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School of Pharmacy : Lazarovici Philip

Researchers

 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Rubin L, Stabler CT, Schumacher-Klinger A, Marcinkiewicz C, Lelkes PI, Lazarovici P. Neurotrophic factors and their receptors in lung development and implications in lung diseases. Cytokine Growth Factor Rev 2021;59:84-94.

(2) Gilon C, Gitlin-Domagalska A, Lahiani A, Yehoshua-Alshanski S, Shumacher-Klinger A, Gilon D, et al. Novel humanin analogs confer neuroprotection and myoprotection to neuronal and myoblast cell cultures exposed to ischemia-like and doxorubicin-induced cell death insults. Peptides 2020;134.

(3) Talhami A, Swed A, Hess S, Ovadia O, Greenberg S, Schumacher-Klinger A, et al. Cyclizing Painkillers: Development of Backbone-Cyclic TAPS Analogs. Front Chem 2020;8.

(4) Fluksman A, Steinberg E, Orehov N, Shai E, Lahiani A, Katzhendler J, et al. Integrin α2β1-Targeted Self-Assembled Nanocarriers for Tumor Bioimaging. ACS Appl Bio Mater 2020;3(9):6059-6070.

(5) Yan F, Liao R, Silva M, Li S, Jiang Y, Peng T, et al. Pristimerin-induced uveal melanoma cell death via inhibiting PI3K/Akt/FoxO3a signalling pathway. J Cell Mol Med 2020;24(11):6208-6219.

(6) Lazarovici P. Snake- and spider-venom-derived toxins as lead compounds for drug development. Methods Mol Biol 2020;2068:3-26.

(7) Maatuf Y, Priel A, Lazarovici P. Measurements of cell death induced by snake and spider’s venoms and derived toxins. Methods Mol Biol 2020;2068:239-268.

(8) Lazarovici P, Marcinkiewicz C, Lelkes PI. Cell-based adhesion assays for isolation of snake venom’s integrin antagonists. Methods Mol Biol 2020;2068:205-223.

(9) Lahiani A, Haham-Geula D, Lankri D, Cornell-Kennon S, Schaefer EM, Tsvelikhovsky D, et al. Neurotropic activity and safety of methylene-cycloalkylacetate (MCA) derivative 3-(3-allyl-2-methylenecyclohexyl) propanoic acid. ACS Chem Neurosci 2020;11(17):2577-2589.

(10) Yan F, Wang R, Li S, Zhao X, Jiang Y, Liu L, et al. Foxo3a suppresses neuropeptide w expression in neuronal cells and in rat hypothalamus and its implication in hypothalamic-pituitary-adrenal (HPA) axis. Int J Biol Sci 2020;16(15):2775-2787.

(11) Jiang Y, Yan F, Feng Z, Lazarovici P, Zheng W. Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction. Cells 2019;9(1).

(12) Fang J, Zhao X, Li S, Xing X, Wang H, Lazarovici P, et al. Protective mechanism of artemisinin on rat bone marrow-derived mesenchymal stem cells against apoptosis induced by hydrogen peroxide via activation of c-Raf-Erk1/2-p90rsk-CREB pathway. Stem Cell Res Ther 2019;10(1).

(13) Lazarovici P, Marcinkiewicz C, Lelkes PI. From snake venom’s disintegrins and C-type lectins to anti-platelet drugs. Toxins 2019;11(5).

(14) Shilo D, Cohen G, Blumenfeld A, Goren K, Hanhan S, Sharon S, et al. Tuftelin Is Required for NGF-Induced Differentiation of PC12 Cells. J Mol Neurosci 2019;68(1):135-143.

(15) Li S, Zhao X, Lazarovici P, Zheng W. Artemether Activation of AMPK/GSK3 β (ser9)/Nrf2 Signaling Confers Neuroprotection towards β- Amyloid-Induced Neurotoxicity in 3xTg Alzheimer's Mouse Model. Oxidative Med Cell Longevity 2019;2019.

(16) Peng T, Jiang Y, Farhan M, Lazarovici P, Chen L, Zheng W. Anti-inflammatory effects of traditional Chinese medicines on preclinical in vivo models of brain ischemia-reperfusion-injury: Prospects for neuroprotective drug discovery and therapy. Front Pharmacol 2019;10(MAR).

(17) Tiram G, Ferber S, Ofek P, Eldar-Boock A, Ben-Shushan D, Yeini E, et al. Reverting the molecular fingerprint of tumor dormancy as a therapeutic strategy for glioblastoma. FASEB J 2018;32(11):5835-5850.

(18) Wang H, Xu J, Lazarovici P, Quirion R, Zheng W. cAMP Response Element-Binding Protein (CREB): A Possible Signaling Molecule Link in the Pathophysiology of Schizophrenia. Front Mol Neurosci 2018;11.

(19) Lankri D, Haham D, Lahiani A, Lazarovici P, Tsvelikhovsky D. Methylene-Cycloalkylacetate (MCA) Scaffold-Based Compounds as Novel Neurotropic Agents. ACS Chem Neurosci 2018;9(4):691-698.

(20) Lahiani A, Brand-Yavin A, Yavin E, Lazarovici P. Neuroprotective effects of bioactive compounds and mapk pathway modulation in “ischemia”—stressed PC12 pheochromocytoma cells. Brain Sci 2018;8(2).

(21) Gincberg G, Shohami E, Lazarovici P, Elchalal U. Human Umbilical Cord Blood CD45+ Pan-Hematopoietic Cells Induced a Neurotherapeutic Effect in Mice with Traumatic Brain Injury: Immunophenotyping, Comparison of Maternal and Neonatal Parameters, and Immunomodulation. J Mol Neurosci 2018;64(2):185-199.

(22) Gincberg G, Shohami E, Trembovler V, Alexandrovich AG, Lazarovici P, Elchalal U. Nerve growth factor plays a role in the neurotherapeutic effect of a CD45 + pan-hematopoietic subpopulation derived from human umbilical cord blood in a traumatic brain injury model. Cytotherapy 2018;20(2):245-261.

(23) Lazarovici P, Lahiani A, Gincberg G, Haham D, Marcinkiewicz C, Lelkes PI. Nerve growth factor-induced angiogenesis: 2. The quail chorioallantoic membrane assay. Methods Mol Biol 2018;1727:251-259.

(24) Lazarovici P, Lahiani A, Gincberg G, Haham D, Fluksman A, Benny O, et al. Nerve growth factor-induced angiogenesis: 1. Endothelial cell tube formation assay. Methods Mol Biol 2018;1727:239-250.

(25) Wang H, Xu J, Lazarovici P, Zheng W. Dysbindin-1 involvement in the etiology of schizophrenia. Int J Mol Sci 2017;18(10).

(26) Amsalem O, Nassar T, Benhamron S, Lazarovici P, Benita S, Yavin E. Solid nano-in-nanoparticles for potential delivery of siRNA. J Control Release 2017;257:144-155.

(27) Wang H, Farhan M, Xu J, Lazarovici P, Zheng W. The involvement of DARPP-32 in the pathophysiology of schizophrenia. Oncotarget 2017;8(32):53791-53803.

(28) Lahiani A, Yavin E, Lazarovici P. The molecular basis of toxins’ interactions with intracellular signaling via discrete portals. Toxins 2017;9(3).

