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The Faculty of Medicine - Biochemistry and Molecular Biology: Honigman Alik


 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Voropaev H, Vatkin MG, Shneor D, Luski S, Honigman A, Frenkel S. Infectious knockdown of CREB and HIF-1 for the treatment of metastatic uveal melanoma. Cancers 2019;11(8).

(2) Neumann-Raizel H, Shilo A, Lev S, Mogilevsky M, Katz B, Shneor D, et al. 2-APB and CBD-mediated targeting of charged cytotoxic compounds into tumor cells suggests the involvement of TRPV2 channels. Front Pharmacol 2019;10.

(3) Shneor D, Tayeb S, Pe'er J, Voropaev H, Gimmelshein M, Cassoux N, et al. A novel combinatorial treatment option for metastatic uveal melanoma. Oncotarget 2018;9(40):26096-26108.

(4) Shneor D, Folberg R, Pe'Er J, Honigman A, Frenkel S. Stable knockdown of CREB, HIF-1 and HIF-2 by replication-competent retroviruses abrogates the responses to hypoxia in hepatocellular carcinoma. Cancer Gene Ther 2017;24(2):64-74.

(5) Goldberg MD, Honigman A, Weinstein J, Chou S, Taraboulos A, Rouvinski A, et al. Human cytomegalovirus UL97 kinase and nonkinase functions mediate viral cytoplasmic secondary envelopment. J Virol 2011;85(7):3375-3384.

(6) Meyuhas R, Pikarsky E, Tavor E, Klar A, Abramovitch R, Hochman J, et al. A key role for cyclic AMP-responsive element binding protein in hypoxia-mediated activation of the angiogenesis factor CCN1(CYR61) in tumor cells. Mol Cancer Res 2008;6(9):1397-1409.

(7) Aframian DJ, Amit D, David R, Shai E, Deutsch D, Honigman A, et al. Reengineering salivary gland cells to enhance protein secretion for use in developing artificial salivary gland device. Tissue Eng 2007;13(5):995-1001.

(8) Soreq H, Honigman A. It is all about resolution: Meeting report based upon presentations at the 10th International Global BioMillennium 2006 symposium on molecular cell biology (Tbilisi, Georgia). FEBS J 2007;274(4):924-927.

(9) Azzeh M, Honigman A, Taraboulos A, Rouvinski A, Wolf DG. Structural changes in human cytomegalovirus cytoplasmic assembly sites in the absence of UL97 kinase activity. Virology 2006;354(1):69-79.

(10) Arnon TI, Achdout H, Levi O, Markel G, Saleh N, Katz G, et al. Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus. Nat Immunol 2005;6(5):515-523.

(11) Matza-Porges S, Horresh I, Tavor E, Panet A, Honigman A. Expression of an anti apoptotic recombinant short peptide in mammalian cells. Apoptosis 2005;10(5):987-996.

(12) Panet A, Braun E, Honigman A, Steiner I. Involvement of cellular death signals in the reactivation of herpes simplex virus type 1 and lambda bacteriophage from a latent state. J Theor Biol 2005;236(1):88-94.

(13) Borkow G, Lara HH, Ayash-Rashkovsky M, Tavor E, Lapidot A, Bentwich Z, et al. Adenovirus expressing a bioluminescence reporter gene and cMAGI cell assay for the detection of HIV-1. Virus Genes 2004;29(2):257-265.

(14) Abramovitch R, Tavor E, Jacob-Hirsch J, Zeira E, Amariglio N, Pappo O, et al. A Pivotal Role of Cyclic AMP-Responsive Element Binding Protein in Tumor Progression. Cancer Res 2004;64(4):1338-1346.

(15) Matza-Porges S, Tavor E, Panet A, Honigman A. Intracellular expression of a functional short peptide confers resistance to apoptosis. Exp Cell Res 2003;290(1):60-67.

(16) Zeira E, Manevitch A, Khatchatouriants A, Pappo O, Hyam E, Darash-Yahana M, et al. Femtosecond infrared laser - An efficient and safe in vivo gene delivery system for prolonged expression. Mol Ther 2003;8(2):342-350.

(17) Bar I, Zilberman Y, Zeira E, Galun E, Honigman A, Turgeman G, et al. Molecular imaging of the skeleton: Quantitative real-time bioluminescence monitoring gene expression in bone repair and development. J Bone Miner Res 2003;18(3):570-578.

(18) Wolf DG, Lurain NS, Zuckerman T, Hoffman R, Satinger J, Honigman A, et al. Emergence of late cytomegalovirus central nervous system disease in hematopoietic stem cell transplant recipients. Blood 2003;101(2):463-465.

