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School of Pharmacy : Friedman Michael

Researchers

 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Steinberg D, Friedman M. Sustained-release delivery of antimicrobial drugs for the treatment of periodontal diseases: Fantasy or already reality? Periodontol 2000 2020;84(1):176-187.

(2) Aqawi M, Gallily R, Sionov RV, Zaks B, Friedman M, Steinberg D. Cannabigerol Prevents Quorum Sensing and Biofilm Formation of Vibrio harveyi. Front Microbiol 2020;11.

(3) Kirmayer D, Grin A, Gefter J, Friedman M, Rachmilewitz J, Mosheiff R, et al. Guided Bone Regeneration with Ammoniomethacrylate-Based Barrier Membranes in a Radial Defect Model. BioMed Res Int 2020;2020.

(4) Funk B, Kirmayer D, Sahar-Heft S, Gati I, Friedman M, Steinberg D. Efficacy and potential use of novel sustained release fillers as intracanal medicaments against Enterococcus faecalis biofilm in vitro. BMC Oral Health 2019;19(1).

(5) Shlezinger M, Friedman M, Houri-Haddad Y, Hazan R, Beyth N. Phages in a thermoreversible sustainedrelease formulation targeting E. faecalis in vitro and in vivo. PLoS ONE 2019;14(7).

(6) Funk B, Sahar-Helft S, Kirmayer D, Friedman M, Steinberg D. Sustained-Release Fillers for Dentin Disinfection: An Ex Vivo Study. Int J Dent 2019;2019.

(7) Avni-Magen N, Eshar D, Friedman M, Kirmayer D, Letschert L, Gati I, et al. Retrospective evaluation of a novel sustained-release ivermectin varnish for treatment of wound myiasis in zoo-housed animals. J Zoo Wildl Med 2018;49(1):201-205.

(8) Gefter (Shenderovich) J, Zaks B, Kirmayer D, Lavy E, Steinberg D, Friedman M. Chlorhexidine sustained-release varnishes for catheter coating – Dissolution kinetics and antibiofilm properties. Eur J Pharm Sci 2018;112:1-7.

(9) Steinberg D, Friedman M. Sustained-release drug delivery of antimicrobials in controlling of supragingival oral biofilms. Expert Opin Drug Deliv 2017;14(4):571-581.

(10) Feldman M, Shenderovich J, Lavy E, Friedman M, Steinberg D. A Sustained-Release Membrane of Thiazolidinedione-8: Effect on Formation of a Candida/Bacteria Mixed Biofilm on Hydroxyapatite in a Continuous Flow Model. BioMed Res Int 2017;2017.

(11) Shenderovich J, Feldman M, Kirmayer D, Al-Quntar A, Steinberg D, Lavy E, et al. Local sustained-release delivery systems of the antibiofilm agent thiazolidinedione-8 for prevention of catheter-associated urinary tract infections. Int J Pharm 2015;485(1-2):164-170.

(12) Nudelman Z, Findler M, Barasch D, Nemirovski A, Pikovsky A, Kirmayer D, et al. Levels of sirolimus in saliva and blood following oral topical sustained-release varnish delivery system application. Cancer Chemother Pharmacol 2015;75(5):969-974.

(13) Feldman M, Shenderovich J, Al-Quntar AAA, Friedman M, Steinberg D. Sustained release of a novel anti-quorum-sensing agent against oral fungal biofilms. Antimicrob Agents Chemother 2015;59(4):2265-2272.

(14) Czerninski R, Pikovsky A, Gati I, Friedman M, Steinberg D. Comparison of the efficacy of a novel sustained release clotrimazole varnish and clotrimazole troches for the treatment of oral candidiasis. Clin Oral Invest 2015;19(2):467-473.

(15) Amit-Romach E, Uni Z, Friedman M, Aizenberg I, Berkovich Z, Reifen R. A new mode of probiotic therapy: Specific targeting. J Funct Foods 2015;16:386-392.

(16) Feldman M, Al-Quntar A, Polacheck I, Friedman M, Steinberg D. Therapeutic potential of thiazolidinedione-8 as an antibiofilm agent against Candida albicans. PLoS ONE 2014;9(5).

(17) Rushinek H, Alterman M, Laviv A, Weiss EI, Friedman M, Casap N. Topical application of slow-release simvastatin as a bone substitute in bone defects in the rat tibia: A pilot study. Int J Oral Maxillofac Implants 2014;29(2):241-246.

(18) Nudelman Z, Friedman M, Barasch D, Nemirovski A, Findler M, Pikovsky A, et al. Levels of sirolimus in saliva and blood following mouthwash application. Oral Dis 2014;20(8):768-772.