(29) Geron M, Kumar R, Matzner H, Lahiani A, Gincberg G, Cohen G, et al. Protein toxins of the Echis coloratus viper venom directly activate TRPV1. Biochim Biophys Acta Gen Subj 2017;1861(3):615-623.

(30) Lahiani A, Hidmi A, Katzhendler J, Yavin E, Lazarovici P. Novel Synthetic PEGylated Conjugate of α-Lipoic Acid and Tempol Reduces Cell Death in a Neuronal PC12 Clonal Line Subjected to Ischemia. ACS Chem Neurosci 2016;7(10):1452-1462.

(31) Zheng W, Chong C-, Wang H, Zhou X, Zhang L, Wang R, et al. Artemisinin conferred ERK mediated neuroprotection to PC12 cells and cortical neurons exposed to sodium nitroprusside-induced oxidative insult. Free Radic Biol Med 2016;97:158-167.

(32) Stabler CT, Caires LC, Mondrinos MJ, Marcinkiewicz C, Lazarovici P, Wolfson MR, et al. Enhanced Re-Endothelialization of Decellularized Rat Lungs. Tissue Eng Part C Methods 2016;22(5):439-450.

(33) Stabler CT, Lecht S, Lazarovici P, Lelkes PI. Mesenchymal stem cells for therapeutic applications in pulmonary medicine. Br Med Bull 2015;115(1):45-56.

(34) Cohen G, Natsheh H, Sunny Y, Bawiec CR, Touitou E, Lerman MA, et al. Enhanced Therapeutic Anti-Inflammatory Effect of Betamethasone on Topical Administration with Low-Frequency, Low-Intensity (20 kHz, 100 mW/cm2) Ultrasound Exposure on Carrageenan-Induced Arthritis in a Mouse Model. Ultrasound Med Biol 2015;41(9):2449-2457.

(35) Ettinger K, Nevo Y, Marcinkiewicz C, Lazarovici P. Nerve growth factor-induced myoprotection in C2C12 muscle cells is mediated by α9β1 integrin via release of PGE2. J Basic Clin Physiol Pharmacol 2015;26(4):411-415.

(36) Ventresca EM, Lecht S, Jakubowski P, Chiaverelli RA, Weaver M, Del Valle L, et al. Association of p75NTR and α9β1 integrin modulates NGF-dependent cellular responses. Cell Signal 2015;27(6):1225-1236.

(37) Wang H, Liao S, Geng R, Zheng Y, Liao R, Yan F, et al. IGF-1 Signaling via the PI3K/Akt Pathway Confers Neuroprotection in Human Retinal Pigment Epithelial Cells Exposed to Sodium Nitroprusside Insult. J Mol Neurosci 2015;55(4):931-940.

(38) Wang R, Yang J, Peng L, Zhao J, Mu N, Huang J, et al. Gardenamide A attenuated cell apoptosis induced by serum deprivation insult via the ERK1/2 and PI3K/AKT signaling pathways. Neuroscience 2015;286:242-250.

(39) Lahiani A, Zahavi E, Netzer N, Ofir R, Pinzur L, Raveh S, et al. Human PLacental eXpanded (PLX) mesenchymal-like adherent stromal cells confer neuroprotection to nerve growth factor (NGF)-differentiated PC12 cells exposed to ischemia by secretion of IL-6 and VEGF. Biochim Biophys Acta Mol Cell Res 2015;1853(2):422-430.

(40) Momic T, Katzhendler J, Shai E, Noy E, Senderowitz H, Aeble J, et al. Vipegitide: A folded peptidomimetic partial antagonist of α2β1 integrin with antiplatelet aggregation activity. Drug Des Dev Ther 2015;9:291-303.

(41) Stabler CT, Lecht S, Mondrinos MJ, Goulart E, Lazarovici P, Lelkes PI. Revascularization of decellularized lung scaffolds: Principles and progress. Am J Physiol Lung Cell Mol Physiol 2015;309(11):L1273-L1285.

(42) Lecht S, Chiaverelli RA, Gerstenhaber J, Calvete JJ, Lazarovici P, Casewell NR, et al. Anti-angiogenic activities of snake venom CRISP isolated from Echis carinatus sochureki. Biochim Biophys Acta Gen Subj 2015;1850(6):1169-1179.

(43) Galski H, Oved-Gelber T, Simanovsky M, Lazarovici P, Gottesman MM, Nagler A. Corrigendum to "P-glycoprotein-dependent resistance of cancer cells toward the extrinsic TRAIL apoptosis signaling pathway" [Biochem. Pharmacol. 86 (2013) 584-596]. Biochem Pharmacol 2014;92(3):518.

(44) Cohen G, Ettinger K, Lecht S, Lelkes PI, Lazarovici P. Transcriptional Down-regulation of Epidermal Growth Factor (EGF) Receptors by Nerve Growth Factor (NGF) in PC12 Cells. J Mol Neurosci 2014;54(3):574-585.

(45) Arien-Zakay H, Gincberg G, Nagler A, Cohen G, Liraz-Zaltsman S, Trembovler V, et al. Neurotherapeutic effect of cord blood derived CD45+ hematopoietic cells in mice after traumatic brain injury. J Neurotrauma 2014;31(16):1405-1416.

(46) Lecht S, Cohen-Arazi N, Cohen G, Ettinger K, Momic T, Kolitz M, et al. Cytocompatibility of novel extracellular matrix protein analogs of biodegradable polyester polymers derived from α-hydroxy amino acids. J Biomater Sci Polym Ed 2014;25(6):608-624.

(47) Momic T, Katzehendler J, Benny O, Lahiani A, Cohen G, Noy E, et al. Vimocin and vidapin, cyclic KTS peptides, are dual antagonists of α1β1/α2β1 integrins with antiangiogenic activity. J Pharmacol Exp Ther 2014;350(3):506-519.

(48) Lin L, Perets A, Har-el Y-, Varma D, Li M, Lazarovici P, et al. Alimentary 'green' proteins as electrospun scaffolds for skin regenerative engineering. J Tissue Eng Regenerative Med 2013;7(12):994-1008.

(49) Bercu MM, Arien-Zakay H, Stoler D, Lecht S, Lelkes PI, Samuel S, et al. Enhanced survival and neurite network formation of human umbilical cord blood neuronal progenitors in three-dimensional collagen constructs. J Mol Neurosci 2013;51(2):249-261.

(50) Karatzas A, Katsanos K, Lilis I, Papadaki H, Kitrou P, Lecht S, et al. NGF promotes hemodynamic recovery in a rabbit hindlimb ischemic model through trkA- and VEGFR2-dependent Pathways. J Cardiovasc Pharmacol 2013;62(3):270-277.

(51) Ettinger K, Cohen G, Momic T, Lazarovici P. The effects of a chactoid scorpion venom and its purified toxins on rat blood pressure and mast cells histamine release. Toxins 2013;5(8):1332-1342.

(52) Cohen G, Lecht S, Oron-Herman M, Momic T, Nissan A, Lazarovici P. Near infrared optical visualization of epidermal growth factor receptors levels in COLO205 colorectal cell line, orthotopic tumor in mice and human biopsies. Int J Mol Sci 2013;14(7):14669-14688.

