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Hadassah Medical Center: Elkin Michael

Last updated June 2021 - Hadassah Medical Center

List of Publications

(1) Hermano E, Carlotti F, Abecassis A, Meirovitz A, Rubinstein AM, Li J-, et al. Dichotomic role of heparanase in a murine model of metabolic syndrome. Cell Mol Life Sci 2021;78(6):2771-2780.

(2) Gnanasekaran J, Gallimidi AB, Saba E, Pandi K, Berchoer LE, Hermano E, et al. Intracellular Porphyromonas gingivalis promotes the tumorigenic behavior of pancreatic carcinoma cells. Cancers 2020;12(8):1-14.

(3) Visochek L, Castiel A, Mittelman L, Elkin M, Atias D, Golan T, et al. Erratum: Exclusive destruction of mitotic spindles in human cancer cells (Oncotarget (2017) 8 (20813-20824) DOI: 10.18632/oncotarget.15343). Oncotarget 2020;11(14):1290-1291.

(4) Elkin M. Role of Heparanase in Macrophage Activation. Adv Exp Med Biol 2020;1221:445-460.

(5) Goldberg R, Meirovitz A, Abecassis A, Hermano E, Rubinstein AM, Nahmias D, et al. Regulation of Heparanase in Diabetes-Associated Pancreatic Carcinoma. Front Oncol 2019;9.

(6) Hermano E, Goldberg R, Rubinstein AM, Sonnenblick A, Maly B, Nahmias D, et al. Heparanase accelerates obesity-associated breast cancer progression. Cancer Res 2019;79(20):5342-5354.

(7) Rabelink TJ, Van Den Berg BM, Garsen M, Wang G, Elkin M, Van Der Vlag J. Heparanase: Roles in cell survival, extracellular matrix remodelling and the development of kidney disease. Nat Rev Nephrol 2017;13(4):201-212.

(8) Gallimidi AB, Nussbaum G, Hermano E, Weizman B, Meirovitz A, Vlodavsky I, et al. Syndecan-1 deficiency promotes tumor growth in a murine model of colitis-induced colon carcinoma. PLoS ONE 2017;12(3).

(9) Sanderson RD, Elkin M, Rapraeger AC, Ilan N, Vlodavsky I. Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy. FEBS J 2017;284(1):42-55.

(10) Goldberg R, Sonnenblick A, Hermano E, Hamburger T, Meirovitz A, Peretz T, et al. Heparanase augments insulin receptor signaling in breast carcinoma. Oncotarget 2017;8(12):19403-19412.

(11) Visochek L, Castiel A, Mittelman L, Elkin M, Atias D, Golan T, et al. Exclusive destruction of mitotic spindles in human cancer cells. Oncotarget 2017;8(13):20813-20824.

(12) Vlodavsky I, Singh P, Boyango I, Gutter-Kapon L, Elkin M, Sanderson RD, et al. Heparanase: From basic research to therapeutic applications in cancer and inflammation. Drug Resist Updates 2016;29:54-75.

(13) Garsen M, Benner M, Dijkman HB, Van Kuppevelt TH, Li J-, Rabelink TJ, et al. Heparanase is essential for the development of acute experimental glomerulonephritis. Am J Pathol 2016;186(4):805-815.

(14) Gallimidi AB, Fischman S, Revach B, Bulvik R, Maliutina A, Rubinstein AM, et al. Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model. Oncotarget 2015;6(26):22613-22623.

(15) Hirshoren N, Bulvik R, Neuman T, Rubinstein AM, Meirovitz A, Elkin M. Induction of heparanase by HPV E6 oncogene in head and neck squamous cell carcinoma. J Cell Mol Med 2014;18(1):181-186.

(16) Hermano E, Meirovitz A, Meir K, Nussbaum G, Appelbaum L, Peretz T, et al. Macrophage polarization in pancreatic carcinoma: Role of heparanase enzyme. J Natl Cancer Inst 2014;106(12).

(17) Lerner I, Zcharia E, Neuman T, Hermano E, Rubinstein AM, Vlodavsky I, et al. Heparanase is preferentially expressed in human psoriatic lesions and induces development of psoriasiform skin inflammation in mice. Cell Mol Life Sci 2014;71(12):2347-2357.

(18) Goldberg R, Rubinstein AM, Gil N, Hermano E, Li J-, Van Der Vlag J, et al. Role of heparanase-driven inflammatory cascade in pathogenesis of diabetic nephropathy. Diabetes 2014;63(12):4302-4313.

(19) Goldberg R, Meirovitz A, Hirshoren N, Bulvik R, Binder A, Rubinstein AM, et al. Versatile role of heparanase in inflammation. Matrix Biol 2013;32(5):234-240.

(20) Meirovitz A, Goldberg R, Binder A, Rubinstein AM, Hermano E, Elkin M. Heparanase in inflammation and inflammation-associated cancer. FEBS J 2013;280(10):2307-2319.

(21) Hermano E, Lerner I, Elkin M. Heparanase enzyme in chronic inflammatory bowel disease and colon cancer. Cell Mol Life Sci 2012;69(15):2501-2513.

(22) Vlodavsky I, Beckhove P, Lerner I, Pisano C, Meirovitz A, Ilan N, et al. Significance of heparanase in cancer and inflammation. Cancer Microenvironment 2012;5(2):115-132.

(23) Gil N, Goldberg R, Neuman T, Garsen M, Zcharia E, Rubinstein AM, et al. Heparanase is essential for the development of diabetic nephropathy in mice. Diabetes 2012;61(1):208-216.

(24) Lerner I, Hermano E, Zcharia E, Rodkin D, Bulvik R, Doviner V, et al. Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice. J Clin Invest 2011;121(5):1709-1721.

(25) Meirovitz A, Hermano E, Lerner I, Zcharia E, Pisano C, Peretz T, et al. Role of heparanase in radiation-enhanced invasiveness of pancreatic carcinoma. Cancer Res 2011;71(7):2772-2780.

(26) Ilan N, Fux L, Elkin M, Vlodavsky I. Molecular and cellular aspects of heparanase. Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy; 2008. p. 247-272.

(27) Vlodavsky I, Elkin M, Abboud-Jarrous G, Levi-Adam F, Fuks L, Shafat I, et al. Heparanase: One molecule with multiple functions in cancer progression. Connect Tissue Res 2008;49(3-4):207-210.

(28) Lerner I, Baraz L, Pikarsky E, Meirovitz A, Edovitsky E, Peretz T, et al. Function of heparanase in prostate tumorigenesis: Potential for therapy. Clin Cancer Res 2008;14(3):668-676.

(29) Patel VN, Knox SM, Likar KM, Lathrop CA, Hossain R, Eftekhari S, et al. Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. Development (Cambridge) 2007;134(23):4177-4186.

(30) Cohen I, Maly B, Simon I, Meirovitz A, Pikarsky E, Zcharia E, et al. Tamoxifen induces heparanase expression in estrogen receptor - Positive breast cancer. Clin Cancer Res 2007;13(14):4069-4077.

(31) Philp D, St-Surin S, Cha H-, Moon H-, Kleinman HK, Elkin M. Thymosin beta 4 induces hair growth via stem cell migration and differentiation. Ann New York Acad Sci 2007;1112:95-103.

(32) Cid MC, Hoffman MP, Hernández-Rodríguez J, Segarra M, Elkin M, Sánchez M, et al. Association between increased CCL2 (MCP-1) expression in lesions and persistence of disease activity in giant-cell arteritis. Rheumatology (UK) 2006;45(11):1356-1363.

(33) Ilan N, Elkin M, Vlodavsky I. Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis. Int J Biochem Cell Biol 2006;38(12):2018-2039.

(34) Baraz L, Haupt Y, Elkin M, Peretz T, Vlodavsky I. Tumor suppressor p53 regulates heparanase gene expression. Oncogene 2006;25(28):3939-3947.

(35) Edovitsky E, Lerner I, Zcharia E, Peretz T, Vlodavsky I, Elkin M. Role of endothelial heparanase in delayed-type hypersensitivity. Blood 2006;107(9):3609-3616.

(36) Vlodavsky I, Abboud-Jarrous G, Elkin M, Naggi A, Casu B, Sasisekharan R, et al. The impact of heparanase and heparin on cancer metastasis and angiogenesis. Pathophysiol Haemost Thromb 2006;35(1-2):P116-P127.

(37) Cohen I, Pappo O, Elkin M, San T, Bar-Shavit R, Hazan R, et al. Heparanase promotes growth, angiogenesis and survival of primary breast tumors. Int J Cancer 2006;118(7):1609-1617.

(38) Zcharia E, Philp D, Edovitsky E, Aingorn H, Metzger S, Kleinman HK, et al. Heparanase regulates murine hair growth. Am J Pathol 2005;166(4):999-1008.

(39) Edovitsky E, Elkin M, Zcharia E, Peretz T, Vlodavsky I. Heparanase gene silencing, tumor invasiveness, angiogenesis, and metastasis. J Natl Cancer Inst 2004;96(16):1219-1230.

(40) Elkin M, Orgel A, Kleinman HK. An angiogenic switch in breast cancer involves estrogen and soluble vascular endothelial growth factor receptor 1. J Natl Cancer Inst 2004;96(11):875-878.

(41) Zcharia E, Metzger S, Chajek-Shaul T, Aingorn H, Elkin M, Friedmann Y, et al. Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior. FASEB J 2004;18(2):252-263.

(42) Philp D, Nguyen M, Scheremeta B, St-Surin S, Villa AM, Orgel A, et al. Thymosin beta4 increases hair growth by activation of hair follicle stem cells. FASEB J 2004;18(2):385-387.