(19) Rosenzweig O, Lavy E, Gati I, Kohen R, Friedman M. Development and in vitro characterization of floating sustained-release drug delivery systems of polyphenols. Drug Deliv 2013;20(3-4):180-189.

(20) Lorber G, Duvdevani M, Friedman M, Lavy E, Landau EH, Gofrit ON, et al. Sustained-release antibacterial varnish-coated biopsy needle for reduction of infection rates following prostate biopsy - In Vitro model. J Endourol 2013;27(3):277-283.

(21) Zelichenko G, Steinberg D, Lorber G, Friedman M, Zaks B, Lavy E, et al. Prevention of initial biofilm formation on ureteral stents using a sustained releasing varnish containing chlorhexidine: In Vitro study. J Endourol 2013;27(3):333-337.

(22) Nudelman Z, Keshet N, Elhalal MD, Friedman M, Czerninski R. Levels of sirolimus in Saliva vs. Blood - the rationale of topical oral use for oral malignancy. Anticancer Res 2013;33(2):661-664.

(23) Burshtein G, Friedman M, Greenberg S, Hoffman A. Transepithelial transport of a natural cholinesterase inhibitor, huperzine a, along the gastrointestinal tract: The role of ionization on absorption mechanism. Planta Med 2013;79(3-4):259-265.

(24) Segev G, Bankirer T, Steinberg D, Duvdevani M, Shapur NK, Friedman M, et al. Evaluation of Urinary Catheters Coated with Sustained-Release Varnish of Chlorhexidine in Mitigating Biofilm Formation on Urinary Catheters in Dogs. J Vet Intern Med 2013;27(1):39-46.

(25) Lavy E, Goldberger D, Friedman M, Steinberg D. pH values and mineral content of saliva in different breeds of dogs. Isr J Vet Med 2012;67(4):244-248.

(26) Lavy E, Ezroni G, Friedman M, Steinberg D. Novel local sustained released varnish for reducing oral bacteria in dogs. Isr J Vet Med 2012;67(3):147-153.

(27) Shapur NK, Duvdevani M, Friedman M, Zaks B, Gati I, Lavy E, et al. Sustained release varnish containing chlorhexidine for prevention of biofilm formation on urinary catheter surface: In vitro study. J Endourol 2012;26(1):26-31.

(28) Horwitz E, Kagan L, Chamisha Y, Gati I, Hoffman A, Friedman M, et al. Novel gastroretentive controlled-release drug delivery system for amoxicillin therapy in veterinary medicine. J Vet Pharmacol Ther 2011;34(5):487-493.

(29) Horwitz E, Kagan L, Avni-Magen N, Daryi D, Gati I, Hoffman A, et al. A novel subcutaneous controlled-release amoxicillin degradable implant for extended-interval administration in veterinary medicine. J Vet Pharmacol Ther 2011;34(5):494-498.

(30) Bakal-Weiss M, Steinberg D, Friedman M, Gati I, Avni-Magen N, Kaufman E, et al. Use of a sustained release chlorhexidine varnish as treatment of oral necrobacillosis in macropus spp. J Zoo Wildl Med 2010;41(2):371-373.

(31) Czerninski R, Sivan S, Steinberg D, Gati I, Kagan L, Friedman M. A novel sustained-release clotrimazole varnish for local treatment of oral candidiasis. Clin Oral Invest 2010;14(1):71-78.

(32) Lavy E, Golani Y, Friedman M, Bdolah-Abram T, Steinberg D. Comparison of the distribution of oral cavity bacteria in various dog populations. Isr J Vet Med 2009;64(3).

(33) Lavy E, Friedman M, Ezroni G, Steinberg D. Evaluation of a novel local sustained-release varnish for prevention and treatment of canine dental diseases. J Vet Pharmacol Ther 2009;32(SUPPL. 1):126-127.

(34) Grin A, Moor E, Friedman M. Sustained release of doxycycline as matrix metalloproteinase inhibitor for treatment of chronic periodontal diseases: In vitro evaluation. J Drug Deliv Sci Technol 2009;19(4):295-300.

(35) Grin A, Sasson Y, Beyth S, Mosheiff R, Rachmilewitz J, Friedman M. In vitro study of a novel polymeric mesenchymal stem-cell coated membrane. J Drug Deliv Sci Technol 2009;19(4):241-246.

(36) Bachrach G, Altman H, Kolenbrander PE, Chalmers NI, Gabai-Gutner M, Mor A, et al. Resistance of Porphyromonas gingivalis ATCC 33277 to direct killing by antimicrobial peptides is protease independent. Antimicrob Agents Chemother 2008;52(2):638-642.

