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The Faculty of Medicine - Microbiology and Molecular Genetics: Taraboulos Albert


 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Requena JR, Kristensson K, Korth C, Zurzolo C, Simmons M, Aguilar-Calvo P, et al. The Priority position paper: Protecting Europe's food chain from prions. Prion 2016;10(3):165-181.

(2) Kovalchuk Ben-Zaken O, Nissan I, Tzaban S, Taraboulos A, Zcharia E, Matzger S, et al. Transgenic over-expression of mammalian heparanase delays prion disease onset and progression. Biochem Biophys Res Commun 2015;464(3):698-704.

(3) Nissan I, Gahali-Sass I, Rouvinski A, Makedonski K, Taraboulos A, Tal Y. Methylphenidate prolongs symptom-free period of experimental prion disease in mice. J Neurol Sci 2015;351(1-2):204-205.

(4) Rouvinski A, Karniely S, Kounin M, Moussa S, Goldberg MD, Warburg G, et al. Live imaging of prions reveals nascent PrPSc in cellsurface, raft-associated amyloid strings and webs. J Cell Biol 2014;204(3):423-441.

(5) Edvardson S, Cinnamon Y, Ta-Shma A, Shaag A, Yim Y-, Zenvirt S, et al. A deleterious mutation in DNAJC6 encoding the neuronal-specific clathrin-uncoating Co-chaperone auxilin, is associated with juvenile parkinsonism. PLoS ONE 2012;7(5).

(6) Aker M, Rouvinski A, Hashavia S, Ta-Shma A, Shaag A, Zenvirt S, et al. An SNX10 mutation causes malignant osteopetrosis of infancy. J Med Genet 2012;49(4):221-226.

(7) Goldberg MD, Honigman A, Weinstein J, Chou S, Taraboulos A, Rouvinski A, et al. Human cytomegalovirus UL97 kinase and nonkinase functions mediate viral cytoplasmic secondary envelopment. J Virol 2011;85(7):3375-3384.

(8) Luhr KM, Löw P, Taraboulos A, Bergman T, Kristensson K. Prion adsorption to stainless steel is promoted by nickel and molybdenum. J Gen Virol 2009;90(11):2821-2828.

(9) Azzeh M, Honigman A, Taraboulos A, Rouvinski A, Wolf DG. Structural changes in human cytomegalovirus cytoplasmic assembly sites in the absence of UL97 kinase activity. Virology 2006;354(1):69-79.

(10) Horonchik L, Tzaban S, Ben-Zaken O, Yedidia Y, Rouvinski A, Papy-Garcia D, et al. Heparan sulfate is a cellular receptor for purified infectious prions. J Biol Chem 2005;280(17):17062-17067.

(11) Yudovin-Farber I, Azzam T, Metzer E, Taraboulos A, Domb AJ. Cationic polysaccharides as antiprion agents. J Med Chem 2005;48(5):1414-1420.

(12) Luhr KM, Nordström EK, Löw P, Ljunggren H-, Taraboulos A, Kristensson K. Scrapie Protein Degradation by Cysteine Proteases in CD11c+ Dendritic Cells and GT1-1 Neuronal Cells. J Virol 2004;78(9):4776-4782.

(13) Schonberger O, Horonchik L, Gabizon R, Papy-Garcia D, Barritault D, Taraboulos A. Novel heparan mimetics potently inhibit the scrapie prion protein and its endocytosis. Biochem Biophys Res Commun 2003;312(2):473-479.

(14) Ben-Zaken O, Tzaban S, Tal Y, Horonchik L, Esko JD, Vlodavsky I, et al. Cellular heparan sulfate participates in the metabolism of prions. J Biol Chem 2003;278(41):40041-40049.

(15) Rouvinski A, Gahali-Sass I, Stav I, Metzer E, Atlan H, Taraboulos A. Both raft- and non-raft proteins associate with CHAPS-insoluble complexes: Some APP in large complexes. Biochem Biophys Res Commun 2003;308(4):750-758.

(16) Cohen E, Taraboulos A. Scrapie-like prion protein accumulates in aggresomes of cyclosporin A-treated cells. EMBO J 2003;22(3):404-417.

(17) Tal Y, Souan L, Cohen IR, Meiner Z, Taraboulos A, Mor F. Complete Freund's adjuvant immunization prolongs survival in experimental prion disease in mice. J Neurosci Res 2003;71(2):286-290.

(18) Luhr KM, Wallin RPA, Ljunggren H-, Löw P, Taraboulos A, Kristensson K. Processing and degradation of exogenous prion protein by CD11c+ myeloid dendritic cells in vitro. J Virol 2002;76(23):12259-12264.

(19) Tzaban S, Friedlander G, Schonberger O, Horonchik L, Yedidia Y, Shaked G, et al. Protease-sensitive scrapie prion protein in aggregates of heterogeneous sizes. Biochemistry 2002;41(42):12868-12875.

(20) Yedidia Y, Horonchik L, Tzaban S, Yanai A, Taraboulos A. Proteasomes and ubiquitin are involved in the turnover of the wild-type prion protein. EMBO J 2001;20(19):5383-5391.

(21) Souan L, Tal Y, Felling Y, Cohen IR, Taraboulos A, Mor F. Modulation of proteinase-K resistant prion protein by prion peptide immunization. Eur J Immunol 2001;31(8):2338-2346.

(22) Shaked GM, Meiner Z, Avraham I, Taraboulos A, Gabizon R. Reconstitution of Prion Infectivity from Solubilized Protease-resistant PrP and Nonprotein Components of Prion Rods. J Biol Chem 2001;276(17):14324-14328.

(23) Yanai A, Meiner Z, Gahali I, Gabizon R, Taraboulos A. Subcellular trafficking abnormalities of a prion protein with a disrupted disulfide loop. FEBS Lett 1999;460(1):11-16.

(24) Naslavsky N, Shmeeda H, Friedlander G, Yanai A, Futerman AH, Barenholz Y, et al. Sphingolipid depletion increases formation of the scrapie prion protein in neuroblastoma cells infected with prions. J Biol Chem 1999;274(30):20763-20771.

(25) Shaked GM, Fridlander G, Meiner Z, Taraboulos A, Gabizon R. Protease-resistant and detergent-insoluble prion protein is not necessarily associated with prion infectivity. J Biol Chem 1999;274(25):17981-17986.

(26) Keshet GI, Ovadia H, Taraboulos A, Gabizon R. Scrapie-infected mice and PrP knockout mice share abnormal localization and activity of neuronal nitric oxide synthase. J Neurochem 1999;72(3):1224-1231.

(27) Solomon B, Taraboulos A, Katchalski-Katzir E. International Workshop on Conformational Diseases, Dead Sea, Israel, November 8-12, 1998 (sponsored by the Center for the Study of Emerging Diseases (CSED)). Amyloid 1999;6(3):225-228.

(28) Caspi S, Halimi M, Yanai A, Sasson SB, Taraboulos A, Gabizon R. The anti-prion activity of Congo red. Putative mechanism. J Biol Chem 1998;273(6):3484-3489.

(29) Gabizon R, Taraboulos A. Of mice and (mad) cows - Transgenic mice help to understand prions. Trends Genet 1997;13(7):264-269.

(30) Naslavsky N, Stein R, Yanai A, Friedlander G, Taraboulos A. Characterization of detergent-insoluble complexes containing the cellular prion protein and its scrapie isoform. J Biol Chem 1997;272(10):6324-6331.

(31) Vey M, Pilkuhn S, Wille H, Nixon R, DeArmond SJ, Smart EJ, et al. Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains. Proc Natl Acad Sci U S A 1996;93(25):14945-14949.

(32) Taraboulos A, Scott M, Semenov A, Avraham D, Laszlo L, Prusiner SB. Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform. J Cell Biol 1995;129(1):121-132.

(33) Taraboulos A, Scott M, Semenov A, Avrahami D, Prusiner SB. Biosynthesis of the prion proteins in scrapie-infected cells in culture. Braz J Med Biol Res 1994;27(2):303-307.

(34) DeArmond SJ, Yang S-, Lee A, Bowler R, Taraboulos A, Groth D, et al. Three scrapie prion isolates exhibit different accumulation patterns of the prion protein scrapie isoform. Proc Natl Acad Sci U S A 1993;90(14):6449-6453.

(35) Kristensson K, Feuerstein B, Taraboulos A, Hyun WC, Prusiner SB, Dearmond SJ. Scrapie prions alter receptor-mediated calcium responses in cultured cells. Neurology 1993;43(11):2335-2341.

(36) Prusiner SB, Füzi M, Scott M, Serban D, Serban H, Taraboulos A, et al. Immunologic and molecular biologic studies of prion proteins in bovine spongiform encephalopathy. J Infect Dis 1993;167(3):602-613.

(37) Borchelt DR, Taraboulos A, Prusiner SB. Evidence for synthesis of scrapie prion proteins in the endocytic pathway. J Biol Chem 1992;267(23):16188-16199.

(38) Taraboulos A, Raeber AJ, Borchelt DR, Serban D, Prusiner SB. Synthesis and trafficking of prion proteins in cultured cells. Mol Biol Cell 1992;3(8):851-863.

(39) Taraboulos A, Jendroska K, Serban D, Yang S-, Dearmond SJ, Prusiner SB. Regional mapping of prion proteins in brain. Proc Natl Acad Sci U S A 1992;89(16):7620-7624.

(40) Hecker R, Taraboulos A, Scott M, Pan K-, Yang S-, Torchia M, et al. Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters. Genes Dev 1992;6(7):1213-1228.

(41) McKinley MP, Taraboulos A, Kenaga L, Serban D, Stieber A, DeArmond SJ, et al. Ultrastructural localization of scrapie prion proteins in cytoplasmic vesicles of infected cultured cells. Lab Invest 1991;65(6):622-630.

(42) Rogers M, Taraboulos A, Scott M, Groth D, Prusiner SB. Intracellular accumulation of the cellular prion protein after mutagenesis of its asnlinked glycosylation sites. Glycobiology 1990;1(1):101-109.

(43) Taraboulos A, Serban D, Prusiner SB. Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cells. J Cell Biol 1990;110(6):2117-2132.

(44) Serban D, Taraboulos A, Dearmond SJ, Prusiner SB. Rapid detection of creutzfeldt-jakob disease and scrapie prion proteins. Neurology 1990;40(1):110-117.

(45) Borchelt DR, Scott M, Taraboulos A, Stahl N, Prusiner SB. Crapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells. J Cell Biol 1990;110(3):743-752.

(46) Taraboulos A, Rogers M, Borchelt DR, McKinley MP, Scott M, Serban D, et al. Acquisition of protease resistance by prion proteins in scrapie-infected cells does not require asparagine-linked glycosylation. Proc Natl Acad Sci U S A 1990;87(21):8262-8266.

(47) Butler DA, Scott MRD, Bockman JM, Borchelt DR, Taraboulos A, Hsiao KK, et al. Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins. J Virol 1988;62(5):1558-1564.

(48) KOLODNY Y, TARABOULOS A, FRIESLANDER U. Participation of fresh water in chert diagenesis: evidence from oxygen isotopes and boron α‐track mapping. Sedimentology 1980;27(3):305-316.