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Hadassah Medical Center: Gorodetsky Raphael

Last updated June 2021 - Hadassah Medical Center

List of Publications

(1) Gorodetsky R, Aicher WK. Allogenic use of human placenta-derived stromal cells as a highly active subtype of mesenchymal stromal cells for cell-based therapies. Int J Mol Sci 2021;22(10).

(2) Volinsky E, Lazmi-Hailu A, Cohen N, Adani B, Faroja M, Grunewald M, et al. Alleviation of acute radiation-induced bone marrow failure in mice with human fetal placental stromal cell therapy. Stem Cell Res Ther 2020;11(1).

(3) Adani B, Basheer M, Hailu AL, Fogel T, Israeli E, Volinsky E, et al. Isolation and expansion of high yield of pure mesenchymal stromal cells from fresh and cryopreserved placental tissues. Cryobiology 2019;89:100-103.

(4) Kuznetsov SA, Hailu-Lazmi A, Cherman N, de Castro LF, Robey PG, Gorodetsky R. In Vivo Formation of Stable Hyaline Cartilage by Naïve Human Bone Marrow Stromal Cells with Modified Fibrin Microbeads. Stem Cells Transl Med 2019;8(6):586-592.

(5) Pinzur L, Akyuez L, Levdansky L, Blumenfeld M, Volinsky E, Aberman Z, et al. Rescue from lethal acute radiation syndrome (ARS) with severe weight loss by secretome of intramuscularly injected human placental stromal cells. J Cachexia Sarcopenia Muscle 2018;9(6):1079-1092.

(6) Pitcovski J, Shahar E, Aizenshtein E, Gorodetsky R. Melanoma antigens and related immunological markers. Crit Rev Oncol Hematol 2017;115:36-49.

(7) Shapira I, Fainstein N, Tsirlin M, Stav I, Volinsky E, Moresi C, et al. Placental stromal cell therapy for experimental autoimmune encephalomyelitis: The role of route of cell delivery. Stem Cells Transl Med 2017;6(4):1286-1294.

(8) Shahar E, Gorodetsky R, Aizenshtein E, Lalush L, Pitcovski J. Modulating the innate immune activity in murine tumor microenvironment by a combination of inducer molecules attached to microparticles. Cancer Immunol Immunother 2015;64(9):1137-1149.

(9) Gaberman E, Pinzur L, Levdansky L, Tsirlin M, Netzer N, Aberman Z, et al. Mitigation of Lethal Radiation Syndrome in Mice by Intramuscular Injection of 3D Cultured Adherent Human Placental Stromal Cells. PLoS ONE 2013;8(6).

(10) Xie MW, Gorodetsky R, Micewicz ED, MacKenzie NC, Gaberman E, Levdansky L, et al. Erratum: Marrow-derived stromal cell delivery on fibrin microbeads can correct radiation-induced wound-healing deficits (Journal of Investigative Dermatology (2013) 133 (553-561) DOI: 10.1038/jid.2012.326). J Invest Dermatol 2013;133(3):859.

(11) Xie MW, Gorodetsky R, Micevicz ED, MacKenzie NC, Gaberman E, Levdansky L, et al. Marrow-derived stromal cell delivery on fibrin microbeads can correct radiation-induced wound-healing deficits. J Invest Dermatol 2013;133(2):553-561.

(12) Basheer M, Schwalb H, Shefler I, Levdansky L, Mekori YA, Gorodetsky R. Blood pressure modulation following activation of mast cells by cationic cell penetrating peptides. Peptides 2011;32(12):2444-2451.

(13) Gorodetsky R, Levdansky L, Gaberman E, Gurevitch O, Lubzens E, McBride WH. Fibrin microbeads loaded with mesenchymal cells support their long-term survival while sealed at room temperature. Tissue Eng Part C Methods 2011;17(7):745-755.

(14) Gefen T, Pitcovski J, Vaya J, Khatib S, Krispel S, Heller ED, et al. Coated cross-species antibodies by mannosamine-biotin adduct confer protection against snake venom without eliciting humoral immune response. Vaccine 2010;28(51):8197-8202.

(15) Basheer M, Schwalb H, Nesher M, Gilon D, Shefler I, Mekori YA, et al. Mast cell activation by fibrinogen-related homologous c-terminal peptides (haptides) modulates systemic blood pressure. J Allergy Clin Immunol 2010;126(5):1041-1048.

(16) Shahar E, Gorodetsky R, Gaberman E, Aizenshtein E, Pitcovski J. Targeted microbeads for attraction and induction of specific innate immune response in the tumor microenvironment. Vaccine 2010;28(45):7279-7287.

(17) Levy-Beladev L, Levdansky L, Gaberman E, Friedler A, Gorodetsky R. A family of cell-adhering peptides homologous to fibrinogen C-termini. Biochem Biophys Res Commun 2010;401(1):124-130.

(18) Basheer M, Schwalb H, Gilon D, Doviner V, Sherman Y, Shapira OM, et al. Short homologous peptides based on C-terminal sequences of fibrinogen β- And γ-chains (haptides) affect cardiovascular function by eNOS inhibition. J Vasc Res 2010;47(6):507-518.

(19) Tzukert K, Shimony N, Krasny L, Urieli-Shoval S, Gorodetsky R, Avrahami I, et al. Human melanoma cells expressing the αvβ3 integrin are partially protected from necrotic cell death induced by dynamic matrix detachment. Cancer Lett 2010;290(2):174-181.

(20) Shainer R, Gaberman E, Levdansky L, Gorodetsky R. Efficient isolation and chondrogenic differentiation of adult mesenchymal stem cells with fibrin microbeads and micronized collagen sponges. Regenerative Med 2010;5(2):255-265.

(21) Krasny L, Shimony N, Tzukert K, Gorodetsky R, Lecht S, Nettelbeck DM, et al. An in-vitro tumour microenvironment model using adhesion to type i collagen reveals Akt-dependent radiation resistance in renal cancer cells. Nephrol Dial Transplant 2010;25(2):373-380.

(22) Ben-Ari A, Rivkin R, Frishman M, Gaberman E, Levdansky L, Gorodetsky R. Isolation and implantation of bone marrow-derived mesenchymal stem cells with fibrin micro beads to repair a critical-size bone defect in mice. Tissue Eng Part A 2009;15(9):2537-2546.

(23) Schäfer R, Dominici M, Müller I, Horwitz E, Asahara T, Bulte JWM, et al. Basic research and clinical applications of non-hematopoietic stem cells, 4-April 2008, Tübingen, Germany. Cytotherapy 2009;11(2):245-255.

(24) Gorodetsky R. Fibrin-based matrix for stem cell isolation and as a basis for new technologies for tissue regeneration. Compos Interfaces 2008;15(7-9):799-805.

(25) Gorodetsky R. The use of fibrin based matrices and fibrin microbeads (FMB) for cell based tissue regeneration. Expert Opin Biol Ther 2008;8(12):1831-1846.

(26) Shimony N, Avrahami I, Gorodetsky R, Elkin G, Tzukert K, Zangi L, et al. A 3D rotary renal and mesenchymal stem cell culture model unveils cell death mechanisms induced by matrix deficiency and low shear stress. Nephrol Dial Transplant 2008;23(6):2071-2080.

(27) Machlenkin A, Uzana R, Frankenburg S, Eisenberg G, Eisenbach L, Pitcovski J, et al. Capture of tumor cell membranes by trogocytosis facilitates detection and isolation of tumor-specific functional CTLs. Cancer Res 2008;68(6):2006-2013.

(28) Marx G, Hotovely-Salomon A, Levdansky L, Gaberman E, Snir G, Sievner Z, et al. Haptide-coated collagen sponge as a bioactive matrix for tissue regeneration. J Biomed Mater Res Part B Appl Biomater 2008;84(2):571-583.

(29) Marx G, Mou X, Hotovely-Salomon A, Levdansky L, Gaberman E, Belenky D, et al. Heat denaturation of fibrinogen to develop a biomedical matrix. J Biomed Mater Res Part B Appl Biomater 2008;84(1):49-57.

(30) Nagler A, Ohana M, Leiba M, Levdansky L, Gorodetsky R. Effect of halofuginone, a collagen α1(I) inhibitor, on wound healing in normal and irradiated skin: Implication for hematopoietic stem cell transplantation. Acta Haematol 2007;118(2):77-83.

(31) Rivkin R, Ben-Ari A, Kassis I, Zangi L, Gaberman E, Levdansky L, et al. High-yield isolation, expansion, and differentiation of murine bone marrow-derived mesenchymal stem cells using fibrin microbeads (FMB). Cloning Stem Cells 2007;9(2):157-175.

(32) Frankenburg S, Grinberg I, Bazak Z, Fingerut L, Pitcovski J, Gorodetsky R, et al. Immunological activation following transcutaneous delivery of HR-gp100 protein. Vaccine 2007;25(23):4564-4570.

(33) Zangi L, Rivkin R, Kassis I, Levdansky L, Marx G, Gorodetsky R. High-yield isolation, expansion, and differentiation of rat bone marrow-derived mesenchymal stem cells with fibrin microbeads. Tissue Eng 2006;12(8):2343-2354.

(34) Kassis I, Zangi L, Rivkin R, Levdansky L, Samuel S, Marx G, et al. Isolation of mesenchymal stem cells from G-CSF-mobilized human peripheral blood using fibrin microbeads. Bone Marrow Transplant 2006;37(10):967-976.

(35) Shimony N, Gorodetsky R, Marx G, Gal D, Rivkin R, Ben-Ari A, et al. Fibrin microbeads (FMB) as a 3D platform for kidney gene and cell therapy. Kidney Int 2006;69(3):625-633.

(36) Gorodetsky R, Peylan-Ramu N, Reshef A, Gaberman E, Levdansky L, Marx G. Interactions of carboplatin with fibrin(ogen), implications for local slow release chemotherapy. J Control Release 2005;102(1):235-245.

(37) Gorodetsky R, Levdansky L, Vexler A, Shimeliovich I, Kassis I, Ben-Moshe M, et al. Liposome transduction into cells enhanced by haptotactic peptides (Haptides) homologous to fibrinogen C-termini. J Control Release 2004;95(3):477-488.

(38) Marx G, Ben-Moshe M, Magdassi S, Gorodetsky R. Fibrinogen C-terminal peptidic sequences (Haptides) modulate fibrin polymerization. Thromb Haemost 2004;91(1):43-51.

(39) Gorodetsky R, Vexler A, Levdansky L, Marx G. Fibrin microbeads (FMB) as biodegradable carriers for culturing cells and for accelerating wound healing. Methods Mol Biol 2004;238:11-24.

(40) Gorodetsky R, Vexler A, Shamir M, An J, Levdansky L, Shimeliovich I, et al. New cell attachment peptide sequences from conserved epitopes in the carboxy termini of fibrinogen. Exp Cell Res 2003;287(1):116-129.

(41) Gurevich O, Vexler A, Marx G, Prigozhina T, Levdansky L, Slavin S, et al. Fibrin microbeads for isolating and growing bone marrow-derived progenitor cells capable of forming bone tissue. Tissue Eng 2002;8(4):661-672.

(42) Gorodetsky R, Lotan C, Piggot K, Pierce L, Polyansky I, Dische S, et al. Erratum: Late effects of dose fractionation on the mechanical properties of breast skin following post-lumpectomy radiotherapy (International Journal of Radiation Oncology Biology Physics (2000) 46 (975-981)). Int J Radiat Oncol Biol Phys 2000;47(2):545.

(43) Gorodetsky R, Lotan C, Piggot K, Pierce LJ, Polyansky I, Dische S, et al. Late effects of dose fractionation on the mechanical properties of breast skin following post-lumpectomy radiotherapy. Int J Radiat Oncol Biol Phys 1999;45(4):893-900.

(44) Vexler A, Polyansky I, Gorodetsky R. Evaluation of skin viscoelasticity and anisotropy by measurement of speed of shear wave propagation with viscoelasticity skin analyzer. J Invest Dermatol 1999;113(5):732-739.

(45) Gorodetsky R, Andriessen A, Polyansky I, Vexler A. Measurement of breast skin viscoelasticity and a pilot study on the potential radioprotective effect of a zinc-based cream. J Wound Care 1999;8(10):514-518.

(46) Gorodetsky R, Clark RAF, An J, Gailit J, Levdansky L, Vexler A, et al. Fibrin microbeads (FMB) as biodegradable carriers for culturing cells and for accelerating wound healing. J Invest Dermatol 1999;112(6):866-872.

(47) Gorodetsky R, Levy-Agababa F, Mou X, Vexler AM. Combination of cisplatin and radiation in cell culture: Effect of duration of exposure to drug and timing of irradiation. Int J Cancer 1998;75(4):635-642.

(48) Gorodetsky R, Levdansky L, Ringel I, Vexler A. Paclitaxel-induced modification of the effects of radiation and alterations in the cell cycle in normal and tumor mammalian cells. Radiat Res 1998;150(3):283-291.

(49) Gorodetsky R, Vexler A, An J, Mou X, Marx G. Haptotactic and growth stimulatory effects of fibrin(ogen) and thrombin on cultured fibroblasts. J Lab Clin Med 1998;131(3):269-280.

(50) Enk CD, Elad S, Vexler A, Kapelushnik J, Gorodetsky R, Kirschbaum M. Chronic graft-versus-host disease treated with UVB phototherapy. Bone Marrow Transplant 1998;22(12):1179-1183.

