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School of Pharmacy : Gibson Dan


 Last updated Septmber 2023 - School of Pharmacy

List of Publications


Babu T, Ghareeb H, Basu U, Schueffl H, Theiner S, Heffeter P, et al. Oral Anticancer Heterobimetallic PtIV−AuI Complexes Show High In Vivo Activity and Low Toxicity. Angewandte Chemie - International Edition [Internet]. 2023;62(10). Available from:


Mendrina T, Poetsch I, Schueffl H, Baier D, Pirker C, Ries A, et al. Influence of the Fatty Acid Metabolism on the Mode of Action of a Cisplatin(IV) Complex with Phenylbutyrate as Axial Ligands. Pharmaceutics [Internet]. 2023;15(2). Available from:


Sarkar A, Novohradsky V, Maji M, Babu T, Markova L, Kostrhunova H, et al. Multitargeting Prodrugs that Release Oxaliplatin, Doxorubicin and Gemcitabine are Potent Inhibitors of Tumor Growth and Effective Inducers of Immunogenic Cell Death. Angewandte Chemie - International Edition [Internet]. 2023; Available from:


Liu X, Barth MC, Cseh K, Kowol CR, Jakupec MA, Keppler BK, et al. Oxoplatin-Based Pt(IV) Lipoate Complexes and Their Biological Activity. Chemistry and Biodiversity [Internet]. 2022;19(10). Available from:


Liu X, Wenisch D, Barth MC, Cseh K, Kowol CR, Jakupec MA, et al. Novel oxaliplatin(iv) complexes conjugated with ligands bearing pendant 1,2-dithiolane/1,2-diselenolane/cyclopentyl motifs. Dalton Transactions [Internet]. 2022;51(44):16824–35. Available from:


Lachowicz JI, Mateddu A, Coni P, Caltagirone C, Murgia S, Gibson D, et al. Study of the DNA binding mechanism and in vitro activity against cancer cells of iron(iii) and aluminium(iii) kojic acid derivative complexes. Dalton Transactions [Internet]. 2022; Available from:


Schmidt C, Babu T, Kostrhunova H, Timm A, Basu U, Ott I, et al. Are Pt(IV) Prodrugs That Release Combretastatin A4 True Multi-action Prodrugs? Journal of Medicinal Chemistry [Internet]. 2021;64(15):11364–78. Available from:


Gibson D. Pt(IV) Anticancer Prodrugs – A Tale of Mice and Men. ChemMedChem [Internet]. 2021;16(14):2188–91. Available from:


Gibson D. Platinum(IV) anticancer agents; are we en route to the holy grail or to a dead end? Journal of Inorganic Biochemistry [Internet]. 2021;217. Available from:


Karmakar S, Kostrhunova H, Ctvrtlikova T, Novohradsky V, Gibson D, Brabec V. Platinum(IV)-Estramustine Multiaction Prodrugs Are Effective Antiproliferative Agents against Prostate Cancer Cells. Journal of Medicinal Chemistry [Internet]. 2020;63(22):13861–77. Available from:


Khattib D, Ishan M, Karmakar S, Kostrhunova H, Brabec V, Gibson D. Oxidation of cis-Diamminediacetato PtII with Hydrogen Peroxide Can Give Rise to Two Isomeric PtIV Products. Chemistry - A European Journal [Internet]. 2020;26(43):9475–80. Available from:


Chen CKJ, Kappen P, Gibson D, Hambley TW. trans-Platinum(iv) pro-drugs that exhibit unusual resistance to reduction by endogenous reductants and blood serum but are rapidly activated inside cells:1H NMR and XANES spectroscopy study. Dalton Transactions [Internet]. 2020;49(23):7722–36. Available from:


Karges J, Yempala T, Tharaud M, Gibson D, Gasser G. A Multi-action and Multi-target RuII–PtIV Conjugate Combining Cancer-Activated Chemotherapy and Photodynamic Therapy to Overcome Drug Resistant Cancers. Angewandte Chemie - International Edition [Internet]. 2020;59(18):7069–75. Available from:


Babu T, Sarkar A, Karmakar S, Schmidt C, Gibson D. Multiaction Pt(IV) Carbamate Complexes Can Codeliver Pt(II) Drugs and Amine Containing Bioactive Molecules. Inorganic Chemistry [Internet]. 2020;59(7):5182–93. Available from:


Yempala T, Babu T, Gibson D, Cassels BK. Dibenzofuran annulated 1-azepines: Synthesis and cytotoxicity. Synthetic Communications [Internet]. 2020;50(3):438–45. Available from:


Karmakar S, Poetsch I, Kowol CR, Heffeter P, Gibson D. Synthesis and Cytotoxicity of Water-Soluble Dual- A nd Triple-Action Satraplatin Derivatives: Replacement of Equatorial Chlorides of Satraplatin by Acetates. Inorganic Chemistry [Internet]. 2019;58(24):16676–88. Available from:


Yempala T, Babu T, Karmakar S, Nemirovski A, Ishan M, Gandin V, et al. Expanding the Arsenal of PtIV Anticancer Agents: Multi-action PtIV Anticancer Agents with Bioactive Ligands Possessing a Hydroxy Functional Group. Angewandte Chemie - International Edition [Internet]. 2019;58(50):18218–23. Available from:


Babak MV, Zhi Y, Czarny B, Toh TB, Hooi L, Chow EKH, et al. Dual-Targeting Dual-Action Platinum(IV) Platform for Enhanced Anticancer Activity and Reduced Nephrotoxicity. Angewandte Chemie - International Edition [Internet]. 2019;58(24):8109–14. Available from:


Kostrhunova H, Zajac J, Novohradsky V, Kasparkova J, Malina J, Aldrich-Wright JR, et al. A Subset of New Platinum Antitumor Agents Kills Cells by a Multimodal Mechanism of Action Also Involving Changes in the Organization of the Microtubule Cytoskeleton. Journal of Medicinal Chemistry [Internet]. 2019;62(10):5176–90. Available from:


Kostrhunova H, Petruzzella E, Gibson D, Kasparkova J, Brabec V. An Anticancer Pt IV Prodrug That Acts by Mechanisms Involving DNA Damage and Different Epigenetic Effects. Chemistry - A European Journal [Internet]. 2019;25(20):5235–45. Available from:


Gibson D. Multi-action Pt(IV) anticancer agents; do we understand how they work? Journal of Inorganic Biochemistry [Internet]. 2019;191:77–84. Available from:


Petruzzella E, Sirota R, Solazzo I, Gandin V, Gibson D. Triple action Pt(iv) derivatives of cisplatin: A new class of potent anticancer agents that overcome resistance. Chemical Science [Internet]. 2018;9(18):4299–307. Available from:


Novohradsky V, Zanellato I, Marzano C, Pracharova J, Kasparkova J, Gibson D, et al. Epigenetic and antitumor effects of platinum(IV)-octanoato conjugates. Scientific Reports [Internet]. 2017;7(1). Available from:


Petruzzella E, Braude JP, Aldrich-Wright JR, Gandin V, Gibson D. A Quadruple-Action Platinum(IV) Prodrug with Anticancer Activity Against KRAS Mutated Cancer Cell Lines. Angewandte Chemie - International Edition [Internet]. 2017;56(38):11539–44. Available from:


Harper BWJ, Friedman-Ezra A, Sirota R, Petruzzella E, Aldrich-Wright JR, Gibson D. Probing the Interactions of Cytotoxic [Pt(1S,2S-DACH)(5,6-dimethyl-1,10-phenanthroline)] and Its PtIV Derivatives with Human Serum. ChemMedChem [Internet]. 2017;12(7):510–9. Available from:


Sirota R, Gibson D, Kohen R. The timing of caffeic acid treatment with cisplatin determines sensitization or resistance of ovarian carcinoma cell lines. Redox Biology [Internet]. 2017;11:170–5. Available from:


Harper BWJ, Petruzzella E, Sirota R, Faccioli FF, Aldrich-Wright JR, Gandin V, et al. Synthesis, characterization and: In vitro and in vIVo anticancer actIVity of Pt(IV) derIVatIVes of [Pt(1 S,2 S -DACH)(5,6-dimethyl-1,10-phenanthroline)]. Dalton Transactions [Internet]. 2017;46(21):7005–19. Available from:


Abu Ammar A, Raveendran R, Gibson D, Nassar T, Benita S. A Lipophilic Pt(IV) Oxaliplatin Derivative Enhances Antitumor Activity. Journal of Medicinal Chemistry [Internet]. 2016;59(19):9035–46. Available from:


Raveendran R, Braude JP, Wexselblatt E, Novohradsky V, Stuchlikova O, Brabec V, et al. Pt(iv) derivatives of cisplatin and oxaliplatin with phenylbutyrate axial ligands are potent cytotoxic agents that act by several mechanisms of action. Chemical Science [Internet]. 2016;7(3):2381–91. Available from:


Zajac J, Kostrhunova H, Novohradsky V, Vrana O, Raveendran R, Gibson D, et al. Potentiation of mitochondrial dysfunction in tumor cells by conjugates of metabolic modulator dichloroacetate with a Pt(IV) derivative of oxaliplatin. Journal of Inorganic Biochemistry [Internet]. 2016;156:89–97. Available from:


Gibson D. Platinum(IV) anticancer prodrugs-hypotheses and facts. Dalton Transactions [Internet]. 2016;45(33):12983–91. Available from:


Novohradsky V, Zerzankova L, Stepankova J, Vrana O, Raveendran R, Gibson D, et al. New insights into the molecular and epigenetic effects of antitumor Pt(IV)-valproic acid conjugates in human ovarian cancer cells. Biochemical Pharmacology [Internet]. 2015;95(3):133–44. Available from:


Sirota R, Gibson D, Kohen R. The role of the catecholic and the electrophilic moieties of caffeic acid in Nrf2/Keap1 pathway activation in ovarian carcinoma cell lines. Redox Biology [Internet]. 2015;4:48–59. Available from:


Brabec V, Pracharova J, Novakova O, Gibson D, Kasparkova J. The induction of lysis in lysogenic strains of Escherichia coli by a new antitumor transplatin derivative and its DNA interactions. Dalton Transactions [Internet]. 2015;44(8):3573–82. Available from:


Wexselblatt E, Raveendran R, Salameh S, Friedman-Ezra A, Yavin E, Gibson D. On the stability of PtIV pro-drugs with haloacetato ligands in the axial positions. Chemistry - A European Journal [Internet]. 2015;21(7):3108–14. Available from:


Li J, Pant A, Chin CF, Ang WH, Ménard-Moyon C, Nayak TR, et al. In vivo biodistribution of platinum-based drugs encapsulated into multi-walled carbon nanotubes. Nanomedicine: Nanotechnology, Biology, and Medicine [Internet]. 2014;10(7):1465–75. Available from:


Novohradsky V, Zerzankova L, Stepankova J, Vrana O, Raveendran R, Gibson D, et al. Antitumor platinum(IV) derivatives of oxaliplatin with axial valproato ligands. Journal of Inorganic Biochemistry [Internet]. 2014;140:72–9. Available from:


Zivi E, Barash D, Aizenman E, Gibson D, Shufaro Y. Zygote serine decreased uptake from the fertilization medium is associated with implantation and pregnancy. Journal of Assisted Reproduction and Genetics [Internet]. 2014;31(7):889–97. Available from:


Wexselblatt E, Yavin E, Gibson D. Platinum(IV) prodrugs with haloacetato ligands in the axial positions can undergo hydrolysis under biologically relevant conditions. Angewandte Chemie - International Edition [Internet]. 2013;52(23):6059–62. Available from:


Prachařová J, Nováková O, Kašpárková J, Gibson D, Brabec V. Toxicity in tumor cells, DNA binding mode, and resistance to decomposition by sulfur nucleophiles of new dinuclear bifunctional trans-PtII complexes containing long alkane linkers. Pure and Applied Chemistry [Internet]. 2013;85(2):343–54. Available from:


Zhang JZ, Bonnitcha P, Wexselblatt E, Klein AV, Najajreh Y, Gibson D, et al. Facile preparation of mono-, Di- and mixed-carboxylato platinum(IV) complexes for versatile anticancer prodrug design. Chemistry - A European Journal [Internet]. 2013;19(5):1672–6. Available from:


Frybortova M, Novakova O, Stepankova J, Novohradsky V, Gibson D, Kasparkova J, et al. Activation of trans geometry in bifunctional mononuclear platinum complexes by a non-bulky methylamine ligand. Journal of Inorganic Biochemistry [Internet]. 2013;126:46–54. Available from:


Zhang JZ, Wexselblatt E, Hambley TW, Gibson D. Pt(iv) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate. Chemical Communications [Internet]. 2012;48(6):847–9. Available from:


Wexselblatt E, Gibson D. What do we know about the reduction of Pt(IV) pro-drugs? Journal of Inorganic Biochemistry [Internet]. 2012;117:220–9. Available from:


Wexselblatt E, Yavin E, Gibson D. Cellular interactions of platinum drugs. Inorganica Chimica Acta [Internet]. 2012;393:75–83. Available from:


Kostrhunova H, Kasparkova J, Gibson D, Brabec V. Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione. Molecular Pharmaceutics [Internet]. 2010;7(6):2093–102. Available from:


Kostrhunova H, Vrana O, Suchankova T, Gibson D, Kasparkova J, Brabec V. Different features of the DNA binding mode of antitumor cis -amminedichlorido(cyclohexylamine)platinum(II) (JM118) and cisplatin in vitro. Chemical Research in Toxicology [Internet]. 2010;23(11):1833–42. Available from:


Nemirovski A, Vinograd I, Takrouri K, Mijovilovich A, Rompel A, Gibson D. New reduction pathways for ctc-[PtCl2(CH3CO 2)2(NH3)(Am)] anticancer prodrugs. Chemical Communications [Internet]. 2010;46(11):1842–4. Available from:


Gibson D. The mechanism of action of platinum anticancer agents - What do we really know about it? Dalton Transactions [Internet]. 2009;(48):10681–9. Available from:


Kasherman Y, Sturup S, Gibson D. Is glutathione the major cellular target of cisplatin? A study of the interactions of cisplatin with cancer cell extracts. Journal of Medicinal Chemistry [Internet]. 2009;52(14):4319–28. Available from:


Kasherman Y, Sturup S, Gibson D. Trans labilization of am(m)ine ligands from platinum(II) complexes by cancer cell extracts. Journal of Biological Inorganic Chemistry [Internet]. 2009;14(3):387–99. Available from:


Gabbiani C, Casini A, Mastrobuoni G, Kirshenbaum N, Moshel O, Pieraccini G, et al. Peculiar mechanistic and structural features of the carboplatin-cytochrome c system revealed by ESI-MS analysis. Journal of Biological Inorganic Chemistry [Internet]. 2008;13(5):755–64. Available from:


Halámiková A, Heringová P, Kašpárková J, Intini FP, Natile G, Nemirovski A, et al. Cytotoxicity, mutagenicity, cellular uptake, DNA and glutathione interactions of lipophilic trans-platinum complexes tethered to 1-adamantylamine. Journal of Inorganic Biochemistry [Internet]. 2008;102(5–6):1077–89. Available from:


Narang S, Gibson D, Wasan AD, Ross EL, Michna E, Nedeljkovic SS, et al. Efficacy of Dronabinol as an Adjuvant Treatment for Chronic Pain Patients on Opioid Therapy. Journal of Pain [Internet]. 2008;9(3):254–64. Available from:


Nemirovski A, Kasherman Y, Tzaraf Y, Gibson D. Reduction of cis,trans,cis-[PtCl2(OCOCH3) 2(NH3)2] by aqueous extracts of cancer cells. Journal of Medicinal Chemistry [Internet]. 2007;50(23):5554–6. Available from:


Brabec V, Christofis P, Slámová M, Kostrhunová H, Nováková O, Najajreh Y, et al. DNA interactions of new cytotoxic tetrafunctional dinuclear platinum complex trans,trans-[PtCl2(NH3)2(piperazine)]. Biochemical Pharmacology [Internet]. 2007;73(12):1887–900. Available from:


Najajreh Y, Khazanov E, Jawbry S, Ardeli-Tzaraf Y, Perez JM, Kasparkova J, et al. Cationic nonsymmetric transplatinum complexes with piperidinopiperidine ligands. Preparation, characterization, in vitro cytotoxicity, in vivo toxicity, and anticancer efficacy studies. Journal of Medicinal Chemistry [Internet]. 2006;49(15):4665–73. Available from:


Najajreh Y, Ardeli-Tzaraf Y, Kasparkova J, Heringova P, Prilutski D, Balter L, et al. Interactions of platinum complexes containing cationic, bicyclic, nonplanar piperidinopiperidine ligands with biological nucleophiles. Journal of Medicinal Chemistry [Internet]. 2006;49(15):4674–83. Available from:


Anzellotti A, Stefan S, Gibson D, Farrell N. Donor atom preferences in substitution reactions of trans-platinum mononucleobase compounds: Implications for DNA-protein selectivity. Inorganica Chimica Acta [Internet]. 2006;359(9):3014–9. Available from:


Gibson D, Kasherman Y, Kowarski D, Freikman I. The trans labilization of cis-[PtCl2(13CH 3NH2)2] by glutathione can be monitored at physiological pH by [1H,13C] HSQC NMR. Journal of Biological Inorganic Chemistry [Internet]. 2006;11(2):179–88. Available from:


Najajreh Y, Kasparkova J, Marini V, Gibson D, Brabec V. Structural characterization and DNA interactions of new cytotoxic transplatin analogues containing one planar and one nonplanar heterocyclic amine ligand. Journal of Biological Inorganic Chemistry [Internet]. 2005;10(7):722–31. Available from:


Jawbry S, Freikman I, Najajreh Y, Perez JM, Gibson D. Preparation, cytotoxicity and interactions with nucleophiles of three isomeric transplatinum complexes containing methylpiperidine ligands. Journal of Inorganic Biochemistry [Internet]. 2005;99(10):1983–91. Available from:


Sobol E, Yagen B, Winkler I, Britzi M, Gibson D, Bialer M. Pharmacokinetics and metabolism of a new potent antiepileptic drug, 2,2,3,3-tetramethycyclopropanecarbonylurea, in rats. Drug Metabolism and Disposition [Internet]. 2005;33(10):1538–46. Available from:


Najajreh Y, Prilutski D, Ardeli-Tzaraf Y, Perez JM, Khazanov E, Barenholz Y, et al. Structure and unique interactions with DNA of a cationic Trans-platinum complex with the nonplanar bicyclic piperidinopiperidine ligand. Angewandte Chemie - International Edition [Internet]. 2005;44(19):2885–7. Available from:


Balter L, Gibson D. Mass spectrometric studies of the formation and reactivity of trans-[PtCl2(Am)(piperidinopiperidine)]·HCl complexes with ubiquitin. Rapid Communications in Mass Spectrometry [Internet]. 2005;19(24):3666–72. Available from:


Kogan NM, Rabinowitz R, Levi P, Gibson D, Sandor P, Schlesinger M, et al. Synthesis and antitumor activity of quinonoid derivatives of cannabinoids. Journal of Medicinal Chemistry [Internet]. 2004;47(15):3800–6. Available from:


Aronov O, Horowitz AT, Gabizon A, Fuertes MA, Pérez JM, Gibson D. Nuclear localization signal-targeted poly(ethylene glycol) conjugates as potential carriers and nuclear localizing agents for carboplatin analogues. Bioconjugate Chemistry [Internet]. 2004;15(4):814–23. Available from:


Kasparkova J, Novakova O, Marini V, Najajreh Y, Gibson D, Perez JM, et al. Activation of trans geometry in bifunctional mononuclear platinum complexes by a piperidine ligand. Mechanistic studies on antitumor action. Journal of Biological Chemistry [Internet]. 2003;278(48):47516–25. Available from:


Kasparkova J, Novakova O, Najajreh Y, Gibson D, Perez JM, Brabec V. Effects of a Piperidine Ligand on DNA Modification by Antitumor Cisplatin Analogues. Chemical Research in Toxicology [Internet]. 2003;16(11):1424–32. Available from:


Kasparkova J, Marini V, Najajreh Y, Gibson D, Brabec V. DNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine, or 4-picoline ligand in cell-free media. Relations to their activity in cancer cell lines. Biochemistry [Internet]. 2003;42(20):6321–32. Available from:


Aronov O, Horowitz AT, Gabizon A, Gibson D. Folate-targeted PEG as a potential carrier for carboplatin analogs. Synthesis and in vitro studies. Bioconjugate Chemistry [Internet]. 2003;14(3):563–74. Available from:


Najajreh Y, Peleg-Shulman T, Moshel O, Farrel N, Gibson D. Ligand effects on the binding of cis- and trans-[PtCl2Am1Am2 to proteins. Journal of Biological Inorganic Chemistry [Internet]. 2003;8(1–2):167–75. Available from:


Najajreh Y, Perez JM, Navarro-Ranninger C, Gibson D. Novel soluble cationic trans-diaminedichloroplatinum(II) complexes that are active against cisplatin resistant ovarian cancer cell lines. Journal of Medicinal Chemistry [Internet]. 2002;45(24):5189–95. Available from:


Khazanov E, Barenholz Y, Gibson D, Najajreh Y. Novel apoptosis-inducing trans-platinum piperidine derivatives: Synthesis and biological characterization. Journal of Medicinal Chemistry [Internet]. 2002;45(24):5196–204. Available from:


Peleg-Shulman T, Najajreh Y, Gibson D. Interactions of cisplatin and transplatin with proteins.Comparison of binding kinetics, binding sites and reactivity of the Pt-protein adducts of cisplatin and transplatin towards biological nucleophiles. Journal of Inorganic Biochemistry [Internet]. 2002;91(1):306–11. Available from:


Gibson D. Drug-DNA interactions and novel drug design. Pharmacogenomics Journal [Internet]. 2002;2(5):275–6. Available from:


Peleg-Shulman T, Gibson D. Cisplatin-protein adducts are efficiently removed by glutathione but not by 5′-guanosine monophosphate. Journal of the American Chemical Society [Internet]. 2001;123(13):3171–2. Available from:


Peleg-Shulman T, Gibson D, Cohen R, Abra R, Barenholz Y. Characterization of sterically stabilized cisplatin liposomes by nuclear magnetic resonance. Biochimica et Biophysica Acta - Biomembranes [Internet]. 2001;1510(1–2):278–91. Available from:


Peleg-Shulman T, Katzhendler J, Gibson D. Effects of monofunctional platinum binding on the thermal stability and conformation of a self-complementary 22-mer. Journal of Inorganic Biochemistry [Internet]. 2000;81(4):313–23. Available from:


Gibson D, Costello CE. Mass spectrometry of biomolecules. Separation Science and Technology [Internet]. 2000;2(C):299–327. Available from:


Gibson D, Costello CE. A mass spectral study of the binding of the anticancer drug cisplatin to ubiquitin. European Journal of Mass Spectrometry [Internet]. 1999;5(6):501–10. Available from:


Bauer C, Peleg-Shulman T, Gibson D, Wang AHJ. Monofunctional platinum amine complexes destabilize DNA significantly. European Journal of Biochemistry [Internet]. 1998;256(2):253–60. Available from:


Ferreira ADQ, Bino A, Gibson D. Preparation, Structure and Stability of cis-Cr(phen)2[OP(O)(OC6H5)2](H 2O)2+ as a Model for Cr(III)-DNA Adducts. Inorganic Chemistry [Internet]. 1998;37(26):6560–1. Available from:


Ferreira ADQ, Bino A, Gibson D. Novel carboplatin analogs containing flexible and potentially intercalating ligands: Preparation and X-ray crystal structures of di-2-pyridyl ketone cyclobutanedicarboxylate platinum(II) and of 2,3-bis(2-pyridyl)pyrazine cyclobutane dicarboxylate platinum(II). Inorganica Chimica Acta [Internet]. 1997;265(1-2 PART II):155–61. Available from:


Gibson D, Binyamin I, Haj M, Ringel I, Ramu A, Katzhendler J. Anthraquinone intercalators as carrier molecules for second-generation platinum anticancer drugs. European Journal of Medicinal Chemistry [Internet]. 1997;32(10):823–31. Available from:


Breuer E, Zaher H, Tashma Z, Gibson D. Acylphosphonamidates and α-hydroxyiminophosphonamidates. Synthesis of N-acylphosphordiamidates by Beckmann rearrangement. Crystal structure of (E)-α-hydroxyiminobenzyl-1-pyrrolidinylphosphinate. Heteroatom Chemistry [Internet]. 1996;7(6):515–20. Available from:


Gibson D, Mansur N, Gean KF. Preparation, characterization, and antitumor properties of cis-PtCl2 complexes linked to anthraquinones through position number 2. Journal of Inorganic Biochemistry [Internet]. 1995;58(2):79–88. Available from:


Doungdee P, Sarel S, Ringel I, Gibson D, Wongvisetsirikul N, Avramovici-Grisaru S. Iron chelators of the pyridoxal 2-pyridyl hydrazone class. part III.1 Ionisation and conformational characteristics of the ligands. Heterocycles [Internet]. 1995;40(1):241–8. Available from:


Arvanitis GM, Gibson D, Emge TJ, Berman HM. Platinum(II) triamine complexes: cis-[PtCl(NH3)2(C10H13N5O5)]NO3.2H2O and [PtCl(C2H8N2)(C4H6N2)]NO3. Acta crystallographica Section C, Crystal structure communications [Internet]. 1994;50 ( Pt 8):1217–20. Available from:


Gibson D, Arvanitis GM, Berman HM. Ternary Pt(II)-amino acid-nucleotide complexes: kinetics of formation. Inorganica Chimica Acta [Internet]. 1994;218(1–2):11–9. Available from:


Rosenfeld A, Blum J, Gibson D, Ramu A. Preparation, characterization and antileukemic properties of diaminemalonatoplatinum(II) complexes tethered to ferrocene. Inorganica Chimica Acta [Internet]. 1992;201(2):219–21. Available from:


Devane WA, Hanuš L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science [Internet]. 1992;258(5090):1946–9. Available from:


Breuer E, Safadi M, Chorev M, Gibson D. Evaluation of the n-phthaloyl moiety as protecting group in aminoacylphosphonic derivatives. Phosphorus, Sulfur, and Silicon and the Related Elements [Internet]. 1991;60(3–4):239–46. Available from:


Gibson D, Gean KF, Ben-Shoshan R, Katzhendler J, Ramu A, Ringel I. Preparation, Characterization, and Anticancer Activity of a Series of cis-PtCl2 Complexes Linked to Anthraquinone Intercalators. Journal of Medicinal Chemistry [Internet]. 1991;34(1):414–20. Available from:


Gean K, Ben-Shoshan R, Ramu A, Ringel I, Katzhendler J, Gibson D. Preparation, characterization and the anticancer activity of a novel series of triaminemonochloroplatinum(II) cations linked to anthraquinone intercalators. European Journal of Medicinal Chemistry [Internet]. 1991;26(6):593–8. Available from:


Schlossman A, Gibson D, Breuer E. Rearrangement and fragmentation reactions of α-hydroxyiminophoshinates. On the nature of the metaphosphonate intermediate involved in phosphonylations by α-hydroxyiminophosphinate. Phosphorus, Sulfur, and Silicon and the Related Elements [Internet]. 1990;49–50(1–4):81–4. Available from:


Breuer E, Schlossman A, Safadi M, Gibson D, Chorev M, Leader H. Stereoselectivity in fragmentation and rearrangement of α-hydroxyimino-phosphinates and -phosphonates. A synthetic approach to acylphosphon- and phosphor-amidates. Crystal structures of methyl (E)-α-hydroxyimino-benzylphenylphosphinate and methyl benzoylphenylphosphonamidate. Journal of the Chemical Society, Perkin Transactions 1 [Internet]. 1990;(12):3263–9. Available from:


