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Hadassah Medical Center: Gileles-Hillel Alex

Last updated June 2021 - Hadassah Medical Center

List of Publications

(1) Dahan T, Nassar S, Yajuk O, Steinberg E, Benny O, Abudi N, et al. Chronic Intermittent Hypoxia during Sleep Causes Browning of Interscapular Adipose Tissue Accompanied by Local Insulin Resistance in Mice. Int J Mol Sci 2022;23(24).

(2) Gileles-Hillel A, Soesman LH, Miari S, Breuer O, Tsabari R, Elyashar-Earon H, et al. The utility of glucose area under the curve from the oral glucose tolerance test as a screening tool for cystic fibrosis-related diabetes. Pediatr Pulmonol 2022;57(11):2774-2780.

(3) Reiter J, Breuer O, Cohen-Cymberknoh M, Forno E, Gileles-Hillel A. Sleep in children with cystic fibrosis: More under the covers. Pediatr Pulmonol 2022;57(8):1944-1951.

(4) Reiter J, Ramagopal M, Gileles-Hillel A, Forno E. Sleep disorders in children with asthma. Pediatr Pulmonol 2022;57(8):1851-1859.

(5) Choshen-Hillel S, Sadras I, Gordon-Hecker T, Genzer S, Rekhtman D, Caruso EM, et al. Physicians prescribe fewer analgesics during night shifts than day shifts. Proc Natl Acad Sci U S A 2022;119(27).

(6) Gileles-Hillel A, Dahan T. Intermittent by day, sustained by night - the worst of both hypoxias? Sleep 2022;45(6).

(7) Israeli T, Eisenstadt I, Shoseyov D, Armoni S, Gileles-Hillel A, Cremisi G, et al. Respiratory physiotherapy in patients with cystic fibrosis and upper limb deep vein thrombosis. Pediatr Pulmonol 2022;57(6):1552-1554.

(8) Biro O, Gileles-Hillel A, Dor-Wollman T, Eisenstein EM, Berkun Y. Neurological and neurodevelopmental symptoms in children with familial Mediterranean fever and their siblings. Eur J Pediatr 2022;181(3):973-978.

(9) Gileles-Hillel A, Yochi Harpaz L, Breuer O, Reiter J, Tsabari R, Kerem E, et al. The clinical yield of bronchoscopy in the management of cystic fibrosis: A retrospective multicenter study. Pediatr Pulmonol 2022.

(10) van der Vaart J, Böttinger L, Geurts MH, van de Wetering WJ, Knoops K, Sachs N, et al. Modelling of primary ciliary dyskinesia using patient-derived airway organoids. EMBO Rep 2021;22(12).

(11) Choshen-Hillel S, Gileles-Hillel A. A wake-up call: Time to raise physicians' awareness of the consequences of fatigue. Med Educ 2021;55(12):1342-1344.

(12) Paltiel O, Hochner H, Chinitz D, Clarfield AM, Gileles-Hillel A, Lahad A, et al. Academic activism on behalf of children during the COVID-19 pandemic in Israel; beyond public health advocacy. Isr J Health Policy Res 2021;10(1).

(13) Bar-Or RL, Levy I, Twig G, Broday DM, Lyubarsky A, Derazne E, et al. Associations of exposure to nitrogen oxides with prevalent asthma and other atopic diseases in Israel. Environ - MDPI 2021;8(10).

(14) Khalyfa A, Trzepizur W, Gileles-Hillel A, Qiao Z, Sanz-Rubio D, Marin JM, et al. Heterogeneity of melanoma cell responses to sleep apnea-derived plasma exosomes and to intermittent hypoxia. Cancers 2021;13(19).

(15) Grunewald M, Kumar S, Sharife H, Volinsky E, Gileles-Hillel A, Licht T, et al. Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span. Science 2021;373(6554).

(16) Kaditis AG, Ohler A, Gileles-Hillel A, Choshen-Hillel S, Gozal D, Bruni O, et al. Effects of the COVID-19 lockdown on sleep duration in children and adolescents: A survey across different continents. Pediatr Pulmonol 2021;56(7):2265-2273.

(17) Cohen-Cymberknoh M, Ben Meir E, Gartner S, Reiter J, Spangenberg A, Garriga L, et al. How abnormal is the normal? Clinical characteristics of CF patients with normal FEV1. Pediatr Pulmonol 2021;56(7):2007-2013.

(18) Barak-Corren Y, Barak-Corren N, Gileles-Hillel A, Heiman E. The effect of C-reactive protein on chest X-ray interpretation: A decision-making experiment among pediatricians. Pediatr Pulmonol 2021;56(6):1644-1650.

(19) Gileles-Hillel A, Guttman S, Breuer O, Reiter J, Leshem R, Shoseyov D, et al. Betamethasone versus dexamethasone for inpatient preschool wheezing—A case-control study. Pediatr Pulmonol 2021;56(5):875-882.

(20) Raz R, Yuval, Bar-Or RL, Kark JD, Sinnreich R, Broday DM, et al. Associations between exposure to industrial air pollution and prevalence of asthma and atopic diseases in haifa bay area. Atmosphere 2021;12(4).

(21) Kerem E, Cohen-Cymberknoh M, Tsabari R, Wilschanski M, Reiter J, Shoseyov D, et al. Ivacaftor in People with Cystic Fibrosis and a 3849110kb C→T or D1152H Residual Function Mutation. Ann Am Thorac Soc 2021;18(3):433-441.

(22) Gileles-Hillel A. Sickle cell disease and obstructive sleep apnea-bad news for the brain. Sleep 2021;44(2).

(23) Choshen-Hillel S, Ishqer A, Mahameed F, Reiter J, Gozal D, Gileles-Hillel A, et al. Acute and chronic sleep deprivation in residents: Cognition and stress biomarkers. Med Educ 2021;55(2):174-184.

(24) Mandelkorn U, Genzer S, Choshen-Hillel S, Reiter J, e Cruz MM, Hochner H, et al. Escalation of sleep disturbances amid the COVID-19 pandemic: A cross-sectional international study. J Clin Sleep Med 2021;17(1):45-53.

(25) Ryan S, Cummins EP, Farre R, Gileles-Hillel A, Jun JC, Oster H, et al. Understanding the pathophysiological mechanisms of cardiometabolic complications in obstructive sleep apnoea: Towards personalised treatment approaches. Eur Respir J 2020;56(2).

(26) Yogev D, Mahameed F, Gileles-Hillel A, Millman P, Davidovics Z, Hashavya S, et al. Hijab pin ingestions. Pediatrics 2020;145(6).

(27) Reiter J, Gileles-Hillel A, Cohen-Cymberknoh M, Rosen D, Kerem E, Gozal D, et al. Sleep disorders in cystic fibrosis: A systematic review and meta-analysis. Sleep Med Rev 2020;51.

(28) Gileles-Hillel A, Mor-Shaked H, Shoseyov D, Reiter J, Tsabari R, Hevroni A, et al. Whole-exome sequencing accuracy in the diagnosis of primary ciliary dyskinesia. ERJ Open Res 2020;6(4).

(29) Lavi E, Gileles-Hillel A, Zangen D. Somatic growth in cystic fibrosis. Curr Opin Endocrinol Diabetes Obes 2020;27(1):38-46.

(30) Sadras I, Reiter J, Fuchs N, Erlichman I, Gozal D, Gileles-Hillel A. Prematurity as a risk factor of sleep-disordered breathing in children younger than two years: A retrospective case-control study. J Clin Sleep Med 2019;15(12):1731-1736.

(31) Gross I, Gordon O, Cohen-Cymberknoh M, Reiter J, Tsabari R, Gileles-Hillel A, et al. Giant lung cysts following necrotizing pneumonia: Resolution with conservative treatment. Pediatr Pulmonol 2019;54(6):901-906.

(32) Cohen-Cymberknoh M, Atia O, Gileles-Hillel A, Kerem E, Reiter J. Sleep disorders in patients with primary ciliary dyskinesia, cystic fibrosis with and without pancreatic insufficiency. Respir Med 2019;151:96-101.

