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Hadassah Medical Center: Gileles-Hillel Alex

Last updated June 2021 - Hadassah Medical Center

List of Publications

1.     Ananth S, Adeoti AO, Ray A, et al. Healthcare worker views on antimicrobial resistance in chronic respiratory disease. Antimicrob Resist Infect Control. 2025;14(1). doi:10.1186/s13756-025-01515-8
2.     Engal E, Kerem L, Gileles-Hillel A. Sleep-disordered breathing and diabetes mellitus: a deadly duo. J Clin Sleep Med. 2025;21(1):3-5. doi:10.5664/jcsm.11462
3.     Gordon-Hecker T, Choshen-Hillel S, Ben-Simon E, Walker MP, Perry A, Gileles-Hillel A. Restless nights, cold hearts: Poor sleep causally blunts empathy. Int J Clin Heal Psychol. 2025;25(1). doi:10.1016/j.ijchp.2025.100548
4.     Guzikevits M, Gordon-Hecker T, Rekhtman D, et al. Sex bias in pain management decisions. Proc Natl Acad Sci U S A. 2024;121(33). doi:10.1073/pnas.2401331121
5.     Yelov L, Reiter J, Cruz MME, Gileles-Hillel A. The association of obstructive sleep apnea and behavioral insomnia in children ages 10 and under. J Clin Sleep Med. 2024;20(2):245-251. doi:10.5664/jcsm.10834
6.     Stein ES, Hevroni A, Zarfati M, Erlichman I, Boursheh L, Gileles-Hillel A. Comprehensive pulmonary function analysis identifies predominant obstructive phenotype in former premature infants around one year of age. Pediatr Pulmonol. 2024;59(12):3667-3676. doi:10.1002/ppul.27287
7.     Cetin-Atalay R, Meliton AY, Tian Y, et al. Sustained hypoxia but not intermittent hypoxia induces HIF-1α transcriptional response in human aortic endothelial cells. Mol Omi. 2024;21(1):19-31. doi:10.1039/d4mo00142g
8.     Levin S, Mayer D, Puius YA, Arora S, Gileles-Hillel A. Things We Do for No ReasonTM: Routine respiratory pathogen panels for emergency department and hospitalized patients. J Hosp Med. 2024;19(12):1170-1173. doi:10.1002/jhm.13365
9.     Gileles-Hillel A, Bhattacharjee R, Gorelik M, Narang I. Advances in Sleep-Disordered Breathing in Children. Clin Chest Med. 2024;45(3):651-662. doi:10.1016/j.ccm.2024.03.004
10.     Cohen-Cymberknoh M, Lehavi M, Gileles-Hillel A, Atia O, Breuer O, Reiter J. Changes in Sleep in Children and Adults with Cystic Fibrosis and Primary Ciliary Dyskinesia over Time and after CFTR Modulator Therapy. J Clin Med. 2023;12(24). doi:10.3390/jcm12247612
11.     Sadras I, Kerem E, Livnat G, et al. Clinical and functional efficacy of elexacaftor/tezacaftor/ivacaftor in people with cystic fibrosis carrying the N1303K mutation. J Cyst Fibros. 2023;22(6):1062-1069. doi:10.1016/j.jcf.2023.06.001
12.     Reiter J, Abuelhija H, Slae M, et al. Sleep disorders in children with celiac disease: a prospective study. J Clin Sleep Med. 2023;19(3):591-594. doi:10.5664/jcsm.10396
13.     Adler-Haltovsky T, Gileles-Hillel A, Erlichman I, Eventov-Friedman S. Changes in ventilation modes in the last decade and their impact on the prevalence of bronchopulmonary dysplasia in preterm infants. Pediatr Pulmonol. 2023;58(7):1959-1966. doi:10.1002/ppul.26418
14.     Gileles-Hillel A, Yochi Harpaz L, Breuer O, et al. The clinical yield of bronchoscopy in the management of cystic fibrosis: A retrospective multicenter study. Pediatr Pulmonol. 2023;58(2):500-506. doi:10.1002/ppul.26216
15.     Reiter J, Breuer O, Cohen-Cymberknoh M, Forno E, Gileles-Hillel A. Sleep in children with cystic fibrosis: More under the covers. Pediatr Pulmonol. 2022;57(8):1944-1951. doi:10.1002/ppul.25462
16.     Dahan T, Nassar S, Yajuk O, et al. Chronic Intermittent Hypoxia during Sleep Causes Browning of Interscapular Adipose Tissue Accompanied by Local Insulin Resistance in Mice. Int J Mol Sci. 2022;23(24). doi:10.3390/ijms232415462
17.     Choshen-Hillel S, Sadras I, Gordon-Hecker T, et al. Physicians prescribe fewer analgesics during night shifts than day shifts. Proc Natl Acad Sci U S A. 2022;119(27). doi:10.1073/pnas.2200047119
18.     Reiter J, Ramagopal M, Gileles-Hillel A, Forno E. Sleep disorders in children with asthma. Pediatr Pulmonol. 2022;57(8):1851-1859. doi:10.1002/ppul.25264
19.     Israeli T, Eisenstadt I, Shoseyov D, et al. Respiratory physiotherapy in patients with cystic fibrosis and upper limb deep vein thrombosis. Pediatr Pulmonol. 2022;57(6):1552-1554. doi:10.1002/ppul.25903
20.     Biro O, Gileles-Hillel A, Dor-Wollman T, Eisenstein EM, Berkun Y. Neurological and neurodevelopmental symptoms in children with familial Mediterranean fever and their siblings. Eur J Pediatr. 2022;181(3):973-978. doi:10.1007/s00431-021-04286-7
21.     Gileles-Hillel A, Soesman LH, Miari S, et al. The utility of glucose area under the curve from the oral glucose tolerance test as a screening tool for cystic fibrosis-related diabetes. Pediatr Pulmonol. 2022;57(11):2774-2780. doi:10.1002/ppul.26100
22.     Gileles-Hillel A, Dahan T. Intermittent by day, sustained by night - the worst of both hypoxias? Sleep. 2022;45(6). doi:10.1093/sleep/zsac016
23.     Paltiel O, Hochner H, Chinitz D, et al. Academic activism on behalf of children during the COVID-19 pandemic in Israel; beyond public health advocacy. Isr J Health Policy Res. 2021;10(1). doi:10.1186/s13584-021-00485-7
24.     Raz R, Bar-Or RL, Kark JD, et al. Associations between exposure to industrial air pollution and prevalence of asthma and atopic diseases in haifa bay area. Atmosphere (Basel). 2021;12(4). doi:10.3390/atmos12040516
25.     Choshen-Hillel S, Gileles-Hillel A. A wake-up call: Time to raise physicians’ awareness of the consequences of fatigue. Med Educ. 2021;55(12):1342-1344. doi:10.1111/medu.14655
26.     Mandelkorn U, Genzer S, Choshen-Hillel S, et al. Escalation of sleep disturbances amid the COVID-19 pandemic: A cross-sectional international study. J Clin Sleep Med. 2021;17(1):45-53. doi:10.5664/JCSM.8800
27.     van der Vaart J, Böttinger L, Geurts MH, et al. Modelling of primary ciliary dyskinesia using patient-derived airway organoids. EMBO Rep. 2021;22(12). doi:10.15252/embr.202052058
28.     Gileles-Hillel A, Guttman S, Breuer O, et al. Betamethasone versus dexamethasone for inpatient preschool wheezing—A case-control study. Pediatr Pulmonol. 2021;56(5):875-882. doi:10.1002/ppul.25274
29.     Choshen-Hillel S, Ishqer A, Mahameed F, et al. Acute and chronic sleep deprivation in residents: Cognition and stress biomarkers. Med Educ. 2021;55(2):174-184. doi:10.1111/medu.14296
30.     Gileles-Hillel A. Sickle cell disease and obstructive sleep apnea-bad news for the brain. Sleep. 2021;44(2). doi:10.1093/sleep/zsaa287
31.     Kerem E, Cohen-Cymberknoh M, Tsabari R, et al. Ivacaftor in People with Cystic Fibrosis and a 3849110kb C→T or D1152H Residual Function Mutation. Ann Am Thorac Soc. 2021;18(3):433-441. doi:10.1513/AnnalsATS.202006-659OC
