) Vlodavsky I, Ishai‐Michaeli R, Bashkin P, Levi E, Korner G, Bar‐Shavit R, et al. Extracellular matrix‐resident basic fibroblast growth factor: Implication for the control of angiogenesis. J Cell Biochem 1991;45(2):167-176.

(60) Vettel U, Bar‐Shavit R, Simon MM, Brunner G, Vlodavsky I, Kramer MD. Coordinate secretion and functional synergism of T cell‐associated serine proteinase‐1 (MTSP‐1) and endoglycosidase(s) of activated T cells. Eur J Immunol 1991;21(9):2247-2251.

(61) Vlodavsky I, Bar-Shavit R, Ishar-Michael R, Bashkin P, Fuks Z. Extracellular sequestration and release of fibroblast growth factor: a regulatory mechanism? Trends Biochem Sci 1991;16(C):268-271.

(62) Vlodavsky I, Korner G, Ishai-Michaeli R, Bashkin P, Bar-Shavit R, Fuks Z. Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis. Cancer Metast Rev 1990;9(3):203-226.

(63) Chajek-Shaul T, Friedman G, Bengtsson-Olivecrona G, Vlodavsky I, Bar-Shavit R. Interaction of lipoprotein lipase with subendothelial extracellular matrix. Biochim Biophys Acta Lipids Lipid Metab 1990;1042(2):168-175.

(64) Bar-Shavit R, Benezra M, Eldor A, Hy-Am E, Fenton II JW, Wilner GD, et al. Thrombin immobilized to extracellular matrix is a potent mitogen for vascular smooth muscle cells: Nonenzymatic mode of action. Mol Biol Cell 1990;1(6):453-463.

(65) Bar-Shavit R, Eldor A, Vlodavsky I. Binding of thrombin to subendothelial extracellular matrix. Protection and expression of functional properties. J Clin Invest 1989;84(4):1096-1104.

(66) Spira O, Atzmon R, Rahamim E, Bar-Shavit R, Gross J, Gordon A, et al. Striated muscle fibers differentiate in primary cultures of adult anterior pituitary cells. Endocrinology 1988;122(6):3002-3004.

(67) Bar‐Shavit R, Hruska KA, Kahn AJ, Wilner GD. Thrombin chemotactic stimulation of HL‐60 cells: Studies on thrombin responsiveness as a function of differentiation. J Cell Physiol 1987;131(2):255-261.

(68) Bar-Shavit R, Kahn AJ, Mann KG, Wilner GD. Identification of a thrombin sequence with growth factor activity on macrophages. Proc Natl Acad Sci U S A 1986;83(4):976-980.

(69) Bar-Shavit R, Kahn AJ, Mann KG, Wilner GD. Growth-promoting effects of esterolytically inactive thrombin on macrophages. J Cell Biochem 1986;32(4):261-272.

(70) Bar-Shavit R, Wilner GD. Biologic activities of nonenzymatic thrombin: Elucidation of a macrophage interactive domain. Semin Thromb Hemost 1986;12(3):244-249.

(71) Bar-Shavit R, Wilner GD. Mediation of cellular events by thrombin. Int Rev Exp Pathol 1986;Vol. 29:213-241.

(72) BAR‐SHAVIT R, HRUSKA KA, KAHN AJ, WILNER GD. Hormone‐Like Activity of Human Thrombin. Ann New York Acad Sci 1986;485(1):335-348.

(73) Bar-Shavit R, Kahn A, Mudd MS, Wilner GD, Mann KG, Fenton JW. Localization of a Chemotactic Domain in Human Thrombin. Biochemistry 1984;23(3):397-400.

(74) Shainberg A, Brik H, Bar Shavit R, Sampson SR. Inhibition of acetylcholine receptor synthesis by thyroid hormones. J Endocrinol 1984;101(2):141-147.

(75) Bar Shavit R, Kahn A, Fenton II JW, Wilner GD. Receptor-mediated chemotactic response of a macrophage cell line (J774) to thrombin. Lab Invest 1983;49(6):702-707.

(76) Bar-Shavit R, Kahn A, Fenton II JW, Wilner GD. Chemotactic response of monocytes to thrombin. J Cell Biol 1983;96(1):282-285.

(77) Bar-Shavit R, Kahn A, Wilner GD, Fenton II JW. Monocyte chemotaxis: Stimulation by specific exosite region in thrombin. Science 1983;220(4598):728-731.

(78) Bar Shavit R, Kahn A, Fenton II JW, Wilner GD. Chemotactic response of monocytes to thrombin. Clin Res 1982;30(4).

(79) DePamphilis ML, Anderson S, Bar-Shavit R, Collins E, Edenberg H, Herman T, et al. Replication and structure of simian virus 40 chromosomes. COLD SPRING HARBOR SYMP QUANT BIOL 1979;43(2):679-692.

(80) Kaufmann G, Bar-Shavit R, Depamphilis ML. Okazaki pieces grow opposite to the replication fork direction during simian virus 40 DNA replication. Nucleic Acids Res 1978;5(7):2535-2546.

(81) Bar-Shavit R, Laub O, Aloni Y. The Frequencies of Transcription from the E- and L-Strands of Polyoma DNA. J Gen Virol 1978;39(2):357-360.