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Hadassah Medical Center: Gileles-Hillel Alex

Last updated June 2021 - Hadassah Medical Center

List of Publications


Adler-Haltovsky T, Gileles-Hillel A, Erlichman I, Eventov-Friedman S. Changes in ventilation modes in the last decade and their impact on the prevalence of bronchopulmonary dysplasia in preterm infants. Pediatric Pulmonology [Internet]. 2023;58(7):1959–66. Available from:


Reiter J, Abuelhija H, Slae M, Millman P, Davidovics Z, Chaimov E, et al. Sleep disorders in children with celiac disease: a prospective study. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine [Internet]. 2023;19(3):591–4. Available from:


Gileles-Hillel A, Yochi Harpaz L, Breuer O, Reiter J, Tsabari R, Kerem E, et al. The clinical yield of bronchoscopy in the management of cystic fibrosis: A retrospective multicenter study. Pediatric Pulmonology [Internet]. 2023;58(2):500–6. Available from:


Sadras I, Kerem E, Livnat G, Sarouk I, Breuer O, Reiter J, et al. Clinical and functional efficacy of elexacaftor/tezacaftor/ivacaftor in people with cystic fibrosis carrying the N1303K mutation. Journal of Cystic Fibrosis [Internet]. 2023; Available from:


Dahan T, Nassar S, Yajuk O, Steinberg E, Benny O, Abudi N, et al. Chronic Intermittent Hypoxia during Sleep Causes Browning of Interscapular Adipose Tissue Accompanied by Local Insulin Resistance in Mice. International Journal of Molecular Sciences [Internet]. 2022;23(24). Available from:


Gileles-Hillel A, Soesman LH, Miari S, Breuer O, Tsabari R, Elyashar-Earon H, et al. The utility of glucose area under the curve from the oral glucose tolerance test as a screening tool for cystic fibrosis-related diabetes. Pediatric Pulmonology [Internet]. 2022;57(11):2774–80. Available from:


Reiter J, Breuer O, Cohen-Cymberknoh M, Forno E, Gileles-Hillel A. Sleep in children with cystic fibrosis: More under the covers. Pediatric Pulmonology [Internet]. 2022;57(8):1944–51. Available from:


Reiter J, Ramagopal M, Gileles-Hillel A, Forno E. Sleep disorders in children with asthma. Pediatric Pulmonology [Internet]. 2022;57(8):1851–9. Available from:


Choshen-Hillel S, Sadras I, Gordon-Hecker T, Genzer S, Rekhtman D, Caruso EM, et al. Physicians prescribe fewer analgesics during night shifts than day shifts. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 2022;119(27). Available from:


Gileles-Hillel A, Dahan T. Intermittent by day, sustained by night - the worst of both hypoxias? Sleep [Internet]. 2022;45(6). Available from:


Israeli T, Eisenstadt I, Shoseyov D, Armoni S, Gileles-Hillel A, Cremisi G, et al. Respiratory physiotherapy in patients with cystic fibrosis and upper limb deep vein thrombosis. Pediatric Pulmonology [Internet]. 2022;57(6):1552–4. Available from:


Biro O, Gileles-Hillel A, Dor-Wollman T, Eisenstein EM, Berkun Y. Neurological and neurodevelopmental symptoms in children with familial Mediterranean fever and their siblings. European Journal of Pediatrics [Internet]. 2022;181(3):973–8. Available from:


van der Vaart J, Böttinger L, Geurts MH, van de Wetering WJ, Knoops K, Sachs N, et al. Modelling of primary ciliary dyskinesia using patient-derived airway organoids. EMBO Reports [Internet]. 2021;22(12). Available from:


Choshen-Hillel S, Gileles-Hillel A. A wake-up call: Time to raise physicians’ awareness of the consequences of fatigue. Medical Education [Internet]. 2021;55(12):1342–4. Available from:


Paltiel O, Hochner H, Chinitz D, Clarfield AM, Gileles-Hillel A, Lahad A, et al. Academic activism on behalf of children during the COVID-19 pandemic in Israel; beyond public health advocacy. Israel Journal of Health Policy Research [Internet]. 2021;10(1). Available from:


Bar-Or RL, Levy I, Twig G, Broday DM, Lyubarsky A, Derazne E, et al. Associations of exposure to nitrogen oxides with prevalent asthma and other atopic diseases in Israel. Environments - MDPI [Internet]. 2021;8(10). Available from:


Khalyfa A, Trzepizur W, Gileles-Hillel A, Qiao Z, Sanz-Rubio D, Marin JM, et al. Heterogeneity of melanoma cell responses to sleep apnea-derived plasma exosomes and to intermittent hypoxia. Cancers [Internet]. 2021;13(19). Available from:


Grunewald M, Kumar S, Sharife H, Volinsky E, Gileles-Hillel A, Licht T, et al. Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span. Science (New York, NY) [Internet]. 2021;373(6554). Available from:


Kaditis AG, Ohler A, Gileles-Hillel A, Choshen-Hillel S, Gozal D, Bruni O, et al. Effects of the COVID-19 lockdown on sleep duration in children and adolescents: A survey across different continents. Pediatric Pulmonology [Internet]. 2021;56(7):2265–73. Available from:


Cohen-Cymberknoh M, Ben Meir E, Gartner S, Reiter J, Spangenberg A, Garriga L, et al. How abnormal is the normal? Clinical characteristics of CF patients with normal FEV1. Pediatric Pulmonology [Internet]. 2021;56(7):2007–13. Available from:


Barak-Corren Y, Barak-Corren N, Gileles-Hillel A, Heiman E. The effect of C-reactive protein on chest X-ray interpretation: A decision-making experiment among pediatricians. Pediatric Pulmonology [Internet]. 2021;56(6):1644–50. Available from:


Gileles-Hillel A, Guttman S, Breuer O, Reiter J, Leshem R, Shoseyov D, et al. Betamethasone versus dexamethasone for inpatient preschool wheezing—A case-control study. Pediatric Pulmonology [Internet]. 2021;56(5):875–82. Available from:


Raz R, Yuval, Bar-Or RL, Kark JD, Sinnreich R, Broday DM, et al. Associations between exposure to industrial air pollution and prevalence of asthma and atopic diseases in haifa bay area. Atmosphere [Internet]. 2021;12(4). Available from:


Kerem E, Cohen-Cymberknoh M, Tsabari R, Wilschanski M, Reiter J, Shoseyov D, et al. Ivacaftor in People with Cystic Fibrosis and a 3849110kb C→T or D1152H Residual Function Mutation. Annals of the American Thoracic Society [Internet]. 2021;18(3):433–41. Available from:


Gileles-Hillel A. Sickle cell disease and obstructive sleep apnea-bad news for the brain. Sleep [Internet]. 2021;44(2). Available from:


Choshen-Hillel S, Ishqer A, Mahameed F, Reiter J, Gozal D, Gileles-Hillel A, et al. Acute and chronic sleep deprivation in residents: Cognition and stress biomarkers. Medical Education [Internet]. 2021;55(2):174–84. Available from:


Mandelkorn U, Genzer S, Choshen-Hillel S, Reiter J, e Cruz MM, Hochner H, et al. Escalation of sleep disturbances amid the COVID-19 pandemic: A cross-sectional international study. Journal of Clinical Sleep Medicine [Internet]. 2021;17(1):45–53. Available from:


Ryan S, Cummins EP, Farre R, Gileles-Hillel A, Jun JC, Oster H, et al. Understanding the pathophysiological mechanisms of cardiometabolic complications in obstructive sleep apnoea: Towards personalised treatment approaches. European Respiratory Journal [Internet]. 2020;56(2). Available from:


Yogev D, Mahameed F, Gileles-Hillel A, Millman P, Davidovics Z, Hashavya S, et al. Hijab pin ingestions. Pediatrics [Internet]. 2020;145(6). Available from:


Reiter J, Gileles-Hillel A, Cohen-Cymberknoh M, Rosen D, Kerem E, Gozal D, et al. Sleep disorders in cystic fibrosis: A systematic review and meta-analysis. Sleep Medicine Reviews [Internet]. 2020;51. Available from:


Gileles-Hillel A, Mor-Shaked H, Shoseyov D, Reiter J, Tsabari R, Hevroni A, et al. Whole-exome sequencing accuracy in the diagnosis of primary ciliary dyskinesia. ERJ Open Research [Internet]. 2020;6(4). Available from:


Lavi E, Gileles-Hillel A, Zangen D. Somatic growth in cystic fibrosis. Current Opinion in Endocrinology, Diabetes and Obesity [Internet]. 2020;27(1):38–46. Available from:


Sadras I, Reiter J, Fuchs N, Erlichman I, Gozal D, Gileles-Hillel A. Prematurity as a risk factor of sleep-disordered breathing in children younger than two years: A retrospective case-control study. Journal of Clinical Sleep Medicine [Internet]. 2019;15(12):1731–6. Available from:


Gross I, Gordon O, Cohen-Cymberknoh M, Reiter J, Tsabari R, Gileles-Hillel A, et al. Giant lung cysts following necrotizing pneumonia: Resolution with conservative treatment. Pediatric Pulmonology [Internet]. 2019;54(6):901–6. Available from:


Cohen-Cymberknoh M, Atia O, Gileles-Hillel A, Kerem E, Reiter J. Sleep disorders in patients with primary ciliary dyskinesia, cystic fibrosis with and without pancreatic insufficiency. Respiratory Medicine [Internet]. 2019;151:96–101. Available from:


Palma JA, Gileles-Hillel A, Norcliffe-Kaufmann L, Kaufmann H. Chemoreflex failure and sleep-disordered breathing in familial dysautonomia: Implications for sudden death during sleep. Autonomic Neuroscience: Basic and Clinical [Internet]. 2019;218:10–5. Available from:


Lavi E, Gileles-Hillel A, Simanovsky N, Averbuch D, Wexler ID, Berkun Y. Pyogenic sacroiliitis in children: don’t forget the very young. European Journal of Pediatrics [Internet]. 2019;178(4):575–9. Available from:


Gileles-Hillel A, Erlichman I, Reiter J. Apnea of Prematurity: An Update. Journal of Child Science [Internet]. 2019;9(1):E50–8. Available from:


Khalyfa A, Poroyko VA, Qiao Z, Gileles-Hillel A, Khalyfa AA, Akbarpour M, et al. Exosomes and metabolic function in mice exposed to alternating dark-light cycles mimicking night shift work schedules. Frontiers in Physiology [Internet]. 2017;8(NOV). Available from:


Khalyfa A, Qiao Z, Gileles-Hillel A, Khalyfa AA, Akbarpour M, Popko B, et al. Activation of the integrated stress response and metabolic dysfunction in a murine model of sleep apnea. American Journal of Respiratory Cell and Molecular Biology [Internet]. 2017;57(4):477–86. Available from:


Cohen-Cymberknoh M, Weigert N, Gileles-Hillel A, Breuer O, Simanovsky N, Boon M, et al. Clinical impact of Pseudomonas aeruginosa colonization in patients with Primary Ciliary Dyskinesia. Respiratory Medicine [Internet]. 2017;131:241–6. Available from:


Gozal D, Gileles-Hillel A, Cortese R, Li Y, Almendros I, Qiao Z, et al. Visceral white adipose tissue after chronic intermittent and sustained hypoxia in mice. American Journal of Respiratory Cell and Molecular Biology [Internet]. 2017;56(4):477–87. Available from:


Gileles-Hillel A, Almendros I, Khalyfa A, Nigdelioglu R, Qiao Z, Hamanaka RB, et al. Prolonged exposures to intermittent hypoxia promote visceral white adipose tissue inflammation in a murine model of severe sleep apnea: Effect of normoxic recovery. Sleep [Internet]. 2017;40(3). Available from:


Cortese R, Gileles-Hillel A, Khalyfa A, Almendros I, Akbarpour M, Khalyfa AA, et al. Aorta macrophage inflammatory and epigenetic changes in a murine model of obstructive sleep apnea: Potential role of CD36. Scientific Reports [Internet]. 2017;7. Available from:


Akbarpour M, Khalyfa A, Qiao Z, Gileles-Hillel A, Almendros I, Farré R, et al. Altered CD8+ t-cell lymphocyte function and tc1 cell stemness contribute to enhanced malignant tumor properties in murine models of sleep apnea. Sleep [Internet]. 2017;40(2). Available from:


Gemel J, Su Z, Gileles-Hillel A, Khalyfa A, Gozal D, Beyer EC. Intermittent hypoxia causes NOX2-dependent remodeling of atrial connexins. BMC Cell Biology [Internet]. 2017;18. Available from:


Almendros I, Khalyfa A, Trzepizur W, Gileles-Hillel A, Huang L, Akbarpour M, et al. Tumor Cell Malignant Properties Are Enhanced by Circulating Exosomes in Sleep Apnea. Chest [Internet]. 2016;150(5):1030–41. Available from:


Poroyko VA, Carreras A, Khalyfa A, Khalyfa AA, Leone V, Peris E, et al. Chronic Sleep Disruption Alters Gut Microbiota, Induces Systemic and Adipose Tissue Inflammation and Insulin Resistance in Mice. Scientific Reports [Internet]. 2016;6. Available from:


Khalyfa A, Gileles-Hillel A, Gozal D. The Challenges of Precision Medicine in Obstructive Sleep Apnea. Sleep Medicine Clinics [Internet]. 2016;11(2):213–26. Available from:


Gileles-Hillel A, Kheirandish-Gozal L, Gozal D. Biological plausibility linking sleep apnoea and metabolic dysfunction. Nature Reviews Endocrinology [Internet]. 2016;12(5):290–8. Available from:


Khalyfa A, Almendros I, Gileles-Hillel A, Akbarpour M, Trzepizur W, Mokhlesi B, et al. Circulating exosomes potentiate tumor malignant properties in a mouse model of chronic sleep fragmentation. Oncotarget [Internet]. 2016;7(34):54676–90. Available from:


Gileles-Hillel A, Kheirandish-Gozal L, Gozal D. Hemoglobinopathies and sleep - The road less traveled. Sleep Medicine Reviews [Internet]. 2015;24:57–70. Available from:


Gileles-Hillel A, Shoseyov D, Polacheck I, Korem M, Kerem E, Cohen-Cymberknoh M. Association of chronic Candida albicans respiratory infection with a more severe lung disease in patients with cystic fibrosis. Pediatric Pulmonology [Internet]. 2015;50(11):1082–9. Available from:


Alkhouri N, Kheirandish-Gozal L, Matloob A, Alonso-Álvarez ML, Khalyfa A, Terán-Santos J, et al. Evaluation of circulating markers of hepatic apoptosis and inflammation in obese children with and without obstructive sleep apnea. Sleep Medicine [Internet]. 2015;16(9):1031–5. Available from:


Kheirandish-Gozal L, Gileles-Hillel A, Alonso-Álvarez ML, Peris E, Bhattacharjee R, Terán-Santos J, et al. Effects of adenotonsillectomy on plasma inflammatory biomarkers in obese children with obstructive sleep apnea: A community-based study. International Journal of Obesity [Internet]. 2015;39(7):1094–100. Available from:


Gileles-Hillel A, Philby MF, Lapping-Carr G. Insights into selected aspects of pediatric sleep medicine. American Journal of Respiratory and Critical Care Medicine [Internet]. 2015;191(12):1459–61. Available from:


Almendros I, Gileles-Hillel A, Khalyfa A, Wang Y, Zhang SX, Carreras A, et al. Adipose tissue macrophage polarization by intermittent hypoxia in a mouse model of OSA: Effect of tumor microenvironment. Cancer Letters [Internet]. 2015;361(2):233–9. Available from:


Carreras A, Zhang SX, Peris E, Qiao Z, Gileles-Hillel A, Li RC, et al. Chronic sleep fragmentation induces endothelial dysfunction and structural vascular changes in mice. Sleep [Internet]. 2014;37(11):1817–24. Available from:


Gileles-Hillel A, Almendros I, Khalyfa A, Zhang SX, Wang Y, Gozal D. Early intermittent hypoxia induces proatherogenic changes in aortic wall macrophages in a murine model of obstructive sleep apnea. American Journal of Respiratory and Critical Care Medicine [Internet]. 2014;190(8):958–61. Available from:


Gileles-Hillel A, Alonso-Álvarez ML, Kheirandish-Gozal L, Peris E, Cordero-Guevara JA, Terán-Santos J, et al. Inflammatory markers and obstructive sleep apnea in obese children: The NANOS study. Mediators of Inflammation [Internet]. 2014;2014. Available from:


Cohen-Cymberknoh M, Simanovsky N, Hiller N, Gileles Hillel A, Shoseyov D, Kerem E. Differences in disease expression between primary ciliary dyskinesia and cystic fibrosis with and without pancreatic insufficiency. Chest [Internet]. 2014;145(4):738–44. Available from:


Milgrom Y, Goldman G, Gileles Hillel A, Pojurovsky S, Ackerman Z. Tuberculosis: A rare cause of peri-anal disease. Israel Medical Association Journal [Internet]. 2013;15(12):782–3. Available from:


Simanovsky N, Gileles-Hillel A, Frenkel R, Shosayov D, Hiller N. Correlation between computed tomography expression of pulmonary hypertension and severity of lung disease in cystic fibrosis patients. Journal of Thoracic Imaging [Internet]. 2013;28(6):383–7. Available from:


Hiller N, Schor-Bardach R, Gileles-Hillel A, Stroumsa D, Simanovsky N. CT appearance of the pelvis after Cesarean delivery-what is considered normal? Clinical Imaging [Internet]. 2013;37(3):514–9. Available from:


Simanovsky N, Cohen-Cymberknoh M, Shoseyov D, Gileles-Hillel A, Wilschanski M, Kerem E, et al. Differences in the pattern of structural abnormalities on CT scan in patients with cystic fibrosis and pancreatic sufficiency or insufficiency. Chest [Internet]. 2013;144(1):208–14. Available from: