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Hadassah Medical Center: Katz-Brull Rachel

Last updated December 2021 - Hadassah Medical Center

List of Publications

(1) Grieb B, Uppala S, Sapir G, Shaul D, Gomori JM, Katz-Brull R. Curbing action potential generation or ATP-synthase leads to a decrease in in-cell pyruvate dehydrogenase activity in rat cerebrum slices. Sci Rep 2021;11(1).

(2) Sapir G, Steinberg DJ, Aqeilan RI, Katz-Brull R. Real-time non-invasive and direct determination of lactate dehydrogenase activity in cerebral organoids—a new method to characterize the metabolism of brain organoids? Pharmaceuticals 2021;14(9).

(3) Shaul D, Grieb B, Sapir G, Uppala S, Sosna J, Gomori JM, et al. The metabolic representation of ischemia in rat brain slices: A hyperpolarized 13C magnetic resonance study. NMR Biomed 2021;34(7).

(4) Sapir G, Shaul D, Lev-Cohain N, Sosna J, Gomori MJ, Katz-Brull R. Ldh and pdh activities in the ischemic brain and the effect of reperfusion—an ex vivo mr study in rat brain slices using hyperpolarized [1-13 c]pyruvate. Metabolites 2021;11(4).

(5) Shaul D, Azar A, Sapir G, Uppala S, Nardi-Schreiber A, Gamliel A, et al. Correlation between lactate dehydrogenase/pyruvate dehydrogenase activities ratio and tissue pH in the perfused mouse heart: A potential noninvasive indicator of cardiac pH provided by hyperpolarized magnetic resonance. NMR Biomed 2021;34(2).

(6) Uppala S, Gamliel A, Sapir G, Sosna J, Gomori JM, Katz-Brull R. Observation of glucose-6-phosphate anomeric exchange in real-time using dDNP hyperpolarised NMR. RSC Adv 2020;10(67):41197-41201.

(7) Kreis F, Wright AJ, Somai V, Katz-Brull R, Brindle KM. Increasing the sensitivity of hyperpolarized [15N2]urea detection by serial transfer of polarization to spin-coupled protons. Magn Reson Med 2020;84(4):1844-1856.

(8) Lev-Cohain N, Sapir G, Harris T, Azar A, Gamliel A, Nardi-Schreiber A, et al. Erratum to: Real-time ALT and LDH activities determined in viable precision-cut mouse liver slices using hyperpolarized [1- 13 C]pyruvate-Implications for studies on biopsied liver tissues (NMR in Biomedicine, (2019), 32, 2, (e4043), 10.1002/nbm.4043). NMR Biomed 2020;33(9).

(9) Harris T, Gamliel A, Nardi-Schreiber A, Sosna J, Gomori JM, Katz-Brull R. The Effect of Gadolinium Doping in [13C6,2H7]Glucose Formulations on 13C Dynamic Nuclear Polarization at 3.35 T. ChemPhysChem 2020;21(3):251-256.

(10) Harris T, Uppala S, Lev-Cohain N, Adler-Levy Y, Shaul D, Nardi-Schreiber A, et al. Hyperpolarized product selective saturating-excitations for determination of changes in metabolic reaction rates in real-time. NMR Biomed 2020;33(2).

(11) Sapir G, Harris T, Uppala S, Nardi-Schreiber A, Sosna J, Gomori JM, et al. [13C6,D8]2-deoxyglucose phosphorylation by hexokinase shows selectivity for the β-anomer. Sci Rep 2019;9(1).

(12) Uppala S, Gamliel A, Harris T, Sosna J, Gomori JM, Jerschow A, et al. 1H-decoupling and Isotopic Labeling for the Measurement of the Longitudinal Relaxation Time of Hyperpolarized 13C-Methylenes in Choline Analogs. Isr J Chem 2019;59(11-12):1014-1019.

(13) Adler-Levy Y, Nardi-Schreiber A, Harris T, Shaul D, Uppala S, Sapir G, et al. In-cell determination of lactate dehydrogenase activity in a luminal breast cancer model – ex vivo investigation of excised xenograft tumor slices using dDNP hyperpolarized [1-13C]pyruvate. Sensors 2019;19(9).

(14) Gamliel A, Uppala S, Sapir G, Harris T, Nardi-Schreiber A, Shaul D, et al. Hyperpolarized [ 15 N]nitrate as a potential long lived hyperpolarized contrast agent for MRI. J Magn Reson 2019;299:188-195.

(15) Lev-Cohain N, Sapir G, Harris T, Azar A, Gamliel A, Nardi-Schreiber A, et al. Real-time ALT and LDH activities determined in viable precision-cut mouse liver slices using hyperpolarized [1-13C]pyruvate—Implications for studies on biopsied liver tissues. NMR Biomed 2019;32(2).

(16) Harris T, Azar A, Sapir G, Gamliel A, Nardi-Schreiber A, Sosna J, et al. Real-time ex-vivo measurement of brain metabolism using hyperpolarized [1-13C]pyruvate. Sci Rep 2018;8(1).

(17) Nardi-Schreiber A, Gamliel A, Harris T, Sapir G, Sosna J, Gomori JM, et al. Correction: Biochemical phosphates observed using hyperpolarized 31P in physiological aqueous solutions (Nature Communications (2017) DOI: 10.1038/s41467-017-00364-3). Nat Commun 2018;9(1).

(18) Harris T, Gamliel A, Sosna J, Gomori JM, Katz-Brull R. Impurities of [1-13C]Pyruvic Acid and a Method to Minimize Their Signals for Hyperpolarized Pyruvate Metabolism Studies. Appl Magn Reson 2018;49(10):1085-1098.

(19) Harris T, Gamliel A, Uppala S, Nardi-Schreiber A, Sosna J, Gomori JM, et al. Long-lived 15N Hyperpolarization and Rapid Relaxation as a Potential Basis for Repeated First Pass Perfusion Imaging – Marked Effects of Deuteration and Temperature. ChemPhysChem 2018;19(17):2148-2152.

(20) Hövener J-, Pravdivtsev AN, Kidd B, Bowers CR, Glöggler S, Kovtunov KV, et al. Parahydrogen-Based Hyperpolarization for Biomedicine. Angew Chem Int Ed 2018;57(35):11140-11162.

(21) Nardi-Schreiber A, Gamliel A, Harris T, Sapir G, Sosna J, Gomori JM, et al. Biochemical phosphates observed using hyperpolarized 31P in physiological aqueous solutions. Nat Commun 2017;8(1).

(22) Grigoletto J, Pukaß K, Gamliel A, Davidi D, Katz-Brull R, Richter-Landsberg C, et al. Higher levels of myelin phospholipids in brains of neuronal α-Synuclein transgenic mice precede myelin loss. Acta Neuropathol Commun 2017;5(1):37.

(23) Nardi-Schreiber A, Sapir G, Gamliel A, Kakhlon O, Sosna J, Gomori JM, et al. Defective ATP breakdown activity related to an: ENTPD1 gene mutation demonstrated using 31P NMR spectroscopy. Chem Commun 2017;53(65):9121-9124.

(24) Banne E, Meiner V, Shaag A, Katz-Brull R, Gamliel A, Korman S, et al. Transaldolase deficiency: A new case expands the phenotypic spectrum. JIMD Reports 2016;26:31-36.

(25) Gamliel A, Chendler N, Moshe Gomori J, Sosna J, Katz-Brull R. The Sensitivity of Phosphocholine 13C Chemical Shifts to pH. Appl Magn Reson 2016;47(1):111-120.

(26) Friesen-Waldner LJ, Wade TP, Thind K, Chen AP, Gomori JM, Sosna J, et al. Hyperpolarized choline as an MR imaging molecular probe: Feasibility of in vivo imaging in a rat model. J Magn Reson Imaging 2015;41(4):917-923.

(27) Friesen-Waldner LJ, Wiens CN, Wade TP, Thind K, Sinclair KP, Hovav Y, et al. Direct enzyme-substrate affinity determination by real-time hyperpolarized 13C-MRS. Chem Commun 2014;50(89):13801-13804.

(28) Allouche-Arnon H, Arazi-Kleinman T, Fraifeld S, Uziely B, Katz-Brull R. MRS of the Breast. Comprehensive Biomedical Physics; 2014. p. 299-314.

(29) Allouche-Arnon H, Hovav Y, Friesen-Waldner L, Sosna J, Moshe Gomori J, Vega S, et al. Quantification of rate constants for successive enzymatic reactions with DNP hyperpolarized MR. NMR Biomed 2014;27(6):656-662.

(30) Allouche-Arnon H, Gamliel A, Sosna J, Moshe Gomori J, Katz-Brull R. In vitro visualization of betaine aldehyde synthesis and oxidation using hyperpolarized magnetic resonance spectroscopy. Chem Commun 2013;49(63):7076-7078.

(31) Allouche-Arnon H, Wade T, Waldner LF, Miller VN, Gomori JM, Katz-Brull R, et al. In vivo magnetic resonance imaging of glucose - initial experience. Contrast Media Mol Imaging 2013;8(1):72-82.

(32) Allouche-Arnon H, Lerche MH, Karlsson M, Lenkinski RE, Katz-Brull R. Deuteration of a molecular probe for DNP hyperpolarization - A new approach and validation for choline chloride. Contrast Media Mol Imaging 2011;6(6):499-506.

(33) Allouche-Arnon H, Gamliel A, Barzilay CM, Nalbandian R, Gomori JM, Karlsson M, et al. A hyperpolarized choline molecular probe for monitoring acetylcholine synthesis. Contrast Media Mol Imaging 2011;6(3):139-147.

(34) Gamliel A, Allouche-Arnon H, Nalbandian R, Barzilay CM, Gomori JM, Katz-Brull R. An Apparatus for Production of Isotopically and Spin-Enriched Hydrogen for Induced Polarization Studies. Appl Magn Reson 2010;39(4):329-345.

(35) Edvardson S, Korman SH, Livne A, Shaag A, Saada A, Nalbandian R, et al. L-arginine:glycine amidinotransferase (AGAT) deficiency: Clinical presentation and response to treatment in two patients with a novel mutation. Mol Genet Metab 2010;101(2-3):228-232.

(36) Lima MA, Katz-Brull R, Lenkinski RE, Nunez R, Feinrider D, Koralnik IJ. Remission of progressive multifocal leukoencephalopathy and primary central nervous system lymphoma in an HIV-infected patient. Eur J Neurol 2007;14(6):598-602.

(37) Katz-Brull R, Alsop DC, Marquis RP, Lenkinski RE. Limits on activation-induced temperature and metabolic changes in the human primary visual cortex. Magn Reson Med 2006;56(2):348-355.

(38) Katz-Brull R, Koudinov AR, Degani H. Direct detection of brain acetylcholine synthesis by magnetic resonance spectroscopy. Brain Res 2005;1048(1-2):202-210.

(39) Katz-Brull R, Rofsky NM, Morrin MM, Pedrosa I, George DJ, Michaelson MD, et al. Decreases in free cholesterol and fatty acid unsaturation in renal cell carcinoma demonstrated by breath-hold magnetic resonance spectroscopy. Am J Physiol Renal Physiol 2005;288(4 57-4):F637-F641.

(40) Katz-Brull R, Lenkinski RE, Du Pasquier RA, Koralnik IJ. Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathy. Neurology 2004;63(5):897-900.

(41) Katz-Brull R, Lenkinski RE. Frame-by-Frame PRESS 1H-MRS of the Brain at 3 T: The Effects of Physiological Motion. Magn Reson Med 2004;51(1):184-187.

(42) Katz-Brull R, Rofsky NM, Lenkinski RE. Breathhold abdominal and thoracic proton MR spectroscopy at 3T. Magn Reson Med 2003;50(3):461-467.

(43) Katz-Brull R, Koudinov AR, Degani H. Choline in the aging brain. Brain Res 2002;951(2):158-165.

(44) Katz-Brull R, Lavin PT, Lenkinski RE. Clinical utility of proton magnetic resonance spectroscopy in characterizing breast lesions. J Natl Cancer Inst 2002;94(16):1197-1203.

(45) Katz-Brull R, Seger D, Rivenson-Segal D, Rushkin E, Degani H. Metabolic markers of breast cancer: Enhanced choline metabolism and reduced choline-ether-phospholipid synthesis. Cancer Res 2002;62(7):1966-1970.

(46) Katz-Brull R, Margalit R, Degani H. Differential routing of choline in implanted breast cancer and normal organs. Magn Reson Med 2001;46(1):31-38.

(47) Katz-Brull R, Margalit R, Bendel P, Degani H. Choline metabolism in breast cancer; 2H-, 13C- and 31P-NMR studies of cells and tumors. Magn Reson Mater Phys Biol Med 1998;6(1):44-52.

(48) Katz-Brull R, Degani H. Kinetics of choline transport and phosphorylation in human breast cancer cells; NMR application of the zero trans method. Anticancer Res 1996;16(3 B):1375-1379.