(53) Jakubowski P, Calvete JJ, Eble JA, Lazarovici P, Marcinkiewicz C. Identification of inhibitors of α2β1 integrin, members of C-lectin type proteins, in Echis sochureki venom. Toxicol Appl Pharmacol 2013;269(1):34-42.

(54) Han J, Gerstenhaber JA, Lazarovici P, Lelkes PI. Tissue factor activity and ECM-related gene expression in human aortic endothelial cells grown on electrospun biohybrid scaffolds. Biomacromolecules 2013;14(5):1338-1348.

(55) Arlinghaus FT, Momic T, Ammar NA, Shai E, Spectre G, Varon D, et al. Identification of α2β1 integrin inhibitor VP-i with anti-platelet properties in the venom of Vipera palaestinae. Toxicon 2013;64:96-105.

(56) Saglam A, Perets A, Canver AC, Li H-, Kollins K, Cohen G, et al. Angioneural crosstalk in scaffolds with oriented microchannels for regenerative spinal cord injury repair. J Mol Neurosci 2013;49(2):334-346.

(57) Strande JL, Routhu KV, Lecht S, Lazarovici P. Nerve growth factor reduces myocardial ischemia/reperfusion injury in rat hearts. J Basic Clin Physiol Pharmacol 2013;24(1):81-84.

(58) Galski H, Oved-Gelber T, Simanovsky M, Lazarovici P, Gottesman MM, Nagler A. P-glycoprotein-dependent resistance of cancer cells toward the extrinsic TRAIL apoptosis signaling pathway. Biochem Pharmacol 2013;86(5):584-596.

(59) Gincberg G, Arien-Zakay H, Lazarovici P, Lelkes PI. Neural stem cells: Therapeutic potential for neurodegenerative diseases. Br Med Bull 2012;104(1):7-19.

(60) Frohbergh ME, Katsman A, Botta GP, Lazarovici P, Schauer CL, Wegst UGK, et al. Electrospun hydroxyapatite-containing chitosan nanofibers crosslinked with genipin for bone tissue engineering. Biomaterials 2012;33(36):9167-9178.

(61) Ettinger K, Lecht S, Arien-Zakay H, Cohen G, Aga-Mizrachi S, Yanay N, et al. Nerve growth factor stimulation of ERK1/2 phosphorylation requires both p75NTR and α9β1 integrin and confers myoprotection towards ischemia in C2C12 skeletal muscle cell model. Cell Signal 2012;24(12):2378-2388.

(62) Cohen G, Lecht S, Arien-Zakay H, Ettinger K, Amsalem O, Oron-Herman M, et al. Bio-Imaging of Colorectal Cancer Models Using Near Infrared Labeled Epidermal Growth Factor. PLoS ONE 2012;7(11).

(63) Lazarovici P, Cohen G, Arien-Zakay H, Chen J, Zhang C, Chopp M, et al. Multimodal neuroprotection induced by PACAP38 in Oxygen-glucose deprivation and middle cerebral artery occlusion stroke models. J Mol Neurosci 2012;48(3):526-540.

(64) Wang H, Zhang Q, Wen Q, Zheng Y, Lazarovici P, Jiang H, et al. Corrigendum to "Proline-rich Akt substrate of 40kDa (PRAS40): A novel downstream target of PI3k/Akt signaling pathway" [Cell. Signal. 2012; 24:17-24]. Cell Signal 2012;24(11):2226.

(65) Momic T, Cohen G, Reich R, Arlinghaus FT, Eble JA, Marcinkiewicz C, et al. Vixapatin (VP12), a C-type lectin-protein from Vipera xantina palestinae venom: Characterization as a novel anti-angiogenic compound. Toxins 2012;4(10):862-877.

(66) Lecht S, Rotfeld E, Arien-Zakay H, Tabakman R, Matzner H, Yaka R, et al. Neuroprotective effects of nimodipine and nifedipine in the NGF-differentiated PC12 cells exposed to oxygen-glucose deprivation or trophic withdrawal. Int J Dev Neurosci 2012;30(6):465-469.

(67) Walsh EM, Kim R, Del Valle L, Weaver M, Sheffield J, Lazarovici P, et al. Importance of interaction between nerve growth factor and α9β1 integrin in glial tumor angiogenesis. Neuro-oncology 2012;14(7):890-901.

(68) Deutsch D, Silverstein N, Shilo D, Lecht S, Lazarovici P, Blumenfeld A. Biphasic influence of hypoxia on tuftelin expression in mouse mesenchymal C3H10T1/2 stem cells. Eur J Oral Sci 2011;119(SUPPL.1):55-61.

(69) Momic T, Arlinghaus FT, Arien-Zakay H, Katzhendler J, Eble JA, Marcinkiewicz C, et al. Pharmacological aspects of Vipera xantina palestinae venom. Toxins 2011;3(11):1420-1432.

(70) Portnoy E, Lecht S, Lazarovici P, Danino D, Magdassi S. Cetuximab-labeled liposomes containing near-infrared probe for in vivo imaging. Nanomed Nanotechnol Biol Med 2011;7(4):480-488.

(71) Arien-Zakay H, Lecht S, Nagler A, Lazarovici P. Neuroprotection by human umbilical cord blood-derived progenitors in ischemic brain injuries. Arch Ital Biol 2011;149(2):233-245.

(72) Nassar T, Attili-Qadri S, Harush-Frenkel O, Farber S, Lecht S, Lazarovici P, et al. High plasma levels and effective lymphatic uptake of docetaxel in an orally available nanotransporter formulation. Cancer Res 2011;71(8):3018-3028.

(73) Han J, Lazarovici P, Pomerantz C, Chen X, Wei Y, Lelkes PI. Co-electrospun blends of PLGA, gelatin, and elastin as potential nonthrombogenic scaffolds for vascular tissue engineering. Biomacromolecules 2011;12(2):399-408.

(74) Pimton P, Sarkar S, Sheth N, Perets A, Marcinkiewicz C, Lazarovici P, et al. Fibronectin-mediated upregulation of α5β1 integrin and cell adhesion during differentiation of mouse embryonic stem cells. Cell Adhesion Migr 2011;5(1):73-82.

(75) Leiser Y, Silverstein N, Blumenfeld A, Shilo D, Haze A, Rosenfeld E, et al. The induction of tuftelin expression in PC12 cell line during hypoxia and NGF-induced differentiation. J Cell Physiol 2011;226(1):165-172.

(76) Arien-Zakay H, Lecht S, Nagler A, Lazarovici P. Human umbilical cord blood stem cells: Rational for use as a neuroprotectant in ischemic brain disease. Int J Mol Sci 2010;11(9):3513-3528.

(77) Lecht S, Arien-Zakay H, Wagenstein Y, Inoue S, Marcinkiewicz C, Lelkes PI, et al. Transient signaling of Erk1/2, Akt and PLCγ induced by nerve growth factor in brain capillary endothelial cells. Vasc Pharmacol 2010;53(3-4):107-114.

(78) Finkelstein Y, Milatovic D, Lazarovici P, Ophir A, Richter ED, Aschner M, et al. Peaceful use of disastrous neurotoxicants. Neurotoxicology 2010;31(5):608-620.

(79) Arien-Zakay H, Lazarovici P, Nagler A. Tissue regeneration potential in human umbilical cord blood. Best Pract Res Clin Haematol 2010;23(2):291-303.

(80) Lecht S, Arien-Zakay H, Kohan M, Lelkes PI, Lazarovici P. Angiostatic effects of K252a, a Trk inhibitor, in murine brain capillary endothelial cells. Mol Cell Biochem 2010;339(1-2):201-213.

(81) Lecht S, Arien-Zakay H, Marcinkiewicz C, Lelkes PI, Lazarovici P. Nerve growth factor-induced protection of brain capillary endothelial cells exposed to oxygen-glucose deprivation involves attenuation of erk phosphorylation. J Mol Neurosci 2010;41(1):183-192.

(82) Lecht S, Foerster C, Arien-Zakay H, Marcinkiewicz C, Lazarovici P, Lelkes PI. Cardiac microvascular endothelial cells express and release nerve growth factor but not fibroblast growth factor-2. In Vitro Cell Dev Biol Anim 2010;46(5):469-476.

(83) Permeability of an In Vitro Model of Blood Brain Barrier (BBB). IFMBE Proceedings; 2009.

(84) Arien-Zakay H, Lecht S, Perets A, Roszell B, Lelkes PI, Lazarovici P. Quantitative assessment of neuronal differentiation in three-dimensional collagen gels using enhanced green fluorescence protein expressing PC12 pheochromocytoma cells. J Mol Neurosci 2009;37(3):225-237.

(85) Arien-Zakay H, Lecht S, Bercu MM, Tabakman R, Kohen R, Galski H, et al. Neuroprotection by cord blood neural progenitors involves antioxidants, neurotrophic and angiogenic factors. Exp Neurol 2009;216(1):83-94.

(86) Arien-Zakay H, Lecht S, Bercu MM, Amariglio N, Rechavi G, Galski H, et al. Interferon-γ-induced neuronal differentiation of human umbilical cord blood-derived progenitors. Leukemia 2009;23(10):1790-1800.

(87) Staniszewska I, Walsh EM, Rothman VL, Gaathon A, Tuszynski GP, Calvete JJ, et al. Effect of VP12 and viperistatin on inhibition of collagen receptors-dependent melanoma metastasis. Cancer Biol Ther 2009;8(15).

(88) Ringel I, Lecht S, Sterin M, Lelkes PI, Lazarovici P. 31P magnetic resonance spectroscopy of endothelial cells grown in three-dimensional matrigel construct as an enabling platform technology: II. The effect of anti-inflammatory drugs on phosphometabolite levels. Endothelium J Endothelial Cell Res 2008;15(5-6):299-307.

(89) Sterin M, Ringel I, Lecht S, Lelkes PI, Lazarovici P. 31P magnetic resonance spectroscopy of endothelial cells grown in three-dimensional matrigel construct as an enabling platform technology: I. The effect of glial cells and valporic acid on phosphometabolite levels. Endothelium J Endothelial Cell Res 2008;15(5-6):288-298.

(90) Kolusheva S, Lecht S, Derazon Y, Jelinek R, Lazarovici P. Pardaxin, a fish toxin peptide interaction with a biomimetic phospholipid/polydiacetylene membrane assay. Peptides 2008;29(9):1620-1625.

(91) Staniszewska I, Sariyer IK, Lecht S, Brown MC, Walsh EM, Tuszynski GP, et al. Integrin α9β1 is a receptor for nerve growth factor and other neurotrophins. J Cell Sci 2008;121(4):504-513.

(92) Brown MC, Staniszewska I, Lazarovici P, Tuszynski GP, Del Valle L, Marcinkiewicz C. Regulatory effect of nerve growth factor in α9β1 integrin-dependent progression of glioblastoma. Neuro-oncology 2008;10(6):968-980.

(93) Lecht S, Haroutiunian S, Hoffman A, Lazarovici P. Rasagiline - A novel MAO B inhibitor in Parkinson's disease therapy. Ther Clin Risk Manage 2007;3(3):467-474.

(94) Arien-Zakay H, Nagler A, Galski H, Lazarovici P. Neuronal conditioning medium and nerve growth factor induce neuronal differentiation of collagen-adherent progenitors derived from human umbilical cord blood. J Mol Neurosci 2007;32(3):179-191.

(95) Brown MC, Calvete JJ, Staniszewska I, Walsh EM, Perez-Liz G, Del Valle L, et al. VEGF-related protein isolated from Vipera palestinae venom, promotes angiogenesis. Growth Factors 2007;25(2):108-117.

(96) Ødegaard E, Staff AC, Abeler VM, Kopolovic J, Onsrud M, Lazarovici P, et al. The activated nerve growth factor receptor p-TrkA is selectively expressed in advanced-stage ovarian carcinoma. Hum Pathol 2007;38(1):140-146.

(97) Lazarovici P, Li M, Perets A, Mondrinos MJ, Lecht S, Koharski CD, et al. Intelligent Biomatrices and Engineered Tissue Constructs: In-Vitro Models for Drug Discovery and Toxicity Testing. Drug Testing in vitro: Breakthroughs and Trends in Cell Culture Technology; 2006. p. 1-51.

(98) Lipman T, Tabakman R, Lazarovici P. Neuroprotective effects of the stable nitroxide compound Tempol on 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in the Nerve Growth Factor-differentiated model of pheochromocytoma PC12 cells. Eur J Pharmacol 2006;549(1-3):50-57.

(99) Galski H, Sivan H, Lazarovici P, Nagler A. In vitro and in vivo reversal of MDR1-mediated multidrug resistance by KT-5720: Implications on hematological malignancies. Leuk Res 2006;30(9):1151-1158.

(100) Lazarovici P, Marcinkiewicz C, Lelkes PI. Cross talk between the cardiovascular and nervous systems: Neurotrophic effects of vascular endothelial growth factor (VEGF) and angiogenic effects of nerve growth factor (NGF)-implications in drug development. Curr Pharm Des 2006;12(21):2609-2622.

(101) Rocha AS, Risberg B, Magalhães J, Trovisco V, de Castro IV, Lazarovici P, et al. The p75 neurotrophin receptor is widely expressed in conventional papillary thyroid carcinoma. Hum Pathol 2006;37(5):562-568.

(102) Lazarovici P, Gazit A, Staniszewska I, Marcinkiewicz C, Lelkes PI. Nerve Growth Factor (NGF) promotes angiogenesis in the quail chorioallantoic membrane. Endothelium J Endothelial Cell Res 2006;13(1):51-59.

(103) Dollé J-, Rezvan A, Allen FD, Lazarovici P, Lelkes PI. Nerve growth factor-induced migration of endothelial cells. J Pharmacol Exp Ther 2005;315(3):1220-1227.

(104) Jiang H, Zhang L, Koubi D, Kuo J, Groc L, Rodriguez AI, et al. Roles of Ras-Erk in apoptosis of PC12 cells induced by trophic factor withdrawal or oxidative stress. J Mol Neurosci 2005;25(2):133-140.

(105) Skaper S, Kuan C-, Lazarovici P, Mandel S, Weinreb O, Ali S. Questions and answers: Session VIII: Mechanisms of neuroprotection (2). Ann New York Acad Sci 2005;1053:405-406.

(106) Tabakman R, Jiang H, Shahar I, Arien-Zakay H, Levine RA, Lazarovici P. Neuroprotection by NGF in the PC12 in vitro OGD model: Involvement of mitogen-activated protein kinases and gene expression. Ann New York Acad Sci 2005;1053:84-96.

(107) Qi X, Hoke A, Turski L, Youdim M, Lazarovici P, Mocchetti I. Questions and answers: Session VI: Neuroprotective agents and mechanisms. Ann New York Acad Sci 2005;1053:287-288.

(108) Hoke A, Lazarovici P, Youdim M, Banik N, Faden A, Doré S, et al. Questions and answers: Session X: Novel approaches to neuroprotection. Ann New York Acad Sci 2005;1053:502-504.

(109) Jevtovic-Todorovic V, Sharma HS, Lazarovici P, Kuan C-, Sanzenbacher K, Wiklund L, et al. Questions and answers: Session VII: The NMDA receptor as a target for neurotoxicity and neuroprotection. Ann New York Acad Sci 2005;1053:330-333.

(110) Wiklund L, Fiskum G, Chuang D-, Slikker Jr. W, Xi X, Banik N, et al. Questions and answers: Session V: Neuroprotective approaches and models. Ann New York Acad Sci 2005;1053:233-236.

(111) Fiskum G, Slikker Jr. W, Lazarovici P, Maynard K, Binienda Z, Sharma H, et al. Questions and answers: Session IV: Role of carnitines and other agents in neuroprotection. Ann New York Acad Sci 2005;1053:192-194.

(112) Banik N, Slikker Jr. W, Sharma H, Qi X, Lazarovici P, Chuang D-, et al. Questions and answers: Session II: Mechanisms of neuroprotection (1). Ann New York Acad Sci 2005;1053:99-106.

(113) Kisiel DG, Calvete JJ, Katzhendler J, Fertala A, Lazarovici P, Marcinkiewicz C. Structural determinants of the selectivity of KTS-disintegrins for the α1β1 integrin. FEBS Lett 2004;577(3):478-482.

(114) Davidson B, Reich R, Lazarovici P, Flørenes VA, Risberg B, Nielsen S, et al. Expression of the nerve growth factor receptors TrkA and p75 in malignant mesothelioma. Lung Cancer 2004;44(2):159-165.

(115) Tabakman R, Jiang H, Schaefer E, Levine RA, Lazarovici P. Nerve growth factor pretreatment attenuates oxygen and glucose deprivation-induced c-Jun amino-terminal kinase 1 and stress-activated kinases p38α and p38β activation and confers neuroprotection in the pheochromocytoma PC12 model. J Mol Neurosci 2004;22(3):237-249.

(116) Tabakman R, Jiang H, Levine RA, Kohen R, Lazarovici P. Apoptotic Characteristics of Cell Death and the Neuroprotective Effect of Homocarnosine on Pheochromocytoma PC12 Cells Exposed to Ischemia. J Neurosci Res 2004;75(4):499-507.

(117) Tabakman R, Lecht S, Lazarovici P. Neuroprotection by monoamine oxidase B inhibitors: A therapeutic strategy for Parkinson's disease? Bioessays 2004;26(1):80-90.

(118) Tabakman R, Lecht S, Sephanova S, Arien-Zakay H, Lazarovici P. Interactions between the cells of the immune and nervous system: Neurotrophins as neuroprotection mediators in CNS injury. Prog Brain Res 2004;146:385-401.

(119) Flørenes VA, Mælandsmo GM, Holm R, Reich R, Lazarovici P, Davidson B. Expression of activated TrkA protein in melanocytic tumors: Relationship to cell profileration and clinical outcome. Am J Clin Pathol 2004;122(3):412-420.

(120) Davidson B, Reich R, Lazarovici P, Flørenes VA, Nielsen S, Nesland JM. Altered expression and activation of the nerve growth factor receptors TrkA and p75 provide the first evidence of tumor progression to effusion in breast carcinoma. Breast Cancer Res Treat 2004;83(2):119-128.

(121) Davidson B, Givant-Horwitz V, Lazarovici P, Risberg B, Nesland JM, Trope CG, et al. Matrix metalloproteinases (MMP), EMMPRIN (extracellular matrix metalloproteinase inducer) and mitogen-activated protein kinases (MAPK): Co-expression in metastatic serous ovarian carcinoma. Clin Exp Metastasis 2003;20(7):621-631.

(122) Katzir I, Shani J, Shabashov D, Dagan J, Lazarovici P. Establishment and characterization of pheochromocytoma tumor models expressing different levels of trkA receptors. Cancer Lett 2003;200(2):177-185.

(123) Givant-Horwitz V, Davidson B, Lazarovici P, Schaefer E, Nesland JM, Tropé CG, et al. Mitogen-activated protein kinases (MAPK) as predictors of clinical outcome in serous ovarian carcinoma in effusions. Gynecol Oncol 2003;91(1):160-172.

(124) Katzir I, Shani J, Goshen G, Sela J, Ninary E, Dogonovski AM, et al. Characterization of nerve growth factors (NGFs) from snake venoms by use of a novel, quantitative bioassay utilizing pheochromocytoma (PC12) cells overexpressing human trkA receptors. Toxicon 2003;42(5):481-490.

(125) Davidson B, Reich R, Lazarovici P, Nesland JM, Skrede M, Risberg B, et al. Expression and activation of the nerve growth factor receptor TrkA in serous ovarian carcinoma. Clin Cancer Res 2003;9(6):2248-2259.

(126) Lazarovici P. The structure and function of pardaxin. J Toxicol Toxin Rev 2002;21(4):391-421.

(127) Bloch-Shilderman E, Abu-Raya S, Trembovler V, Boschwitz H, Gruzman A, Linial M, et al. Pardaxin stimulation of phospholipases A2 and their involvement in exocytosis in PC-12 cells. J Pharmacol Exp Ther 2002;301(3):953-962.

(128) Vaudry D, Stork PJS, Lazarovici P, Eiden LE. Signaling pathways for PC12 cell differentiation: Making the right connections. Science 2002;296(5573):1648-1649.

(129) Tabakman R, Lazarovici P, Kohen R. Neuroprotective effects of carnosine and homocarnosine on pheochromocytoma PC12 cells exposed to ischemia. J Neurosci Res 2002;68(4):463-469.

(130) Abu-Raya S, Tabakman R, Blaugrund E, Trembovler V, Lazarovici P. Neuroprotective and neurotoxic effects of monoamine oxidase-B inhibitors and derived metabolites under ischemia in PC12 cells. Eur J Pharmacol 2002;434(3):109-116.

(131) Bloch-Shilderman E, Jiang H, Dingel JD, Lazarovici P. Pardaxin, an ionophore neurotoxin, induces PC12 cell death: Activation of stress kinases and production of reactive oxygen species. J Nat Toxins 2002;11(2):71-85.

(132) Katzir I, Shani J, Regev K, Shabashov D, Lazarovici P. A quantitative bioassay for nerve growth factor, using PC12 clones expressing different levels of trkA receptors. J Mol Neurosci 2002;18(3):251-264.

(133) Cantarella G, Lempereur L, Presta M, Ribatti D, Lombardo G, Lazarovici P, et al. Nerve growth factor-endothelial cell interaction leads to angiogenesis in vitro and in vivo. FASEB J 2002;16(10):1307-1309.

(134) Chiarenza A, Lazarovici P, Lempereur L, Cantarella G, Bianchi A, Bernardini R. Tamoxifen inhibits nerve growth factor-induced proliferation of the human breast cancerous cell line MCF-7. Cancer Res 2001;61(7):3002-3008.

(135) Bloch-Shilderman E, Jiang H, Abu-Raya S, Linial M, Lazarovici P. Involvement of extracellular signal-regulated kinase (ERK) in pardaxin-induced dopamine release from PC12 cells. J Pharmacol Exp Ther 2001;296(3):704-711.

(136) Weinstock M, Kirschbaum-Slager N, Lazarovici P, Bejar C, Youdim MBH, Shoham S. Neuroprotective effects of novel cholinesterase inhibitors derived from rasagiline as potential anti-Alzheimer drugs. Ann New York Acad Sci 2001;939:148-161.

(137) Davidson B, Nesland JM, Berner A, Risberg B, Goscinski M, Tropé CG, et al. Expression levels of the nerve growth factor receptors TrkA and p75 in effusions and solid tumors of serous ovarian carcinoma patients. Clin Cancer Res 2001;7(11):3457-3464.

(138) Desai R, Peretz A, Idelson H, Lazarovici P, Attali B. Ca2+-activated K+ channels in human leukemic Jurkat T cells. J Biol Chem 2000;275(51):39954-39963.

(139) Monshipouri M, Jiang H, Lazarovici P. NGF stimulation of erk phosphorylation is impaired by a point mutation in the transmembrane domain of trkA receptor. J Mol Neurosci 2000;14(1-2):69-76.

(140) Abu-Raya S, Blaugrund E, Trembovler V, Lazarovici P. Rasagiline, a novel monoamine oxidase-B inhibitor with neuroprotective effects under ischemic conditions in PC12 cells. Drug Dev Res 2000;50(3-4):285-290.

(141) Moalem G, Gdalyahu A, Shani Y, Otten U, Lazarovici P, Cohen IR, et al. Production of neurotrophins by activated T cells: Implications for neuroprotective autoimmunity. J Autoimmun 2000;15(3):331-345.

(142) Abu-Raya S, Blaugrund E, Trembovler V, Shilderman-Bloch E, Shohami E, Lazarovici P. Rasagiline, a monoamine oxidase-B inhibitor, protects NGF-differentiated PC12 cells against oxygen-glucose deprivation. J Neurosci Res 1999;58(3):456-463.

(143) Stein S, Weiss A, Adermann K, Lazarovici P, Hochman J, Wellhöner H. A disulfide conjugate between anti-tetanus antibodies and HIV (37-72)Tat neutralizes tetanus toxin inside chromaffin cells. FEBS Lett 1999;458(3):383-386.

(144) Jiang H, Takeda K, Lazarovici P, Katagiri Y, Yu Z-, Dickens G, et al. Nerve growth factor (NGF)-induced calcium influx and intracellular calcium mobilization in 3T3 cells expressing NGF receptors. J Biol Chem 1999;274(37):26209-26216.

(145) Brodie C, Bogi K, Acs P, Lazarovici P, Petrovics G, Anderson WB, et al. Protein kinase C-ε plays a role in neurite outgrowth in response to epidermal growth factor and nerve growth factor in PC12 cells. Cell Growth Differ 1999;10(3):183-191.

(146) Abu-Raya S, Bloch-Shilderman E, Lelkes PI, Trembovler V, Shohami E, Gutman Y, et al. Characterization of pardaxin-induced dopamine release from pheochromocytoma cells: Role of calcium and eicosanoids. J Pharmacol Exp Ther 1999;288(2):399-406.

(147) Lazarovici P, Donald Jr. F. Heterologous upregulation of nerve growth factor-TrkA receptors in PC12 cells by pituitary adenylate cyclase-activating polypeptide (PACAP). Mol Cell Biol Res Commun 1999;2(2):97-102.

(148) Abu-Raya S, Bloch-Shilderman E, Jiang H, Adermann K, Schaefer EM, Goldin E, et al. Cellular signaling in PC12 affected by pardaxin. ACS Symp Ser 1999;745:22-42.

(149) Abu-Raya S, Bloch-Shilderman E, Shohami E, Trembovler V, Shai Y, Weidenfeld J, et al. Pardaxin, a new pharmacological tool to stimulate the arachidonic acid cascade in PC12 cells. J Pharmacol Exp Ther 1998;287(3):889-896.

(150) Fisher A, Haring R, Pittel Z, Brandeis R, Esshar N, Karton Y, et al. Novel therapeutic avenues in Alzheimer's disease based on m1 muscarinic agonists - An unifying concept. Int J Geriatr Psychopharmacol 1998;1(3):150-157.

(151) Paul Y, Weiss A, Adermann K, Erdmann G, Kassebaum C, Lazarovici P, et al. Translocation of acylated pardaxin into cells. FEBS Lett 1998;440(1-2):131-134.

(152) Adermann K, Raida M, Paul Y, Abu-Raya S, Bloch-Shilderman E, Lazarovici P, et al. Isolation, characterization and synthesis of a novel pardaxin isoform. FEBS Lett 1998;435(2-3):173-177.

(153) Beit-Yannai E, Trembovler V, Horowitz M, Lazarovici P, Kohen R, Shohami E. Neuroprotection against oxidative stress by serum from heat acclimated rats. Neurosci Lett 1998;254(2):89-92.

(154) Shibutani M, Lazarovici P, Johnson AC, Katagiri Y, Guroff G. Transcriptional down-regulation of epidermal growth factor receptors by nerve growth factor treatment of PC12 cells. J Biol Chem 1998;273(12):6878-6884.

(155) Lazarovici P, Jiang H, Fink Jr. D. The 38-amino-acid form of pituitary adenylate cyclase-activating polypeptide induces neurite outgrowth in PC12 cells that is dependent on protein kinase C and extracellular signal-regulated kinase but not on protein kinase A, nerve growth factor receptor tyrosine kinase, p21(ras) G protein, and pp60(c-src) cytoplasmic tyrosine kinase. Mol Pharmacol 1998;54(3):547-558.

(156) Tabakman R, Lazarovici P, Matsuda Y, Brodie C, Ovadia H. Protein kinase C-independent selective induction of nitric oxide synthase activity in rat alveolar macrophages by staurosporine. Nitric Oxide Biol Chem 1998;2(4):250-258.

(157) Ellren-Kashi O, Trembovler V, Abu-Raya S, Lazarovici P, Shohami E. Neuroprotective effects of gangliosides on pardaxin-induced toxicity in PC12 cells. J Nat Toxins 1997;6(3):285-292.

(158) Jiang H, Movsesyan V, Fink Jr. DW, Fasler M, Whalin M, Katagiri Y, et al. Expression of human p140trk receptors in p140trk-deficient, PC12/endothelial cells results in nerve growth factor-induced signal transduction and DNA synthesis. J Cell Biochem 1997;66(2):229-244.

(159) Lazarovici P, Oshima M, Shavit D, Shibutani M, Jiang H, Monshipouri M, et al. Down-regulation of epidermal growth factor receptors by nerve growth factor in PC12 cells is p140(trk)-, Ras-, and Src-dependent. J Biol Chem 1997;272(17):11026-11034.

(160) Jiang H, St. Ulme D, Dickens G, Chabuk A, Lavarreda M, Lazarovici P, et al. Both p140(trk) and p75(NGFR) nerve growth factor receptors mediate nerve growth factor-stimulated calcium uptake. J Biol Chem 1997;272(11):6835-6837.

(161) Lazarovici P, Galski H, Matsuda Y, Hochman J. KT-5720, a new bacterial alkaloid antibiotic, reverses multidrug resistance (MDR) in lymphoma and carcinoma cells overexpressing MDR1 gene. J Nat Toxins 1997;6(1):19-33.

(162) Friedman LM, Matsuda Y, Lazarovici P. The microbial alkaloid toxin staurosporine blocks the phorbol ester-induced increase in β-amyloid precursor protein in PC12 cells. Nat Toxins 1997;5(5):173-179.

(163) Rasouly D, Shavit D, Zuniga R, Elejalde RB, Unsworth BR, Yayon A, et al. Staurosporine induces neurite outgrowth in neuronal hybrids (PC12EN) lacking NGF receptors. J Cell Biochem 1996;62(3):356-371.

(164) Sadot E, Heicklen-Klein A, Barg J, Lazarovici P, Ginzburg I. Identification of a tau promoter region mediating tissue-specific-regulated expression in PC12 cells. J Mol Biol 1996;256(5):805-812.

(165) Sadot E, Heicklen-Klein A, Barg J, Lazarovici P, Ginzburg I. Erratum: Identification of a tau promoter region mediating tissue-specific-regulated expression in PC12 cells (Journal of Molecular Biology (1995) 256 (805-812)). J Mol Biol 1996;258(3):539.

(166) Shibutani M, Kim E, Lazarovici P, Oshima M, Guroff G. Preparation of a cell-free translation system from PC12 cells. Neurochem Res 1996;21(7):801-807.

(167) Lazarovici P, Rasouly D, Friedman L, Tabekman R, Ovadia H, Matsuda Y. K252a and staurosporine microbial alkaloid toxins aS prototype of neurotropic drugs. Adv Exp Med Biol 1996;391:367-377.

(168) Shi YL, Edwards C, Lazarovici P. Ion selectivity of the channels formed by pardaxin, an lonophore, in bilayer membranes. Nat Toxins 1995;3(3):151-155.

(169) Sadot E, Barg J, Rasouly D, Lazarovici P, Ginzburg I. Short- and long-term mechanisms of tau regulation in PC12 cells. J Cell Sci 1995;108(8):2857-2864.

(170) Galski H, Lazarovici P, Gottesman MM, Murakata C, Matsuda Y, Hochman J. Kt-5720 reverses multidrug resistance in variant S49 mouse lymphoma cells transduced with the human MDR1 cDNA and in human multidrug-resistant carcinoma cells. Eur J Cancer 1995;31(3):380-388.

(171) Rasouly D, Lazarovici P. Staurosporine induces tyrosine phosphorylation of a 145 kDa protein but does not activate gp140trk in PC12 cells. Eur J Pharmacol Mol Pharmacol Sect 1994;269(2):255-264.

(172) Lazarovici P. Challenging catecholamine exocytosis with pardaxin, an excitatory ionophore fish toxin. Toxin Rev 1994;13(1):45-63.

(173) Rasouly D, Lazarovici P. Staurosporine, a streptomyces alkaloid toxin as a neurotropic tool. Toxin Rev 1994;13(1):11-23.

(174) Rasouly D, Rahamim E, Ringel I, Ginzburg I, Muarakata C, Matsuda Y, et al. Neurites induced by staurosporine in PC12 cells are resistant to colchicine and express high levels of tau proteins. Mol Pharmacol 1994;45(1):29-35.

(175) Arribas M, Blasi J, Lazarovici P, Marsal J. Calcium‐Dependent and ‐Independent Acetylcholine Release from Electric Organ Synaptosomes by Pardaxin: Evidence of a Biphasic Action of an Excitatory Neurotoxin. J Neurochem 1993;60(2):552-558.

(176) Raya SA, Trembovler V, Shohami E, Lazarovici P. Cytolysins increase intracellular calcium and induce eicosanoids release by pheochromocytoma PC12 cell cultures. Nat Toxins 1993;1(5):263-270.

(177) Raya SA, Trembovler V, Shohami E, Lazarovici P. A tissue culture ischemic device to study eicosanoid release by pheochromocytoma PC12 cultures. J Neurosci Methods 1993;50(2):197-203.

(178) Lazarovici P, Lelkes PI. Pardaxin induces exocytosis in bovine adrenal medullary chromaffin cells independent of calcium. J Pharmacol Exp Ther 1992;263(3):1317-1326.

(179) Rasouly D, Rahamim E, Lester D, Matsuda Y, Lazarovici P. Staurosporine-induced neurite outgrowth in PC12 cells is independent of protein kinase C inhibition. Mol Pharmacol 1992;42(1):35-43.

(180) Nikodijevic B, Nikodijevic D, Lazarovici P. Pardaxin-stimulated calcium uptake in pc12 cells is blocked by cadmium and is not mediated by l-type calcium channels. J Basic Clin Physiol Pharmacol 1992;3(4):359-370.

(181) Lazarovici P, Bergel M, Hasson T, Rahamim E, Hochman J. Immunomagnetic separation and analysis of non‐malignant variants and parental malignant mouse lymphoma cells. J Mol Recogn 1991;4(4):143-149.

(182) Hochman J, Park SS, Lazarovici P, Bergel M, Gottesman MM. Monoclonal antibodies to immunogenic lymphoma cell variants displaying impaired neoplastic properties: Characterization and applications. J Natl Cancer Inst 1990;82(23):1821-1826.

(183) Lazarovici P. Characterization and visualization of tetanus toxin acceptors on adrenal chromaffin granules. J PHYSIOL 1990;84(3):197-205.

(184) Fujita K, Guroff G, Yavin E, Goping G, Orenberg R, Lazarovici P. Preparation of affinity-purified, biotinylated tetanus toxin, and characterization and localization of cell surface binding sites on nerve growth factor-treated PC12 cells. Neurochem Res 1990;15(4):373-383.

(185) Lazarovici P, Fujita K, Contreras ML, DiOrio JP, Lelkes PI. Affinity purified tetanus toxin binds to isolated chromaffin granules and inhibits catecholamine release in digitonin-permeabilized chromaffin cells. FEBS Lett 1989;253(1-2):121-128.

(186) Fujita K, Lazarovici P, Guroff G. Regulation of the differentiation of PC12 pheochromocytoma cells. Environ Health Perspect 1989;80:127-142.

(187) Fink D, Contreras ML, Lelkes PI, Lazarovici P. Staphylococcus aureus α-toxin activates phospholipases and induces a Ca2+ influx in PC12 cells. Cell Signal 1989;1(4):387-393.

(188) Rudkin BB, Lazarovici P, Levi B-, Abe Y, Fujita K, Guroff G. Cell cycle-specific action of nerve growth factor in PC12 cells: Differentiation without proliferation. EMBO J 1989;8(11):3319-3325.

(189) Lazarovici P, Levi B‐, Lelkes PI, Koizumi S, Fujita K, Matsuda Y, et al. K‐252a inhibits the increase in c‐fos transcription and the increase in intracellular calcium produced by nerve growth factor in PC12 cells. J Neurosci Res 1989;23(1):1-8.

(190) Shai Y, Fox J, Caratsch C, Shih Y-, Edwards C, Lazarovici P. Sequencing and synthesis of pardaxin, a polypeptide from the Red Sea Moses sole with ionophore activity. FEBS Lett 1988;242(1):161-166.

(191) Lelkes PI, Lazarovici P. Pardaxin induces aggregation but not fusion of phosphatidylserine vesicles. FEBS Lett 1988;230(1-2):131-136.

(192) Koizumi S, Contreras ML, Matsuda Y, Hama T, Lazarovici P, Guroff G. K-252a: A specific inhibitor of the action of nerve growth factor on PC 12 cells. J Neurosci 1988;8(2):715-721.

(193) Lazarovici P, Yanai P, Yavin E. Molecular interactions between micellar polysialogangliosides and affinity-purified tetanotoxins in aqueous solution. J Biol Chem 1987;262(6):2645-2651.

(194) Lazarovici P, Chan K-J. Staphylococcus aureus α-toxin. 2. Reduction of epidermal growth factor receptor affinity in PC12 cells. Toxicon 1987;25(6):637-647.

(195) Chan K-J, Lazarovici P. Staphylococcus aureus α-toxin. 1. Effect on protein phosphorylation in myelin. Toxicon 1987;25(6):631-636.

(196) Lazarovici P, Dickens G, Kuzuya H, Guroff G. Long-term, heterologous down-regulation of the epidermal growth factor receptor in PC12 cells by nerve growth factor. J Cell Biol 1987;104(6):1611-1621.

(197) Renner P, Caratsch CG, Waser PG, Lazarovici P, Primor N. Presynaptic effects of the Pardaxins, polypeptides isolated from the gland secretion of the flatfish Pardachirus marmoratus. Neuroscience 1987;23(1):319-325.

(198) Wan YY, Orrison BM, Lieberman R, Lazarovici P, Ozato K. Induction of major histocompatibility class I antigens by interferons in undifferentiated F9 cells. J Cell Physiol 1987;130(2):276-283.

(199) Lazarovici P, Primor N, Loew LM. Purification and pore-forming activity of two hydrophobic polypeptides from the secretion of the Red Sea Moses sole (Pardachirus marmoratus). J Biol Chem 1986;261(35):16704-16713.

(200) Lazarovici P, Yavin E. Affinity-Purified Tetanus Neurotoxin Interaction with Synaptic Membranes: Properties of a Protease-Sensitive Receptor Component. Biochemistry 1986;25(22):7047-7054.

(201) Loew LM, Benson L, Lazarovici P, Rosenberg I. Fluorometric Analysis of Transferable Membrane Pores. Biochemistry 1985;24(9):2101-2104.

(202) Lazarovici P, Yavin E. Tetanus toxin interaction with human erythrocytes. II. Kinetic properties of toxin association and evidence for a ganglioside-toxin macromolecular complex formation. Biochim Biophys Acta Biomembr 1985;812(2):532-542.

(203) Lazarovici P, Yavin E. Tetanus toxin interaction with human erythrocytes. I. Properties of polysialoganglioside association with the cell surface. Biochim Biophys Acta Biomembr 1985;812(2):523-531.

(204) Lazarovici P, Menashe M, Zlotkin E. Toxicity to crustacea due to polypeptide-phospholipase interaction in the venom of a chactoid scorpion. Arch Biochem Biophys 1984;229(1):270-286.

(205) Lazarovici P, Tayot JL, Yavin E. Affinity chromatographic purification and characterization of two iodinated tetanus toxin fractions exhibiting different binding properties. Toxicon 1984;22(3):401-413.

(206) Lazarovici P, Shapira D, Pisarev V, Shaaya E. Ecdysteroid level and the change in sensitivity to a juvenile hormone analogue in Ephestia cautella larvae (Lepidoptera, Phycitidae). Arch Insect Biochem Physiol 1984;1(4):409-415.

(207) Lazarovici P, Shapira D, Shaaya E. Determination of ecdysteroid titers by a double-antibody precipitation in the tropical warehouse moth, Ephestia cautella (Lepidoptera, phycitidae). Comparative Biochemistry and Physiology -- Part A: Physiology 1983;74(3):525-529.

(208) Lazarovici P, Hochman J, Menashe M, Primor N, Zlotkin E. The cytotoxicity of a cobra venom phospholipase to mouse lymphoma cells. Arch Toxicol 1982;51(2):167-173.

(209) Lester D, Lazarovici P, Pelhate M, Zlotkin E. Purification, characterization and action of two insect toxins from the venom of the scorpion buthotus judaicus. Biochim Biophys Acta Protein Struct Mol Enzymol 1982;701(3):370-381.

(210) Lazarovici P, Zlotkin E. A mammal toxin derived from the venom of a chactoid scorpion. Comparative Biochemistry and Physiology.Part C, Comparative 1982;71(2):177-181.

(211) Breuer E, Deutsch J, Lazarovici P. A practical synthesis of the aggregation pheromone of Tribolium castaneum and Tribolium confusum. Chem Ind 1982;No. 22:907-908.

(212) Lazarovici P, Yanai P, Pelhate M, Zlotkin E. Insect toxic components from the venom of a chactoid scorpion, Scorpio maurus palmatus (Scorpionidae). J Biol Chem 1982;257(14):8397-8404.

(213) Zlotkin E, Lester D, Lazarovici P, Pelhate M. The chemistry and axonal action of two insect toxins derived from the venom of the scorpion Buthotus judaicus. Toxicon 1982;20(1):323-331.

(214) Primor N, Lazarovici P. Pardachirus marmoratus (Red Sea flatfish) secretion and its isolated toxic fraction pardaxin: The relationship between hemolysis and ATPase inhibition. Toxicon 1981;19(4):573-578.

(215) PENER MP, LAZAROVICI P. Effect of exogenous juvenile hormones on mating behaviour and yellow colour in allatectomized adult male desert locusts. Physiol Entomol 1979;4(3):251-261.

(216) Lazarovici P, Zlotkin E. Toxins specifically active to arthropods and mammals from the venom of the scorpion Scorpio maurus palmatus (Scorpionidae). Toxicon 1979;17(Suppl 1):98.

(217) Teitelbaum Z, Lazarovici P, Zlotkin E. Selective binding of the scorpion venom insect toxin to insect nervous tissue. Insect Biochemistry 1979;9(4):343-346.

(218) Zlotkin E, Teitelbaum Z, Lester D, Lazarovici P. Toxins selective to insects derived from scorpion venoms. Toxicon 1979;17(Suppl 1):208.

(219) Lazarovici P, Lester D, Menashá M, Hochman Y, Zlotkin E. Phospholipases and direct lytic factors (DLFs) derived from the venom of the scorpion Scorpio maurus palmatus (Scorpionidae). Toxicon 1979;17(Suppl 1):97.

(220) Lazaroviçi P, Pener MP. Juvenile hormones (JHs) and completion of oöcyte development in the African migratory locust: A comparative and quantitative study. Gen Comp Endocrinol 1977;33(3):434-452.