(33) Palma J-, Gileles-Hillel A, Norcliffe-Kaufmann L, Kaufmann H. Chemoreflex failure and sleep-disordered breathing in familial dysautonomia: Implications for sudden death during sleep. Auton Neurosc Basic Clin 2019;218:10-15.

(34) Lavi E, Gileles-Hillel A, Simanovsky N, Averbuch D, Wexler ID, Berkun Y. Pyogenic sacroiliitis in children: don’t forget the very young. Eur J Pediatr 2019;178(4):575-579.

(35) Gileles-Hillel A, Erlichman I, Reiter J. Apnea of Prematurity: An Update. Journal of Child Science 2019;9(1):E50-E58.

(36) Khalyfa A, Poroyko VA, Qiao Z, Gileles-Hillel A, Khalyfa AA, Akbarpour M, et al. Exosomes and metabolic function in mice exposed to alternating dark-light cycles mimicking night shift work schedules. Front Physiol 2017;8(NOV).

(37) Khalyfa A, Qiao Z, Gileles-Hillel A, Khalyfa AA, Akbarpour M, Popko B, et al. Activation of the integrated stress response and metabolic dysfunction in a murine model of sleep apnea. Am J Resp Cell Mol Biol 2017;57(4):477-486.

(38) Cohen-Cymberknoh M, Weigert N, Gileles-Hillel A, Breuer O, Simanovsky N, Boon M, et al. Clinical impact of Pseudomonas aeruginosa colonization in patients with Primary Ciliary Dyskinesia. Respir Med 2017;131:241-246.

(39) Gozal D, Gileles-Hillel A, Cortese R, Li Y, Almendros I, Qiao Z, et al. Visceral white adipose tissue after chronic intermittent and sustained hypoxia in mice. Am J Resp Cell Mol Biol 2017;56(4):477-487.

(40) Gileles-Hillel A, Almendros I, Khalyfa A, Nigdelioglu R, Qiao Z, Hamanaka RB, et al. Prolonged exposures to intermittent hypoxia promote visceral white adipose tissue inflammation in a murine model of severe sleep apnea: Effect of normoxic recovery. Sleep 2017;40(3).

(41) Cortese R, Gileles-Hillel A, Khalyfa A, Almendros I, Akbarpour M, Khalyfa AA, et al. Aorta macrophage inflammatory and epigenetic changes in a murine model of obstructive sleep apnea: Potential role of CD36. Sci Rep 2017;7.

(42) Akbarpour M, Khalyfa A, Qiao Z, Gileles-Hillel A, Almendros I, Farré R, et al. Altered CD8+ t-cell lymphocyte function and tc1 cell stemness contribute to enhanced malignant tumor properties in murine models of sleep apnea. Sleep 2017;40(2).

(43) Gemel J, Su Z, Gileles-Hillel A, Khalyfa A, Gozal D, Beyer EC. Intermittent hypoxia causes NOX2-dependent remodeling of atrial connexins. BMC Cell Biol 2017;18.

(44) Almendros I, Khalyfa A, Trzepizur W, Gileles-Hillel A, Huang L, Akbarpour M, et al. Tumor Cell Malignant Properties Are Enhanced by Circulating Exosomes in Sleep Apnea. Chest 2016;150(5):1030-1041.

(45) Poroyko VA, Carreras A, Khalyfa A, Khalyfa AA, Leone V, Peris E, et al. Chronic Sleep Disruption Alters Gut Microbiota, Induces Systemic and Adipose Tissue Inflammation and Insulin Resistance in Mice. Sci Rep 2016;6.

(46) Khalyfa A, Gileles-Hillel A, Gozal D. The Challenges of Precision Medicine in Obstructive Sleep Apnea. Sleep Med Clin 2016;11(2):213-226.

(47) Gileles-Hillel A, Kheirandish-Gozal L, Gozal D. Biological plausibility linking sleep apnoea and metabolic dysfunction. Nat Rev Endocrionol 2016;12(5):290-298.

(48) Khalyfa A, Almendros I, Gileles-Hillel A, Akbarpour M, Trzepizur W, Mokhlesi B, et al. Circulating exosomes potentiate tumor malignant properties in a mouse model of chronic sleep fragmentation. Oncotarget 2016;7(34):54676-54690.

(49) Gileles-Hillel A, Kheirandish-Gozal L, Gozal D. Hemoglobinopathies and sleep - The road less traveled. Sleep Med Rev 2015;24:57-70.

(50) Gileles-Hillel A, Shoseyov D, Polacheck I, Korem M, Kerem E, Cohen-Cymberknoh M. Association of chronic Candida albicans respiratory infection with a more severe lung disease in patients with cystic fibrosis. Pediatr Pulmonol 2015;50(11):1082-1089.

(51) Alkhouri N, Kheirandish-Gozal L, Matloob A, Alonso-Álvarez ML, Khalyfa A, Terán-Santos J, et al. Evaluation of circulating markers of hepatic apoptosis and inflammation in obese children with and without obstructive sleep apnea. Sleep Med 2015;16(9):1031-1035.

(52) Kheirandish-Gozal L, Gileles-Hillel A, Alonso-Álvarez ML, Peris E, Bhattacharjee R, Terán-Santos J, et al. Effects of adenotonsillectomy on plasma inflammatory biomarkers in obese children with obstructive sleep apnea: A community-based study. Int J Obes 2015;39(7):1094-1100.

(53) Gileles-Hillel A, Philby MF, Lapping-Carr G. Insights into selected aspects of pediatric sleep medicine. Am J Respir Crit Care Med 2015;191(12):1459-1461.

(54) Almendros I, Gileles-Hillel A, Khalyfa A, Wang Y, Zhang SX, Carreras A, et al. Adipose tissue macrophage polarization by intermittent hypoxia in a mouse model of OSA: Effect of tumor microenvironment. Cancer Lett 2015;361(2):233-239.

(55) Carreras A, Zhang SX, Peris E, Qiao Z, Gileles-Hillel A, Li RC, et al. Chronic sleep fragmentation induces endothelial dysfunction and structural vascular changes in mice. Sleep 2014;37(11):1817-1824.

(56) Gileles-Hillel A, Almendros I, Khalyfa A, Zhang SX, Wang Y, Gozal D. Early intermittent hypoxia induces proatherogenic changes in aortic wall macrophages in a murine model of obstructive sleep apnea. Am J Respir Crit Care Med 2014;190(8):958-961.

(57) Gileles-Hillel A, Alonso-Álvarez ML, Kheirandish-Gozal L, Peris E, Cordero-Guevara JA, Terán-Santos J, et al. Inflammatory markers and obstructive sleep apnea in obese children: The NANOS study. Mediators Inflamm 2014;2014.

(58) Cohen-Cymberknoh M, Simanovsky N, Hiller N, Gileles Hillel A, Shoseyov D, Kerem E. Differences in disease expression between primary ciliary dyskinesia and cystic fibrosis with and without pancreatic insufficiency. Chest 2014;145(4):738-744.

(59) Milgrom Y, Goldman G, Gileles Hillel A, Pojurovsky S, Ackerman Z. Tuberculosis: A rare cause of peri-anal disease. Isr Med Assoc J 2013;15(12):782-783.

(60) Simanovsky N, Gileles-Hillel A, Frenkel R, Shosayov D, Hiller N. Correlation between computed tomography expression of pulmonary hypertension and severity of lung disease in cystic fibrosis patients. J Thorac Imaging 2013;28(6):383-387.

(61) Hiller N, Schor-Bardach R, Gileles-Hillel A, Stroumsa D, Simanovsky N. CT appearance of the pelvis after Cesarean delivery-what is considered normal? Clin Imaging 2013;37(3):514-519.

(62) Simanovsky N, Cohen-Cymberknoh M, Shoseyov D, Gileles-Hillel A, Wilschanski M, Kerem E, et al. Differences in the pattern of structural abnormalities on CT scan in patients with cystic fibrosis and pancreatic sufficiency or insufficiency. Chest 2013;144(1):208-214.