(51) Tirosh O, Kohen R, Katzhendler J, Gorodetsky R, Barenholz Y. Novel synthetic phospholipid protects lipid bilayers against oxidation damage: Role of hydration layer and bound water. J Chem Soc Perkin Trans 2 1997(2):383-389.

(52) Gorodetsky R, Vexler A, Bar-Khaim Y, Biran H. Plasma platinum elimination in a hemodialysis patient treated with cisplatin. Ther Drug Monit 1995;17(2):203-206.

(53) Vexler AM, Mou X, Gabizon AA, Gorodetsky R. Reduction of the systemic toxicity of cisplatin by intra‐arterial hepatic route administration for liver malignancies. Int J Cancer 1995;60(5):611-615.

(54) Gorodetsky R, Mou X, Pfeffer MR, Peretz T, Levy-Agababa F, Vexler AM. Sub-additive effect of the combination of radiation and cisplatin in cultured murine and human cell lines. Isr J Med Sci 1995;31(2-3):95-100.

(55) Hoffman A, Alfon J, Habib G, Pinto E, Gorodetsky R. The Effect of Immunosuppression by Total-Body Irradiation on the Pharmacodynamics of Centrally Active Drugs in Rats. Pharm Res 1994;11(5):704-708.

(56) Barak V, Gorodetsky R, Weidenfeld J, Peritt D, Yanai P, Halperin T, et al. In vivo anti-inflammatory effects of the M20 IL-1 Inhibitor: II. Effects on serum reactants. Biotherapy 1993;6(4):271-277.

(57) Gorodetsky R, Amselem S, Barenholz Y. Trace element analysis of liposomal formulations by diagnostic X-ray fluorescence spectrometry (DXS). Chem Phys Lipids 1993;64(1-3):31-34.

(58) Gorodetsky R, Mou X, Blankenfeld A, Marx G. Platelet multielemental composition, lability, and subcellular localization. Am J Hematol 1993;42(3):278-283.

(59) Marx G, Korner G, Mou X, Gorodetsky R. Packaging zinc, fibrinogen, and factor XIII in platelet α‐granules. J Cell Physiol 1993;156(3):437-442.

(60) Gorodetsky R, Vexler A, Mou X, Kaufman B, Loewenthal E. A sensitive noninvasive analysis of Pt in external tissues. Followup of Pt deposition following cisplatin treatment. Med Phys 1993;20(4):1007-1012.

(61) Gorodetsky R, Mou X, Vexler A, Kaufman B, Catane R, Loewenthal E. Noninvasive follow‐up of platinum pharmacokinetics in the skin of patients on cisplatin chemotherapy. Cancer 1993;72(2):446-454.

(62) Kohen R, Tirosh O, Gorodetsky R. The biological reductive capacity of tissues is decreased following exposure to oxidative stress: A cyclic voltammetry study of irradiated rats. Free Radic Res 1992;17(4):239-248.

(63) Gorodetsky R, Amir G, Yarom R. Effect of ionizing radiation on neuromuscular junctions in mouse tongues. Int J Radiat Biol 1992;61(4):539-544.

(64) Neumann R, Belkin M, Loewenthal E, Gorodetsky R. A Long-term Follow-up of Metallic Intraocular Foreign Bodies, Employing Diagnostic X-ray Spectrometry. Arch Ophthalmol 1992;110(9):1269-1272.

(65) Marx G, Blankenfeld A, Panet R, Gorodetsky R. Model for the regulation of platelet volume and responsiveness by the trans‐membrane Na+/K+‐pump. J Cell Physiol 1992;151(2):249-254.

(66) Ramu A, Ramu N, Gorodetsky R. Reduced ouabain-sensitive potassium entry as a possible mechanism of multidrug-resistance in P388 cells. Biochem Pharmacol 1991;42(9):1699-1704.

(67) Marx G, Gorodetsky R, BarShany S. Reducing white cells in platelet units. Transfusion 1991;31(8):743-747.

(68) Gorodetsky R, McBride WH, Withers HR, Miller GG. Effect of fibroblast implants on wound healing of irradiated skin: Assay of wound strength and quantitative immunohistology of collagen. Radiat Res 1991;125(2):181-186.

(69) Gomori JM, Horev G, Tamary H, Zandback J, Kornreich L, Zaizov R, et al. Hepatic iron overload: Quantitative MR imaging. Radiology 1991;179(2):367-369.

(70) GORODETSKY R, LOEWENTHAL E, GOLDFARB A, RACHMILEWITZ EA. Non‐Invasive Evaluation of Iron Load and Clearance in Patients with β‐Thalassemia. Ann New York Acad Sci 1990;612(1):568-572.

(71) Gorodetsky R, Mou X, Fisher DR, Taylor JMG, Withers HR. Radiation effect in mouse skin: Dose fractionation and wound healing. Int J Radiat Oncol Biol Phys 1990;18(5):1077-1081.

(72) Ackerman Z, Loewenthal E, Seidenbaum M, Rubinow A, Gorodetsky R. Skin Zinc Concentrations in Patients with Varicose Ulcers. Int J Dermatol 1990;29(5):360-362.

(73) Gorodetsky R, McBride WH, Withers HR. Assay of radiation effects in mouse skin as expressed in wound healing. Radiat Res 1988;116(1):135-144.

(74) Friedlaender MM, Kaufman B, Rubinger D, Gorodetsky R. Normal skin zinc content in hemodialysis patients. TRACE ELEM MED 1987;4(3):105-106.

(75) Yarom R, Sherman Y, Sagher U, Peled IJ, Wexler MR, Gorodetsky R. Elevated concentrations of elements and abnormalities of neuromuscular junctions in tongue muscles of Down's syndrome. J Neurol Sci 1987;79(3):315-326.

(76) Ginsburg H, Gorodetsky R, Krugliak M. The status of zinc in malaria (Plasmodium falciparum) infected human red blood cells: stage dependent accumulation, compartmentation and effect of dipicolinate. Biochim Biophys Acta Mol Cell Res 1986;886(3):337-344.

(77) Ginsburg H, Handeli S, Friedman S, Gorodetsky R, Krugliak M. Effects of red blood cell potassium and hypertonicity on the growth of Plasmodium falciparum in culture. Z Parasitenkd 1986;72(2):185-199.

(78) Ackerman Z, Michaeli J, Gorodetsky R. Skin discoloration in chronic idiopathic thrombocytopenic purpura: Detection of local iron deposition by X-ray spectrometry. Dermatologica 1986;172(4):222-224.

(79) Gorodetsky R, Sheskin J, Weinreb A. Iron, Copper, and Zinc Concentrations in Normal Skin and in Various Nonmalignant and Malignant Lesions. Int J Dermatol 1986;25(7):440-445.

(80) Gorodetsky R, Fuks Z, Peretz T, Ginsburg H. Elevation of erythrocyte zinc- and free protoporphyrins with metastatic spread in cancer patients. Eur J Cancer Clin Oncol 1986;22(12):1515-1521.

(81) Gorodetsky R, Goldfarb A, Dagan I, Rachmilewitz EA. Noninvasive analysis of skin iron and zinc levels in β-thalassemia major and intermedia. J Lab Clin Med 1985;105(1):44-51.

(82) Gorodetsky R, Fuks Z, Peretz T, Ginsburg H. Direct fluorometric determination of erythrocyte free and zinc protoporphyrins in health and disease. Clin Biochem 1985;18(6):362-368.

(83) Gorodetsky R, Fuks Z, Sulkes A, Ginsburg H, Weshler Z. Correlation of erythrocyte and plasma levels of zinc, copper, and iron with evidence of metastatic spread in cancer patients. Cancer 1985;55(4):779-787.

(84) Sheskin J, Gorodetsky R, Weinreb A, Loewinger E. Iron content of skin before and after thalidomide treatment of lepra reaction: A preliminary report. Dermatology 1981;163(2):145-150.

(85) Maunder‐Sewry CA, Gorodetsky R, Yarom R, Dubowitz V. Element analysis of skeletal muscle in duchenne muscular dystrophy using x‐ray fluorescence spectrometry. Muscle Nerve 1980;3(6):502-508.

(86) Yarom R, Robin GC, Gorodetsky R. X-ray fluorescence analysis of muscles in scoliosis. Spine 1978;3(2):142-145.

(87) Zeimer R, Gorodetsky R, Lahav M, Belkin M. Experimental Chalcosis: A Comparison Between in Vivo and in Vitro Findings. Arch Ophthalmol 1978;96(1):115-119.

(88) Yarom R, Havivi Y, Notowitz L, Friedman M, Gorodetsky R, Zeimer R. Elements in muscle measured in vivo and in vitro with X‐ray spectrometry. Muscle Nerve 1978;1(6):486-494.

(89) Gorodetsky R, Weinreb A, Zeimer R, Belkin M. Noninvasive Copper Measurement in Chalcosis: Comparison with Electroretinography and Ophthalmoscopy. Arch Ophthalmol 1977;95(6):1059-1064.