(19) Shai E, Falk H, Honigman A, Panet A, Palmon A. Gene transfer mediated by different viral vectors following direct cannulation of mouse submandibular salivary glands. Eur J Oral Sci 2002;110(3):254-260.

(20) Goren I, Tavor E, Goldblum A, Honigman A. Two cysteine residues in the DNA-binding domain of CREB control binding to CRE and CREB-mediated gene expression. J Mol Biol 2001;313(4):695-709.

(21) Segev H, Honigman A, Rosen H, Leitersdorf E. Transcriptional regulation of the human sterol 27-hydroxylase gene (CYP27) and promoter mapping. Atherosclerosis 2001;156(2):339-347.

(22) Wolf DG, Yaniv I, Ashkenazi S, Honigman A. Emergence of multiple human cytomegalovirus ganciclovir-resistant mutants with deletions and substitutions within the UL97 gene in a patient with severe combined immunodeficiency. Antimicrob Agents Chemother 2001;45(2):593-595.

(23) Honigman A, Zeira E, Ohana P, Abramovitz R, Tavor E, Bar I, et al. Imaging transgene expression in live animals. Mol Ther 2001;4(3):239-249.

(24) Axelrod JH, Honigman A. A sensitive and versatile bioluminescence bioassay for HIV type 1 based on adenoviral vectors. AIDS Res Hum Retroviruses 1999;15(8):759-767.

(25) Goren I, Tavor E, Honigman A. Gene regulation mediated by interaction between HTLV-1 promoter elements and transcription factors Tax and CREB. Virology 1999;256(2):303-312.

(26) Wolf DG, Honigman A, Lazarovits J, Tavor E, Panet A. Characterization of the human cytomegalovirus UL97 gene product as a virion-associated protein kinase. Brief report. Arch Virol 1998;143(6):1223-1232.

(27) Wolf DG, Yaniv I, Honigman A, Kassis I, Schonfeld T, Ashkenazi S. Early emergence of ganciclovir-resistant human cytomegalovirus strains in children with primary combined immunodeficiency. J Infect Dis 1998;178(2):535-538.

(28) Nir-paz R, Israel S, Honigman A, Kahane I. Mycoplasmas regulate HIV-LTR-dependent gene expression. FEMS Microbiol Lett 1995;128(1):63-68.

(29) Honigman A, Falk H, Mador N, Rosental T, Panet A. Translation efficiency of the human T-cell leukemia virus (HTLV-2) gag gene modulates the frequency of ribosomal frameshifting. Virology 1995;208(1):312-318.

(30) Israel S, Mendelovitz M, Honigman A. Transactivation of human T-cell leukemia virus type 1 by herpes simplex virus type 1. Virus Genes 1995;9(3):269-276.

(31) Kollmus H, Honigman A, Panet A, Hauser H. The sequences of and distance between two cis-acting signals determine the efficiency of ribosomal frameshifting in human immunodeficiency virus type 1 and human T-cell leukemia virus type II in vivo. J Virol 1994;68(9):6087-6091.

(32) Falk H, Mador N, Udi R, Panet A, Honigman A. Two cis-acting signals control ribosomal frameshift between human T-cell leukemia virus type II gag and pro genes. J Virol 1993;67(10):6273-6277.

(33) Israel S, Honigman A. A bioluminescence assay for gene expression by continuously growing mammalian cells: application for detection of human immunodeficiency virus type 1 (HIV-1). Gene 1991;104(2):139-145.

(34) Bar-Shira A, Panet A, Honigman A. An RNA secondary structure juxtaposes two remote genetic signals for human T-cell leukemia virus type I RNA 3'-end processing. J Virol 1991;65(10):5165-5173.

(35) Honigman A, Wolf D, Yaish S, Falk H, Panet A. cis acting RNA sequences control the gag-pol translation readthrough in murine leukemia virus. Virology 1991;183(1):313-319.

(36) Unge T, Ahola H, Bhikhabhai R, Bäckbro K, Lövgren S, Strandberg B, et al. Expression, Purification, and Crystallization of the HIV-1 Reverse Transcriptase (RT). AIDS Res Hum Retroviruses 1990;6(11):1297-1303.

(37) Mador N, Panet A, Honigman A. Translation of gag, pro, and pol gene products of human T-cell leukemia virus type 2. J Virol 1989;63(5):2400-2404.

(38) Hyman HC, Honigman A. Transcription termination and processing sites in the bacteriophage λ pL operon. J Mol Biol 1986;189(1):131-141.

(39) Honigman A, Nedjar-Pazerini G, Yawetz A, Oron U, Schuster S, Broza M, et al. Cloning and expression of the lepidopteran toxin produced by Bacillus thuringiensis var. thuringiensis in Escherichia coli. Gene 1986;42(1):69-77.

(40) Honigman A, Bar-Shira A, Silberberg H, Panet A. Generation of a uniform 3' end RNA of murine leukemia virus. J Virol 1985;53(1):330-334.

(41) Oron U, Sokolover M, Yawetz A, Broza M, Sneh B, Honigman A. Ultrastructural changes in the larval midgut epithelium of Spodoptera littoralis following ingestion of δ-endotoxin of Bacillus thuringiensis var. entomocidus. J Invertebr Pathol 1985;45(3):353-355.

(42) Honigman A, Mahajna J, Altuvia S, Koby S, Teff D, Locker-Giladi H, et al. Plasmid vectors designed for the analysis of transcription termination signals. Gene 1985;36(1-2):131-141.

(43) Honigman A, Kronman C, Nur I, Greenberg N, Rottem S. Cloning of L-2 DNA in Escherichia coli pOL4 plasmid. Isr J Med Sci 1984;20(9):793-796.

(44) Honigman A, Panet A. A unique sequence in murine leukemia virus long terminal repeat functions as a termination signal for transcription in Escherichia coli. J Virol 1983;45(1):456-461.

(45) Becker Y, Shtram Y, Honigman A, Laban A, Cohen A. Herpes simplex virus type 1 thymidine kinase gene expression in Escherichia coli. Gene 1983;21(1-2):51-58.

(46) Hyman HC, Honigman A. The use of the plasmid pHA10 in the isolation of λPL promoter mutations. Mol Gen Genet 1982;185(3):515-517.

(47) Honigman A. Cloning and characterization of a transcription termination signal in bacteriophage λ unresponsive to the N gene product. Gene 1981;13(3):299-309.

(48) Honigman A, Oppenheim AB, Hohn B, Hohn T. Plasmid vectors for positive selection of DNA inserts controlled by the λ pl promoter, repressor and antitermination function. Gene 1981;13(3):289-298.

(49) Fuchs C, Rosenvold EC, Honigman A, Szybalski W. Identification of palindromic sequences recognized by restriction endonucleases, as based on the tabularized sequencing data for seven viral and plasmid DNAs. Gene 1980;10(4):357-370.

(50) Honigman A, Hu S-, Szybalski W. Regulation of integration by coliphage λ: Activation of int transcription by the cII and cIII proteins. Virology 1979;92(2):542-556.

(51) Enquist L, Honigman A, Hu S-, Szybalski W. Expression of λ int gene function in ColE1 hybrid plasmids carrying the C fragment of bacteriophage λ. Virology 1979;92(2):557-560.

(52) Fuchs C, Rosenvold EC, Honigman A, Szybalski W. A simple method for identifying the palindromic sequences recognized by restriction endonucleases: the nucleotide sequence of the AvaII site. Gene 1978;4(1):1-23.

(53) Rosenvold EC, Honigman A. Mapping of AvaI and XmaI cleavage sites in bacteriophage DNA including a new technique of DNA digestion in agarose gels. Gene 1977;2(5-6):273-288.

(54) Fiandt M, Honigman A, Rosenvold EC, Szybalski W. Precise measurement of the b2 deletion in coliphage lambda. Gene 1977;2(5-6):289-293.

(55) Szybalski EH, Honigman A, Rosenvold EC, Fiandt M, Szybalski W. A deletion in the P-Q (ninR) region of phage λb2imm21 conferring partial gene N21 independence. Gene 1977;2(5-6):295-297.

(56) Honigman A, Hu S-, Chase R, Szybalski W. 4S oop RNA is a leader sequence for the immunity-establishment transcription in coliphage λ. Nature 1976;262(5564):112-116.

(57) Honigman A, Oppenheim A, Oppenheim AB, Stevens WF. A pleiotropic regulatory mutation in λ bacteriophage. Molec Gen Genet 1975;138(2):85-111.

(58) Oppenheim A, Honigman A, Oppenheim AB. Interference with phage lambda cro gene function by a colicin-tolerant Escherichia coli mutant. Virology 1974;61(1):1-10.

(59) Echols H, Green L, Oppenheim AB, Oppenheim A, Honigman A. Role of the cro gene in bacteriophage λ development. J Mol Biol 1973;80(2):203-216.