Gibson D, Rosenfeld A, Apfelbaum H, Blum J. Multinuclear (195Pt, 15N, 13C) NMR studies of the reactions between cis-diaminediaquaplatinum(ii) complexes and aminomalonate. Inorganic Chemistry [Internet]. 1990;29(25):5125–9. Available from:


Breuer E, Safadi M, Chorev M, Gibson D. Novel Amino Acid Derivatives. Preparation and Properties of Aminoacylphosphonates and Amino Hydroxyimino Phosphonates. Journal of Organic Chemistry [Internet]. 1990;55(25):6147–53. Available from:


Coll M, Sherman SE, Gibson D, Lippard SJ, Wang AHJ. Molecular structure of the complex formed between the anticancer drug cisplatin and d(PGpG): C2221 crystal form. Journal of Biomolecular Structure and Dynamics [Internet]. 1990;8(2):315–30. Available from:


Breuer E, Karaman R, Goldblum A, Gibson D, Leader H, Potter BVL, et al. Erratum: α-Oxyiminophosphonates: Chemical and physical properties. Reactions, theoretical calculations and crystal structures of (E)- And (Z)-dimethyl α-Hydroxyiminobenzylphosphonates (Journal of the Chemical Society, Perkin Transactions 1 (1988) 3047). Journal of the Chemical Society, Perkin Transactions 1 [Internet]. 1989;(7):1367. Available from:


Katzhendler J, Ringel I, Goldblum A, Gibson D, Tashma Z. Conformational studies of substituted five-membered cyclic carbonates and related compounds by MNDO, and the X-ray crystal structure of 4-chlorophenyloxymethyl-1,3-dioxolan-2-one. Journal of the Chemical Society, Perkin Transactions 2 [Internet]. 1989;(11):1729–39. Available from:


Breuer E, Karaman R, Gibson D, Goldblum A. Structure and reactivity of 2-hydroxyiminobenzyl-2-oxo-4,4,5,5-tetramethyl[1,3,2]dioxaphospholanes. Phosphorus, Sulfur, and Silicon and the Related Elements [Internet]. 1989;41(3–4):433–7. Available from:


Gibson D, Karaman R. Metal complexes of α-hydroxyiminophosphonic acid derivatives. Preparation and crystal structures of calcium and cadmium complexes of methyl (E)-α-hydroxyiminobenzylphosphonate. Journal of the Chemical Society, Dalton Transactions [Internet]. 1989;(10):1911–4. Available from:


Katzhendler J, Karaman R, Gibson D, Breuer E, Leader H. Fragmentation of methyl hydrogen α-hydroxyiminophosphonates to monomeric methyl metaphosphate: Stereochemistry and mechanism. Journal of the Chemical Society, Perkin Transactions 2 [Internet]. 1989;(6):589–94. Available from:


Gibson D, Karaman R. Metal complexes of α-hydroxyimino phosphonic acid derivatives. Separation of the E and Z isomers by metal chelation and the preparation and characterization of copper bis[-(α-(hydroxyimino)benzyl)phosphonate]-water. Inorganic Chemistry [Internet]. 1989;28(10):1928–32. Available from:


Ringel I, Bakshi O, Mellado W, Ramu A, Gibson D, Katzhendler J. N-Alkyl colchiceineamides: their inhibition of GTP or taxol-induced assembly of tubulin. Biochemical Pharmacology [Internet]. 1988;37(12):2487–9. Available from:


Breuer E, Karaman R, Goldblum A, Gibson D, Leader H, Potter BVL, et al. α-Oxyiminophosphonates: Chemical and physical properties. Reactions, theoretical calculations, and x-ray crystal structures of (E) and (Z)-dimethyl α-hydroxyiminobenzylphosphonates. Journal of the Chemical Society, Perkin Transactions 1 [Internet]. 1988;(11):3047–57. Available from:


Breuer E, Karaman R, Gibson D, Leader H, Goldblum A. α-hydroxyiminophosphonic acids. New types of phosphorylating agents through monomeric metaphosphate. Journal of the Chemical Society, Chemical Communications [Internet]. 1988;(7):504–6. Available from:


Kitov S, Ben-Shoshan R, Ringel I, Gibson D, Katzhendler J. The effect of cis-platin analogues derived from aminoalkylaminoanthraquinones on DNA cleavage: an electron microscopy study. European Journal of Medicinal Chemistry [Internet]. 1988;23(4):381–3. Available from:


Sherman SE, Gibson D, Lippard SJ, Wang AHJ. Crystal and Molecular Structure of cis-[Pt(NH3)2d(pGpG)], the Principal Adduct Formed by cis-Diamminedichloroplatinum(II) with DNA. Journal of the American Chemical Society [Internet]. 1988;110(22):7368–81. Available from:


Villacorta GM, Gibson D, Williams ID, Whang E, Lippard SJ. Alkyne-Bridged Dicopper(I) Complexes of the Tropocoronand Macrocycles. Organometallics [Internet]. 1987;6(11):2426–31. Available from:


Gibson D, Lippard SJ. Synthesis and NMR Structural Studies of the Adduct of trans -Diamminedichloroplatinum(II) with the DNA Fragment d(GpCpG). Inorganic Chemistry [Internet]. 1987;26(14):2275–9. Available from:


Gibson D, Lippard SJ. Preparation and Structural Characterization of a Novel Hexanuclear Complex of Platinum(II) with 2-Aminoethanethiolate. Inorganic Chemistry [Internet]. 1986;25(2):219–22. Available from:


Bino A, Gibson D. Tritungsten(IV) cluster compounds with hydroxo ligands. Preparation and structure of [W3O2(O2CCH3)6(H2O)(OH)2]·16H2O and [W3O2(O2CCH3)6(H2O)(OH)2]·KBr·15H2O. Inorganica Chimica Acta [Internet]. 1985;104(3):155–60. Available from:


Shamir J, Luski S, Bino A, Cohen S, Gibson D. Tetrachloro-phosphonium salts of hexachloro antimonate and niobate and their solvates. Preparation and structure by vibrational spectroscopy and x-ray crystallography. Inorganica Chimica Acta [Internet]. 1985;104(2):91–7. Available from:


Shamir J, Luski S, Bino A, Cohen S, Gibson D. Reactions of Phosphorus Pentachloride with Tin Tetrachloride. Tetrachlorophosphonium Salts with SnCl62-, Sn2Cl102-, and SnCl5- Anions: Preparation and Structure by Vibrational Spectra and X-ray Crystallography. Inorganic Chemistry [Internet]. 1985;24(14):2301–9. Available from:


Bino A, Gibson D. Hydrogen oxide (H3O2) bridge formation in trinuclear metal cluster systems. The structure of [W3O2(O2CCH3)6(H2O)(H3O2)] NCS·H2O. Inorganica Chimica Acta [Internet]. 1985;101(1):L9. Available from:


Benory E, Bino A, Gibson D, Cotton FA, Dori Z. Oxalato complexes of the trinuclear aquo ion of molybdenum(IV), [Mo3O4]4+. Inorganica Chimica Acta [Internet]. 1985;99(2):137–42. Available from:


Sherman SE, Gibson D, Wang AHJ, Lippard SJ. X-ray structure of the major adduct of the anticancer drug cisplatin with DNA: cis-[Pt(NH3)2d(pGpG)]. Science [Internet]. 1985;230(4724):412–7. Available from:


Villacorta GM, Gibson D, Williams ID, Lippard SJ. Dicopper(I) Tropocoronands: Synthesis, X-ray Crystal Structure, and Spectral Properties of Neutral Binuclear Copper(I) Complexes Bridged by Symmetrically Substituted Alkynes. Journal of the American Chemical Society [Internet]. 1985;107(23):6732–4. Available from:


Feinstein-Jaffe I, Gibson D, Lippard SJ, Schrock RR, Spool A. A Molecule Containing the OWOWO Unit. Synthesis, Structure, and Spectroscopy of W2O3(CH2CMe3)6. Journal of the American Chemical Society [Internet]. 1984;106(21):6305–10. Available from:


Bino A, Gibson D. The Hydrogen Oxide Bridging Ligand (H302-). 2. Effect of the Hydrogen Ion Concentration. Inorganic Chemistry [Internet]. 1984;23(1):109–15. Available from:


Bino A, Gibson D. Trinuclear Mo(IV) cluster ion with a propylidyne cap. Inorganica Chimica Acta [Internet]. 1982;65(C):L37–8. Available from:


Bino A, Gibson D. The Hydrogen Oxide Bridging Ligand (H3O2−). 1. Dimerization and Polymerization of Hydrolyzed Trinuclear Metal Cluster Ions. Journal of the American Chemical Society [Internet]. 1982;104(16):4383–8. Available from:


Bino A, Gibson D. A New Bridging Ligand, the Hydrogen Oxide Ion (H302−). Journal of the American Chemical Society [Internet]. 1981;103(22):6741–2. Available from:


Bino A, Gibson D. A New, Convenient, and Efficient Route to Dimolybdenum(II) Compounds from MoO3. Journal of the American Chemical Society [Internet]. 1980;102(12):4277–8. Available from: