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Hadassah Medical Center: Melloul Danielle

Last updated June 2021 - Hadassah Medical Center

List of Publications

(1) Sever D, Hershko-Moshe A, Srivastava R, Eldor R, Hibsher D, Keren-Shaul H, et al. NF-κB activity during pancreas development regulates adult β-cell mass by modulating neonatal β-cell proliferation and apoptosis. Cell Death Discov 2021;7(1).

(2) Amior L, Srivastava R, Nano R, Bertuzzi F, Melloul D. The role of Cox-2 and prostaglandin E2 receptor EP3 in pancreatic b-cell death. FASEB J 2019;33(4):4975-4986.

(3) Ntimbane T, Mailhot G, Spahis S, Rabasa-Lhoret R, Kleme M-, Melloul D, et al. CFTR silencing in pancreaticβ-cells reveals a functional impact on glucose-stimulated insulin secretion and oxidative stress response. Am J Physiol Endocrinol Metab 2016;310(3):E200-E212.

(4) Eldor R, Abel R, Sever D, Sadoun G, Peled A, Sionov R, et al. Inhibition of Nuclear Factor-κB Activation in Pancreatic β-Cells Has a Protective Effect on Allogeneic Pancreatic Islet Graft Survival. PLoS ONE 2013;8(2).

(5) Reich E, Tamary A, Vogt Sionov R, Melloul D. Involvement of thioredoxin-interacting protein (TXNIP) in glucocorticoid-mediated beta cell death. Diabetologia 2012;55(4):1048-1057.

(6) Sever D, Eldor R, Sadoun G, Amior L, Dubois D, Boitard C, et al. Evaluation of impaired β-cell function in nonobese-diabetic (NOD) mouse model using bioluminescence imaging. FASEB J 2011;25(2):676-684.

(7) Eldor R, Baum K, Abel R, Sever D, Melloul D. The ToI-β transgenic mouse: a model to study the specific role of NF-κB in β-cells. Diabetes Res Clin Pract 2009;86(SUPLL.1):S7-S14.

(8) Melloul D. Role of NF-κB in β-cell death. Biochem Soc Trans 2008;36(3):334-339.

(9) Eldor R, Yeffet A, Baum K, Doviner V, Amar D, Ben-Neriah Y, et al. Conditional and specific NF-κB blockade protects pancreatic beta cells from diabetogenic agents. Proc Natl Acad Sci U S A 2006;103(13):5072-5077.

(10) Neve B, Fernandez-Zapico ME, Ashkenazi-Katalan V, Dina C, Hamid YH, Joly E, et al. Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function. Proc Natl Acad Sci U S A 2005;102(13):4807-4812.

(11) Melloul D. Transcription factors in islet development and physiology: Role of PDX-1 in beta-cell function. Ann New York Acad Sci 2004;1014:28-37.

(12) Melloul D, Stoffel M. Regulation of transcriptional coactivator PGC-1alpha. Sci Aging Knowledge Environ 2004;2004(9).

(13) Schwitzgebel VM, Mamin A, Brun T, Ritz-Laser B, Zaiko M, Maret A, et al. Agenesis of human pancreas due to decreased half-life of insulin promoter factor 1. J Clin Endocrinol Metab 2003;88(9):4398-4406.

(14) Melloul D, Marshak S, Cerasi E. Regulation of pdx-1 gene expression. Diabetes 2002;51(SUPPL. 3):S320-S325.

(15) Melloul D, Marshak S, Cerasi E. Regulation of insulin gene transcription. Diabetologia 2002;45(3):309-326.

(16) Melloul D, Tsur A, Zangen D. Pancreatic Duodenal Homeobox (PDX-1) in health and disease. J Pediatr Endocrinol Metab 2002;15(9):1461-1472.

(17) Ben-Shushan E, Marshak S, Shoshkes M, Cerasi E, Melloul D. A Pancreatic β-Cell-specific Enhancer in the Human PDX-1 Gene Is Regulated by Hepatocyte Nuclear Factor 3β (HNF-3β), HNF-1α, and SPs Transcription Factors. J Biol Chem 2001;276(20):17533-17540.

(18) Marshak S, Ben-Shushan E, Shoshkes M, Havin L, Cerasi E, Melloul D. Regulatory elements involved in human pdx-1 gene expression. Diabetes 2001;50(SUPPL. 1):S37-S38.

(19) Leibowitz G, Ferber S, Apelqvist Å, Edlund H, Gross DJ, Cerasi E, et al. IPF1/PDX1 Deficiency and β-Cell Dysfunction in Psammomys obesus, an Animal with Type 2 Diabetes. Diabetes 2001;50(8):1799-1806.

(20) Leibowitz G, Melloul D, Yuli M, Gross DJ, Apelqvist Å, Edlund H, et al. Defective glucose-regulated insulin gene expression associated with PDX-1 deficiency in the Psammomys obesus model of type 2 diabetes. Diabetes 2001;50(SUPPL. 1):S138-S139.

(21) Leibowitz G, Yuli M, Donath MY, Nesher R, Melloul D, Cerasi E, et al. β-cell glucotoxicity in the Psammomys obesus model of type 2 diabetes. Diabetes 2001;50(SUPPL. 1):S113-S117.

(22) Marshak S, Benshushan E, Shoshkes M, Leibovitz G, Kaiser N, Gross D, et al. β-cell-specific expression of insulin and PDX-1 genes. Diabetes 2001;50(SUPPL. 1):S131-S132.

(23) Marshak S, Leibowitz G, Bertuzzi F, Socci C, Kaiser N, Gross DJ, et al. Impaired β-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose. Diabetes 2000;48(6):1230-1236.

(24) Melloul D, Kaiser N, Cerasi E. Chronic exposure to high glucose impairs multiple β-cell functions in cultured human pancreatic islets. Curr Opin Endocrinol Diabetes 2000;7(1):44-48.

(25) Marshak S, Benshushan E, Shoshkes M, Havin L, Cerasi E, Melloul D. Functional conservation of regulatory elements in the pdx-1 gene: PDX-1 and hepatocyte nuclear factor 3β transcription factors mediate β-cell-specific expression. Mol Cell Biol 2000;20(20):7583-7590.

(26) Shushan EB, Cerasi E, Melloul D. Regulation of the insulin gene by glucose: Stimulation of trans- activation potency of human PDX-1 N-terminal domain. DNA Cell Biol 1999;18(6):471-479.

(27) Cerasi E, Marshak S, Totary H, Melloul D. 1997 Maurice Dérot. Transcriptional regulation of the insulin gene: a step toward gene therapy of diabetes. Journ Annu Diabetol Hotel Dieu 1997:299-304.

(28) Marshak S, Totary H, Cerasi E, Melloul D. Purification of the β-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells. Proc Natl Acad Sci U S A 1996;93(26):15057-15062.

(29) German M, Ashcroft S, Docherty K, Edlund H, Edlund T, Goodison S, et al. The insulin gene promoter: A simplified nomenclature. Diabetes 1995;44(8):1002-1004.

(30) Zion M, Ben-Yehuda D, Avraham A, Cohen O, Wetzler M, Melloul D, et al. Progressive de novo DNA methylation at the bcr-abl locus in the course of chronic myelogenous leukemia. Proc Natl Acad Sci U S A 1994;91(22):10722-10726.

(31) Melloul D, Cerasi E. Transcription of the insulin gene: towards defining the glucosesensitive cis-element and trans-acting factors. Diabetologia 1994;37(2 Supplement):S3-S10.

(32) Melloul D, Ben-Neriah Y, Cerasi E. Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters. Proc Natl Acad Sci U S A 1993;90(9):3865-3869.

(33) Sasson S, Ashhab Y, Melloul D, Cerasi E. Autoregulation of glucose transport: Effects of glucose on glucose transporter expression and cellular location in muscle. ADV EXP MED BIOL 1993;334:113-127.

(34) Yisraeli J, Adelstein RS, Melloul D, Nudel U, Yaffe D, Cedar H. Muscle-specific activation of a methylated chimeric actin gene. Cell 1986;46(3):409-416.

(35) Yaffe D, Nudel U, Czosnek H, Melloul D, Aloni B. The chromosomal assignment of muscle-specific genes. Adv Exp Med Biol 1985;182:295-307.

(36) Melloul D, Aloni B, Calvo J, Yaffe D, Nudel U. Developmentally regulated expression of chimeric genes containing muscle actin DNA sequences in transfected myogenic cells. EMBO J 1984;3(5):983-990.

(37) Herzberg M, Palmon T, Melloul D. A cellular model of ribosomal aging in eukaryotic cells. Biol Cell 1980;39(2):179-182.

(38) Herzberg M, Melloul D. Plasma membrane RNase activity in mammalian cells. Exp Cell Res 1979;122(2):410-416.

(39) WRESCHNER D, MELLOUL D, HERZBERG M. Interaction between Membrane Functions and Protein Synthesis in Reticulocytes: Isolation of RNase M, a Membrane Component Inhibiting Protein Synthesis through Specific Endonucleolytic Activity. Eur J Biochem 1978;89(2):341-352.

(40) WRESCHNER D, MELLOUL D, HERZBERG M. Interaction between Membrane Functions and Protein Synthesis in Reticulocytes: Specific Cleavage of 28‐S Ribosomal RNA by a Membrane Constituent. Eur J Biochem 1978;85(1):233-240.

(41) Wreschner D, Melloul D, Herzberg M. Specific degradation of ribosomal RNA in rabbit reticulocyte membrane-bound ribosomes. FEBS Lett 1977;77(1):83-86.