Skip to Main Content

HUJI logo Hebrew
The Library Authority    רשות הספריות

Library Research Guides    מדריכים לפי תחומים


Hadassah Medical Center: Gorodetsky Raphael

Last updated September 2024 - Hadassah Medical Center

List of Publications

1.            Gadomski, S. J. et al. Time- and cell-specific activation of BMP signaling restrains chondrocyte hypertrophy. iScience 27, (2024).

2.            Amend, B. et al. Regulation of Immune Checkpoint Antigen CD276 (B7-H3) on Human Placenta-Derived Mesenchymal Stromal Cells in GMP-Compliant Cell Culture Media. Int. J. Mol. Sci. 24, (2023).

3.            Adani, B., Sapir, E., Volinsky, E., Lazmi-Hailu, A. & Gorodetsky, R. Alleviation of Severe Skin Insults Following High-Dose Irradiation with Isolated Human Fetal Placental Stromal Cells. Int. J. Mol. Sci. 23, (2022).

4.            Gorodetsky, R. & Aicher, W. K. Allogenic use of human placenta-derived stromal cells as a highly active subtype of mesenchymal stromal cells for cell-based therapies. Int. J. Mol. Sci. 22, (2021).

5.            Volinsky, E. et al. Alleviation of acute radiation-induced bone marrow failure in mice with human fetal placental stromal cell therapy. Stem Cell Res. Ther. 11, (2020).

6.            Adani, B. et al. Isolation and expansion of high yield of pure mesenchymal stromal cells from fresh and cryopreserved placental tissues. Cryobiology 89, 100–103 (2019).

7.            Kuznetsov, S. A. et al. In Vivo Formation of Stable Hyaline Cartilage by Naïve Human Bone Marrow Stromal Cells with Modified Fibrin Microbeads. Stem Cells Transl. Med. 8, 586–592 (2019).

8.            Pinzur, L. et al. Rescue from lethal acute radiation syndrome (ARS) with severe weight loss by secretome of intramuscularly injected human placental stromal cells. J. Cachexia. Sarcopenia Muscle 9, 1079–1092 (2018).

9.            Pitcovski, J., Shahar, E., Aizenshtein, E. & Gorodetsky, R. Melanoma antigens and related immunological markers. Crit. Rev. Oncol. Hematol. 115, 36–49 (2017).

10.          Shapira, I. et al. Placental stromal cell therapy for experimental autoimmune encephalomyelitis: The role of route of cell delivery. Stem Cells Transl. Med. 6, 1286–1294 (2017).

11.          Shahar, E., Gorodetsky, R., Aizenshtein, E., Lalush, L. & Pitcovski, J. Modulating the innate immune activity in murine tumor microenvironment by a combination of inducer molecules attached to microparticles. Cancer Immunol. Immunother. 64, 1137–1149 (2015).

12.          Gaberman, E. et al. Mitigation of Lethal Radiation Syndrome in Mice by Intramuscular Injection of 3D Cultured Adherent Human Placental Stromal Cells. PLoS One 8, (2013).

13.          Xie, M. W. et al. Erratum: Marrow-derived stromal cell delivery on fibrin microbeads can correct radiation-induced wound-healing deficits (Journal of Investigative Dermatology (2013) 133 (553-561) DOI: 10.1038/jid.2012.326). J. Invest. Dermatol. 133, 859 (2013).

14.          Xie, M. W. et al. Marrow-derived stromal cell delivery on fibrin microbeads can correct radiation-induced wound-healing deficits. J. Invest. Dermatol. 133, 553–561 (2013).

15.          Basheer, M. et al. Blood pressure modulation following activation of mast cells by cationic cell penetrating peptides. Peptides 32, 2444–2451 (2011).

16.          Gorodetsky, R. et al. Fibrin microbeads loaded with mesenchymal cells support their long-term survival while sealed at room temperature. Tissue Eng. - Part C Methods 17, 745–755 (2011).

17.          Gefen, T. et al. Coated cross-species antibodies by mannosamine-biotin adduct confer protection against snake venom without eliciting humoral immune response. Vaccine 28, 8197–8202 (2010).

18.          Basheer, M. et al. Mast cell activation by fibrinogen-related homologous c-terminal peptides (haptides) modulates systemic blood pressure. J. Allergy Clin. Immunol. 126, 1041–1048 (2010).

19.          Shahar, E., Gorodetsky, R., Gaberman, E., Aizenshtein, E. & Pitcovski, J. Targeted microbeads for attraction and induction of specific innate immune response in the tumor microenvironment. Vaccine 28, 7279–7287 (2010).

20.          Levy-Beladev, L., Levdansky, L., Gaberman, E., Friedler, A. & Gorodetsky, R. A family of cell-adhering peptides homologous to fibrinogen C-termini. Biochem. Biophys. Res. Commun. 401, 124–130 (2010).

21.          Basheer, M. et al. Short homologous peptides based on C-terminal sequences of fibrinogen β- And γ-chains (haptides) affect cardiovascular function by eNOS inhibition. J. Vasc. Res. 47, 507–518 (2010).

22.          Tzukert, K. et al. Human melanoma cells expressing the αvβ3 integrin are partially protected from necrotic cell death induced by dynamic matrix detachment. Cancer Lett. 290, 174–181 (2010).

23.          Shainer, R., Gaberman, E., Levdansky, L. & Gorodetsky, R. Efficient isolation and chondrogenic differentiation of adult mesenchymal stem cells with fibrin microbeads and micronized collagen sponges. Regen. Med. 5, 255–265 (2010).

24.          Krasny, L. et al. An in-vitro tumour microenvironment model using adhesion to type i collagen reveals Akt-dependent radiation resistance in renal cancer cells. Nephrol. Dial. Transplant. 25, 373–380 (2010).

25.          Ben-Ari, A. et al. Isolation and implantation of bone marrow-derived mesenchymal stem cells with fibrin micro beads to repair a critical-size bone defect in mice. Tissue Eng. - Part A 15, 2537–2546 (2009).

26.          Schäfer, R. et al. Basic research and clinical applications of non-hematopoietic stem cells, 4-April 2008, Tübingen, Germany. Cytotherapy 11, 245–255 (2009).

27.          Gorodetsky, R. Fibrin-based matrix for stem cell isolation and as a basis for new technologies for tissue regeneration. Compos. Interfaces 15, 799–805 (2008).

28.          Gorodetsky, R. The use of fibrin based matrices and fibrin microbeads (FMB) for cell based tissue regeneration. Expert Opin. Biol. Ther. 8, 1831–1846 (2008).

29.          Shimony, N. et al. A 3D rotary renal and mesenchymal stem cell culture model unveils cell death mechanisms induced by matrix deficiency and low shear stress. Nephrol. Dial. Transplant. 23, 2071–2080 (2008).

30.          Machlenkin, A. et al. Capture of tumor cell membranes by trogocytosis facilitates detection and isolation of tumor-specific functional CTLs. Cancer Res. 68, 2006–2013 (2008).

31.          Marx, G. et al. Haptide-coated collagen sponge as a bioactive matrix for tissue regeneration. J. Biomed. Mater. Res. - Part B Appl. Biomater. 84, 571–583 (2008).

32.          Marx, G. et al. Heat denaturation of fibrinogen to develop a biomedical matrix. J. Biomed. Mater. Res. - Part B Appl. Biomater. 84, 49–57 (2008).

33.          Nagler, A., Ohana, M., Leiba, M., Levdansky, L. & Gorodetsky, R. Effect of halofuginone, a collagen α1(I) inhibitor, on wound healing in normal and irradiated skin: Implication for hematopoietic stem cell transplantation. Acta Haematol. 118, 77–83 (2007).

34.          Rivkin, R. et al. High-yield isolation, expansion, and differentiation of murine bone marrow-derived mesenchymal stem cells using fibrin microbeads (FMB). Cloning Stem Cells 9, 157–175 (2007).

35.          Frankenburg, S. et al. Immunological activation following transcutaneous delivery of HR-gp100 protein. Vaccine 25, 4564–4570 (2007).

36.          Zangi, L. et al. High-yield isolation, expansion, and differentiation of rat bone marrow-derived mesenchymal stem cells with fibrin microbeads. Tissue Eng. 12, 2343–2354 (2006).

37.          Kassis, I. et al. Isolation of mesenchymal stem cells from G-CSF-mobilized human peripheral blood using fibrin microbeads. Bone Marrow Transplant. 37, 967–976 (2006).

38.          Shimony, N. et al. Fibrin microbeads (FMB) as a 3D platform for kidney gene and cell therapy. Kidney Int. 69, 625–633 (2006).

39.          Gorodetsky, R. et al. Interactions of carboplatin with fibrin(ogen), implications for local slow release chemotherapy. J. Control. Release 102, 235–245 (2005).

40.          Gorodetsky, R. et al. Liposome transduction into cells enhanced by haptotactic peptides (Haptides) homologous to fibrinogen C-termini. J. Control. Release 95, 477–488 (2004).

41.          Marx, G., Ben-Moshe, M., Magdassi, S. & Gorodetsky, R. Fibrinogen C-terminal peptidic sequences (Haptides) modulate fibrin polymerization. Thromb. Haemost. 91, 43–51 (2004).

42.          Gorodetsky, R., Vexler, A., Levdansky, L. & Marx, G. Fibrin microbeads (FMB) as biodegradable carriers for culturing cells and for accelerating wound healing. Methods Mol. Biol. 238, 11–24 (2004).

43.          Gorodetsky, R. et al. New cell attachment peptide sequences from conserved epitopes in the carboxy termini of fibrinogen. Exp. Cell Res. 287, 116–129 (2003).

44.          Gurevich, O. et al. Fibrin microbeads for isolating and growing bone marrow-derived progenitor cells capable of forming bone tissue. Tissue Eng. 8, 661–672 (2002).

45.          Gorodetsky, R. et al. Erratum: Late effects of dose fractionation on the mechanical properties of breast skin following post-lumpectomy radiotherapy (International Journal of Radiation Oncology Biology Physics (2000) 46 (975-981)). Int. J. Radiat. Oncol. Biol. Phys. 47, 545 (2000).

46.          Gorodetsky, R. et al. Late effects of dose fractionation on the mechanical properties of breast skin following post-lumpectomy radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 45, 893–900 (1999).

47.          Gorodetsky, R., Andriessen, A., Polyansky, I. & Vexler, A. Measurement of breast skin viscoelasticity and a pilot study on the potential radioprotective effect of a zinc-based cream. J. Wound Care 8, 514–518 (1999).

48.          Gorodetsky, R. et al. Fibrin microbeads (FMB) as biodegradable carriers for culturing cells and for accelerating wound healing. J. Invest. Dermatol. 112, 866–872 (1999).

49.          Vexler, A., Polyansky, I. & Gorodetsky, R. Evaluation of skin viscoelasticity and anisotropy by measurement of speed of shear wave propagation with viscoelasticity skin analyzer. J. Invest. Dermatol. 113, 732–739 (1999).

50.          Gorodetsky, R., Levy-Agababa, F., Mou, X. & Vexler, A. M. Combination of cisplatin and radiation in cell culture: Effect of duration of exposure to drug and timing of irradiation. Int. J. Cancer 75, 635–642 (1998).

51.          Enk, C. D. et al. Chronic graft-versus-host disease treated with UVB phototherapy. Bone Marrow Transplant. 22, 1179–1183 (1998).

52.          Gorodetsky, R., Vexler, A., An, J., Mou, X. & Marx, G. Haptotactic and growth stimulatory effects of fibrin(ogen) and thrombin on cultured fibroblasts. J. Lab. Clin. Med. 131, 269–280 (1998).

53.          Gorodetsky, R., Levdansky, L., Ringel, I. & Vexler, A. Paclitaxel-induced modification of the effects of radiation and alterations in the cell cycle in normal and tumor mammalian cells. Radiat. Res. 150, 283–291 (1998).

54.          Moyna, G. et al. Conformational studies of paclitaxel analogs modified at the C-2’ position in hydrophobic and hydrophilic solvent systems. J. Med. Chem. 40, 3305–3311 (1997).

55.          Tirosh, O., Kohen, R., Katzhendler, J., Gorodetsky, R. & Barenholz, Y. Novel synthetic phospholipid protects lipid bilayers against oxidation damage: Role of hydration layer and bound water. J. Chem. Soc. Perkin Trans. 2 383–389 (1997) doi:10.1039/a601955b.

56.          Gorodetsky, R. et al. Sub-additive effect of the combination of radiation and cisplatin in cultured murine and human cell lines. Isr. J. Med. Sci. 31, 95–100 (1995).

57.          Gorodetsky, R., Vexler, A., Bar-Khaim, Y. & Biran, H. Plasma platinum elimination in a hemodialysis patient treated with cisplatin. Ther. Drug Monit. 17, 203–206 (1995).

58.          Vexler, A. M., Mou, X., Gabizon, A. A. & Gorodetsky, R. Reduction of the systemic toxicity of cisplatin by intra‐arterial hepatic route administration for liver malignancies. Int. J. Cancer 60, 611–615 (1995).

59.          Hoffman, A., Alfon, J., Habib, G., Pinto, E. & Gorodetsky, R. The Effect of Immunosuppression by Total-Body Irradiation on the Pharmacodynamics of Centrally Active Drugs in Rats. Pharm. Res. An Off. J. Am. Assoc. Pharm. Sci. 11, 704–708 (1994).

60.          Barak, V. et al. In vivo anti-inflammatory effects of the M20 IL-1 Inhibitor: II. Effects on serum reactants. Biotherapy 6, 271–277 (1993).

61.          Gorodetsky, R., Amselem, S. & Barenholz, Y. Trace element analysis of liposomal formulations by diagnostic X-ray fluorescence spectrometry (DXS). Chem. Phys. Lipids 64, 31–34 (1993).

62.          Gorodetsky, R., Mou, X., Blankenfeld, A. & Marx, G. Platelet multielemental composition, lability, and subcellular localization. Am. J. Hematol. 42, 278–283 (1993).

63.          Marx, G., Korner, G., Mou, X. & Gorodetsky, R. Packaging zinc, fibrinogen, and factor XIII in platelet α‐granules. J. Cell. Physiol. 156, 437–442 (1993).

64.          Gorodetsky, R. et al. Noninvasive follow‐up of platinum pharmacokinetics in the skin of patients on cisplatin chemotherapy. Cancer 72, 446–454 (1993).

65.          Gorodetsky, R., Vexler, A., Mou, X., Kaufman, B. & Loewenthal, E. A sensitive noninvasive analysis of Pt in external tissues. Followup of Pt deposition following cisplatin treatment. Med. Phys. 20, 1007–1012 (1993).

66.          Kohen, R., Tirosh, O. & Gorodetsky, R. The biological reductive capacity of tissues is decreased following exposure to oxidative stress: A cyclic voltammetry study of irradiated rats. Free Radic. Res. 17, 239–248 (1992).

67.          Neumann, R., Belkin, M., Loewenthal, E. & Gorodetsky, R. A Long-term Follow-up of Metallic Intraocular Foreign Bodies, Employing Diagnostic X-ray Spectrometry. Arch. Ophthalmol. 110, 1269–1272 (1992).

68.          Marx, G., Blankenfeld, A., Panet, R. & Gorodetsky, R. Model for the regulation of platelet volume and responsiveness by the trans‐membrane Na+/K+‐pump. J. Cell. Physiol. 151, 249–254 (1992).

69.          Gorodetsky, R., Amir, G. & Yarom, R. Effect of ionizing radiation on neuromuscular junctions in mouse tongues. Int. J. Radiat. Biol. 61, 539–544 (1992).

70.          Ramu, A., Ramu, N. & Gorodetsky, R. Reduced ouabain-sensitive potassium entry as a possible mechanism of multidrug-resistance in P388 cells. Biochem. Pharmacol. 42, 1699–1704 (1991).

71.          Gorodetsky, R., McBride, W. H., Withers, H. R. & Miller, G. G. Effect of fibroblast implants on wound healing of irradiated skin: Assay of wound strength and quantitative immunohistology of collagen. Radiat. Res. 125, 181–186 (1991).

72.          Marx, G., Gorodetsky, R. & BarShany, S. Reducing white cells in platelet units. Transfusion 31, 743–747 (1991).

73.          Gomori, J. M. et al. Hepatic iron overload: Quantitative MR imaging. Radiology 179, 367–369 (1991).

74.          GORODETSKY, R., LOEWENTHAL, E., GOLDFARB, A. & RACHMILEWITZ, E. A. Non‐Invasive Evaluation of Iron Load and Clearance in Patients with β‐Thalassemia. Annals of the New York Academy of Sciences vol. 612 568–572 (1990).

75.          Gorodetsky, R., Mou, X., Fisher, D. R., Taylor, J. M. G. & Withers, H. R. Radiation effect in mouse skin: Dose fractionation and wound healing. Int. J. Radiat. Oncol. Biol. Phys. 18, 1077–1081 (1990).

76.          Ackerman, Z., Loewenthal, E., Seidenbaum, M., Rubinow, A. & Gorodetsky, R. Skin Zinc Concentrations in Patients with Varicose Ulcers. Int. J. Dermatol. 29, 360–362 (1990).

77.          Gorodetsky, R., McBride, W. H. & Withers, H. R. Assay of radiation effects in mouse skin as expressed in wound healing. Radiat. Res. 116, 135–144 (1988).

78.          Yarom, R. et al. Elevated concentrations of elements and abnormalities of neuromuscular junctions in tongue muscles of Down’s syndrome. J. Neurol. Sci. 79, 315–326 (1987).

79.          Friedlaender, M. M., Kaufman, B., Rubinger, D. & Gorodetsky, R. Normal skin zinc content in hemodialysis patients. Trace Elem. Med. 4, 105–106 (1987).

80.          Ginsburg, H., Gorodetsky, R. & Krugliak, M. The status of zinc in malaria (Plasmodium falciparum) infected human red blood cells: stage dependent accumulation, compartmentation and effect of dipicolinate. BBA - Mol. Cell Res. 886, 337–344 (1986).

81.          Ginsburg, H., Handeli, S., Friedman, S., Gorodetsky, R. & Krugliak, M. Effects of red blood cell potassium and hypertonicity on the growth of Plasmodium falciparum in culture. Zeitschrift für Parasitenkd. Parasitol. Res. 72, 185–199 (1986).

82.          Gorodetsky, R., Fuks, Z., Peretz, T. & Ginsburg, H. Elevation of erythrocyte zinc- and free protoporphyrins with metastatic spread in cancer patients. Eur. J. Cancer Clin. Oncol. 22, 1515–1521 (1986).

83.          Ackerman, Z., Michaeli, J. & Gorodetsky, R. Skin discoloration in chronic idiopathic thrombocytopenic purpura: Detection of local iron deposition by X-ray spectrometry. Dermatologica 172, 222–224 (1986).

84.          Gorodetsky, R., Sheskin, J. & Weinreb, A. Iron, Copper, and Zinc Concentrations in Normal Skin and in Various Nonmalignant and Malignant Lesions. Int. J. Dermatol. 25, 440–445 (1986).

85.          Gorodetsky, R., Goldfarb, A., Dagan, I. & Rachmilewitz, E. A. Noninvasive analysis of skin iron and zinc levels in β-thalassemia major and intermedia. J. Lab. Clin. Med. 105, 44–51 (1985).

86.          Gorodetsky, R., Fuks, Z., Peretz, T. & Ginsburg, H. Direct fluorometric determination of erythrocyte free and zinc protoporphyrins in health and disease. Clin. Biochem. 18, 362–368 (1985).

87.          Gorodetsky, R., Fuks, Z., Sulkes, A., Ginsburg, H. & Weshler, Z. Correlation of erythrocyte and plasma levels of zinc, copper, and iron with evidence of metastatic spread in cancer patients. Cancer 55, 779–787 (1985).

88.          Sheskin, J., Gorodetsky, R., Weinreb, A. & Loewinger, E. Iron content of skin before and after thalidomide treatment of lepra reaction: A preliminary report. Dermatology 163, 145–150 (1981).

89.          Maunder‐Sewry, C. A., Gorodetsky, R., Yarom, R. & Dubowitz, V. Element analysis of skeletal muscle in duchenne muscular dystrophy using x‐ray fluorescence spectrometry. Muscle Nerve 3, 502–508 (1980).

90.          Yarom, R. et al. Elements in muscle measured in vivo and in vitro with X‐ray spectrometry. Muscle Nerve 1, 486–494 (1978).

91.          Yarom, R., Robin, G. C. & Gorodetsky, R. X-ray fluorescence analysis of muscles in scoliosis. Spine (Phila. Pa. 1976). 3, 142–145 (1978).

92.          Zeimer, R., Gorodetsky, R., Lahav, M. & Belkin, M. Experimental Chalcosis: A Comparison Between in Vivo and in Vitro Findings. Arch. Ophthalmol. 96, 115–119 (1978).

93.          Gorodetsky, R., Weinreb, A., Zeimer, R. & Belkin, M. Noninvasive Copper Measurement in Chalcosis: Comparison with Electroretinography and Ophthalmoscopy. Arch. Ophthalmol. 95, 1059–1064 (1977).