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School of Pharmacy : Wormser Uri

Researchers

 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Wormser U, Mandrioli J, Vinceti M, Fini N, Sintov A, Brodsky B, et al. Reduced levels of alpha-1-antitrypsin in cerebrospinal fluid of amyotrophic lateral sclerosis patients: A novel approach for a potential treatment. J Neuroinflamm 2016;13(1).

(2) Wormser U, Finkelstein Y, Proscura E, Brodsky B, Aschner M. Chemical warfare agents. Studies on Experimental Toxicology and Pharmacology; 2015. p. 369-379.

(3) Ophir A, Karakis I, Richter ED, Abarbanel JM, Wormser U, Aschner M, et al. An uncommon pattern of polyneuropathy induced by lifetime exposures to drift containing organophosphate pesticides. Neurotoxicology 2014;45:338-346.

(4) Wormser U, Brodsky B, Milatovic D, Finkelstein Y, Farina M, Rocha JB, et al. Protective effect of a novel peptide against methylmercury-induced toxicity in rat primary astrocytes. Neurotoxicology 2012;33(4):763-768.

(5) Shapira E, Proscura E, Brodsky B, Wormser U. Novel peptides as potential treatment of systemic lupus erythematosus. Lupus 2011;20(5):463-472.

(6) Berman T, Hochner-Celnikier D, Barr DB, Needham LL, Amitai Y, Wormser U, et al. Pesticide exposure among pregnant women in Jerusalem, Israel: Results of a pilot study. Environ Int 2011;37(1):198-203.

(7) Schussheim Y, Aschner M, Brodsky B, Proscura E, Erlanger-Rosengarten A, Feldman R, et al. Anti-inflammatory effects of peptide fragments of H2A histone and Oryza Sativa Japonica protein. Peptides 2011;32(1):125-130.

(8) Finkelstein Y, Milatovic D, Lazarovici P, Ophir A, Richter ED, Aschner M, et al. Peaceful use of disastrous neurotoxicants. Neurotoxicology 2010;31(5):608-620.

(9) Shapira E, Brodsky B, Proscura E, Nyska A, Erlanger-Rosengarten A, Wormser U. Amelioration of experimental autoimmune encephalitis by novel peptides: Involvement of T regulatory cells. J Autoimmun 2010;35(1):98-106.

(10) Berman T, Hochner-Celnikier D, Calafat AM, Needham LL, Amitai Y, Wormser U, et al. Phthalate exposure among pregnant women in Jerusalem, Israel: Results of a pilot study. Environ Int 2009;35(2):353-357.

(11) Brodsky B, Erlanger-Rosengarten A, Proscura E, Shapira E, Wormser U. From topical antidote against skin irritants to a novel counter-irritating and anti-inflammatory peptide. Toxicol Appl Pharmacol 2008;229(3):342-350.

(12) Sintov AC, Wormser U. Topical iodine facilitates transdermal delivery of insulin. J Control Release 2007;118(2):185-188.

(13) Brodsky B, Wormser U. Protection from toxicants. Curr Probl Dermatol 2007;34:76-86.

(14) Berman-Shlomovich T, Wormser U, Brodsky B. Toxic serum factor long after single exposure to organophosphate; a new approach for biomonitoring. Arch Toxicol 2006;80(5):269-274.

(15) Tam A, Shemesh M, Wormser U, Sintov A, Steinberg D. Effect of different iodine formulations on the expression and activity of Streptococcus mutans glucosyltransferase and fructosyltransferase in biofilm and planktonic environments. J Antimicrob Chemother 2006;57(5):865-871.

(16) Brodsky B, Trivedi S, Peddada S, Flagler N, Wormser U, Nyska A. Early effects of iodine on DNA synthesis in sulfur mustard-induced skin lesions. Arch Toxicol 2006;80(4):212-216.

(17) Wormser U, Brodsky B, Proscura E, Foley JF, Jones T, Nyska A. Involvement of tumor necrosis factor-α in sulfur mustard-induced skin lesion; effect of topical iodine. Arch Toxicol 2005;79(11):660-670.

(18) Ben-Shabat S, Benisty R, Wormser U, Sintov AC. Vitamin D3-based conjugates for topical treatment of psoriasis: Synthesis, antiproliferative activity, and cutaneous penetration studies. Pharm Res 2005;22(1):50-57.

(19) Wormser U, Izrael M, Van Der Zee EA, Brodsky B, Yanai J. A chick model for the mechanisms of mustard gas neurobehavioral teratogenicity. Neurotoxicol Teratol 2005;27(1):65-71.

(20) Wormser U, Langenbach R, Peddada S, Sintov A, Brodsky B, Nyska A. Reduced sulfur mustard-induced skin toxicity in cyclooxygenase-2 knockout and celecoxib-treated mice. Toxicol Appl Pharmacol 2004;200(1):40-47.

(21) Wormser U, Sintov A, Brodsky B, Casillas RP, Nyska A. Protective effect of topical iodine containing anti-inflammatory drugs against sulfur mustard-induced skin lesions. Arch Toxicol 2004;78(3):156-166.

(22) Kohen R, Oron M, Zelkowicz A, Kanevsky E, Farfouri S, Wormser U. Low molecular weight antioxidants released from the skin's epidermal layers: An age dependent phenomenon in the rat. Exp Gerontol 2004;39(1):67-72.

(23) Finkelstein Y, Shnaider H, Wormser U. Ammonia and ammonium salts: Remedy and poison, myth and time honored reality. Harefuah 2003;142(4):301-303+316.

(24) Wormser U, Brodsky B, Sintov A. Skin toxicokinetics of mustard gas in the guinea pig: Effect of hypochlorite and safety aspects. Arch Toxicol 2002;76(9):517-522.

(25) Wormser U, Sintov A, Brodsky B, Amitai Y, Nyska A. Protective effect of topical iodine preparations upon heat-induced and hydrofluoric acid-induced skin lesions. Toxicol Pathol 2002;30(5):552-558.

(26) Wormser U, Brodsky B, Reich R. Topical treatment with povidone iodine reduces nitrogen mustard-induced skin collagenolytic activity. Arch Toxicol 2002;76(2):119-121.

(27) Nyska A, Lomnitski L, Maronpot R, Moomaw C, Brodsky B, Sintov A, et al. Effects of iodine on inducible nitric oxide synthase and cyclooxygenase-2 expression in sulfur mustard-induced skin injury in guinea pigs. Arch Toxicol 2001;74(12):768-774.

(28) Wormser U, Brodsky B, Green BS, Arad-Yellin R, Nyska A. Intervention of sulfur mustard toxicity by downregulation of cell proliferation and metabolic rates. J Appl Toxicol 2001;21(SUPPL. 1):S87-S91.

(29) Wormser U, Sintov A, Brodsky B, Nyska A. Topical iodine preparation as therapy against sulfur mustard-induced skin lesions. Toxicol Appl Pharmacol 2000;169(1):33-39.

(30) Wormser U, Brodsky B, Green BS, Arad-Yellin R, Nyska A. Protective effect of povidone iodine ointment against skin lesions induced by chemical and thermal stimuli. J Appl Toxicol 2000;20(SUPPL. 1):S183-S185.

(31) Wormser U, Shoham S, Brodsky B. Release of amino acids, fluorescamine-reactive substances and substance P from the epidermis of the living animal. Skin Pharmacol Appl Skin Physiol 1999;12(1-2):98-104.

(32) Wormser U, Raibstein I, Kritzler JS, Nyska A. High-molecular weight serum cytotoxic factor in rats treated with triphenyl phosphite: An approach for biological monitoring. J Pharmacol Toxicol Methods 1998;39(4):241-243.

(33) Wormser U. Early topical treatment with povidone-iodine oitment reduces, and sometimes prevents, skin damage following heat stimulus [1]. Burns 1998;24(4):383.

(34) Wormser U, Brodsky B, Moor EV, Eldad A, Gal R, Nyska A, et al. Skin surface proteolytic activity: Partial characterization and identification. Adv Exp Med Biol 1998;436:207-212.

(35) Wormser U, Kohen R, Moor EV, Eldad A, Gal R, Nyska A, et al. Noninvasive procedure for in situ determination of skin surface aspartic proteinase activity in animals; Implications for human skin. Arch Dermatol Res 1997;289(12):686-691.

(36) Wormser U, Brodsky B, Green BS, Arad-Yellin R, Nyska A. Protective effect of povidone-iodine ointment against skin lesions induced by sulphur and nitrogen mustards and by non-mustard vesicants. Arch Toxicol 1997;71(3):165-170.

(37) Wormser U, Shatz I, Furth M. A new approach for evaluation of human exposure to environmental hazardous agents: a preliminary study. J Occup Environ Med 1997;39(4):285-286.

(38) Wormser U, Weisman Y, Ashash E, Nyska A. In vitro cytotoxicity of sera of paralysed ostriches showing serological positivity for Borna disease virus. Vet Rec 1996;138(17):418-419.

(39) Wormser U, Green BS, Arad-Yellin R, Brodsky B, Shatz I, Nyska A. In vivo and in vitro toxicity of newly synthesized Monofunctional sulfur mustard derivatives. Toxicology 1996;108(1-2):125-128.

(40) Nyska A, Waner T, Wormser U, Gur E, Kuttin E, Dayan D. Possible pitfalls in rat extended dermal toxicity testing: An hepatic-ocular syndrome. Arch Toxicol 1992;66(5):339-346.

(41) Wormser U, Nyska A. Protective effect of O-phenanthroline against mechlorethamine toxicity in the rat liver slice system and in the guinea pig skin. Arch Toxicol 1991;65(8):666-670.

(42) Wormser U, BenZakine S, Nyska A. Hepatic and renal metallothionein induction in the rat and mouse after treatment with furosemide. Biochem Int 1991;23(2):419-428.

(43) Wormser U, BenZakine S. Increased levels of hepatic and renal metallothionein in the rat and guinea pig after percutaneous application of zinc chloride. Bull Environ Contam Toxicol 1991;46(2):249-254.

(44) Wormser U. Toxicology of mustard gas. Trends Pharmacol Sci 1991;12(C):164-167.

(45) Wormser U, Ben-Zakine S. The mouse liver slice system as an in vitro model for testing the protective effect of n-acetylcysteine against hepatotoxic agents. Toxicol Mechan Methods 1991;1(1):66-74.

(46) Wormser U, Ben-Zakine S. The liver slice system: An in vitro acute toxicity test for assessment of hepatotoxins and their antidotes. Toxicol Vitro 1990;4(4-5):449-451.

(47) Wormser U, Ben Zakine S, Nyska A. Cadmium-induced metallothionein synthesis in the rat liver slice system. Toxicol Vitro 1990;4(6):791-794.

(48) Wormser U, Ben Zakine S, Stivelband E, Eizen O, Nyska A. The liver slice system: A rapid in vitro acute toxicity test for primary screening of hepatotoxic agents. Toxicol Vitro 1990;4(6):783-789.

(49) Wormser U, Laufer R, Chorev M, Gilon C, Selinger Z. Proteolytic resistance and biological activity of N-methylated analogs of [pGlu6] substance P6-11. Neuropeptides 1990;16(1):41-49.

(50) Wormser U, Ben-Zakine S. Protective effect of zinc against hepatotoxic agents in the rat liver slice system: Role of metallothionein. Arch Toxicol 1989;63(SUPPL. 13):316-318.

(51) Wormser U, Calp D. Increased levels of hepatic metallothionein in rat and mouse after injection of acetaminophen. Toxicology 1988;53(2-3):323-329.

(52) Wormser U, Nir I. Effect of age on cadmium-induced metallothionein synthesis in the rat. Arch Toxicol 1988;62(5):392-394.

(53) Wormser U, Calp D. Metallothionein induction by cadmium and zinc in rat secretory organs. Experientia 1988;44(9):754-755.

(54) Wormser U, Calp D. Induction of hepatic metallothionein following acetaminophen administration. Arch Toxicol 1988;62(SUPPL. 12):375-377.

(55) Chorev M, Rubini E, Hart Y, Gilon C, Wormser U, Selinger Z. Metabolically stable analogues of substance P: Persistent action of partially modified retro-inverso analogues of substance P on rat parotid and hypothalamic slices. Eur J Pharmacol 1986;127(3):187-195.

(56) Wormser U, Zbinden G. Quantitative and qualitative changes of serum proteolytic activity in rats with liver damage induced by galactosamine. Arch Toxicol 1986;59(2):111-114.

(57) Chorev M, Yaion M, Wormser U. Partially modified retro-inverso peptides analogs: [pGlu6, Phe7ψ(NH-CO)Phe8]substance P (6-11), synthesis and biological activity. Eur J Med Chem 1986;21(2):96-102.

(58) Wormser U, Laufer R, Hart Y, Chorev M, Gilon C, Selinger Z. Highly selective agonists for substance P receptor subtypes. EMBO J 1986;5(11):2805-2808.

(59) Laufer R, Wormser U, Friedman ZY, Gilon C, Chorev M, Selinger Z. Neurokinin B is a preferred agonist for a neuronal substance P receptor and its action is antagonized by enkephalin. Proc Natl Acad Sci U S A 1985;82(21):7444-7448.

(60) Friedman ZY, Wormser U, Rubini E, Chorev M, Gilon C, Selinger Z. Desensitization of substance P-induced K+ release in rat parotid. Eur J Pharmacol 1985;117(3):323-328.

(61) Wormser U, Zbinden G. Characterization of proteolytic systems in human and rat urine. Biochem Biophys Res Commun 1985;127(1):191-197.

(62) Wormser U, Chorev M, Gilon C, Laufer R, Friedman ZY, Selinger Z. Substance P degrading systems of rat parotid and hypothalamus. Biochim Biophys Acta Gen Subj 1984;798(1):28-36.

(63) Laufer R, Wormser U, Selinger Z, Chorev M, Gilon C. Ion-exchange chromatographic assay of peptidases acting on the C-terminal hexapeptide sequence of substance P. J Chromatogr A 1984;301(C):415-424.

(64) Chorev M, Rubini E, Gilon C, Wormser U, Selinger Z. Synthesis of Partially Modified Retro-Inverso Substance P Analogues and Their Biological Activity. J Med Chem 1983;26(2):129-135.

(65) Laufer R, Chorev M, Gilon C, Friedman ZY, Wormser U, Selinger Z. Persistent action of N-mthylated analogs of substance P on rat parotid slices. FEBS Lett 1981;123(2):291-294.