(43) Elkin M, Cohen I, Zcharia E, Orgel A, Guatta-Rangini Z, Peretz T, et al. Regulation of Heparanase Gene Expression by Estrogen in Breast Cancer. Cancer Res 2003;63(24):8821-8826.

(44) Vlodavsky I, Goldshmidt O, Zcharia E, Atzmon R, Rangini-Guatta Z, Elkin M, et al. Mammalian heparanase: Involvement in cancer metastasis, angiogenesis and normal development. Semin Cancer Biol 2002;12(2):121-129.

(45) Zcharia E, Metzger S, Chajek-Shaul T, Friedmann Y, Pappo O, Aviv A, et al. Molecular properties and involvement of heparanase in cancer progression and mammary gland morphogenesis. J Mammary Gland Biol Neoplasia 2001;6(3):311-322.

(46) Song Gho Y, Kim PN, Li H-, Elkin M, Kleinman HK. Stimulation of tumor growth by human soluble intercellular adhesion molecule-1. Cancer Res 2001;61(10):4253-4257.

(47) Elkin M, Vlodavsky I. Tail vein assay of cancer metastasis. Curr Protoc Cell Biol 2001;Chapter 19.

(48) Elkin M, Ilan N, Ishai-Michaeli R, Friedmann Y, Papo O, Pecker I, et al. Heparanase as mediator of angiogenesis: mode of action. FASEB J 2001;15(9):1661-1663.

(49) Vlodavsky I, Elkin M, Pappo O, Aingorn H, Atzmon R, Ishai-Michaeli R, et al. Mammalian heparanase as mediator of tumor metastasis and angiogenesis. Isr Med Assoc J 2000;2(SUPPL. JULY):37-45.

(50) Elkin M, Miao H-, Nagler A, Aingorn E, Reich R, Hemo I, et al. Halofuginone: A potent inhibitor of critical steps in angiogenesis progression. FASEB J 2000;14(15):2477-2485.

(51) Miao H-, Elkin M, Aingorn E, Ishai-Michaeli R, Stein CA, Vlodavsky I. Inhibition of heparanase activity and tumor metastasis by laminarin sulfate and synthetic phosphorothioate oligodeoxynucleotides. Int J Cancer 1999;83(3):424-431.

(52) Elkin M, Ariel I, Miao H-, Nagler A, Pines M, De-Groot N, et al. Inhibition of bladder carcinoma angiogenesis, stromal support, and tumor growth by halofuginone. Cancer Res 1999;59(16):4111-4118.

(53) Elkin M, Reich R, Nagler A, Aingorn E, Pines M, De-Groot N, et al. Inhibition of matrix metalloproteinase-2 expression and bladder carcinoma metastasis by halofuginone. Clin Canc Res 1999;5(8):1982-1988.

(54) Vlodavsky I, Friedmann Y, Elkin M, Aingorn H, Atzmon R, Ishai-Michaeli R, et al. Mammalian heparanase: Gene cloning, expression and function in tumor progression and metastasis. Nat Med 1999;5(7):793-802.

(55) Elkin M, Ayesh S, Schneider T, De Groot N, Hochberg A, Ariel I. The dynamics of the imprinted H19 gene expression in the mouse model of bladder carcinoma induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis 1998;19(12):2095-2099.

(56) Rachmilewitz J, Elkin M, Looijenga LHJ, Verkerk AJMH, Gonik B, Lustig O, et al. Characterization of the imprinted IPW gene: Allelic expression in normal and tumorigenic human tissues. Oncogene 1996;13(8):1687-1692.

(57) Goshen R, Hochberg AA, Korner G, Levy E, Ishai-Michaeli R, Elkin M, et al. Purification and characterization of placental heparanase and its expression by cultured cytotrophoblasts. Mol Hum Reprod 1996;2(9):679-684.

(58) Elkin M, Shevelev A, Schulze E, Tykocinsky M, Cooper M, Ariel I, et al. The expression of the imprinted H19 and IGF-2 genes in human bladder carcinoma. FEBS Lett 1995;374(1):57-61.

(59) Rachmilewitz J, Goshen R, Elkin M, Gonik B, Neaman Z, Giloh H, et al. The interaction between cytotrophoblasts and their derived tumor cells. Gynecol Oncol 1995;57(3):356-365.

(60) Rachmilewitz J, Elkin M, Rosensaft J, Gelman-Kohan Z, Ariel I, Lustig O, et al. H19 expression and tumorigenicity of choriocarcinoma derived cell lines. Oncogene 1995;11(5):863-870.

(61) Ariel I, Lustig O, Oyer CE, Elkin M, Gonik B, Rachmilewitz J, et al. Relaxation of Imprinting in Trophoblastic Disease. Gynecol Oncol 1994;53(2):212-219.