32.     Kaditis AG, Ohler A, Gileles-Hillel A, et al. Effects of the COVID-19 lockdown on sleep duration in children and adolescents: A survey across different continents. Pediatr Pulmonol. 2021;56(7):2265-2273. doi:10.1002/ppul.25367
33.     Khalyfa A, Trzepizur W, Gileles-Hillel A, et al. Heterogeneity of melanoma cell responses to sleep apnea-derived plasma exosomes and to intermittent hypoxia. Cancers (Basel). 2021;13(19). doi:10.3390/cancers13194781
34.     Cohen-Cymberknoh M, Ben Meir E, Gartner S, et al. How abnormal is the normal? Clinical characteristics of CF patients with normal FEV1. Pediatr Pulmonol. 2021;56(7):2007-2013. doi:10.1002/ppul.25371
35.     Grunewald M, Kumar S, Sharife H, et al. Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span. Science. 2021;373(6554). doi:10.1126/science.abc8479
36.     Barak-Corren Y, Barak-Corren N, Gileles-Hillel A, Heiman E. The effect of C-reactive protein on chest X-ray interpretation: A decision-making experiment among pediatricians. Pediatr Pulmonol. 2021;56(6):1644-1650. doi:10.1002/ppul.25299
37.     Bar-Or RL, Levy I, Twig G, et al. Associations of exposure to nitrogen oxides with prevalent asthma and other atopic diseases in Israel. Environ - MDPI. 2021;8(10). doi:10.3390/environments8100110
38.     Gileles-Hillel A, Mor-Shaked H, Shoseyov D, et al. Whole-exome sequencing accuracy in the diagnosis of primary ciliary dyskinesia. ERJ Open Res. 2020;6(4). doi:10.1183/23120541.00213-2020
39.     Ryan S, Cummins EP, Farre R, et al. Understanding the pathophysiological mechanisms of cardiometabolic complications in obstructive sleep apnoea: Towards personalised treatment approaches. Eur Respir J. 2020;56(2). doi:10.1183/13993003.02295-2019
40.     Lavi E, Gileles-Hillel A, Zangen D. Somatic growth in cystic fibrosis. Curr Opin Endocrinol Diabetes Obes. 2020;27(1):38-46. doi:10.1097/MED.0000000000000522
41.     Yogev D, Mahameed F, Gileles-Hillel A, et al. Hijab pin ingestions. Pediatrics. 2020;145(6). doi:10.1542/peds.2019-3472
42.     Reiter J, Gileles-Hillel A, Cohen-Cymberknoh M, et al. Sleep disorders in cystic fibrosis: A systematic review and meta-analysis. Sleep Med Rev. 2020;51. doi:10.1016/j.smrv.2020.101279
43.     Lavi E, Gileles-Hillel A, Simanovsky N, Averbuch D, Wexler ID, Berkun Y. Pyogenic sacroiliitis in children: don’t forget the very young. Eur J Pediatr. 2019;178(4):575-579. doi:10.1007/s00431-019-03333-8
44.     Gileles-Hillel A, Erlichman I, Reiter J. Apnea of Prematurity: An Update. J Child Sci. 2019;9(1):E50-E58. doi:10.1055/s-0039-1678669
45.     Palma J-A, Gileles-Hillel A, Norcliffe-Kaufmann L, Kaufmann H. Chemoreflex failure and sleep-disordered breathing in familial dysautonomia: Implications for sudden death during sleep. Auton Neurosci Basic Clin. 2019;218:10-15. doi:10.1016/j.autneu.2019.02.003
46.     Sadras I, Reiter J, Fuchs N, Erlichman I, Gozal D, Gileles-Hillel A. Prematurity as a risk factor of sleep-disordered breathing in children younger than two years: A retrospective case-control study. J Clin Sleep Med. 2019;15(12):1731-1736. doi:10.5664/jcsm.8072
47.     Cohen-Cymberknoh M, Atia O, Gileles-Hillel A, Kerem E, Reiter J. Sleep disorders in patients with primary ciliary dyskinesia, cystic fibrosis with and without pancreatic insufficiency. Respir Med. 2019;151:96-101. doi:10.1016/j.rmed.2019.03.022
48.     Gross I, Gordon O, Cohen-Cymberknoh M, et al. Giant lung cysts following necrotizing pneumonia: Resolution with conservative treatment. Pediatr Pulmonol. 2019;54(6):901-906. doi:10.1002/ppul.24321
49.     Akbarpour M, Khalyfa A, Qiao Z, et al. Altered CD8+ t-cell lymphocyte function and tc1 cell stemness contribute to enhanced malignant tumor properties in murine models of sleep apnea. Sleep. 2017;40(2). doi:10.1093/sleep/zsw040
50.     Gileles-Hillel A, Almendros I, Khalyfa A, et al. Prolonged exposures to intermittent hypoxia promote visceral white adipose tissue inflammation in a murine model of severe sleep apnea: Effect of normoxic recovery. Sleep. 2017;40(3). doi:10.1093/sleep/zsw074
51.     Gozal D, Gileles-Hillel A, Cortese R, et al. Visceral white adipose tissue after chronic intermittent and sustained hypoxia in mice. Am J Respir Cell Mol Biol. 2017;56(4):477-487. doi:10.1165/rcmb.2016-0243OC
52.     Gemel J, Su Z, Gileles-Hillel A, Khalyfa A, Gozal D, Beyer EC. Intermittent hypoxia causes NOX2-dependent remodeling of atrial connexins. BMC Cell Biol. 2017;18. doi:10.1186/s12860-016-0117-5
53.     Khalyfa A, Poroyko VA, Qiao Z, et al. Exosomes and metabolic function in mice exposed to alternating dark-light cycles mimicking night shift work schedules. Front Physiol. 2017;8(NOV). doi:10.3389/fphys.2017.00882
54.     Cohen-Cymberknoh M, Weigert N, Gileles-Hillel A, et al. Clinical impact of Pseudomonas aeruginosa colonization in patients with Primary Ciliary Dyskinesia. Respir Med. 2017;131:241-246. doi:10.1016/j.rmed.2017.08.028
55.     Khalyfa A, Qiao Z, Gileles-Hillel A, et al. Activation of the integrated stress response and metabolic dysfunction in a murine model of sleep apnea. Am J Respir Cell Mol Biol. 2017;57(4):477-486. doi:10.1165/rcmb.2017-0057OC
56.     Cortese R, Gileles-Hillel A, Khalyfa A, et al. Aorta macrophage inflammatory and epigenetic changes in a murine model of obstructive sleep apnea: Potential role of CD36. Sci Rep. 2017;7. doi:10.1038/srep43648
57.     Khalyfa A, Almendros I, Gileles-Hillel A, et al. Circulating exosomes potentiate tumor malignant properties in a mouse model of chronic sleep fragmentation. Oncotarget. 2016;7(34):54676-54690. doi:10.18632/oncotarget.10578
58.     Gileles-Hillel A, Kheirandish-Gozal L, Gozal D. Biological plausibility linking sleep apnoea and metabolic dysfunction. Nat Rev Endocrinol. 2016;12(5):290-298. doi:10.1038/nrendo.2016.22
59.     Poroyko VA, Carreras A, Khalyfa A, et al. Chronic Sleep Disruption Alters Gut Microbiota, Induces Systemic and Adipose Tissue Inflammation and Insulin Resistance in Mice. Sci Rep. 2016;6. doi:10.1038/srep35405
60.     Almendros I, Khalyfa A, Trzepizur W, et al. Tumor Cell Malignant Properties Are Enhanced by Circulating Exosomes in Sleep Apnea. Chest. 2016;150(5):1030-1041. doi:10.1016/j.chest.2016.08.1438
61.     Khalyfa A, Gileles-Hillel A, Gozal D. The Challenges of Precision Medicine in Obstructive Sleep Apnea. Sleep Med Clin. 2016;11(2):213-226. doi:10.1016/j.jsmc.2016.01.003
62.     Kheirandish-Gozal L, Gileles-Hillel A, Alonso-Álvarez ML, et al. Effects of adenotonsillectomy on plasma inflammatory biomarkers in obese children with obstructive sleep apnea: A community-based study. Int J Obes. 2015;39(7):1094-1100. doi:10.1038/ijo.2015.37
63.     Gileles-Hillel A, Kheirandish-Gozal L, Gozal D. Hemoglobinopathies and sleep - The road less traveled. Sleep Med Rev. 2015;24:57-70. doi:10.1016/j.smrv.2015.01.002
64.     Gileles-Hillel A, Philby MF, Lapping-Carr G. Insights into selected aspects of pediatric sleep medicine. Am J Respir Crit Care Med. 2015;191(12):1459-1461. doi:10.1164/rccm.201502-0279RR
65.     Almendros I, Gileles-Hillel A, Khalyfa A, et al. Adipose tissue macrophage polarization by intermittent hypoxia in a mouse model of OSA: Effect of tumor microenvironment. Cancer Lett. 2015;361(2):233-239. doi:10.1016/j.canlet.2015.03.010
66.     Alkhouri N, Kheirandish-Gozal L, Matloob A, et al. Evaluation of circulating markers of hepatic apoptosis and inflammation in obese children with and without obstructive sleep apnea. Sleep Med. 2015;16(9):1031-1035. doi:10.1016/j.sleep.2015.05.002
67.     Gileles-Hillel A, Shoseyov D, Polacheck I, Korem M, Kerem E, Cohen-Cymberknoh M. Association of chronic Candida albicans respiratory infection with a more severe lung disease in patients with cystic fibrosis. Pediatr Pulmonol. 2015;50(11):1082-1089. doi:10.1002/ppul.23302
68.     Carreras A, Zhang SX, Peris E, et al. Chronic sleep fragmentation induces endothelial dysfunction and structural vascular changes in mice. Sleep. 2014;37(11):1817-1824. doi:10.5665/sleep.4178
69.     Gileles-Hillel A, Almendros I, Khalyfa A, Zhang SX, Wang Y, Gozal D. Early intermittent hypoxia induces proatherogenic changes in aortic wall macrophages in a murine model of obstructive sleep apnea. Am J Respir Crit Care Med. 2014;190(8):958-961. doi:10.1164/rccm.201406-1149LE
70.     Cohen-Cymberknoh M, Simanovsky N, Hiller N, Gileles Hillel A, Shoseyov D, Kerem E. Differences in disease expression between primary ciliary dyskinesia and cystic fibrosis with and without pancreatic insufficiency. Chest. 2014;145(4):738-744. doi:10.1378/chest.13-1162
71.     Gileles-Hillel A, Alonso-Álvarez ML, Kheirandish-Gozal L, et al. Inflammatory markers and obstructive sleep apnea in obese children: The NANOS study. Mediators Inflamm. 2014;2014. doi:10.1155/2014/605280
72.     Simanovsky N, Gileles-Hillel A, Frenkel R, Shosayov D, Hiller N. Correlation between computed tomography expression of pulmonary hypertension and severity of lung disease in cystic fibrosis patients. J Thorac Imaging. 2013;28(6):383-387. doi:10.1097/RTI.0b013e3182956be2
73.     Hiller N, Schor-Bardach R, Gileles-Hillel A, Stroumsa D, Simanovsky N. CT appearance of the pelvis after Cesarean delivery-what is considered normal? Clin Imaging. 2013;37(3):514-519. doi:10.1016/j.clinimag.2012.09.022
74.     Milgrom Y, Goldman G, Gileles Hillel A, Pojurovsky S, Ackerman Z. Tuberculosis: A rare cause of peri-anal disease. Isr Med Assoc J. 2013;15(12):782-783. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84893089568&partnerID=40&md5=8019dbb79b3228179f82d1b99bc6402f
75.     Simanovsky N, Cohen-Cymberknoh M, Shoseyov D, et al. Differences in the pattern of structural abnormalities on CT scan in patients with cystic fibrosis and pancreatic sufficiency or insufficiency. Chest. 2013;144(1):208-214. doi:10.1378/chest.12-1226