(37) Avni-Magen N, Elad D, Friedman M, Gati I, Kaufman E, Lavy E. Use of a sustained release preparation of clotrimazole to treat dermatophytosis in a siamang (Hylobates syndactylus). J Zoo Wildl Med 2008;39(1):115-117.

(38) Kagan L, Lapidot N, Afargan M, Kirmayer D, Moor E, Mardor Y, et al. Gastroretentive Accordion Pill: Enhancement of riboflavin bioavailability in humans. J Control Release 2006;113(3):208-215.

(39) Altman H, Steinberg D, Porat Y, Mor A, Fridman D, Friedman M, et al. In vitro assessment of antimicrobial peptides as potential agents against several oral bacteria. J Antimicrob Chemother 2006;58(1):198-201.

(40) Bachrach G, Friedman M, Gilinski G, Steinberg D. Soluble sustained release gene delivery system. J Biomed Mater Res Part A 2006;77(4):811-814.

(41) Steinberg D, Tal T, Friedman M. Sustained-release delivery systems of triclosan for treatment of Streptococcus mutans biofilm. J Biomed Mater Res Part B Appl Biomater 2006;77(2):282-286.

(42) Nasser NJ, Friedman A, Friedman M, Moor E, Mosheiff R. Guided bone regeneration in the treatment of segmental diaphyseal defects: A comparison between resorbable and non-resorbable membranes. Injury 2005;36(12):1460-1466.

(43) Hoffman A, Stepensky D, Lavy E, Eyal S, Klausner E, Friedman M. Pharmacokinetic and pharmacodynamic aspects of gastroretentive dosage forms. Int J Pharm 2004;277(1-2):141-153.

(44) Klausner EA, Lavy E, Barta M, Cserepes E, Friedman M, Hoffman A. Novel gastroretentive dosage forms: Evaluation of gastroretentivity and its effect on levodopa absorption in humans. Pharm Res 2003;20(9):1466-1473.

(45) Mosheiff R, Friedman A, Friedman M, Liebergall M. Quantification of guided regeneration of weight-bearing bones. Orthopedics 2003;26(8):789-794.

(46) Klausner EA, Lavy E, Stepensky D, Cserepes E, Barta M, Friedman M, et al. Furosemide pharmacokinetics and pharmacodynamics following gastroretentive dosage form administration to healthy volunteers. J Clin Pharmacol 2003;43(7):711-720.

(47) Klausner EA, Lavy E, Friedman M, Hoffman A. Expandable gastroretentive dosage forms. J Control Release 2003;90(2):143-162.

(48) Ziskind D, Gleitman J, Rotstein I, Friedman M. Evaluation of cetylpyridinium chloride for infection control in storage solution. J Oral Rehabil 2003;30(5):477-481.

(49) Klausner EA, Eyal S, Lavy E, Friedman M, Hoffman A. Novel levodopa gastroretentive dosage form: In-vivo evaluation in dogs. J Control Release 2003;88(1):117-126.

(50) Beyth N, Redlich M, Harari D, Friedman M, Steinberg D. Effect of sustained-release chlorhexidine varnish on Streptococcus mutans and Actinomyces viscosus in orthodontic patients. Am J Orthod Dentofacial Orthop 2003;123(3):345-348.

(51) Klausner EA, Lavy E, Stepensky D, Friedman M, Hoffman A. Novel gastroretentive dosage forms: Evaluation of gastroretentivity and its effect on riboflavin absorption in dogs. Pharm Res 2002;19(10):1516-1523.

(52) Stepensky D, Friedman M, Raz I, Hoffman A. Pharmacokinetic-pharmacodynamic analysis of the glucose-lowering effect of metformin in diabetic rats reveals first-pass pharmacodynamic effect. Drug Metab Dispos 2002;30(8):861-868.

(53) Steinberg D, Rozen R, Klausner EA, Zachs B, Friedman M. Formulation, development and characterization of sustained release varnishes containing amine and stannous fluorides. Caries Res 2002;36(6):411-416.

(54) Doron S, Friedman M, Falach M, Sadovnic E, Zvia H. Antibacterial effect of parabens against planktonic and biofilm Streptococcus sobrinus. Int J Antimicrob Agents 2001;18(6):575-578.

(55) Stepensky D, Friedman M, Srour W, Raz I, Hoffman A. Preclinical evaluation of pharmacokinetic-pharmacodynamic rationale for oral CR metformin formulation. J Control Release 2001;71(1):107-115.

(56) Baluom M, Friedman M, Rubinstein A. Improved intestinal absorption of sulpiride in rats with synchronized oral delivery systems. J Control Release 2001;70(1-2):139-147.

(57) Katzhendler I, Priev A, Friedman M. Correlation between drug release kinetics from proteineous matrices and protein folding: Elasticity and compressibility study. J Control Release 2000;67(2-3):261-274.

(58) Katzhendler I, Mäder K, Friedman M. Structure and hydration properties of hydroxypropyl methylcellulose matrices containing naproxen and naproxen sodium. Int J Pharm 2000;200(2):161-179.

(59) Katzhendler I, Azoury R, Friedman M. The effect of egg albumin on the crystalline properties of carbamazepine in sustained release hydrophilic matrix tablets and in aqueous solutions. J Control Release 2000;65(3):331-343.

(60) Steinberg D, Friedman M. Development of sustained-release devices for modulation of dental plaque biofilm and treatment of oral infectious diseases. Drug Dev Res 2000;50(3-4):555-565.

(61) Katzhendler I, Mäder K, Friedman M. Correlation between drug release kinetics from proteineous matrix and matrix structure: EPR and NMR study. J Pharm Sci 2000;89(3):365-381.

(62) Steinberg D, Friedman M, Steinberg D. The Anticariogenic Effect of Amine Fluorides on Streptococcus sobrinus and Glucosyltransferase in Biofilms. Caries Res 2000;34(3):260-267.

(63) Baluom M, Friedman M, Rubinstein A. Erratum: The importance of intestinal residence time of absorption enhancer on drug absorption and implication on formulative considerations (International Journal of Pharmaceutics (1998) 176 (21-30) PII: S0378517398002889). Int J Pharm 2000;193(2):265-266.

(64) Lomnicky Y, Haimov T, Luria MH, Friedman M, Hoffman A. Pharmacodynamic effects of bezafibrate and niacin combination: Implications of the mode of administration. J Pharm Sci 2000;89(8):1046-1053.

(65) Baluom M, Friedman M, Assaf P, Haj-Yehia AI, Rubinstein A. Synchronized release of sulpiride and sodium decanoate from HPMC matrices: A rational approach to enhance sulpiride absorption in the rat intestine. Pharm Res 2000;17(9):1071-1076.

(66) Hoffman A, Lomnicky Y, Luria MH, Gilhar D, Friedman M. Improved lipid lowering activity of bezafibrate following continuous gastrointestinal administration: Pharmacodynamic rationale for sustained release preparation of the drug. Pharm Res 1999;16(7):1093-1097.

(67) Role of synchronous release of sodium decanoate on sulpiride absorption in the intestine of the rat. American Chemical Society, Polymer Preprints, Division of Polymer Chemistry; 1999.

(68) Steinberg D, Hirschfeld Z, Tayeb I, Ben-Yosef S, David A, Friedman M. The effect of parabens in a mouthwash and incorporated into a sustained release varnish on salivary bacteria. J Dent 1999;27(2):101-106.

(69) Steinberg D, Friedman M. Dental drug-delivery devices: Local and sustained-release applications. Crit Rev Ther Drug Carrier Syst 1999;16(5):425-459.

(70) Baluom M, Friedman M, Rubinstein A. Erratum: The importance of intestinal residence time of absorption enhancer on drug absorption and implication on formulative considerations (International Journal of Pharmaceutics 176 (1998) (21-30) PII: S0378517398002889). Int J Pharm 1999;185(1):123-124.

(71) Baluom M, Friedman M, Rubinstein A. The involvement of P-glycoprotein in intestinal absorption and its implication on the design of oral delivery systems of sulpiride. Proc Control Release Soc 1999(26):329-330.

(72) Baluom M, Friedman M, Rubinstein A. The importance of intestinal residence time of absorption enhancer on drug absorption and implication on formulative considerations. Int J Pharm 1998;176(1):21-30.

(73) Salnikow J, Zemser M, Gorinstein S, Friedman M, Scheler C, Paredes-Lopez O. Structure-Function Relationships of Folded and Unfolded Amaranth Proteins. Protein J 1998;17(6):542.

(74) Salnikow J, Zemser M, Gorinstein S, Friedman M, Scheler C, Paredes-Lopez O. Structure-Function relationships of folded and unfolded amaranth proteins. J Protein Chem 1998;17(6):543-545.

(75) Katzhendler I, Azoury R, Friedman M. Crystalline properties of carbamazepine in sustained release hydrophilic matrix tablets based on hydroxypropyl methylcellulose. J Control Release 1998;54(1):69-85.

(76) Hoffman A, Danenberg HD, Katzhendler I, Shuval R, Gilhar D, Friedman M. Pharmacodynamic and pharmacokinetic rationales for the development of an oral controlled-release amoxicillin dosage form. J Control Release 1998;54(1):29-37.

(77) Shani S, Friedman M, Steinberg D. In vitro assessment of the antimicrobial activity of a local sustained release device containing amine fluoride for the treatment of oral infectious diseases. Diagn Microbiol Infect Dis 1998;30(2):93-97.

(78) Zemser M, Gorinstein S, Friedman M. The structure-function relationship of ovalbumin matrix as the result of protein denaturation (Short communication). Nahrung Food 1998;42(3-4):252-253.

(79) Katzhendler I, Azoury R, Friedman M. The effect of hydroxypropyl methylcellulose on the crystalline properties of carbamazepine. Proc Control Release Soc 1998(25):838-839.

(80) Lomnicky Y, Friedman M, Luria MH, Raz I, Hoffman A. The effect of the mode of administration on the hypolipidaemic activity of niacin: Continuous gastrointestinal administration of low-dose niacin improves lipid-lowering efficacy in experimentally-induced hyperlipidaemic rats. J Pharm Pharmacol 1998;50(11):1233-1239.

(81) Rubinstein A, Radai R, Friedman M, Fischer P, Rokem JS. The effect of intestinal bacteria adherence on drug diffusion through solid films under stationary conditions. Pharm Res 1997;14(4):503-507.

(82) Rubinstein A, Tirosh B, Baluom M, Nassar T, David A, Radai R, et al. The rationale for peptide drug delivery to the colon and the potential of polymeric carriers as effective tools. J Control Release 1997;46(1-2):59-73.

(83) Tirosh B, Baluom M, Nassar T, Friedman M, Rubinstein A. The effect of Eudragit RL-100 on the mechanical and mucoadhesion properties of polycarbophil dosage forms. J Control Release 1997;45(1):57-64.

(84) Katzhendler I, Hoffman A, Friedman M. Drug release mechanism from hydrophilic matrix tablets. PROC CONTROL RELEASE SOC 1997(24):441-442.

(85) Katzhendler I, Hoffman A, Goldberger A, Friedman M. Modeling of Drug Release from Erodible Tablets. J Pharm Sci 1997;86(1):110-115.

(86) Shani S, Friedman M, Steinberg D. Relation between surface activity and antibacterial activity of amine-fluorides. Int J Pharm 1996;131(1):33-39.

(87) Gorinstein S, Zemser M, Friedman M, Vasco-Méndez NL, Paredes-López O. Denaturant-Induced Conformations of Globulins. J Agric Food Chem 1996;44(1):93-99.

(88) Gorinstein S, Zemser M, Friedman M, Rodrigues WA, Martins PS, Vello NA, et al. Physicochemical characterization of the structural stability of some plant globulins. Food Chem 1996;56(2):131-138.

(89) Tirosh B, Nasser T, Friedman M, Rubinstein A. Eudragit RL-100 as a physical stabilizer of polycarbophil hydrogels. PROC CONTROL RELEASE SOC 1995(22):358-359.

(90) GORINSTEIN S, ZEMSER M, FRIEDMAN M, CHANG S‐. Simultaneous differential scanning calorimetry, X‐ray diffraction and FTIR spectrometry in studies of ovalbumin denaturation. Int J Pept Protein Res 1995;45(3):248-256.

(91) Zemser M, Friedman M, Katzhendler J, Greene LL, Minsky A, Gorinstein S. Relationship between functional properties and structure of ovalbumin. J Protein Chem 1994;13(2):261-274.

(92) Bialer M, Hadad S, Golomb G, Barel S, Samara E, Salach OA, et al. Pharmacokinetic analysis of two new sustained‐release products of diltiazem designed for twice‐and once‐daily treatment. Biopharm Drug Dispos 1994;15(1):45-52.

(93) Egbaria K, Friedman M. Physicochemical properties of albumin microspheres determined by spectroscopic studies. J Pharm Sci 1992;81(2):186-190.

(94) Egbaria K, Friedman M. Adsorption of Fluorescein Dyes on Albumin Microspheres. Pharm Res 1992;9(5):629-635.

(95) Hussein Z, Friedman M. Effect of simulated gastrointestinal changes on the in vitro release of theophylline from novel sustained-release matrix tablets with a protein carrier. J Control Release 1992;18(3):271-277.

(96) Zyskind D, Steinberg D, Friedman M, Bernimoulin JP. Inhibition of plaque accumulation under periodontal dressing by sustained-release varnish of chlorhexidine. Clin Prev Dent 1992;14(3):29-33.

(97) Rotstein I, Lewinstein I, Zuwabi O, Stabholz A, Friedman M. Effect of cervical coating of ethyl cellulose polymer and metacrylic acid copolymer on the radicular penetration of hydrogen peroxide during bleaching. Dent Traumatol 1992;8(5):202-205.

(98) Hildebrandt GH, Pape HR, Syed SA, Gregory WA, Friedman M. Effect of slow-release chlorhexidine mouthguards on the levels of selected salivary bacteria. Caries Res 1992;26(4):268-274.

(99) HELING I, SOMMER M, STEINBERG D, FRIEDMAN M, SELA MN. Microbiological evaluation of the efficacy of chlorhexidine in a sustained‐release device for dentine sterilization. Int Endod J 1992;25(1):15-19.

(100) HELING I, STEINBERG D, KENIG S, GAVRILOVICH I, SELA MN, FRIEDMAN M. Efficacy of a sustained‐release device containing chlorhexidine and Ca(OH)2 in preventing secondary infection of dentinal tubules. Int Endod J 1992;25(1):20-24.

(101) Mazor Z, Brayer L, Friedman M, Steinberg D. Topical varnish containing strontium in a sustained-release device as treatment for dentin hypersensitivity. Clin Prev Dent 1991;13(3):21-25.

(102) Stabholz A, Soskolne WA, Friedman M, Sela MN. The use of sustained release delivery of chlorhexidine for the maintenance of periodontal pockets: 2-year clinical trial. J Periodontol 1991;62(7):429-433.

(103) Friedman M, Steinberg D, Sela MN, Soskolne A. Structural and microbiological evaluation of a degradable sustained-release device for use in periodontal therapy. Drug Des Deliv 1991;7(3):241-250.

(104) Steinberg D, Amit U, Brayer L, Sela MN, Friedman M. The effect of sustained-release varnish of chlorhexidine in dental plastic shells on salivary Streptococcus mutans. Clin Prev Dent 1991;13(2):9-12.

(105) Stabholz A, Shapira J, Shur D, Friedman M, Guberman R, Sela MN. Local application of sustained-release delivery system of chlorhexidine in Down's syndrome population. Clin Prev Dent 1991;13(5):9-14.

(106) Egbaria K, Friedman M. Release profiles of metronidazole and l-phenylalanine from individual albumin microspheres. J Control Release 1990;14(3):215-220.

(107) Hussein Z, Friedman M. Release and Absorption Characteristics of Novel Theophylline Sustained-Release Formulations: In Vitro-in Vivo Correlation. Pharm Res 1990;7(11):1167-1171.

(108) Egbaria K, Friedman M. Sustained release albumin microspheres containing antibacterial drugs: Effects of preparation conditions on kinetics of drug release. J Control Release 1990;14(1):79-94.

(109) Egbaria K, Friedman M. Sustained in vitro activity of human albumin microspheres containing chlorhexidine dihydrochloride against bacteria from cultures of organisms that cause urinary tract infections. Antimicrob Agents Chemother 1990;34(11):2118-2121.

(110) Friedman M, Steinberg D. Sustained-Release Delivery Systems for Treatment of Dental Diseases. Pharm Res 1990;7(4):313-317.

(111) Azoury R, Elkayam R, Friedman M. The effect of crystallization properties and casting solvent on the release of tetracycline from ethyl cellulose films. J Cryst Growth 1990;99(1-4):1044-1047.

(112) Steinberg D, Friedman M, Soskolne A, Sela MN. A new degradable controlled release device for treatment of periodontal disease: In vitro release study. J Periodontol 1990;61(7):393-398.

(113) ZYSKIND D, STEINBERG D, STABHOLZ A, FRIEDMAN M, SELA MN. The effect of sustained release application of chlorhexidine on salivary levels of Streptococcus mutans in partial denture wearers. J Oral Rehabil 1990;17(1):61-66.

(114) Azoury R, Elkayam R, Friedman M. Nuclear magnetic resonance study of an ethyl cellulose sustained‐release delivery system I: Effect of casting solvent on hydration properties. J Pharm Sci 1988;77(5):425-427.

(115) Azoury R, Elkayam R, Friedman M. Nuclear magnetic resonance study of an ethyl cellulose sustained‐release delivery system II: Release rate behavior of tetracycline. J Pharm Sci 1988;77(5):428-431.

(116) Friedman M, Harrari D, Rimer A, Stabholz A. Inhibition of plaque formation by a sustained release delivery system for cetylpyridinium chloride. Int J Pharm 1988;44(1-3):243-247.

(117) Brayer L, Schwartz Z, Stabholtz A, Schibli H, Friedman M. The effect of local application of a sustained release delivery system of chlorhexidine on plaque accumulation. Clin Prev Dent 1988;10(1):23-27.

(118) Elkayam R, Friedman M, Stabholz A, Soskolne AW, Sela MN, Golub L. Sustained release device containing minocycline for local treatment of periodontal disease. J Control Release 1988;7(3):231-236.

(119) Hussein Z, Bialer M, Friedman M, Raz I. Pharmacokinetic analysis of sustained‐release dosage forms of theophylline in humans: Comparison of single and multiple dose studies. Biopharm Drug Dispos 1987;8(5):427-435.

(120) Hussein Z, Bialer M, Friedman M, Raz I. Comparative pharmacokinetic evaluation of sustained-release theophylline formulations in dogs and humans. Int J Pharm 1987;37(1-2):97-102.

(121) Rubinstein A, Gonen A, Friedman M. Computerized model for evaluating the kinetics of in vitro release of valpromide from controlled‐release tablets under nonsink conditions. J Pharm Sci 1986;75(10):959-961.

(122) Bialer M, Friedman M, Dubrovsky J. Relation between absorption half‐life values of four novel sustained‐release dosage forms of valproic acid in dogs and human. Biopharm Drug Dispos 1986;7(5):495-500.

(123) Friedman M, Kalderon Y, Breyer L, Gedalia. Inhibition of enamel dissolution rates by sodium fluoride and amine fluorides in the presence or absence of strontium ions. Pharm Acta Helv 1986;61(1):30-32.

(124) Stabholz A, Sela MN, Friedman M, Golomb G, Soskolne A. Clinical and microbiological effects of sustained release chlorhexidine in periodontal pockets. J Clin Periodontol 1986;13(8):783-788.

(125) Rubinstein A, Bialer M, Friedman M, Raz I, Abramsky O. A combined approach to control valproic acid release via novel delivery system of valpromide: A kinetic and pharmacokinetic study. J Control Release 1986;4(1):33-38.

(126) Friedman M, Golomb G, Brayer L. Plaque Inhibition by Sustained Release of Chlorhexidine from Removable Appliances. J Dent Res 1985;64(11):1319-1321.

(127) Bialer M, Friedman M, Dubrovsky J, Raz I, Abramsky O. Pharmacokinetic evaluation of novel sustained‐release dosage forms of valproic acid in humans. Biopharm Drug Dispos 1985;6(4):401-411.

(128) Bialer M, Friedman M, Dubrovsky J. Comparative pharmacokinetic analysis of a novel sustained release dosage form of valproic acid in dogs. Biopharm Drug Dispos 1984;5(1):1-10.

(129) Bialer M, Friedman M, Dubrovsky J. Effect of sustained release on the pharmacokinetics of valproic acid in the dog. Int J Pharm 1984;20(1-2):53-63.

(130) Bialer M, Friedman M, Rubinstein A. Rapid gas chromatographic assay for monitoring valproic acid and valpromide in plasma. J Pharm Sci 1984;73(7):991-993.

(131) Kohen R, Friedman M, Chevion M. Iron-treated hydroxyapatite: Structure and function. Pharm Acta Helv 1984;59(8):228-234.

(132) JERUSHALMI I, MARKITZIU A, FRIEDMAN M, GEDALIA I. Enamel dissolution and fluoride uptake from sugar solutions. J Oral Rehabil 1984;11(6):555-559.

(133) Friedman M, Brayer L, Golomb G, Hiller H. Prevention of plaque accumulation by local application of a sustained release delivery system of chlorhexidine. J Control Release 1984;1(2):157-160.

(134) HIRSCHFELD Z, FRIEDMAN M, GOLOMB G, BEN‐YAACOV D. New sustained release dosage form of chlorhexidine for dental use: use for plaque control in partial denture wearers. J Oral Rehabil 1984;11(5):477-482.

(135) BEN‐YAAKOV D, FRIEDMAN M, HIRSCHFELD Z, GEDALIA I. Fluoride enhancement of chlorhexidine uptake by hydroxyapatite and enamel powders. J Oral Rehabil 1984;11(1):65-70.

(136) Golomb G, Friedman M, Soskolne A, Stabholz A, Sela MN. Sustained Release Device Containing Metronidazole for Periodontal Use. J Dent Res 1984;63(9):1149-1153.

(137) Friedman M, Solouki S, Gurevitz S, Gedalia I, Onisi M. Fluoride concentrations in tea. Its uptake by hydroxyapatite and effect on dissolution rate. Clin Prev Dent 1984;6(1):20-22.

(138) Soskolne A, Golomb G, Friedman M, Sela MN. New sustained release dosage form of chlorhexidine for dental use: II. Use in periodontal therapy. J Periodontal Res 1983;18(3):330-336.

(139) Friedman M, Golomb G. New sustained release dosage form of chlorhexidine for dental use: I. Development and kinetics of release. J Periodontal Res 1982;17(3):323-328.

(140) FRIEDMAN M, HIRSCHFELD Z. EDTA enhancement of strontium uptake by intact human enamel. J Oral Rehabil 1982;9(4):327-333.

(141) Soskolne WA, Friedman M, Golomb G, Sela M. Sustained release reservoirs of chlorhexidine in periodontal pockets. J Dent Res 1982;61(Abs.).

(142) Hirschfeld Z, Friedman M. The release rate of fluorides: a new laboratory test for availability of therapeutic dentifrices. Refuat Hapeh Vehashinayim 1981;29(1-2):45-52.

(143) Friedman M. The release rate of fluorides: a laboratory test for fluoride availability of therapeutic dentifrices. Pharm Acta Helv 1981;56(1):9-13.

(144) Friedman M. Fluoride uptake by powdered human enamel treated with prolonged acting fluoride pellets in vitro. Arch Oral Biol 1981;26(2):131-134.

(145) GALON E, FRIEDMAN M, GEDALIA I, RAJSTEIN J. Solubility of enamel powder following treatments with 1% sodium dodecyl sulphate in the presence and absence of fluoride. J Oral Rehabil 1981;8(4):359-362.

(146) Friedman M, Donbrow M. Diffusion of drugs through multibarrier. Pharm Weekbl Sci Ed 1980;2(1):1417-1420.

(147) Friedman M. Fluoride Prolonged Release Preparations for Topical Use. J Dent Res 1980;59(8):1392-1397.

(148) Friedman M, Golomb G. Dissolution rate of fluorides: Quality test of dentifrices. J Dent Res 1980;59(SPEC.1SS. DI):1879.

(149) Friedman M, Donbrow M. Diffusion of drugs through multibarrier. Pharm Weekbl 1980;115(47 SCI. ED. 2/5):149-152.

(150) Friedman M, Golomb G, Brayer L, Hiller Ch. Sustained release chlorhexidine preparations for topical use. J Dent Res 1980;59(SPEC. ISSUE B).

(151) Friedman M. Kinetics and mechanism of hydroxyapatite dissolution in acidic solutions containing dentifrice binders. Pharm Acta Helv 1979;54(7-8):234-238.

(152) Friedman M. The inhibition of hydroxyapatite dissolution rates by hydrophilic polymers. J Dent Res 1979;58(Spec. C):1278.

(153) Samuelov Y, Donbrow M, Friedman M. Sustained release of drugs from ethylcellulose‐polyethylene glycol films and kinetics of drug release. J Pharm Sci 1979;68(3):325-329.

(154) FRIEDMAN M, DONBROW M, SAMUELOV Y. Placebo granules as cores for timed release drug delivery systems. J Pharm Pharmacol 1979;31(1):396-399.

(155) Samuelov Y, Donbrow M, Friedman M. Effect of pH on salicylic acid permeation through ethyl cellulose‐PEG 4000 films. J Pharm Pharmacol 1979;31(1):120-121.

(156) Friedman M, Donbrow M, Samuelov Y. Release rate of drugs from ethyl cellulose coated granules containing caffeine and salicylic acid. Drug Dev Ind Pharm 1979;5(4):407-424.

(157) Friedman M, Donbrow M. Fluidized bed coating technique for production of sustained release granules. Drug Dev Ind Pharm 1978;4(4):319-331.

(158) wu M-, Higuchi WI, Fox JL, Friedman M. Kinetics and Mechanism of Hydroxyapatite Crystal Dissolution in Weak Acid Buffers Using the Rotating Disk Method. J Dent Res 1976;55(3):496-505.

(159) DONBROW M, FRIEDMAN M. Enhancement of permeability of ethyl cellulose films for drug penetration. J Pharm Pharmacol 1975;27(9):633-646.

(160) Donbrow M, Friedman M. Timed release from polymeric films containing drugs and kinetics of drug release. J Pharm Sci 1975;64(1):76-80.

(161) Donbrow M, Friedman M. Permeability of films of ethyl cellulose and PEG to caffeine. J Pharm Pharmacol 1974;26(2):148-150.

(162) Donbrow M, Friedman M. The use of a membrane of ethylcellulose for the controlled entry of certain drugs into the body. HAROKEACH HAIVRI 1973;16(3):255-254.