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School of Pharmacy : Wormser Uri


 Last updated Septmber 2023 - School of Pharmacy

List of Publications


Wormser U, Mandrioli J, Vinceti M, Fini N, Sintov A, Brodsky B, et al. Reduced levels of alpha-1-antitrypsin in cerebrospinal fluid of amyotrophic lateral sclerosis patients: A novel approach for a potential treatment. Journal of Neuroinflammation [Internet]. 2016;13(1). Available from:


Wormser U, Finkelstein Y, Proscura E, Brodsky B, Aschner M. Chemical warfare agents [Internet]. Studies on Experimental Toxicology and Pharmacology. 2015. Available from:


Ophir A, Karakis I, Richter ED, Abarbanel JM, Wormser U, Aschner M, et al. An uncommon pattern of polyneuropathy induced by lifetime exposures to drift containing organophosphate pesticides. NeuroToxicology [Internet]. 2014;45:338–46. Available from:


Wormser U, Brodsky B, Milatovic D, Finkelstein Y, Farina M, Rocha JB, et al. Protective effect of a novel peptide against methylmercury-induced toxicity in rat primary astrocytes. NeuroToxicology [Internet]. 2012;33(4):763–8. Available from:


Shapira E, Proscura E, Brodsky B, Wormser U. Novel peptides as potential treatment of systemic lupus erythematosus. Lupus [Internet]. 2011;20(5):463–72. Available from:


Schussheim Y, Aschner M, Brodsky B, Proscura E, Erlanger-Rosengarten A, Feldman R, et al. Anti-inflammatory effects of peptide fragments of H2A histone and Oryza Sativa Japonica protein. Peptides [Internet]. 2011;32(1):125–30. Available from:


Berman T, Hochner-Celnikier D, Barr DB, Needham LL, Amitai Y, Wormser U, et al. Pesticide exposure among pregnant women in Jerusalem, Israel: Results of a pilot study. Environment International [Internet]. 2011;37(1):198–203. Available from:


Finkelstein Y, Milatovic D, Lazarovici P, Ophir A, Richter ED, Aschner M, et al. Peaceful use of disastrous neurotoxicants. NeuroToxicology [Internet]. 2010;31(5):608–20. Available from:


Shapira E, Brodsky B, Proscura E, Nyska A, Erlanger-Rosengarten A, Wormser U. Amelioration of experimental autoimmune encephalitis by novel peptides: Involvement of T regulatory cells. Journal of Autoimmunity [Internet]. 2010;35(1):98–106. Available from:


Berman T, Hochner-Celnikier D, Calafat AM, Needham LL, Amitai Y, Wormser U, et al. Phthalate exposure among pregnant women in Jerusalem, Israel: Results of a pilot study. Environment International [Internet]. 2009;35(2):353–7. Available from:


Brodsky B, Erlanger-Rosengarten A, Proscura E, Shapira E, Wormser U. From topical antidote against skin irritants to a novel counter-irritating and anti-inflammatory peptide. Toxicology and Applied Pharmacology [Internet]. 2008;229(3):342–50. Available from:


Sintov AC, Wormser U. Topical iodine facilitates transdermal delivery of insulin. Journal of Controlled Release [Internet]. 2007;118(2):185–8. Available from:


Brodsky B, Wormser U. Protection from toxicants. Current Problems in Dermatology [Internet]. 2007;34:76–86. Available from:


Berman-Shlomovich T, Wormser U, Brodsky B. Toxic serum factor long after single exposure to organophosphate; a new approach for biomonitoring. Archives of Toxicology [Internet]. 2006;80(5):269–74. Available from:


Tam A, Shemesh M, Wormser U, Sintov A, Steinberg D. Effect of different iodine formulations on the expression and activity of Streptococcus mutans glucosyltransferase and fructosyltransferase in biofilm and planktonic environments. Journal of Antimicrobial Chemotherapy [Internet]. 2006;57(5):865–71. Available from:


Brodsky B, Trivedi S, Peddada S, Flagler N, Wormser U, Nyska A. Early effects of iodine on DNA synthesis in sulfur mustard-induced skin lesions. Archives of Toxicology [Internet]. 2006;80(4):212–6. Available from:


Wormser U, Brodsky B, Proscura E, Foley JF, Jones T, Nyska A. Involvement of tumor necrosis factor-α in sulfur mustard-induced skin lesion; effect of topical iodine. Archives of Toxicology [Internet]. 2005;79(11):660–70. Available from:


Ben-Shabat S, Benisty R, Wormser U, Sintov AC. Vitamin D3-based conjugates for topical treatment of psoriasis: Synthesis, antiproliferative activity, and cutaneous penetration studies. Pharmaceutical Research [Internet]. 2005;22(1):50–7. Available from:


Wormser U, Izrael M, Van Der Zee EA, Brodsky B, Yanai J. A chick model for the mechanisms of mustard gas neurobehavioral teratogenicity. Neurotoxicology and Teratology [Internet]. 2005;27(1):65–71. Available from:


Wormser U, Langenbach R, Peddada S, Sintov A, Brodsky B, Nyska A. Reduced sulfur mustard-induced skin toxicity in cyclooxygenase-2 knockout and celecoxib-treated mice. Toxicology and Applied Pharmacology [Internet]. 2004;200(1):40–7. Available from:


Wormser U, Sintov A, Brodsky B, Casillas RP, Nyska A. Protective effect of topical iodine containing anti-inflammatory drugs against sulfur mustard-induced skin lesions. Archives of Toxicology [Internet]. 2004;78(3):156–66. Available from:


Kohen R, Oron M, Zelkowicz A, Kanevsky E, Farfouri S, Wormser U. Low molecular weight antioxidants released from the skin’s epidermal layers: An age dependent phenomenon in the rat. Experimental Gerontology [Internet]. 2004;39(1):67–72. Available from:


Finkelstein Y, Shnaider H, Wormser U. Ammonia and ammonium salts: Remedy and poison, myth and time honored reality. Harefuah [Internet]. 2003;142(4):301-303+316. Available from:


Wormser U, Brodsky B, Sintov A. Skin toxicokinetics of mustard gas in the guinea pig: Effect of hypochlorite and safety aspects. Archives of Toxicology [Internet]. 2002;76(9):517–22. Available from:


Wormser U, Sintov A, Brodsky B, Amitai Y, Nyska A. Protective effect of topical iodine preparations upon heat-induced and hydrofluoric acid-induced skin lesions. Toxicologic Pathology [Internet]. 2002;30(5):552–8. Available from:


Wormser U, Brodsky B, Reich R. Topical treatment with povidone iodine reduces nitrogen mustard-induced skin collagenolytic activity. Archives of Toxicology [Internet]. 2002;76(2):119–21. Available from:


Nyska A, Lomnitski L, Maronpot R, Moomaw C, Brodsky B, Sintov A, et al. Effects of iodine on inducible nitric oxide synthase and cyclooxygenase-2 expression in sulfur mustard-induced skin injury in guinea pigs. Archives of Toxicology [Internet]. 2001;74(12):768–74. Available from:


Wormser U, Brodsky B, Green BS, Arad-Yellin R, Nyska A. Intervention of sulfur mustard toxicity by downregulation of cell proliferation and metabolic rates. Journal of Applied Toxicology [Internet]. 2001;21(SUPPL. 1):S87–91. Available from:


Wormser U, Sintov A, Brodsky B, Nyska A. Topical iodine preparation as therapy against sulfur mustard-induced skin lesions. Toxicology and Applied Pharmacology [Internet]. 2000;169(1):33–9. Available from:


Wormser U, Brodsky B, Green BS, Arad-Yellin R, Nyska A. Protective effect of povidone iodine ointment against skin lesions induced by chemical and thermal stimuli. Journal of Applied Toxicology [Internet]. 2000;20(SUPPL. 1):S183–5. Available from:


Wormser U, Shoham S, Brodsky B. Release of amino acids, fluorescamine-reactive substances and substance P from the epidermis of the living animal. Skin Pharmacology and Applied Skin Physiology [Internet]. 1999;12(1–2):98–104. Available from:


Wormser U, Raibstein I, Kritzler JS, Nyska A. High-molecular weight serum cytotoxic factor in rats treated with triphenyl phosphite: An approach for biological monitoring. Journal of Pharmacological and Toxicological Methods [Internet]. 1998;39(4):241–3. Available from:


Wormser U, Brodsky B, Moor EV, Eldad A, Gal R, Nyska A, et al. Skin surface proteolytic activity: Partial characterization and identification. Advances in Experimental Medicine and Biology [Internet]. 1998;436:207–12. Available from:


Wormser U. Early topical treatment with povidone-iodine oitment reduces, and sometimes prevents, skin damage following heat stimulus [1]. Burns [Internet]. 1998;24(4):383. Available from:


Wormser U, Kohen R, Moor EV, Eldad A, Gal R, Nyska A, et al. Noninvasive procedure for in situ determination of skin surface aspartic proteinase activity in animals; Implications for human skin. Archives of Dermatological Research [Internet]. 1997;289(12):686–91. Available from:


Wormser U, Brodsky B, Green BS, Arad-Yellin R, Nyska A. Protective effect of povidone-iodine ointment against skin lesions induced by sulphur and nitrogen mustards and by non-mustard vesicants. Archives of Toxicology [Internet]. 1997;71(3):165–70. Available from:


Wormser U, Shatz I, Furth M. A new approach for evaluation of human exposure to environmental hazardous agents: a preliminary study. Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine [Internet]. 1997;39(4):285–6. Available from:


Wormser U, Weisman Y, Ashash E, Nyska A. In vitro cytotoxicity of sera of paralysed ostriches showing serological positivity for Borna disease virus. Veterinary Record [Internet]. 1996;138(17):418–9. Available from:


Wormser U, Green BS, Arad-Yellin R, Brodsky B, Shatz I, Nyska A. In vivo and in vitro toxicity of newly synthesized Monofunctional sulfur mustard derivatives. Toxicology [Internet]. 1996;108(1–2):125–8. Available from:


Nyska A, Waner T, Wormser U, Gur E, Kuttin E, Dayan D. Possible pitfalls in rat extended dermal toxicity testing: An hepatic-ocular syndrome. Archives of Toxicology [Internet]. 1992;66(5):339–46. Available from:


Wormser U, Nyska A. Protective effect of O-phenanthroline against mechlorethamine toxicity in the rat liver slice system and in the guinea pig skin. Archives of Toxicology [Internet]. 1991;65(8):666–70. Available from:


Wormser U, BenZakine S, Nyska A. Hepatic and renal metallothionein induction in the rat and mouse after treatment with furosemide. Biochemistry International [Internet]. 1991;23(2):419–28. Available from:


Wormser U, BenZakine S. Increased levels of hepatic and renal metallothionein in the rat and guinea pig after percutaneous application of zinc chloride. Bulletin of Environmental Contamination and Toxicology [Internet]. 1991;46(2):249–54. Available from:


Wormser U, Ben-Zakine S. The mouse liver slice system as an in vitro model for testing the protective effect of n-acetylcysteine against hepatotoxic agents. Toxicology Mechanisms and Methods [Internet]. 1991;1(1):66–74. Available from:


Wormser U. Toxicology of mustard gas. Trends in Pharmacological Sciences [Internet]. 1991;12(C):164–7. Available from:


Wormser U, Ben Zakine S, Nyska A. Cadmium-induced metallothionein synthesis in the rat liver slice system. Toxicology in Vitro [Internet]. 1990;4(6):791–4. Available from:


Wormser U, Ben Zakine S, Stivelband E, Eizen O, Nyska A. The liver slice system: A rapid in vitro acute toxicity test for primary screening of hepatotoxic agents. Toxicology in Vitro [Internet]. 1990;4(6):783–9. Available from:


Wormser U, Laufer R, Chorev M, Gilon C, Selinger Z. Proteolytic resistance and biological activity of N-methylated analogs of [pGlu6] substance P6-11. Neuropeptides [Internet]. 1990;16(1):41–9. Available from:


Wormser U, Ben-Zakine S. The liver slice system: An in vitro acute toxicity test for assessment of hepatotoxins and their antidotes. Toxicology in Vitro [Internet]. 1990;4(4–5):449–51. Available from:


Wormser U, Ben-Zakine S. Protective effect of zinc against hepatotoxic agents in the rat liver slice system: Role of metallothionein. Archives of Toxicology [Internet]. 1989;63(SUPPL. 13):316–8. Available from:


Wormser U, Calp D. Increased levels of hepatic metallothionein in rat and mouse after injection of acetaminophen. Toxicology [Internet]. 1988;53(2–3):323–9. Available from:


Wormser U, Nir I. Effect of age on cadmium-induced metallothionein synthesis in the rat. Archives of Toxicology [Internet]. 1988;62(5):392–4. Available from:


Wormser U, Calp D. Metallothionein induction by cadmium and zinc in rat secretory organs. Experientia [Internet]. 1988;44(9):754–5. Available from:


Wormser U, Calp D. Induction of hepatic metallothionein following acetaminophen administration. Archives of Toxicology [Internet]. 1988;62(SUPPL. 12):375–7. Available from:


Chorev M, Rubini E, Hart Y, Gilon C, Wormser U, Selinger Z. Metabolically stable analogues of substance P: Persistent action of partially modified retro-inverso analogues of substance P on rat parotid and hypothalamic slices. European Journal of Pharmacology [Internet]. 1986;127(3):187–95. Available from:


Wormser U, Zbinden G. Quantitative and qualitative changes of serum proteolytic activity in rats with liver damage induced by galactosamine. Archives of Toxicology [Internet]. 1986;59(2):111–4. Available from:


Wormser U, Laufer R, Hart Y, Chorev M, Gilon C, Selinger Z. Highly selective agonists for substance P receptor subtypes. The EMBO journal [Internet]. 1986;5(11):2805–8. Available from:


Chorev M, Yaion M, Wormser U. Partially modified retro-inverso peptides analogs: [pGlu6, Phe7ψ(NH-CO)Phe8]substance P (6-11), synthesis and biological activity. European Journal of Medicinal Chemistry [Internet]. 1986;21(2):96–102. Available from:


Laufer R, Wormser U, Friedman ZY, Gilon C, Chorev M, Selinger Z. Neurokinin B is a preferred agonist for a neuronal substance P receptor and its action is antagonized by enkephalin. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 1985;82(21):7444–8. Available from:


Friedman ZY, Wormser U, Rubini E, Chorev M, Gilon C, Selinger Z. Desensitization of substance P-induced K+ release in rat parotid. European Journal of Pharmacology [Internet]. 1985;117(3):323–8. Available from:


Wormser U, Zbinden G. Characterization of proteolytic systems in human and rat urine. Biochemical and Biophysical Research Communications [Internet]. 1985;127(1):191–7. Available from:


Wormser U, Chorev M, Gilon C, Laufer R, Friedman ZY, Selinger Z. Substance P degrading systems of rat parotid and hypothalamus. BBA - General Subjects [Internet]. 1984;798(1):28–36. Available from:


Laufer R, Wormser U, Selinger Z, Chorev M, Gilon C. Ion-exchange chromatographic assay of peptidases acting on the C-terminal hexapeptide sequence of substance P. Journal of Chromatography A [Internet]. 1984;301(C):415–24. Available from:


Chorev M, Rubini E, Gilon C, Wormser U, Selinger Z. Synthesis of Partially Modified Retro-Inverso Substance P Analogues and Their Biological Activity. Journal of Medicinal Chemistry [Internet]. 1983;26(2):129–35. Available from:


Laufer R, Chorev M, Gilon C, Friedman ZY, Wormser U, Selinger Z. Persistent action of N-mthylated analogs of substance P on rat parotid slices. FEBS Letters [Internet]. 1981;123(2):291–4. Available from: