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School of Pharmacy : Ringel Israel

Researchers

 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Shemesh A, Ginsburg A, Levi-Kalisman Y, Ringel I, Raviv U. Structure, Assembly, and Disassembly of Tubulin Single Rings. Biochemistry 2018;57(43):6153-6165.

(2) Ginsburg A, Shemesh A, Millgram A, Dharan R, Levi-Kalisman Y, Ringel I, et al. Structure of Dynamic, Taxol-Stabilized, and GMPPCP-Stabilized Microtubule. J Phys Chem B 2017;121(36):8427-8436.

(3) Ginsburg A, Ben-Nun T, Asor R, Shemesh A, Ringel I, Raviv U. Reciprocal Grids: A Hierarchical Algorithm for Computing Solution X-ray Scattering Curves from Supramolecular Complexes at High Resolution. J Chem Inf Model 2016;56(8):1518-1527.

(4) Abramov Y, Carmi S, Anteby SO, Ringel I. Characterization of ovarian cancer cell metabolism and response to chemotherapy by 31P magnetic resonance spectroscopy. Oncol Res 2013;20(11):529-536.

(5) Abramov Y, Carmi S, Anteby SO, Ringel I. Ex vivo 1H and 31P magnetic resonance spectroscopy as a means for tumor characterization in ovarian cancer patients. Oncol Rep 2013;29(1):321-328.

(6) Freikman I, Ringel I, Fibach E. Shedding of phosphatidylserine from developing erythroid cells involves microtubule depolymerization and affects membrane lipid composition. J Membr Biol 2012;245(12):779-787.

(7) Abramov Y, Carmi S, Cohen JS, Anteby SO, Ringel I. 31P-Magnetic resonance spectra of ovarian cancer cells exposed to chemotherapy within a three-dimensional Matrigel construct. Oncol Rep 2012;28(2):735-741.

(8) Kolevzon N, Kuflik U, Shmuel M, Benhamron S, Ringel I, Yavin E. Multiple triphenylphosphonium cations as a platform for the delivery of a pro-apoptotic peptide. Pharm Res 2011;28(11):2780-2789.

(9) Freikman I, Ringel I, Fibach E. Oxidative stress-induced membrane shedding from RBCs is Ca flux-mediated and affects membrane lipid composition. J Membr Biol 2011;240(2):73-82.

(10) Freikman I, Amer J, Ringel I, Fibach E. A flow cytometry approach for quantitative analysis of cellular phosphatidylserine distribution and shedding. Anal Biochem 2009;393(1):111-116.

(11) Abu-Gosh SE, Kolvazon N, Tirosh B, Ringel I, Yavin E. Multiple triphenylphosphonium cations shuttle a hydrophilic peptide into mitochondria. Mol Pharm 2009;6(4):1138-1144.

(12) Goldfinger M, Laviad EL, Hadar R, Shmuel M, Dagan A, Park H, et al. De novo ceramide synthesis is required for n-linked glycosylation in plasma cells. J Immunol 2009;182(11):7038-7047.

(13) Ringel I, Lecht S, Sterin M, Lelkes PI, Lazarovici P. 31P magnetic resonance spectroscopy of endothelial cells grown in three-dimensional matrigel construct as an enabling platform technology: II. The effect of anti-inflammatory drugs on phosphometabolite levels. Endothelium J Endothelial Cell Res 2008;15(5-6):299-307.

(14) Sterin M, Ringel I, Lecht S, Lelkes PI, Lazarovici P. 31P magnetic resonance spectroscopy of endothelial cells grown in three-dimensional matrigel construct as an enabling platform technology: I. The effect of glial cells and valporic acid on phosphometabolite levels. Endothelium J Endothelial Cell Res 2008;15(5-6):288-298.

(15) Freikman I, Amer J, Cohen JS, Ringel I, Fibach E. Oxidative stress causes membrane phospholipid rearrangement and shedding from RBC membranes-An NMR study. Biochim Biophys Acta Biomembr 2008;1778(10):2388-2394.

(16) Muhlrad A, Ringel I, Pavlov D, Peyser TM, Reisler E. Antagonistic effects of cofilin, beryllium fluoride complex, and phalloidin on subdomain 2 and nucleotide-binding cleft in F-actin. Biophys J 2006;91(12):4490-4499.

(17) Sterin M, Cohen JS, Ringel I. Hormone sensitivity is reflected in the phospholipid profiles of breast cancer cell lines. Breast Cancer Res Treat 2004;87(1):1-11.

(18) Cohen JS, Motiei M, Carmi S, Shiperto D, Yefet O, Ringel I. Determination of Intracellular pH and Compartmentation Using Diffusion-Weighted NMR Spectroscopy with pH-Sensitive Indicators. Magn Reson Med 2004;51(5):900-903.

(19) Sterin M, Ringel I, Ringel I, Berman E, Cohen JS, Mardor Y. Levels of phospholipid metabolites in breast cancer cells treated with antimitotic drugs: A 31P-magnetic resonance spectroscopy study. Cancer Res 2001;61(20):7536-7543.

(20) Mardor Y, Kaplan O, Sterin M, Ruiz-Cabello J, Ash E, Roth Y, et al. Noninvasive real-time monitoring of intracellular cancer cell metabolism and response to lonidmnine treatment using diffusion weighted proton magnetic resonance spectroscopy. Cancer Res 2000;60(18):5179-5186.

(21) Epstein E, Sela-Brown A, Ringel I, Kilav R, King SM, Benashski SE, et al. Dynein light chain binding to a 3'-untranslated sequence mediates parathyroid hormone mRNA association with microtubules. J Clin Invest 2000;105(4):505-512.

(22) Barasch D, Zipori O, Ringel I, Ginsburg I, Samuni A, Katzhendler J. Novel anthraquinone derivatives with redox-active functional groups capable of producing free radicals by metabolism: Are free radicals essential for cytotoxicity? Eur J Med Chem 1999;34(7-8):597-615.

(23) Gorodetsky R, Levdansky L, Ringel I, Vexler A. Paclitaxel-induced modification of the effects of radiation and alterations in the cell cycle in normal and tumor mammalian cells. Radiat Res 1998;150(3):283-291.

(24) Moyna G, Williams HJ, Scott AI, Ringel I, Gorodetsky R, Swindell CS. Conformational studies of paclitaxel analogs modified at the C-2' position in hydrophobic and hydrophilic solvent systems. J Med Chem 1997;40(20):3305-3311.

(25) Nativ O, Aronson M, Medalia O, Moldavsky T, Sabo E, Ringel I, et al. Anti-neoplastic activity of paclitaxel on experimental superficial bladder cancer: In vivo and in vitro studies. Int J Cancer 1997;70(3):297-301.

(26) Katzhendler J, Ringel I, Karaman R, Zaher H, Breuer E. Acylphosphonate hemiketals - Formation rate and equilibrium. The electron-withdrawing effect of dimethoxyphosphinyl group. J Chem Soc Perkin Trans 2 1997(2):341-349.

(27) Gibson D, Binyamin I, Haj M, Ringel I, Ramu A, Katzhendler J. Anthraquinone intercalators as carrier molecules for second-generation platinum anticancer drugs. Eur J Med Chem 1997;32(10):823-831.

(28) Photodynamic activity of porphines on tubulin assembly. Proceedings of SPIE - The International Society for Optical Engineering; 1996.

(29) Muhlrad A, Ringel I. Use of vanadate-induced photocleavage for detecting phosphate binding sites in proteins. Met Ions Biol Syst 1995;31:211-230.

(30) Elisha Z, Havin L, Ringel I, K.yisraeli J. Vg1 RNA binding protein mediates the association of Vg1 RNA with microtubules in Xenopus oocytes. EMBO J 1995;14(20):5109-5114.

(31) Doungdee P, Sarel S, Ringel I, Gibson D, Wongvisetsirikul N, Avramovici-Grisaru S. Iron chelators of the pyridoxal 2-pyridyl hydrazone class. part III.1 Ionisation and conformational characteristics of the ligands. Heterocycles 1995;40(1):241-248.

(32) Rao S, Krauss NE, Heerding JM, Swindell CS, Ringel I, Orr GA, et al. 3'-(p-Azidobenzamido)taxol photolabels the N-terminal 31 amino acids of β-tubulin. J Biol Chem 1994;269(5):3132-3134.

(33) Swindell CS, Heerding JM, Krauss NE, Horwitz SB, Ringel I. Characterization of the taxol structure-activity profile for the locus of the A-ring side chain. Bioorg Med Chem Lett 1994;4(12):1531-1536.

(34) Swindell CS, Heerding JM, Krauss NE, Horwitz SB, Rao S, Ringel I. Characterization of Two Taxol Photoaffinity Analogues Bearing Azide and Benzophenone-Related Photoreactive Substituents in the A-Ring Side Chain. J Med Chem 1994;37(10):1446-1449.

(35) Domb AJ, Ringel I. Polymeric Drug Carrier Systems in the Brain. Methods Neurosci 1994;21(C):169-183.

(36) Rasouly D, Rahamim E, Ringel I, Ginzburg I, Muarakata C, Matsuda Y, et al. Neurites induced by staurosporine in PC12 cells are resistant to colchicine and express high levels of tau proteins. Mol Pharmacol 1994;45(1):29-35.

(37) Horwitz SB, Cohen D, Rao S, Ringel I, Shen HJ, Yang CP. Taxol: mechanisms of action and resistance. J Natl Cancer Inst Monographs 1993(15):55-61.

(38) Carboni JM, Farina V, Rao S, Hauck SI, Horwitz SB, Ringel I. Synthesis of a Photoaffinity Analog of Taxol as an Approach To Identify the Taxol Binding Site on Microtubules. J Med Chem 1993;36(4):513-515.

(39) Rao S, Horwitz SB, Ringel I. Direct photoaffinity labeling of tubulin with taxol. J Natl Cancer Inst 1992;84(10):785-788.

(40) Ringel I, Horwitz SB. Effect of alkaline pH on taxol-microtubule interactions. J Pharmacol Exp Ther 1991;259(2):855-860.

(41) Ringel I, Jaffe D, Alerhand S, Boye O, Muzaffar A, Brossi A. Fluorinated Colchicinoids: Antitubulin and Cytotoxic Properties. J Med Chem 1991;34(11):3334-3338.

(42) Osei AA, Everett GW, Ringel I, Himes RH. The interaction of [13C]-enriched colchicine with tubulin as determined by NMR spectroscopy. Biochim Biophys Acta Protein Struct Mol Enzymol 1991;1078(3):339-344.

(43) Swindell CS, Krauss NE, Horwitz SB, Ringel I. Biologically Active Taxol Analogues with Deleted A-Ring Side Chain Substituents and Variable C-2′ Configurations. J Med Chem 1991;34(3):1176-1184.

(44) Ringel I, Horwitz SB. Studies with RP 56976 (taxotere): A semisynthetic analogue of taxol. J Natl Cancer Inst 1991;83(4):288-291.

(45) Muhlrad A, Michael Peyser Y, Ringel I. Effect of Actin, ATP, Phosphates, and pH on Vanadate-Induced Photocleavage of Myosin Subfragment 1. Biochemistry 1991;30(4):958-965.

(46) MUHLRAD A, PEYSER YM, RINGEL I. Effects of ions on vanadate‐induced photocleavage of myosin subfragment 1. Eur J Biochem 1991;201(2):409-415.

(47) Gibson D, Gean K-, Ben-Shoshan R, Katzhendler J, Ramu A, Ringel I. Preparation, Characterization, and Anticancer Activity of a Series of cis-PtCl2 Complexes Linked to Anthraquinone Intercalators. J Med Chem 1991;34(1):414-420.

(48) Gean K, Ben-Shoshan R, Ramu A, Ringel I, Katzhendler J, Gibson D. Preparation, characterization and the anticancer activity of a novel series of triaminemonochloroplatinum(II) cations linked to anthraquinone intercalators. Eur J Med Chem 1991;26(6):593-598.

(49) Ringel I, Peyser YM, Muhlrad A. 51V NMR Study of Vanadate Binding to Myosin and Its Subfragment 1. Biochemistry 1990;29(38):9091-9096.

(50) Katzhendler J, Ringel I, Goldblum A, Gibson D, Tashma Z. Conformational studies of substituted five-membered cyclic carbonates and related compounds by MNDO, and the X-ray crystal structure of 4-chlorophenyloxymethyl-1,3-dioxolan-2-one. Journal of the Chemical Society, Perkin Transactions 2 1989(11):1729-1739.

(51) Katzhendler J, Cohen S, Rahamim E, Weisz M, Ringel I, Deutsch J. The effect of spacer, linkage and solid support on the synthesis of oligonucleotides. Tetrahedron 1989;45(9):2777-2792.

(52) Katzhendler J, Gean K-, Bar-Ad G, Tashma Z, Ben-Shoshan R, Ringel I, et al. Synthesis of aminoanthraquinone derivatives and their in vitro evaluation as potential anti-cancer drugs. Eur J Med Chem 1989;24(1):23-30.

(53) Katzhendler J, Bar-Ad G, Haran M, Gean KF, Tashma Z, Ringel I, et al. The effect of substituted aminoalkylaminoanthraquinones on eukaryotic cells. Drug Des Deliv 1989;4(4):289-294.

(54) Ringel I, Bakshi O, Mellado W, Ramu A, Gibson D, Katzhendler J. N-Alkyl colchiceineamides: their inhibition of GTP or taxol-induced assembly of tubulin. Biochem Pharmacol 1988;37(12):2487-2489.

(55) Katzhendler J, Goldblum A, Ringel I. Kinetic and theoretical considerations in the hydrolysis of iminocarbonates. Journal of the Chemical Society, Perkin Transactions 2 1988(9):1653-1660.

(56) Rav-Acha C, Ringel I, Sarel S, Katzhendler J. The catalytic effect of catiohic amino micelles on the hydrolysis of substituted phenyl esters. Tetrahedron 1988;44(18):5879-5892.

(57) Kitov S, Ben-Shoshan R, Ringel I, Gibson D, Katzhendler J. The effect of cis-platin analogues derived from aminoalkylaminoanthraquinones on DNA cleavage: an electron microscopy study. Eur J Med Chem 1988;23(4):381-383.

(58) Tashma Z, Deutsch J, Cohen S, Weisz M, Katzhendler J, Ringel I. An improved method for the preparation of methyl dichlorophosphite. A key reagent in the phosphite method of oligonucleotide synthesis. Nucleosides Nucleotides 1987;6(3):589-595.

(59) Ringel I, Horwitz SB. Taxol is converted to 7-epitaxol, a biologically active isomer, in cell culture medium. J Pharmacol Exp Ther 1987;242(2):692-698.

(60) Katzhendler J, Cohen S, Weisz M, Ringel I, Camerini-Oterio RD, Deutsch J. Spacer effect on the synthesis of oligodeoxynucleotides by the phosphite method. Reactive Polymers, Ion Exchangers, Sorbents 1987;6(2-3):175-187.

(61) Ringel I, Sternlicht H. Carbon-13 Nuclear Magnetic Resonance Study of Microtubule Protein: Evidence for a Second Colchicine Site Involved in the Inhibition of Microtubule Assembly. Biochemistry 1984;23(23):5644-5653.

(62) Sternlicht H, Ringel I, Szasz J. Theory for modeling the copolymerization of tubulin and tubulin-colchicine complex. Biophys J 1983;42(3):255-267.

(63) Sternlicht H, Ringel I, Szasz J. The co-polymerization of tubulin and tubulin chochicine complex in the absence and presence of associated proteins. J Biol Chem 1980;255(19):9138-9148.

(64) Sternlicht H, Ringel I, Szasz J. A kinetic model for colchicine inhibition of microtubule assembly. Biophys J 1980;32(1):445-448.

(65) Sternlicht H, Ringel I. Colchicine inhibition of microtubule assembly via copolymer formation. J Biol Chem 1979;254(20):10540-10550.

(66) Sarel S, Langbeheim M, Ringel I. Trieneiron tricarbonyl and bisallyldi-iron hexacarbonyl π-complexes from photolysis of divinylcyclopropanes induced by iron pentacarbonyl. Journal of the Chemical Society, Chemical Communications 1979(2):73-75.

(67) Sternlicht H, Ringel I, Szasz J. Colchicine inhibition of microtubule assembly via copolymer formation. J Cell Biol 1979;83(2 II).

(68) Sternlicht H, Ringel I, Szasz J, Burns R. Nuclear magnetic resonance studies of methylated tubulin and colchicine-tubulin binding. J Cell Biol 1979;83(2 II).

(69) Victor R, Ringel I. 1H and 13C n.m.r. study of butatriene‐bis‐tricarbonyliron complexes. Assignment of geometric orientation by comparative J(CCCH) values. Magn Reson Chem 1978;11(1):31-33.

(70) Sternlicht H, Ringel I. Colchicine inhibition of microtubule assembly. Fed Proc 1978;37(3).

(71) Sternlicht H, Ringel I. Colchicine inhibition of microtubule assembly. Fed Proc 1978;37(6).

(72) Breuer E, Somekh L, Ringel I. N.m.r. spectra of cyclic amines. II—Factors influencing the chemical shifts of α‐protons in aziridines. Magn Reson Chem 1977;9(6):328-332.

(73) Katzhendler J, Ringel I, Sarel S. Organic carbonates. Part XIV. Polar and steric effects of substituents influencing the modes of ring-opening of highly-branched ethylene and trimethylene carbonates by various nucleophiles: A nuclear magnetic resonance study. Journal of the Chemical Society, Perkin Transactions 2 1972(14):2019-2025.

(74) Lichtenberg D, Bergmann F, Ringel I. Assignment of individual signals of aromatic protons in the NMR spectrum of 6-substituted purines. Journal of Magnetic Resonance (1969) 1972;6(4):600-604.